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  • 1
    Electronic Resource
    Electronic Resource
    Metabolic and toxic behaviours of phthalimide derivatives in albino rat (1978)
    Springer
    Archives of toxicology 40 (1978), S. 255-261 
    Details
    ISSN: 1432-0738
    Keywords: Chloromethyl phthalimide ; Oxymethyl phthalimide ; Phthalimide ; Fetus ; Metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Chlormethylphthalimid, Oxymethylphthalimid und Phthalimid werden verhältnismäßig schnell von der Albinoratte resorbiert. Nach oraler Verabreichung von Chlormethyl- und Oxymethylphthalimid an die Muttertiere ist in den Feten nur das Stoffwechselprodukt Phthalimid nachweisbar. Diese Befunde weisen im Zusammenhang mit Stoffwechseluntersuchungen an isolierten Feten auf einen intensiven Stoffwechsel in fetalen Geweben hin. Unterschiede zwischen dünnschichtchromatographischen und 15N-Untersuchungen lassen vermuten, daß Phthalimid durch Öffnung des Imidringes weiter zur Phthalamidsäure metabolisiert wird.
    Notes: Abstract Chloromethyl phthalimide, oxymethyl phthalimide, and phthalimide are absorbed by the albino rat at a comparatively high rate. Only phthalimide, the metabolic product, will be recordable from fetuses, following oral administration of chloromethyl phthalimide and oxymethyl phthalimide to pregnant rats. Those findings, in conjunction with metabolic studies applied to fetuses isolated by caesarian section, appear to suggest the occurrence of an intensive metabolism in fetal tissue. Certain differences established between results of thin-layer chromatography, on the one hand, and 15N studies, on the other, are likely to support the assumption that phthalimide is further metabolised by splitting the imide ring yielding phthalamic acid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310330
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A liver-function test using 15N-labelled ammonium chloride (1985)
    Springer
    European journal of nuclear medicine 11 (1985), S. 62-64 
    Details
    ISSN: 1619-7089
    Keywords: Ammonia ; Diagnosis ; Emission spectroscopy ; Isotope application ; Liver ; Nitrogen-15 ; Tracer technique ; Urea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Malfunction of the liver involves disturbances of urea synthesis and ammonia detoxification. These phenomena became apparent, especially during ammonia loading of patients. The functional state of the liver can be assessed by oral administration of 15NH4Cl and subsequent analysis of 15N-urea and 15N-ammonia in urine by emission spectrometry. Clinical tests based on the ratio of the excess abundances (see Appendix) of 15N-ammonia to 15N-urea excreted in urine 3 h after oral administration gave values for patients with liver disease which differed significantly from those for healthy subjects. Absorption disturbances, which often accompany liver diseases, do not influence the effectiveness of the method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252134
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Nuclear medicine liver-function tests for pregnant women and children (1985)
    Springer
    European journal of nuclear medicine 11 (1985), S. 58-61 
    Details
    ISSN: 1619-7089
    Keywords: Children ; Diagnostic techniques ; Diseases ; Drugs ; Function tests ; Isotope applications ; Liver ; Metabolism ; Nitrogen-15 ; Pregnant women ; Stable isotopes ; Urine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A simple, non-invasive, non-radioactive liverfunction test is proposed. After an oral dose of 3 mg 15N-methacetin per kilogram body mass, the kinetics of 15N excretion via urine were characterized by the quotient of the amounts of 15N excreted in two successive urine samples (Q value). The stable nitrogen isotope 15N was found to be an excellent and easily detectable indicator of the sum of all methacetin metabolites present in urine. Alterations in the nature or ratio of methacetin metabolites due to liver diseases could not be found. From the investigation of 11 men, 3 pregnant women and 15 children, a clear difference was observed in Q values of healthy persons and patients suffering from liver-cell-activity diseases. The discriminating power of our new liver-function test is shown to be equivalent to that of the 14CO2 breath test.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252133
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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