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  • AbbreviationsHCC hepatocellular carcinoma  (1)
  • Age-hardening  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 126 (2000), S. 153-160 
    ISSN: 1432-1335
    Keywords: Key words Hepatocellular carcinoma ; Vascular endothelial growth factor ; Endothelial cells ; CD34 ; AbbreviationsHCC hepatocellular carcinoma ; VEGF vascular endothelial growth factor ; ALT alanine amino transferase ; TAE transcatheter arterial embolization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: Vascular endothelial growth factor (VEGF) has been reported to play an important role in angiogenesis in hepatocellular carcinoma (HCC). However, there is great variation in reports on the distribution of VEGF expression, especially in non-carcinoma liver cells. Furthermore, some reports have mentioned that endothelial cells were positive for VEGF antibody but have not evaluated its significance. In this study, we focused our attention to these problems and try to solve them. We also analyzed the factors influencing VEGF expression and evaluated the prognostic potential of VEGF protein in HCC. Methods: We examined the VEGF expression in specimens surgically removed from 46 HCC patients and 3 patients with liver cancer metastatic from the colon, and in 4 specimens of liver tissue with benign disease, by immunohistochemical methods. Results/conclusions: VEGF was expressed in HCC cells and hepatocytes and on vascular endothelial cells. Our finding that about seven times more endothelial cells were positive for VEGF antibody in carcinoma areas than in non-carcinoma areas (P 〈 0.001) suggests that VEGF is a very important angiogenesis factor for HCC growth. VEGF expression in HCC cells and non-carcinoma liver cells and on endothelial cells did not closely correlate with the disease recurrence rate (P 〉 0.05), suggesting that VEGF expression may not be useful as an individual factor for estimating the prognosis of HCC. A statistical analysis of the relationships between VEGF expression and clinicopathological variables revealed the following: preoperative transcatheter arterial embolization enhanced VEGF expression in both HCC cells and non-carcinoma liver cells. The histological grade of HCC and the level of alanine aminotransferase was related to VEGF expression in non-carcinoma liver cells and on endothelial cells in HCC areas. Tumor size and the histological status of the accompanying chronic hepatitis also influenced the VEGF expression on endothelial cells. Our findings concerning not only HCC but also the surrounding liver and endothelial cells may provide useful information for further research on the role of VEGF expression in HCC patients.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-1536
    Keywords: Neutron Scattering ; Small-angle Scattering ; Al-Zn Alloys ; Guinier-Preston zone ; Age-hardening
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Zusammenfassung Die Kleinwinkelstreuung der Neutronen von A1-6.8 at % Zn und Al-6.8 at % Zn- 0.1 at % Mg-Legierungen während der Guinier-Preston-Zonen-Bildung wurde am KUR (Kyoto Universität Reaktor) gemessen. Die Proben wurden aus 300 °C in Salzwasser von — 20 °C abgeschreckt und bei 77 K gehalten. Sie wurden bei 40 °C während der verschiedenen Zeitdauer von 0 bis 1000 Minuten mit der nachfolgenden Neutronenmessung bei 77 K gealtert. Die gemessene zeitliche Entwicklung des Streuquerschnittes kann qualitativ erklärt werden in übereinstimmung mit Saitos Formel, die aus zwei verschiedenen Teilen besteht, die der inkohärenten anomalen Schwankung und der kohärenten geordneten Struktur der Konzentration entsprechen.
    Notes: Summary Small-angle neutron scattering from A1-6.8 at % Zn and Al-6.8 at % Zn-0.1 at % Mg alloys during Guinier-Preston zone formation have been measured at KUR (Kyoto University Reactor). The samples were quenched from 300 °C into brine at -20 °C and kept at 77 K. They were aged at 40 °C for various periods ranging from 0 up to 1000 minutes each with subsequent neutron measurement at 77 K. The observed temporal evolution of the cross section can be interpreted qualitatively in terms of Saito's formula which consists of two distinct parts due to the incoherent anomalous fluctuation and to the coherent ordered structure of the concentration.
    Type of Medium: Electronic Resource
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