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  • 1
    Electronic Resource
    Electronic Resource
    Comparison of131I-metaiodobenzylguanidine scintigraphy with urinary and plasma catecholamine determinations in the diagnosis of pheochromocytoma (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 627-630 
    Details
    ISSN: 1432-1440
    Keywords: Pheochromocytoma ; Catecholamines ; Scintigraphy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a retrospective study of 31 patients with suspected pheochromocytoma we examined the preoperative results of131I-metaiodobenzylguanidine (131-I-MIBG) scintigraphy and a fluorimetric urine catecholamine determination test. An additional radioenzymatic plasma catecholamine determination test was performed in 25 patients. In 14 of the 31 patients the diagnosis of pheochromocytoma was later histologically confirmed. In the remaining 17 patients the suspected diagnosis was finally rejected after a clinical decision had been made on the basis of clinical history, symptoms, laboratory and imaging tests. 131-I-MIBG scintigraphy apparently had a very high specificity (no false-positive results among the patients with rejected diagnosis), but showed the least sensitivity (3 of 14 tumours were not detected). Urine cate-cholamines showed two false-negative and three false-positive results. Plasma catecholamines had the highest sensitivity and gave only one false-positive result. Because of its high pathognomonic value 131-MIBG scintigraphy can be helpful not only for localization, but also for confirmation of diagnosis when catecholamine determination tests are contradictory. On the basis of our experience with false-positive results after interfering medication therapy, urine and plasma catecholamine determination tests should only be carried out after purification with thin layer chromatography or high performance liquid chromatography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732857
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The diagnostic significance of cholescintigraphy and ultrasound examination in cholestatic syndromes in infancy (1988)
    Springer
    Pediatric surgery international 3 (1988), S. 37-42 
    Details
    ISSN: 1437-9813
    Keywords: Biliary atresia ; Neonatal hepatitis ; Cholestatic syndrome ; Ultrasound examination ; Cholescintigraphy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thirty-three neonates and infants with cholestatic syndromes of various etiologies were evaluated by cholescintigraphy and ultrasound examinations. The results of these two diagnostic procedures were compared with the final diagnosis as confirmed by liver biopsy and/or laparotomy and the clinica follow-up of the infants. Fourteen patients had an obstructive cholangiopathy (11 biliary atresia, 2 choledochal cysts, 1 congenital choledochal stenosis), 13 had neonatal hepatitis, and 6 had cholestasis of another etiology. Typical ultrasonic and/or scintigraphic findings confirmed or excluded the need for surgical exploration in 28 patients. Thus, for must infants with cholestatic syndromes it is possible to differentiate the cause without invasive diagnostic techniques such as liver biopsy or exploratory laparotomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00177078
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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