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  • 1
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Hemihepatektomie ; Hämodynamik ; Oxygenierung ; Lebervenenkatheter ; Key words Hemihepatectomy ; Hemodynamic ; Oxygenation ; Liver venous catheter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Objective: The aim of this study was to compare low dose dopamine and dopexamine with respect to of liver-venous oxygen saturation, oxygen delivery and – demand, liver function tests and cardiocirculatory effects in the reperfusion period during a hemihepatectomy operation with occlusion of the liver hilus. Methods: Twenty patients were studied in a randomised, doubleblind setting. They either received 2 µg/kg per min dopamine or 0.5 µg/kg per min dopexamine perioperatively. For monitoring purposes a pulmonary artery and a liver venous catheter were placed. At four different time points hemodynamic parameter were assessed and blood samples were drawn. Results: Significant changes between groups were found 5 min after opening the liver hilus for the cardiac index and the systemic oxygen delivery, as well as at the end of the operation for pulmonary shunt volume, which had increased more in the dopexamine group. No significant difference between liver venous oxygen saturation and liver function tests was found. Conclusion: Until more detailed studies concerning the influence of dopamine on the hepatic-splanchnic region during liver surgery are performed, dopexamine can not be considered superior to dopamine during these operations.
    Notes: Zusammenfassung Fragestellung: Gibt es einen Unterschied bezüglich der leber-venösen Sauerstoffsättigung, des Sauerstoffangebots und -verbrauchs, der Leberfunktion sowie der kardiozirkulatorischen Effekte während der Reperfusion zwischen niedrig dosiertem Dopamin und Dopexamin bei Leberteilresektionen mit Leberhilusokklusion? Methodik: 20 Patienten wurden randomisiert, doppelblind in zwei Gruppen eingeteilt und erhielten entweder 2 µg/kg/min Dopamin oder 0,5 µg/kg/min Dopexamin. Für das perioperative Monitoring wurden ein pulmonalarterieller- und ein Lebervenenkatheter gelegt. Zu vier Meßzeitpunkten wurden Parameter der Hämodynamik erhoben und Blut abgenommen. Ergebnisse: Ein signifikanter Unterschied zwischen den Gruppen bestand 5 min nach Eröffnung des Leberhilus in einem stärker angestiegenen Cardiacindex und systemischen Sauerstoffangebot sowie am OP-En-de in einem stärker angestiegenen pulmonalen Shuntvolumen in der Dopexamingruppe. Es gab keinen Unterschied bezüglich der leber-venösen Sauerstoffsättigung und der Leberfunktionsparameter. Schlußfolgerung: Bis weiterführende Untersuchungen mit differenzierter Betrachtung der Wirkung von Dopexamin bei leber-chirurgischen Eingriffen vorliegen, ist Dopexamin bei diesen Operationen gegenüber Dopamin nicht als überlegen zu betrachten.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1238
    Keywords: Key words Alcohol withdrawal syndrome ; Ethanol kinetics ; Ethanol dosage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Alcohol withdrawal syndrome (AWS) is a severe complication during postoperative treatment of alcohol-dependent patients. Besides the use of clomethiazole, clonidine, and benzodiazepines, there is another possible way to prevent AWS by deliberate administration of ethanol. The appropriate dosage of ethanol has not been known up to now and it could be defined according to the average ethanol elimination rate (EER) which, from forensic analysis, is known to be 15 mg/dl per h in a normal population. However, it is questionable whether these data are suitable for the calculation of the correct dosage in alcohol-dependent patients. Design: Preliminary retrospective descriptive study. Setting: Intensive care unit of a university teaching hospital. Patients: 11 alcohol-dependent patients (9 males, 2 females, mean age 50.8 years, range 33 to 60 years). Interventions: Ethanol substitution (ES) by parenteral application. Measurements and results: Ethanol kinetics were evaluated by repeated measurement of the blood ethanol concentration (BEC) over a period of at least 6 h parallel to the administration of ethanol. The average EER was found to be 28 mg/dl per h with a standard deviation of 11 mg/dl per h. The minimum value was 18 mg/dl per h and the maximum 50 mg/dl per h. These EERs were significantly higher than the EERs known from forensic analysis. AWS was prevented in all 11 patients. Conclusions: Close control of BEC and precise adjustment of ethanol administration are necessary prerequisites for ES. The standard EER is not sufficient to define the appropriate ethanol dosage due to enormous variations in the ethanol metabolism of alcohol-dependent patients.
    Type of Medium: Electronic Resource
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