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  • 1
    Electronic Resource
    Electronic Resource
    Effect of intraperitoneally administered GABA on haloperidol-induced catalepsy in the rat (1980)
    Springer
    Psychopharmacology 68 (1980), S. 105-107 
    Details
    ISSN: 1432-2072
    Keywords: GABA ; Haloperidol ; Catalepsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pretreatment with GABA (250–1,000 mg/kg, IP) potentiated the cataleptogenic effect of haloperidol in a dose-dependent manner in rats. GABA (GABA, B.D.H. Ltd.) alone in a dose of 2,000 mg/kg (IP) also induced catalepsy. The results may be due to partial access of blood-borne GABA to the CNS, leading to inhibition of nigro-striatal dopaminergic neurons involved in the functioning of the corpus striatum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426658
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of baclofen on dopamine-dependent behaviors in mice (1981)
    Springer
    Psychopharmacology 75 (1981), S. 396-399 
    Details
    ISSN: 1432-2072
    Keywords: Baclofen ; Methamphetamine ; Apomorphine ; Catalepsy ; Stereotypy ; Cage climbing behavior ; Traction response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Baclofen, the parachlorophenyl analog of GABA, was found to induce catalepsy and to inhibit the traction response in mice. However, baclofen pretreatment, instead of antagonizing methamphetamine stereotypy and apomorphine-induced cage climbing behavior, was found to potentiate these behaviors, thereby ruling out the possibility of its possessing postsynaptic dopamine (DA) receptor blocking activity. The possible mechanism involved in the induction of catalepsy and in the inhibition of the traction response by baclofen is discussed on the basis that baclofen, by inhibiting the firing of the nigrostriatal and mesolimbic DA neurons, reduces the release of DA and thereby produces a functional lack of DA at postsynaptic DA receptor sites with resultant induction of catalepsy and inhibition of the traction response. Further, the hyper-responsiveness to methamphetamine and apomorphine is explained on the basis that, as the postsynaptic DA receptors are acutely deprived of their transmitter, following baclofen pretreatment, they become supersensitive to the DA agonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00435861
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Small doses of apomorphine induced catalepsy and antagonize methamphetamine stereotypy in rats (1982)
    Springer
    Psychopharmacology 78 (1982), S. 192-194 
    Details
    ISSN: 1432-2072
    Keywords: Apomorphine ; Molindone ; Methamphetamine ; Catalepsy ; Stereotypy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Small doses of apomorphine (AP, 31.25–125 μg/kg IP) induced dose-dependent catalepsy in rats. However. unlike the stereotyped behavior induced by high doses of AP which has a rapid onset and is short-lasting, the cataleptic effect induced by small doses of AP was evident 30 min after AP injection and was unusually long-lasting. Further, AP (31.25–125 μg/kg) administered 60 min before methamphetamine was found to significantly antagonize the methamphetamine-induced stereotyped behavior. Pretreatment with molindone (0.45 and 0.8 mg/kg IP), in doses reported to selectively block the presynaptic DA receptors, not only decreased the cataleptic effect of AP but also reversed the AP antagonism of methamphetamine stereotypy. The results suggest that small doses of AP induce catalepsy and antagonize methamphetamine stereotypy probably by an action at presynaptic DA receptor sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432262
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of drugs influencing central serotonergic mechanisms on haloperidol-induced catalepsy (1979)
    Springer
    Psychopharmacology 62 (1979), S. 67-69 
    Details
    ISSN: 1432-2072
    Keywords: Quipazine ; Clomiprimine ; Methysergide ; Haloperidol ; Catalepsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pretreatment with quipazine, a serotonin agonist, and clomipramine, a selective serotonin neuronal uptake blocker, was found to potentiate the cataleptic effect of haloperidol in a dose-dependent manner in rats. Pretreatment with methysergide, a serotonin antagonist, reduced the cataleptic effect of haloperidol. The results indicate that the cataleptic effect of neuroleptics depends on the balance between the dopaminergic and serotonergic systems, and that the serotonergic system exerts an inhibitory influence on the dopaminergic system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426037
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of drugs influencing central serotonergic mechanisms on methamphetamine-induced stereotyped behavior in the rat (1979)
    Springer
    Psychopharmacology 64 (1979), S. 303-307 
    Details
    ISSN: 1432-2072
    Keywords: l-tryptophan ; Quipazine ; Clomipramine ; Methysergide ; Methamphetamine ; Stereotyped behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pretreatment with l-tryptophan, a precursor of serotonin, was found to decrease the intensity of stereotyped behavior induced by methamphetamine, while methysergide, a serotonin antagonist, was found to increase the intensity of methamphetamine-induced stereotyped behavior. These results suggest that the intensity of methamphetamine-induced stereotypy depends on the balance between central dopaminergic and serotonergic systems and that the central serotonergic system may have an opposing, tonic effect upon central dopaminergic systems involved in the mediation of stereotypy. In contrast to l-tryptophan, however, pretreatment with quipazine, a serotonin agonist, and clomipramine, a selective, serotonin neuronal uptake blocker, was found to potentiate the stereotyped behavior induced by methamphetamine. The probable mechanisms by which quipazine and clomipramine might have potentiated the methamphetamine-induced stereotypy are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427514
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of naloxone on methamphetamine and apomorphine stereotypy and on haloperidol catalepsy in rats (1984)
    Springer
    Psychopharmacology 82 (1984), S. 237-240 
    Details
    ISSN: 1432-2072
    Keywords: Naloxone ; Methamphetamine ; Apomorphine ; Haloperidol ; Stereotypy ; Catalepsy ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pretreatment with the opiate antagonist naloxone, at 1.25–5 mg/kg, increased the intensity of methamphetamine stereotypy, had no effect (over a range of 0.3125–5 mg/kg) on apomorphine stereotypy, and antagonized haloperidol catalepsy in rats at 1.25–5 mg/kg. It is suggested that naloxone, by blocking the opiate receptors located on the nigro-striatal and mesolimbic dopamine (DA) nerve terminals, releases the DA systems from endogenous inhibition, presumably caused by endogenous opiate systems, and thereby potentiates methamphetamine stereotypy and antagonizes haloperidol catalepsy. However, the possibility that naloxone might have affected methamphetamine stereotypy and haloperidol catalepsy by modulating the activity of the central noradrenergic and GABAergic systems, which are reported to influence dopaminergically mediated behaviours, also needs to be considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427781
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    Paper (German National Licenses)
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