Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Changes in the immunoreactivity of protein gene product (PGP) 9.5 in the cochlea of spontaneously diabetic WBN/Kob rats (1997)
    Springer
    Diabetologia 40 (1997), S. 173-178 
    Details
    ISSN: 1432-0428
    Keywords: Keywords PGP 9.5 ; hearing impairment ; diabetes mellitus ; WBN/Kob rats ; cochlea.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mechanism of hearing impairment due to diabetes mellitus was examined in relation to changes in the level of the immunoreaction for the protein gene product 9.5 in the cochlea of spontaneously diabetic WBN/Kob rats. At 7 months (33 weeks) of age, when half of the males of this strain manifest diabetes, male WBN/Kob rats were divided into two groups as follows: one group consisted of prediabetic animals showing slightly decreased tolerance to glucose with a normal plasma concentration of glucose, normal urinary excretion of glucose, and functional hearing impairment (assessed in terms of elevation of hearing threshold). The second group consisted of diabetic animals with glucose intolerance, high plasma glucose level, polyuria, urinary glucose excretion, and more apparent elevation of hearing threshold. According to morphometric analysis of the spiral ganglion, the number of ganglion cells was significantly smaller in both the prediabetic and the diabetic animals than in the age-matched control Wistar rats. The staining intensity for protein gene product 9.5 was increased in some spiral ganglion cells of diabetic animals, but decreased in others according to quantitative immunohistochemical analysis. On the other hand, the immunoreactivity for protein gene product 9.5 was similar in the prediabetic animals to that in the control Wistar rats. These results suggest that numerical and immunohistochemical changes in the spiral ganglion cells reflect the onset and degree of the diabetic hearing impairment. [Diabetologia (1997) 40: 173–178]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050659
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Hearing impairment in WBN/Kob rats with spontaneous diabetes mellitus (1995)
    Springer
    Diabetologia 38 (1995), S. 649-655 
    Details
    ISSN: 1432-0428
    Keywords: Key words Diabetes mellitus ; hearing impairment ; WBN/Kob rats ; inner ear ; lectins.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The inner ear of spontaneously diabetic WBN/Kob rats was functionally and morphologically examined in order to elucidate the relationship between diabetes mellitus and hearing impairment. At 3 months of age, WBN/Kob rats were non-diabetic, and their hearing function was normal. At 6–7 months of age, they showed decreased glucose tolerance and an increasing tendency toward urinary excretion of glucose without high plasma concentration of glucose, and were therefore judged to be pre-diabetic. They also displayed a significant elevation of hearing threshold in the auditory brainstem response, but showed little morphological and histochemical changes in the inner ear. At 12–13 months of age, they were spontaneously diabetic and showed a more apparent elevation of hearing threshold in auditory brainstem response than that in pre-diabetic animals. In addition, they displayed a marked decrease in the number of spiral ganglion cells and oedematous changes in the stria vascularis. The stria vascularis also showed a decrease in the intensity of staining with some lectins, i. e., wheat germ agglutinin, succinylated wheat germ agglutinin, Soranum tuberosum lectin, and concanavalin A. In conclusion, hearing impairment is induced by diabetes in the WBN/Kob rats first as an elevation of hearing threshold along with glucose intolerance; secondly, as a decrease in the number of spiral ganglion cells; and thirdly, as oedematous change of the stria vascularis with decreased intensity of lectin staining. [Diabetologia (1995) 38: 649–655]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401834
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Hearing impairment in WBN/Kob rats with spontaneous diabetes mellitus (1995)
    Springer
    Diabetologia 38 (1995), S. 649-655 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; hearing impairment ; WBN/Kob rats ; inner ear ; lectins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The inner ear of spontaneously diabetic WBN/Kob rats was functionally and morphologically examined in order to elucidate the relationship between diabetes mellitus and hearing impairment. At 3 months of age, WBN/Kob rats were non-diabetic, and their hearing function was normal. At 6–7 months of age, they showed decreased glucose tolerance and an increasing tendency toward urinary excretion of glucose without high plasma concentration of glucose, and were therefore judged to be pre-diabetic. They also displayed a significant elevation of hearing threshold in the auditory brainstem response, but showed little morphological and histochemical changes in the inner ear. At 12–13 months of age, they were spontaneously diabetic and showed a more apparent elevation of hearing threshold in auditory brainstem response than that in pre-diabetic animals. In addition, they displayed a marked decrease in the number of spiral ganglion cells and oedematous changes in the stria vascularis. The stria vascularis also showed a decrease in the intensity of staining with some lectins, i. e., wheat germ agglutinin, succinylated wheat germ agglutinin, Soranum tuberosum lectin, and concanavalin A. In conclusion, hearing impairment is induced by diabetes in the WBN/ Kob rats first as an elevation of hearing threshold along with glucose intolerance; secondly, as a decrease in the number of spiral ganglion cells; and thirdly, as oedematous change of the stria vascularis with decreased intensity of lectin staining.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401834
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Collisionally-activated dissociation spectra of linear peptides in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (1995)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 9 (1995), S. 1342-1344 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Collisionally-activated dissociation (CAD) studies of linear peptides were performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Four different gases, viz. helium, nitrogen, argon and xenon, were introduced into a gas cell, installed close to the ion source of TOF mass spectrometer, to obtain high-energy CAD information. The CAD spectral patterns for the linear peptides obtained using the four gases were almost the same as each other. The fragments characteristically obtained in conventional high-energy CAD using tandem mass spectrometry were observed also in these spectra. A difference between CAD spectra and post-source decay product-ion spectra has been demonstrated.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290091404
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    The effect of copper(II) on the Crystallization of α-FeOOH (1972)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 391 (1972), S. 86-96 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Der Einfluß von Kupfer(II) auf die Kristallisation von α-FeOOHα-FeOOH wurde in mehreren Proben ohne und mit Zusatz von Cu(II)-Ionen (bis zu 5 Atom-%) unter bestimmten Bedingungen dargestellt und röntgeno-graphisch, durch BET, DTA und elektronenmikroskopisch untersucht. Durch Zusatz von 2,5 Atom-% wird die Kristallisation des α-FeOOH vollständig verhindert. Geringe Cu-Zusätze verzögern die Kristallisation. Das Wachsen der Partikel- und Kristallitgrößen von reinem und Cu-dotiertem α-FeOOH unterscheidet sich. Nach der Theorie des Autors wird der Einfluß der Cu2+-Ionen auf die Verzerrung des Koordinationsgitters diskutiert. Es besteht vermutlich ein Zusammenhang zür korrosionshemmenden Wirkung von Kupferzusätzen im Stahl.
    Notes: Various α-FeOOH samples have been prepared with or without addition of Cu(II) (0-5% Cu/Fe) and examined by X-ray diffraction, BET surface area determination, electron-microscopical observation and DTA. Doping with Cu in suitable amounts impedes completely the formation of α-FeOOH. The mechanism of growth, based on the changes of particle size and crystallite dimension, appears to be different between pure and Cu-doped α-FeOOH. The reason of the remarkable effect of Cu on the crystallization process of α-FeOOH is discussed. The effect of Cu is likely relevant to the role of Cu added to anticorrosive steel used in atmospheric environment.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19723910111
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    The effect of copper(II) on the Formation of Magnetite from Colloidal Iron (II) Hydroxide (1971)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 386 (1971), S. 340-344 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Die Geschwindigkeit der Selbstzersetzung von Fe(OH)2 unter Luftausschluß wurde unter Zusatz von Cu(II) (0-6 Atom-%) bei 30 bis 50°C bestimmt. Das Maximum der Geschwindigkeit und ein Minimum der Aktivierungsenergie tritt bei 1% Cu/Fe auf. Dies wird zwei gleichzeitig wirksamen Einflüssen des Cu zugeschrieben: Erstens der Verzerrung des Koordinationskomplexes durch Cu2+, die die Strukturumwandlung in Magnetit erleichtert, dagegen wirkt negativ der Einfluß des Cu, der zur Vergrößerung der Fe(OH)2-Kristalle führt. Röntgenaufnahmen und elektronenmikroskopische Beobachtungen bestätigen die Annahme.
    Notes: The rate of self-decomposition of iron(II) hydroxide doped with various amounts (0-6 atomic%) of Cu(II) was determined in the absence of oxygen at the temperature range of 30 to 50°C. The maximum rate and the minimum activation energy were observed at 1% Cu/Fe. The result was attributed to the two simultaneous actions of Cu2+, i.e., the distortion effect on coordination complex of Fe2+ by Cu2+ to ease the structural transformation to magnetite and the hindering effect on magnetite formation revealed consequently in the growth of Fe(OH)2 crystals. Both effects were proved by X-ray diffraction and election-microscopic observations.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19713860312
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...