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  • 1
    Electronic Resource
    Electronic Resource
    Comparative studies on thein vitro andin vivo morphology of clones of experimental CNS tumours in the rat (1972)
    Springer
    Acta neuropathologica 20 (1972), S. 248-257 
    Details
    ISSN: 1432-0533
    Keywords: Experimental CNS Tumours ; N-Nitrosomethylurea ; Ethylnitrosourea ; Cell Culture ; Clonal Growth ; Aggregation Pattern ; Transplantation ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two sarcomas, one neurosarcoma and one polymorphous tumour of uncertain classification of the central nervous system of the rat induced by N-nitrosomethylurea or ethylnitrosourea were the source of 14 clones. The cytomorphology and the aggregation pattern of the clonesin vitro are described. The malignancy and histology were checked by homologous transplantation. All the clones formed sarcoma-like structuresin vivo, but it was difficult to decide whether these neoplasias were real sarcomas or very dedifferentiated glial tumours. The differences in cytology observedin vitro were greater than the histological differencesin vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686906
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Differential morphological reaction of experimental CNS tumour clonesin vitro to dibutyryl cyclic AMP or serum-free medium, resp. (1975)
    Springer
    Acta neuropathologica 33 (1975), S. 325-332 
    Details
    ISSN: 1432-0533
    Keywords: Experimental CNS tumours ; Methylnitrosourea ; Ethylnitrosourea ; Clonal growth ; Serum-free culture ; db cAMP treatment ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Six clones from methylnitrosourea (MNU) or ethylnitrosourea (ENU) induced tumours obtained in the nervous system of the rat were cultured in serum-free medium or treated with dibutyryl cyclic AMP (db cAMP) in vitro. All clones originated from longterm cultures. Three clones forming sarcomas after syngeneic transplantation showed only very slight changes following treatment, whereas the three glioma clones showed striking alterations. They formed long processes or showed rounding of their perikarya. In serum-free medium the cellular shape is intermediate between that seen in normal conditions and that seen in db cAMP treated cultures. The altered cultures resemble the primary cultures of the respective tumours. The relationship of these alterations to tumour types are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686164
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The morphology of experimental tumours of the nervous system (1974)
    Springer
    Acta neuropathologica 27 (1974), S. 25-32 
    Details
    ISSN: 1432-0533
    Keywords: Experimental CNS Tumours ; Nitrosomethylurea ; Ethylnitrosourea ; Primary Cultures ; Tumour Classification ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary By means of the explant technique a series of primary tumours induced by methylnitrosourea (MNU) or ethylnitrosourea (ENU) in the brain of rats were cultured in vitro. The morphology of isomorphic oligodendrogliomas, astrocytomas, glioblastomas and sarcomas under in vitro conditions is described. All these neoplasias show a very distinct morphological picture and growth behaviour, thus permitting their classification. Most of the tumours tend to anaplastic changes during longer cultivation, but in some cases, preferably in well differentiated gliomas, the cytological properties are maintained even during longterm cultivation. The role of anaplasia and intermingling of different neoplastic cell types in experimental tumours are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687237
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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