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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 39 (1980), S. 359-364 
    ISSN: 1432-1106
    Keywords: Pain ; Brain-evoked potentials ; Aspirin central action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mechanism of aspirin analgesia is still unclear, but it is generally assumed that aspirin exerts its analgesic effect mainly on peripheral nociceptors. In this study, we demonstrate possible brain effects of 975 mg aspirin in man. When brain electrical potentials evoked by painful electrical tooth shocks were examined, aspirin was observed to significantly reduce the amplitude of the late waveform components, but it did not affect the earlier components. Since our earlier findings suggest that early waveform components reflect the energy transmission and the late components manifest the brain activities in an individual's perception of painful information, we postulate that aspirin may act centrally in pain processing.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 76 (1997), S. 116-121 
    ISSN: 1439-6327
    Keywords: Key words Warm-water immersion ; Esophageal temperature ; Cutaneous vasodilation ; Thermoregulation ; Heat loss
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We demonstrated previously that esophageal temperature (T es) remains elevated by ≈0.5°C for at least 65 min after intense exercise. Following exercise, average skin temperature (T avg) and skin blood flow returned rapidly to pre-exercise values even though T es remained elevated, indicating that the T es threshold for vasodilation is elevated during this period. The present study evaluates the hypothesis that the threshold for sweating is also increased following intense exercise. Four males and three females were immersed in water (water temperature, T w = 42°C) until onset of sweating (Immersion 1), followed by recovery in air (air temperature, T a = 24°C). At a T a of 24°C, 15 min of cycle ergometry (70% VO2max) (Exercise) was then followed by 30 min of recovery. Subjects were then immersed again (T w = 42°C) until onset of sweating (Immersion 2). Baseline T es and T skavg were 37.0 (0.1)°C and 32.3 (0.3)°C, respectively. Because the T skavg at the onset of sweating was different during Exercise [30.9 (0.3)°C] than during Immersion 1 and Immersion 2 [36.8 (0.2)°C and 36.4 (0.2)°C, respectively] a corrected core temperature, T es (calculated), was calculated at a single designated skin temperature, T sk(designated), as follows: T es(calculated) = T es + [β/(1−β)][T skavg−T sk(designated)]. The T sk(designated) was set at 36.5°C (mean of Immersion 1 and Immersion 2 conditions) and β represents the fractional contribution of T skavg to the sweating response (β for sweating = 0.1). While T es(calculated) at the onset of sweating was significantly lower during exercise [36.7 (0.2)°C] than during Immersion 1 [37.1 (0.1)°C], the threshold of sweating during Immersion 2 [37.3 (0.1)°C] was greater than during both Exercise and Immersion 1 (P 〈 0.05). We conclude that intense exercise decreases the sweating threshold during exercise itself, but elicits a subsequent short-term increase in the resting sweating threshold.
    Type of Medium: Electronic Resource
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