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  • Creutzfeldt-Jakob  (1)
  • Electron microscopy  (1)
  • GABAA receptors  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Acta neuropathologica 49 (1980), S. 79-83 
    ISSN: 1432-0533
    Schlagwort(e): Alzheimer's disease ; Dementia ; Aging ; Cortical capillaries ; Basement membrane ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Data concerning width and surface of the basement membrane of cortical capillaries in three patients with Alzheimer's disease five age-matched controls, have been submitted to statistical analysis to ascertain the role of the aging process upon thickening of the basement membrane itself. The analysis showed that there was a significant difference between patients with Alzheimer's disease and controls (P〈0.01) as to both width and surface of the basement membrane, so suggesting that in these patients aging was not the only factor which thickening of the basement membrane of cortical capillaries was related to.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1590-3478
    Schlagwort(e): CSF ; Neurological diseases ; Macromolecules ; GABAA receptors
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Sommario Campioni di liquido cefalo-rachidiano di pazienti analizzati per casi di sospette malattie neurologiche sono stati separati nella componente macromolecolare (Peso Molecolare 〉3000 Daltons) ed in quella delle piccole molecole (PM〈3000 Daltons). La c omponente macromolecolare è stata testata per la sua possibile interferenza con l'accumulo di36Cl−, stimolato dal GABA, in “microsacs” della corteccia cerebrale di ratto. Per molte patologie non è stata rilevata alcuna interferenza. Fanno eccezione i pochi (2) casi di morbo di Parkinson; in entrambi i casi vi è una chiara stimolazione dell'attività GABAergica. Quest' ultima indicazione sembra degna di ulteriori indagini.
    Notizen: Abstract Cerebrospinal fluid (CSF) samples from patients undergoing lumbar puncture for suspected neurological diseases were fractioned into macromolecular (MW〉3000 Daltons) and small molecule components (MW〈3000 Daltons). The macromolecular component was tested for its interference with GABA stimulation of36Cl− accumulation in rat cerebral cortex microsacs. For many pathologies, no interference was apparent; an exception was two patients with Parkinson's disease in whom there were clear signs of stimulated GABA activity. This last result seems worthy of further investigation.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1590-3478
    Schlagwort(e): Alzheimer's disease ; Creutzfeldt-Jakob ; Transmissible dementias
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Sommario Una grande quantità di neuroni in degenerazione neurofibrillare e di placche senili, fu trovata nella corteccia cerebrale di una donna di 52 anni affetta da una demenza ad evoluzione subacuta, mioclonie e alterazioni elettroencefalografiche periodiche. È questo un caso sporadico di demenza presenile di Alzheimer clinicamente sovrapponibile alla malattia di Creutzfeldt-Jakob, che si presta a ipotizzare un rapporto fra quella malattia e le demenze trasmissibili.
    Notizen: Abstract Large numbers of neurofibrillary tangles and neuritic plaques were found in a cerebral biopsy from a 52-year-old woman suffering from subacute dementia with early myoclonus and quasiperiodic EEG changes. This case, which appeared to be an example of non-familial Alzheimer's disease, is commented in the context of possible relation of Alzheimer's disease to transmissible dementia.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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