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  • 1
    Electronic Resource
    Electronic Resource
    Chemotherapy studies in autochthonous rat tumors: Carcinomas of the forestomach (1979)
    Springer
    Journal of cancer research and clinical oncology 95 (1979), S. 39-42 
    Details
    ISSN: 1432-1335
    Keywords: Tumors of the forestomach ; Acetoxymethyl-methyl nitrosamine ; Experimental chemotherapy ; Bleomycin, methotrexate, 5-fluorouracil, 1,2-bis-(2-chloroethyl)-1-nitrosourea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tumors of the forestomach were induced in male Sprague-Dawley rats by oral application of acetoxymethyl-methylnitrosamine (AMMN) in single weekly doses of 3.5 mg/kg body weight for 10 weeks. 100±5 days after the beginning of carcinogen treatment exploratory laparotomy was performed. One hundred animals in the same stage of tumor development were divided at random into one control group and four groups treated with cytostatics. Bleomycin (BLM), methotrexate (MTX), 5-fluorouracil (5FU), and 1,2-bis-(2-chloroethyl)-1-nitrosourea (BCNU) were tested in groups of 20 rats each. Only in animals receiving repeated doses of BLM a slight tumor response was observed but no increase in median survival times was seen. No therapeutic effects of the other drugs used were demonstrable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00411107
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  • 2
    Electronic Resource
    Electronic Resource
    Antitumor activity of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-(4-methyl-cyclohexyl)-1-nitrosourea (MeCCNU) on yoshida sarcoma ascites cells implanted into the colon wall of rats (1979)
    Springer
    Journal of cancer research and clinical oncology 94 (1979), S. 63-67 
    Details
    ISSN: 1432-1335
    Keywords: Sprague-Dawley-Ratten ; Verimpfen von Yoshida-Sarkom-Zellen ; Colon descendens ; Cyclophosphamid ; BCNU ; Methyl-CCNU ; Sprague-Dawley rats ; Inoculation of Yoshida sarcoma cells ; Descending colon ; Cyclophosphamide ; BCNU ; Methyl-CCNU
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Three thousand Yoshida sarcoma cells were inoculated into the wall of the descending colon of each of 120 male Sprague-Dawley rats. On day 8 after the tumor implantation, the animals were at random divided into four groups of 30 rats each. The effect of cyclophosphamide (70 mg/kg), BCNU (25 mg/kg), and methyl-CCNU (45 mg/kg) after single i.p. application was investigated. The Yoshida sarcoma transplanted into the colon is sensitive to all three chemotherapeutic drugs. At the doses given cyclophosphamide showed the best results. The two nitrosoureas had a comparable antitumor activity but methyl-CCNU showed a more distinct toxic effect. The introduction of this model for testing new cytostatics in animal experiments is discussed.
    Notes: Zusammenfassung Einhundertzwanzig männlichen Sprague-Dawley-Ratten wurden jeweils 3000 Zellen eines Yoshida-Sarkoms in die Wand des Colon descendens verimpft. Am 8. Tag nach der Tumorimplantation wurden die Tiere randomisiert in vier Versuchsgruppen von jeweils 30 Ratten aufgeteilt. Die Wirkung von Cyclophosphamid (70 mg/kg), BCNU (25 mg/kg) und Methyl-CCNU (45 mg/kg) bei einmaliger i.p. Gabe wurde untersucht. Das ins Colon transplantierte Yoshida-Sarkom ist gegeüber allen drei Chemotherapeutika sensibel. Bei den gewählten Dosierungen zeigte Cyclophosphamide die günstigsten Ergebnisse. Die beiden Nitrosoharnstoffe waren in ihrer Antitumoraktivität vergleichbar, während bei Methyl-CCNU die toxischen Wirkungen sich als ausgeprägter erwiesen. Der Einsatz des Modells im Rahmen der tierexperimentellen Prüfung neuer Cytostatika wird diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00405350
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  • 3
    Electronic Resource
    Electronic Resource
    Antitumor activity of new nitrosoureas on Yoshida sarcoma ascites cells implanted into the colon wall of rats (1981)
    Springer
    Journal of cancer research and clinical oncology 101 (1981), S. 285-302 
    Details
    ISSN: 1432-1335
    Keywords: Yoshida sarcoma ; Descending colon ; 2-Chloroethyl-nitrosoureas ; Sprague-Dawley rats ; Yoshida-Sarkom ; Colon descendens ; 2-Chlorethyl-nitrosoharnstoffe ; Sprague-Dawley-Ratten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die chemotherapeutische Wirkung von 12 neu entwickelten Nitrosoharnstoffen wurde vergleichend an Yoshida-Sarkom-Asziteszellen experimentell untersucht, die in die Wand des Colon descendens von Sprague-Dawley-Ratten implantiert worden waren. Cyclophosphamid sowie die Nitrosoharnstoffe BCNU, MeCCNU und Chlorozotocin dienten als positive Kontrolle. Unter den untersuchten Nitrosoharnstoffen zeigten 1-(2-Hydroxyethyl)-3-(2-chlorethyl)-3-nitrosoharnstoff (Hydroxyethyl-CNU), Chlorozotocin, 1-(2-Chlorethyl)-1-nitroso-3-(4-morpholino)-harnstoff, 1-(2-Chlorethyl)-1-nitroso-3-(1-piperidino)-harnstoff, 4-[1-(2-Chlorethyl)-1-nitroso]-3-[4-(2,6-dimethylmorpholino)]-harnstoff und 1-(2-Chlorethyl)-1-nitroso-3-(3,4-methylendioxybenzyl)-harnstoff die stärkste Aktivität in diesem Tumormodell. Auf Grund der vorliegenden Ergebnisse ist Morpholino-CNU als die erfolgversprechendste Substanz unter den neu synthetisierten BCNU-Analogen anzusehen.
    Notes: Summary The chemotherapeutic activity of 12 newly synthesized nitrosoureas was compared in tests using Yoshida sarcoma ascites cells implanted into the wall of the descending colon in Sprague-Dawley rats. Cyclophosphamide and the nitrosoureas, BCNU, MeCCNU, and chlorozotocin served as positive controls. Among the nitrosoureas tested, 1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea (hydroxyethyl-CNU), chlorozotocin, 1-(2-chloroethyl)-1-nitroso-3-(4-morpholino) urea, 1-(2-chloroethyl)-1-nitroso-3-(1-piperidino) urea, 4-[1-(2-chloroethyl)-1-nitroso]-3-[4-(2,6-dimethylmorpholino)] urea, and 1-(2-chloroethyl)-1-nitroso-3-(3,4-methylenedioxybenzyl) urea were found to be the most active compounds in this tumor model. Based on the present results, morpholino-CNU is considered the most promising compound among these newly synthesized BCNU analogues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410114
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  • 4
    Electronic Resource
    Electronic Resource
    Cytostatic activity of steroid linked nitrosoureas (1984)
    Springer
    Journal of cancer research and clinical oncology 108 (1984), S. 164-168 
    Details
    ISSN: 1432-1335
    Keywords: Steroidal alkylating agents ; receptor agents ; Steroids ; Nitrosoureas ; CNC-l-alanine esters ; Experimental chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary First investigations on the therapeutic activity of a new group of steroid-linked N-(2-chloroethyl)-N-nitrosocarbamoyl-l-alanine esters (CNC-l-alanine esters) in a nitrosourea-sensitive rat leukemia (L 5222) characterized by a relatively high content of glucocorticoid binding sites are presented. Despite a considerable range of optimal and toxic doses of the different analogs, the respective therapeutic ratios do not appear to be significantly influenced by the nature of the carrier molecules to which CNC-l-alanine is attached. However several steroid-linked representatives are distinctly more active than CNC-l-alanine. The androsterone-3-ester and the dihydrotestosterone-17-ester, in particular effected high percentages of cures in contrast to CNC-l-alanine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390991
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