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  • 1
    Electronic Resource
    Electronic Resource
    Presence of non-fibrillar amyloid b protein in skin biopsies of Alzheimer's disease (AD), Down's syndrome and non-AD normal persons (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 201-206 
    Details
    ISSN: 1432-0533
    Keywords: Key words Amyloid β protein ; Skin biopsy ; Alzheimer's disease ; Down's syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A total of 66 skin biopsies from persons with Alzheimer's disease (AD) or Down's syndrome (DS) and from persons without AD were used in this study. The age range was from 7 to 89 years. Positive immunoreactivity of skin biopsies to monoclonal antibody 4G8, which is reactive to amino acid residue 17 – 24 of synthetic amyloid β protein (Aβ), and 4G8-Fab (the antigen-binding fragment of 4G8 IgG, reactive only to amyloid plaque) was observed in the epidermis-dermis junction or the basement membrane of the epidermis and in some blood vessels of the biopsy skins of 13/18 (72  %) AD, 9/10 (90  %) DS, and 14/38 (37  %) non-AD control cases. The Fisher exact probability test revealed a significant difference (P=0.0415 one-tailed) in immunoreactivity between AD and age-matched controls. There was also a significant difference (P=0.0152 one-tailed; P=0.0200 two-tailed) between DS and age-matched control in the same test. Immuno-gold electron microscopy examination of these cases with positive immunoreactivity revealed that the gold particles were deposited along the basement membrane of the epidermis. Amyloid fibrils were not observed in the regions with gold particles. Results of this study suggest that Aβ is associated with the basement membrane of skin and is present in amorphous, non-fibrillar form as soluble Aβ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293394
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  • 2
    Electronic Resource
    Electronic Resource
    Presence of non-fibrillar amyloid β protein in skin biopsies of Alzheimer's disease (AD), Down's syndrome and non-AD normal persons (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 201-206 
    Details
    ISSN: 1432-0533
    Keywords: Amyloid β protein ; Skin biopsy Alzheimer's disease ; Down's syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A total of 66 skin biopsies from persons with Alzheimer's disease (AD) or Down's syndrome (DS) and from persons without AD were used in this study. The age range was from 7 to 89 years. Positive immunoreactivity of skin biopsies to monoclonal antibody 4G8, which is reactive to amino acid residue 17–24 of synthetic amyloid β protein (Aβ), and 4G8-Fab (the antigen-binding fragment of 4G8 IgG, reactive only to amyloid plaque) was observed in the epidermis-dermis junction or the basement membrane of the epidermis and in some blood vessels of the biopsy skins of 13/18 (72%) AD, 9/10 (90%) DS, and 14/38 (37%) non-AD control cases. The Fisher exact probability test revealed a significant difference (P=0.0415 one-tailed) in immunoreactivity between AD and age-matched controls. There was also a significant difference (P=0.0152 one-tailed; P=0.0200 two-tailed) between DS and age-matched control in the same test. Immuno-gold electron microscopy examination of these cases with positive immunoreactivity revealed that the gold particles were deposited along the basement membrane of the epidermis. Amyloid fibrils were not observed in the regions with gold particles. Results of this study suggest that Aβ is associated with the basement membrane of skin and is present in amorphous, non-fibrillar form as soluble Aβ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293394
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  • 3
    Electronic Resource
    Electronic Resource
    Drop-size distributions from pneumatic atomizers (1971)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 17 (1971), S. 575-584 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A study was made of the atomizing characteristics of convergent-type pneumatic nozzles. Drop-size correlations were obtained for the following ranges: drop size, 6 to 350 μ, mass median diameter; mass flow ratio, 0.06 to 40; relative velocity, 250 ft./sec. to sonic velocity; and viscosity. 1 to 50 cp. The technique employed was to spray cool a molten wax, and melts of wax-polyethylene mixtures. The most important operating variables in pneumatic atomization are the dynamic force of the atomizing gas, and the mass flow ratio of air to liquid. The cumulative volume drop-size distribution of spray from a pneumatic nozzle was fitted by a modified logistic equation. Empirical correlations developed in the study can be used to design nozzles or to predict drop size for sprays produced by the types of nozzles studied. In particular, this study provides new experimental data on the performance of pneumatic atomizers in producing relatively large drops.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690170318
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  • 4
    Electronic Resource
    Electronic Resource
    Diffusion in nickel oxide pellets-effects of sintering and reduction (1974)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 20 (1974), S. 670-678 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Diffusion rates were measured at 25°C and 1 atm by a steady state method in pellets of nonporous nickel oxide particles in order to determine the effects of sintering and chemical reduction. Sintering led to a striking decrease in diffusion flux; tortuosities above 100 were found for highly sintered (porosity 0.03) pellets. Reduction caused a sharp increase in diffusion rate when the original pellet was highly sintered. For an originally unsintered pellet the diffusion rate decreased with extent of reduction.These phenomena were explained quantitatively by using: (1) the random pore model to predict tortuosity factors for an unsintered, unreduced pellet, and (2) the extent of pore interconnections and the fractional reduction to treat the effects of sintering and reduction. In this way an approximate, predictive equation was derived which contained no arbitrary parameters and which required for application only data on porosity and extent of chemical reduction.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690200407
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  • 5
    Electronic Resource
    Electronic Resource
    Polymer-mediated crystallization of inorganic solids: Calcite nucleation on poly(organosiloxane) surfaces (1993)
    Weinheim : Wiley-Blackwell
    Advanced Materials 5 (1993), S. 49-51 
    Details
    ISSN: 0935-9648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/adma.19930050111
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of membrane morphology and operation on protein deposition in ultrafiltration membranes (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 47 (1995), S. 174-180 
    Details
    ISSN: 0006-3592
    Keywords: ultrafiltration membranes ; protein fouling ; BET measurements ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Membrane morphology is compared to protein depostion under passive adsorption and ultrafiltration conditions. Solute resistance of protein deposits for membranes of varying roughness, structure, and permeability can vary dramatically with operating conditions. Using Brunauer-Emmett-Teller adsorption isotherm (BET), study of the internal area and accessibility of several uttrafiltration membranes to protein deposition allows better understanding of the fouling mechanisms and interpretation of adsorbed protein quantities. © 1995 John Wiley & Sons, Inc.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260470208
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  • 7
    Electronic Resource
    Electronic Resource
    Some factors determining protein aggregation during ultrafiltration (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 42 (1993), S. 260-265 
    Details
    ISSN: 0006-3592
    Keywords: fouling ; ultrafiltration ; protein aggregates ; field emission scanning electron microscopy (FESEM) ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The factors contributing to protein aggregation in albumin ultrafiltration were investigated as a function of operation conditions. The nature of protein deposits was examined by electron microscopy. Protein aggregation appears to occur as a result of rapid supersaturation of protein molecules and high solvent velocity (shear) in the concentrated layer near the membrane surface. The shear occurring in the solvent flow on the membrane surface probably unfolds protein molecules and thus promotes flocculation due to collision between particles. © 1993 John Wiley & Sons, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260420216
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  • 8
    Electronic Resource
    Electronic Resource
    GaAs/AlAs superlattice as a proposed new reference material for sputter depth profiling (1993)
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 20 (1993), S. 1061-1066 
    Details
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: A GaAs/AlAs superlattice growth by metal-organic chemical vapour deposition is being proposed as the single crystalline multilayer reference material for sputter depth profiling. This material was characterized by transmission electron microscopy experiments, which showed that the interface between GaAs and AlAs is atomically flat. The preliminary depth profiling experiments were carried out by AES and SIMS.The AES experiments were performed using a Perkin-Elmer SAM 660 scanning Auger microprobe and the SIMS experiments were carried out using a VSW multitechnique XPS/SIMS surface analysis system.The AES and SIMS sputter depth profiling experiments proved that the depth resolution was found to be almost constant for each interface when an Ar+ beam was used for sputtering. Therefore the sputtering-induced roughness is very small for this material with Ar+ beam profiling, the depth resolution deteriorated as a function of depth, indicating oxygen ion beam-induced surface roughening.For both AES and SIMS, the depth resolution improved for ion beams with lower kinetic energy and more glancing angles of incidence.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/sia.740201306
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  • 9
    Electronic Resource
    Electronic Resource
    XPS sputter depth profiling of the chemical states for SrTiO3/Si interface by O2+ ion beams (1995)
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 23 (1995), S. 851-857 
    Details
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Because the chemical states of the elements in SrTiO3 thin film on Si are reduced by argon ion beam bombardment, it was impossible to sputter depth profile the chemical states of SrTiO3 thin film by argon ion beams. In this paper, it is reported that the undistorted chemical states of Ti and Si at the SrTiO3/Si interface can be determined with oxygen ion beams at the appropriate 70° angle of incidence, with which either metallic Ti is not oxidized or Ti in SrTiO3 is not reduced. Under the sputter depth profiling conditions, the chemical state of Ti at the SrTiO3/Si interface could be successfully characterized and the effects of post-annealing at high temperature on the chemical state of Ti were studied. A significant number of Ti atoms in the metallic state were observed at the SrTiO3/Si interface without any post-annealing but all of them were oxidized to the Ti4+ chemical state after 2 h post-annealing at the temperatures above 600°C under oxygen flow. The dielectric properties of SrTiO3 thin films on Si were well correlated to the oxidation state of Ti and the broadening of the interface SiO2 layer induced by post-annealing at high temperature.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/sia.740231302
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  • 10
    Electronic Resource
    Electronic Resource
    A comparison of measurements of the viscoelastic properties of polymer melts by means of the Han slit/capillary rheometer and the Weissenberg rheogoniometer (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 17 (1973), S. 95-103 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Measurements were taken of the viscoelastic properties of six polymer melts by mean of the Weissenberg rheogoniometer and the Han slit/capillary rheometer. Polymers in vestigated were three high-density polyethylenes of different polydispersity, a low-density polyethylene, a polypropylene, and a polystyrene. The range of shear rates tested was from about 5.0 × 10-3 to 10 sec-1 with the Weissenberg rheogoniometer, from about 10 to 102 sec-1 with the slit rheometer, and from about 102 and 103 with the capillary rheometer: the temperature of measurement was 200°C. The three different apparatuses give consistent results over almost six decades of shear rates, yielding satisfactory correlations of shear viscosity to shear rate and of normal stress difference to shear rate.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1973.070170107
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