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  • 1
    Electronic Resource
    Electronic Resource
    Equilibration of methionine into the Met-tRNA pool of rabbit reticulocyte lysates - Additional evidence that deacylation of ribosomal subunit-bound Met-tRNA"f does occur in heme-deficiency
    Amsterdam : Elsevier
    FEBS Letters 160 (1983), S. 249-254 
    Details
    ISSN: 0014-5793
    Keywords: Deacylation ; Hemin ; Met-tRNA ; Protein synthesis ; Reticulocyte lysate ; Translational control
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(83)80976-4
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    CpA containing oligoribonucleotides specifically inhibit protein synthesis in rabbit reticulocytes
    Amsterdam : Elsevier
    FEBS Letters 212 (1987), S. 317-322 
    Details
    ISSN: 0014-5793
    Keywords: (Rabbit, Wheat germ) ; 3'-Exonucleolytic cleavage ; Cell-free system ; Oligoribonucleotide ; Protein synthesis ; Reticulocyte lysate
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(87)81368-6
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Mechanism of inhibition of eukaryotic translational initiation by the trinucleotide ApUpG
    Amsterdam : Elsevier
    FEBS Letters 250 (1989), S. 147-152 
    Details
    ISSN: 0014-5793
    Keywords: 80 S complex ; Initiation codon ; Oligoribonucleotide ; Protein synthesis ; Reticulocyte lysate
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(89)80708-2
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Wird die Diagnose bei persistierenden kindlichen Hörstörungen immer noch zu spät gestellt? (1998)
    Springer
    HNO 46 (1998), S. 598-602 
    Details
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Diagnosezeitpunkt ; Verzögerte Diagnose ; Medizinische Register ; Datenerhebung ; Kindliche Hörstörungen ; Key words Age at diagnosis ; Delay of diagnosis ; Medical registries ; Data collection ; Hearing loss in childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Since 1994, the German Registry for Hearing Loss in Children has registered data of 1500 children and by now can present results concerning the age at diagnosis of permanent hearing loss in children in Germany. The mean age at diagnosis is still very high. There is a strong correlation between age at diagnosis and degree of hearing loss, i.e., severe and profound hearing loss, is diagnosed distinctly earlier than mild and moderate hearing loss. On average, mild hearing loss is diagnosed with 6.2 years, moderate h.l. with 4.4 years, severe hearing loss with 2.5 years and profound hearing loss with 1.9 years. This corresponds with the results of regional German studies. At least regionally, in other European countries the age at diagnosis is known to be distinctly lower. In 36% of the children registered in Germany the delay between first suspicion and diagnosis of permanent hearing loss is 1 year or more.
    Notes: Zusammenfassung Das Deutsche Zentralregister (DZH) für kindliche Hörstörungen hat seit 1994 Patientendatensätze von 1500 Kindern erfaßt und kann mittlerweile u.a. Aussagen und Ergebnisse zum Diagnosezeitpunkt persistierender kindlicher Hörstörungen in der Bundesrepublik Deutschland vorlegen. Nach wie vor ist das mittlere Alter bei der Diagnose persistierender kindlicher Hörstörungen sehr hoch. Das Diagnosealter korreliert stark mit dem Grad der Hörstörung, d.h. an Taubheit grenzende und hochgradige Hörstörungen werden deutlich früher diagnostiziert als leichte und mittlere. So werden leichte Hörstörungen im Durchschnitt erst mit 6;2 Jahren diagnostiziert, mittlere mit 4;4 Jahren, hochgradige mit 2;5 Jahren und an Taubheit grenzende mit 1;9 Jahren. Dies entspricht den Ergebnissen bereits vorliegender regionaler deutscher Studien [1–2]. Aus anderen europäischen Länderen sind zumindest regional deutlich frühere Diagnosezeitpunkte bekannt [3–5]. Bei 36% der im DZH erfaßten Kinder liegt zwischen dem ersten Verdacht auf Vorliegen einer persistierenden kindlichen Hörstörung und der Sicherstellung der Diagnose ein Jahr und mehr.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050279
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  • 5
    Electronic Resource
    Electronic Resource
    Datenschutz innerhalb des länderübergreifenden Deutschen Zentralregisters für kindliche Hörstörungen (1998)
    Springer
    HNO 46 (1998), S. 339-345 
    Details
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Datenschutz ; Datensicherheit ; Medizinische Register ; Datenerhebung ; Kindliche Hörstörungen ; Key words Medical registries ; Data collection and security ; Hearing loss and childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The German Registry for Hearing Loss in Children (DZH) processes nationwide data from audiological centers. Coping with the accrued data and its subsequent management and analysis requires a high degree of security and control. To establish a nationwide registry it is necessary at an early stage to take into consideration the legal requirements of the participating states. Use of the DZH as an example demonstrates how a pragmatic solution can be reached. Special issues concerning data collection, transfer, storage and deletion, coding strategies to ensure anonymity, checking for duplicate entries, data separation, and automated data analysis and data protection are explained.
    Notes: Zusammenfassung Das Deutsche Zentralregister für kindliche Hörstörungen (DZH) verarbeitet bundesweit Daten von verschiedenen audiologischen Einrichtungen. Die Bewältigung der anfallenden Datenmengen, die nachfolgende Datenverwaltung und -analyse erfordern neben einer differenzierten und kontrollierbaren Verarbeitung ein Höchstmaß an Datensicherheit. Vor allem die länderübergreifende Struktur eines Registers erfordert schon bei der Planung engste Zusammenarbeit mit dem zuständigen Landesdatenschutzbeauftragten und auch mit den Landesdatenschutzbeauftragten anderer beteiligter Bundesländer. Am Beispiel des DZH wird demonstriert, wie eine kooperative Zusammenarbeit pragmatisch realisiert werden kann. Besonderheiten bei der Datenerhebung, Datentransfer, Speicherung und Löschung von Daten, technische Datenschutzmaßnahmen, Sicherstellung von Anonymität durch Codierungsstrategien, Duplikatsprüfung, Datentrennung und automatisierte Datenauswertung werden an Beispielen erläutert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050249
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    FAB and tandem mass spectrometry for endorphin- and ACTH peptides of molecular weight to 2000 (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 649-657 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Four β-endorphins (β-endorphin 6-17, 2-17, 1-16, and 1-17) and two adrenocorticotropic hormone (ACTH) peptides (ACTH 1-10 and (1-16)-NH2) were studied by using fast atom bombardment coupled with tandem mass spectrometry. The capability to reproduce metastable ion and collisionally activated decomposition spectra on two different commercial sector mass spectrometers in two different laboratories was found to be acceptable (deviations in relative abundance are less than ± 50%). The endorphin peptides fragment metastably or upon collisional activation to give abundant B-series ions as well as Y-series ions, whereas Y-series ions are the principal ionic species produced upon the desorption by fast atom bombardment. The ACTH peptides also fragment to give Y-series ions, but of relatively low abundance compared to those from the endorphins. For both sets of peptides, high-energy collisionally activated decomposition and metastable ion decomposition daughter ion spectra are precise, structurally informative - even for peptides up to m/z 2000 - and complementary to spectra of daughter ions produced by desorption ionization alone.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151203
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  • 7
    Electronic Resource
    Electronic Resource
    Fast atom bombardment and tandem mass spectrometry for structure determination: Remote site fragmentation of steroid conjugates and bile salts (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 89-98 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A series of 35 steroid conjugates (sulfates and glucuronides) and bile salts were investigated by using fast atom bombardment and tandem mass spectrometry. Collisional activation of the [M - H]- anions of sulfate conjugates and bile salts predominantly yields fragment ions arising by reactions occurring remote from the charge site. These reactions are sometimes sensitive to differences in stereochemistry at positions remote from the charge site and are useful for positional isomer differentiation. On the other hand, collisional activation of the [M - H]- anions of the glucouronide conjugates leads primarily to charge-driven fragementations.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200150206
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  • 8
    Electronic Resource
    Electronic Resource
    Synthese von Hydroxyguanidinen aus Chlorformamidinen und OximenTeil der Dissertation M. Gross, Martin-Luther-Universität, Halle 1971. (1974)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 316 (1974), S. 434-442 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: N2-Aryl-N1,N1-dialkylchlorformamidine 1 reagieren mit Oximen über hydrolyseempfindliche Zwischenprodukte zu 2-Hydroxy-1-aryl-3,3-dialkylguanidinen 3.Diese Hydroxyguanidine bilden mit Benzoylchlorid O- und O,N-acylierte Verbindungen, mit Chlorameisensäureestern entstehen 3-Dialkylamino-4-aryl-5-oxo-Δ2-1,2,4-oxadiazoline 7. Die Reaktion mit Alkylhalogeniden führt zu 2-Alkoxy-1-aryl-3,3-dialkylguanidinen 8, und die katalytische Hydrierung liefert 1-Aryl-3,3-dialkylguanidine. Bei der Abspaltung der Oximinogruppe im saure Medium in Gegenwart von Oxydationsmitteln entstehen entsprechend substituierte Harnstoffe.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19743160311
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  • 9
    Electronic Resource
    Electronic Resource
    Reactions of propene and cyclopropane radical cations with neutral ethylene (1993)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 28 (1993), S. 185-192 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The gas-phase reactions of propene and cyclopropane radical cations with neutral ethylene were investigated by using Fourier transform, chemical ionization and tandem mass spectrometries. Both reactions form covalent C5H10 adduct ions. The adduct ions are hypothesized to form initially as distonic radical cations that isomerize via a substituted cyclopropane intermediate and are detected as the most stable C5H10 isomer, the 2-methylbut-2-ene radical cation. The rate constant for each reaction is approximately 20% of the theoretical collision rate, indicating that product ions are formed in one out of every five collisions of the C3H6 radical cations with neutral C2H4.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210280309
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Anodic oxidation of mercury in the presence of monocyclic ligands in propylene carbonate (1989)
    Weinheim : Wiley-Blackwell
    Electroanalysis 1 (1989), S. 493-499 
    Details
    ISSN: 1040-0397
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A series of 12 macrocycles containing 4, 6, or 8 N, S, and O heteroatoms (with increasing size from 14 to 24 atoms in the cycle) was studied to ascertain size and heteroatoms effects on the formation and 14 redox characteristics of their mercuric complexes. The concentration dependence of anodic currents at mercury electrodes in solutions of these ligands led to the determination of the formation constants of the complexes generated according to the folling of \documentclass{article}\pagestyle{empty}\begin{document}$$ {\rm Hg} \mathbin{\lower.3ex\hbox{$\buildrel\textstyle\rightarrow\over {\smash{\leftarrow}\vphantom{_{\vbox to.5ex{\vss}}}}$}} {\rm Hg}^{{\rm 2 + }} {\rm + 2e}^{\rm - } {\rm,}\,{\rm Hg}^{{\rm 2 + }} {\rm + jL} \mathbin{\lower.3ex\hbox{$\buildrel\textstyle\rightarrow\over {\smash{\leftarrow}\vphantom{_{\vbox to.5ex{\vss}}}}$}} {\rm (HgL}_{\rm j} {\rm)}^{{\rm 2 + }} $$\end{document} In propylene carbonate, the resulting mercuric complexes were stable (log Ks up to 40) mono- and dinuclear species. Their stability depends both on the nature of the heteroatoms and on the size of the macrocycle. For identical ligand sizes, the stability sequence N 〉 S 〉 O was established for mercuric complexes.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140010604
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