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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 58 (1980), S. 551-556 
    ISSN: 1432-1440
    Keywords: Plasmapheresis ; Plasma separation ; Membranes for filtration ; Goodpasture's syndrome ; Hyperproteinemia ; Plasmapherese ; Plasmaseparation ; Proteinfiltration durch Membranen ; Goodpasture Syndrom ; Hyperproteinämie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Plasmaseparation wurde mit Hilfe von Zellulose-Diacetat-Hohlfasermodulen durchgeführt. Die Porengröße der Membranen betrug 0.2 µm und hatte eine obere Ausschlußgrenze von ungefähr 3 Millionen Dalton. Fünf Liter Filtrat konnten durchschnittlich in 80 min separiert werden. Der Proteingehalt des Filtrates lag bei etwa 60% des Proteingehaltes im Blut. Die Realtionen der Immunglobuline unterschieden sich im Plasma und im Filtrat nur gering. Durch eine Plasmaseparation gelang es, die Konzentration an Immunglobulinen auf etwa 40% der initialen Konzentration zu senken.
    Notes: Summary Plasma separation was carried out using a new cellulose diacetate hollow-fibre module. The pore size of the membranes used was 0.2 µm and the cut-off at approximately 3 million dalton. Five litres of filtrate was separated in 80 min. The protein content of the filtrate was 60% of that in the blood plasma. When plasma and filtrate were compared, there was little difference in the proportions of the immunoglobulins. At the end of treatment, the immunoglobulin content of the plasma had been reduced to 40% of its initial concentration.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: Thrombopoesis ; Cell separation ; Platelet count ; Platelet function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary About 50% of the circulating platelets can be taken from healthy donors by means of the cell separation technique. In order to investigate the effect of cell separation on thrombopoesis bone marrow samples were taken from 12 voluntary donors up to 5 times. The megacaryocytes were analyzed before and after cell separation by morphometric measures and determinations of platelet count and platelet function (adhesion, aggregation, spreading, retraction) were carried out. Removing of large amounts of platelets form the circulation by stimulation of thrombopoesis resulted in an increase of the peripherical platelet count already 48 h after cell separation. Of the platelet functions tested only aggregation induced by collagen was found to be increased after cell separation as compared to that before the procedure.
    Type of Medium: Electronic Resource
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