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  • Column liquid chromatography  (6)
  • Allele frequency  (1)
  • 1
    Digitale Medien
    Digitale Medien
    A Korean population study of the nine STR loci FGA, VWA, D3S1358, D18S51, D21S11, D8S1179, D7S820, D13S317 and D5S818 (2000)
    Springer
    International journal of legal medicine 114 (2000), S. 41-44 
    Details
    ISSN: 1437-1596
    Schlagwort(e): Key words STR ; Allele frequency ; Korea
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Rechtswissenschaft
    Notizen: Abstract DNA typing was performed on 379 randomly selected unrelated Koreans using the nine short tandem repeat loci FGA, VWA, D3S1358, D18S51, D21S11, D8S1179, D7S820, D13S317 and D5S818 present in the AmpFlSTR Profiler Plus PCR amplification kit. Allele frequencies, heterozygosity, power of discrimination, mean exclusion chance, and polymorphism information content of each locus were calculated by statistical analysis. All nine loci were in Hardy-Weinberg equilibrium. The combined discrimination index and the combined mean exclusion chance in Koreans was 2.31 × 10–12 and 0.99983, respectively. By evaluation of 297 children from 128 families, 2 mutations were found at the FGA locus and 1 each at the D18S51 and D13S317 loci. This study demonstrates that this multiplex system is a useful and convenient tool for forensic identification and parentage testing in Korea.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004140000137
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  • 2
    Digitale Medien
    Digitale Medien
    High-performance liquid chromatographic determination of meropenem in rat plasma using column-switching (1996)
    Springer
    Chromatographia 42 (1996), S. 405-408 
    Details
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Meropenem in rat plasma ; Column-switching
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The purpose of this study was to develop a columnswitching HPLC method for the determination of meropenem in plasma. This method showed excellent precision and accuracy with good sensitivity and speed. The total analysis time per sample was less than 20 min and the mean coefficients of variation for intra- and inter-assay were less than 4.0%. The method has been successfully applied to plasma samples from rats receiving an intraperitoneal injection of meropenem.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02272131
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  • 3
    Digitale Medien
    Digitale Medien
    Determination of myristicin in rat serum samples using microbore high performance liquid chromatography with column-switching (1998)
    Springer
    Chromatographia 48 (1998), S. 365-368 
    Details
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Microbore columns ; Column-switching ; Myristicin ; Serum
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A microbore high-performance liquid chromatographic method with column-switching was developed for the analysis of myristicin from rat serum without prepurification. Deproteinization, fractionation, concentration and separation of analyte were carried out by appropriate switching of columns and using solvent mixtures. The method showed excellent precision, accuracy and speed with a detection limit of 10 ng mL−1 from 25 μL of serum. The total analysis time per sample was 25 min and the coefficients of variation for intra- and inter-assay were less than 1.8%.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02467705
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  • 4
    Digitale Medien
    Digitale Medien
    Simultaneous determination of Ibuproxam and Ibuprofen in human plasma by HPLC with column switching (1993)
    Springer
    Chromatographia 37 (1993), S. 618-622 
    Details
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Ibuproxam and Ibuprofen in plasma ; Column switching
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A new high-performance liquid chromatographic method with column switching has been developed for the simultaneous determination of Ibuproxam and its metabolite Ibuprofen in plasma. The plasma samples were injected onto a LiChrosorb RP-8 precolumn after dilution with an internal standard solution in phosphoric acid. Polar plasma components were eluted with 0.05 M phosphoric acid. After valve switching, the concentrated drugs were eluted in the back-flush mode and separated on an Inertsil ODS-2-column with acetonitrile-methanolphosphate buffer as mobile phase. The method showed excellent precision, accuracy and speed with detection limit of 0.1 μg ml−1. Total analysis time per sample was less than 30 min and the coefficients of variation for intra and inter-assay were less than 3.5%. This method has been successfully applied to plasma samples from human volunteers after oral administration of Ibuproxam.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02274112
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  • 5
    Digitale Medien
    Digitale Medien
    Simultaneous determination of parathion and metabolites in serum by HPLC with column switching (1997)
    Springer
    Chromatographia 44 (1997), S. 473-476 
    Details
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Column-switching ; Parathion, and metabolites in serum
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A new high-performance liquid chromatographic method with column-switching has been developed for the simultaneous determination of parathion and its metabolites such asp-nitrophenol and paraoxon in serum. Serum samples were injected onto a precolumn packed with LiChroprep RP-8 after simple dilution with 20% phosphoric acid. Polar plasma components were washed with 0.02 M phosphate buffer (pH 3.0). After valve switching, the concentrated compounds were eluted in back-flush mode and separated on a Ultracarb ODS 30 column with a gradient of acetonitrile −0.01 M phosphate buffer (pH 3.0) as mobile phase. The method showed excellent precision, accuracy and speed with detection limit of 0.1 μg mL−1. Total analysis time per sample was 〈40 min and coefficients of variation for intra-and inter-assay were 〈4.5%.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02466739
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  • 6
    Digitale Medien
    Digitale Medien
    Effect of triethylamine in the mobile phase on the retention properties of conventional polymeric and horizontally polymerized octadecylsilica in RPLC (1999)
    Springer
    Chromatographia 49 (1999), S. 635-642 
    Details
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Interaction of mobile and stationary phases ; Linear solvation energy relationships ; Triethylamine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The effect of triethylamine (TEA) in the mobile phase on the RPLC retention behavior of small organic solutes has been studied on a conventional polymeric octadecylsilica (ODS) and on a horizontally polymerized ODS. Retention factors for a set of solutes were measured on the two phases with methanol-water mobile phases containing triethylamine at different concentrations and analyzed by use of linear solvation energy relationships (LSER). Variation of the resulting LSER coefficients—v (hydrophobicity),r (polarizability),s (dipolarity),b (hydrogen-bond (HB) donating acidity), anda (HB accepting strength)—were examined to see how TEA affects the intermolecular interaction properties of the mobile and stationary phases and hence the retention of the solutes. Addition of TEA to the mobile phase changes the interaction properties of both conventionally polymerized and horizontally polymerized ODS; the effect is greater for the conventional phase. The HB donating acidity (b) of conventional polymeric ODS is significantly reduced by addition of TEA. For the mobile phases studied the magnitudes of theb andv coefficients for the horizontally polymerized ODS phase are greater than for the conventional phase. The different interaction properties of the two polymeric phases arise mainly as a result of differential adsorption of TEA, because of the very different amounts of surface silanol groups present on the two phases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02466905
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  • 7
    Digitale Medien
    Digitale Medien
    Simultaneous determination of cefoxitin, cefuroxime, cephalexin and cephaloridine in plasma using HPLC and a column-switching technique (1990)
    Springer
    Chromatographia 30 (1990), S. 80-84 
    Details
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Cephalosporins ; Column switching in HPLC ; On-line plasma sample clean-up
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A new high performance liquid chromatographic method was developed using a column-switching technique for the simultaneous determination of cephalexin, cefuroxime, cefoxitin and cephaloridine in plasma. The plasma samples were injected onto a precolumn packed with Corasil RP C18 (37–50 μm) after simple dilution with an internal standard solution in 0.01 M acetate buffer (pH 3.5). Polar plasma components were washed out using 0.01 M acetate buffer (pH 3.5). After valve switching, the concentrated drugs were desorbed in back-flush mode and separated on a Partisil ODS-3 column using acetonitrile in 0.02 M acetate buffer (pH 4.3) (15∶85, v/v) as the mobile phase. The method showed excellent precision with good sensitivity and speed with a detection limit of 0.5 μg/ml. The total analysis time per sample was less than 25 min, and the mean coefficients of variation for intra- and inter-assay were both less than 4.9 %. This method has been successfully applied to plasma from rats after subcutaneous injection of cefuroxime.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02270453
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