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  • 1
    Electronic Resource
    Electronic Resource
    Enzymcytochemische Untersuchung der Gelenkpunktatzellen (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 699-700 
    Details
    ISSN: 1432-1440
    Keywords: Rheumatoid arthritis ; cytochemical enzymes ; lymphocyte stimulation and transformation ; synovial fluid cells ; monocytes ; Chronische Polyarthritis ; Enzymcytochemie ; Lymphozytenstimulation bzw.-transformation ; Synoviazellen — Monozyten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An 42 Kniegelenkspunktaten verschiedenster rheumatischer Erkrankungen wurden enzymcytochemisch die saure Phosphatase, Beta-Glukuronidase, Alpha-Naphthylacetatesterase, Peroxydase und PAS-Reaktion in den Zellen der Synovia bestimmt und nach einem semiquantitativen Verfahren ausgewertet. Bei arthritischen Gelenkergüssen war der Aktivitätsindex der sauren Phosphatase und Beta-Glukuronidase in den Lymphozyten erhöht. Dieser Befund wird im Hinblick auf eine mögliche in vivo Stimulation bzw. Transformation der Lymphozyten diskutiert. In den Monozyten fiel bei Arthritiden eine Erhöhung des Aktivitätsindex der Alpha-Naphthylacetatesterase und Erniedrigung der Beta-Glukuronidase auf.
    Notes: Summary Acid phosphatase, ß-glucuronidase, alpha-naphthylacetatesterase, peroxidase and PAS-reaction were investigated by cytochemical enzyme reactions in synovial fluid cells of 42 samples from knee joints with various rheumatic diseases. These were calculated by a semi-quantitative method. The activity index of acid phosphatase and ß-glucuronidase was increased in lymphocytes of inflammatory synovial fluids. This finding is discussed in view of a possible in vivo stimulation or transformation of the lymphocytes. Concerning the monocytes there was an increase of the activity index of alpha-naphthylacetatesterase and a decrease of ß-glucuronidase in arthritic joint diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468482
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  • 2
    Electronic Resource
    Electronic Resource
    Auranofin and gold sodium thiomalate in the treatment of rheumatoid arthritis: A one-year, double-blind, comparative multicenter study (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 167-174 
    Details
    ISSN: 1432-1440
    Keywords: Auranofin ; Gold sodium thiomalate ; Rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a 48-week, double-blind trial, 122 patients were randomly assigned to treatment with auranofin (60) and gold sodium thiomalate (GST) (62) at five centers. Both groups showed significant improvement (P〈0.05) from baseline in parameters of disease activity. Results of the covariance analysis for all patients who completed the trial showed no significant differences (P〈0.05) in efficacy between the two groups. The proportions of patients showing 50% or greater improvement in tender joints, swollen joints, activity index, severity of pain, general health rating, and erythrocyte sedimentation rate (ESR) were similar for both auranofin-treated and GST-treated patients who completed the 48-week trial. When all patients who entered the trial were evaluated, a slightly greater proportion of patients on auranofin had improved. Diarrhea occurred more frequently with auranofin (32%) compared to GST (19%), whereas rash and pruritus were twice as common in those patients treated with GST compared to those treated with auranofin. The withdrawal rate due to adverse reactions was 10% for auranofin vs 26% for GST. It was concluded that the efficacy of auranofin was comparable to that of injectable gold and was better tolerated, as evidenced by the lower withdrawal rate from adverse events for the auranofin patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727786
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  • 3
    Electronic Resource
    Electronic Resource
    TCR1+ large granular lymphocyte proliferation in rheumatoid arthritis (1994)
    Springer
    Rheumatology international 14 (1994), S. 163-168 
    Details
    ISSN: 1437-160X
    Keywords: Tγ-lymphoproliferative syndrome ; Large granular lymphocytes ; Rheumatoid arthritis ; α/β T cell receptor (TCR2) ; γ/δ TCR1+
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Tγ-lymphoproliferative syndrome is characterized by a proliferation of large granular lymphocytes (LGL). It is often associated with neutropenia, and in 30% of cases with rheumatoid arthritis (RA). Phenotypic analysis has demonstrated that in most cases of RA with Tγ-proliferative disease, the LGL represent T cells with a clonal rearrangement of the α/β T cell receptor (TCR2). Here, three patients with γ/δ TCR1+ LGL proliferation suffering from long-standing arthritis and neutropenia are described. The first patient with RA showed an expansion of a heterogeneous CD2+ CD16+ CD56- LGL population, of which 30% coexpressed TCR1 with Vδ1 rearrangement. The second patient with ankylosing spondylitis and RA was suffering from proliferation of TCR1+ (Vγ9-, Vδ1-), CD2+ CD16- CD56- LGL with low coexpression of CD8. The third patient with RA was suffering from a proliferation of TCR1+ (Vδ1+, Vγ9-) CD4- CE8- CD16- CD56- lymphocytes. On the basis of these unusual findings, the pathogenetic role of TCR1+ T cells in RA is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00579702
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    Paper (German National Licenses)
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