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  • Polymer and Materials Science  (3)
  • Variable-metric methods  (2)
  • interaction  (2)
  • pharmacokinetics  (2)
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  • 1
    Digitale Medien
    Digitale Medien
    Should erythromycin dose be altered in haemodialysis patients? (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 435-440 
    Details
    ISSN: 1432-1041
    Schlagwort(e): erythromycin ; haemodialysis ; dosage adjustment ; pharmacokinetics ; protein-binding
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Erythromycin kinetics were studied in 17 patients with end stage renal failure treated with maintenance haemodialysis and 9 normal volunteers to discover if dialysis patients needed a modified dose. The elimination half life in dialysis patients (on dialysis days) was similar to that reported in normal subjects. Only small amounts of drug appeared in the dialysate, no patient loosing more than 9 mg in one dialysis. Both patients and volunteers had similar plasma concentrations 8 h after the end of a 5-day course. Protein-binding did not change significantly during dialysis and was similar to that reported in normal subjects. We conclude that dialysis patients requiring 1.5 g of erythromycin stearate daily or less can be given normal doses.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00605994
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  • 2
    Digitale Medien
    Digitale Medien
    Methods of comparing pharmacokinetics of slow release preparations: a comparison of “Theo-Dur” and “Phyllocontin” in patients with asthma (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 313-317 
    Details
    ISSN: 1432-1041
    Schlagwort(e): theophylline ; aminophylline ; slow release formulations ; bronchial asthma ; pharmacokinetics ; methods of comparison
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of two slow release theophylline preparations “Theo-Dur” (T) containing theophylline only and “Phyllocontin” (P) containing aminophylline have been compared in 12 patients with asthma. Each patient received both treatments in random order. The dose of treatment administered 12 hourly was increased or decreased to produce plasma theophylline concentrations of 10–20 mg/l at clinic visits normally 7 to 8 h after dosing. Pharmacokinetic studies were carried out after at least one week's treatment with this dose. After the first study day patients were crossed over to the second treatment at a dosage providing a similar amount of theophylline. They returned for a second study day after at least one week. Comparison of the dose corrected AUC, time to peak concentrations, within patient coefficients of variation (CV), number of concentration time points falling within 25% of Cmax and percentage fluctuations in plasma concentration showed no significant differences between the two preparations.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00541535
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  • 3
    Digitale Medien
    Digitale Medien
    The effect of buffered aspirin on plasma indomethacin (1975)
    Springer
    European journal of clinical pharmacology 8 (1975), S. 107-113 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Aspirin ; indomethacin ; plasma levels ; dissolution ; interaction ; toxicity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Plasma indomethacin levels have been compared in 10 subjects following 100 mg of indomethacin from two different formulations, with similar disintegration and dissolution profiles. In four of these ten subjects plasma indomethacin levels were estimated after pretreatment with, and concurrent administration of, a buffered aspirin. The percentage of protein binding of indomethacin in the presence of salicylate was also estimated. No significant differences between peak plasma indomethacin levels with or without buffered aspirin were detected, but the rate of indomethacin absorption as shown by plasma levels, was significantly increased by pretreatment with and concurrent administration of, buffered aspirin. This was associated with a marked increase in side effects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00561558
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  • 4
    Digitale Medien
    Digitale Medien
    An examination of a possible pharmacokinetic interaction between nifedipine and antipyrine (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 405-407 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Nifedipine ; antipyrine ; interaction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The influence of 2 weeks oral intake of nifedipine (2×20 mg) on the oxidative metabolism of antipyrine was investigated in 12 normal volunteers, who had 1050 mg antipyrine solution orally before and after the course of nifedipine. There were no statistically significant differences in the saliva pharmacokinetic parameters of antipyrine on both occasions. However, the metabolite profile of antipyrine in urine showed a significant reduction in the amount of norantipyrine excreted after compared to that before nifedipine administration (16.5 vs 19.6%). This may have implications for drugs that share a similar demethylation pathway with norantipyrine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00315420
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  • 5
    Digitale Medien
    Digitale Medien
    Direct prediction methods in Hilbert space with applications to control problems (1977)
    Springer
    Journal of optimization theory and applications 22 (1977), S. 399-415 
    Details
    ISSN: 1573-2878
    Schlagwort(e): Variable-metric methods ; optimization theorems ; Hilbert spaces ; control theory
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract In this paper, the convergence of variable-metric methods without line searches (direct prediction methods) applied to quadratic functionals on a Hilbert space is established. The methods are then applied to certain control problems with both free endpoints and fixed endpoints. Computational results are reported and compared with earlier results. The methods discussed here are found to compare favorably with earlier methods involving line searches and with other direct prediction quasi-Newton methods.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00932863
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  • 6
    Digitale Medien
    Digitale Medien
    Direct-prediction quasi-Newton methods in Hilbert space with applications to control problems (1977)
    Springer
    Journal of optimization theory and applications 21 (1977), S. 199-211 
    Details
    ISSN: 1573-2878
    Schlagwort(e): Variable-metric methods ; optimization theorems ; Hilbert spaces ; control theory
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract In this paper, the Hilbert-space analogue of a result of Huang, that all the methods in the Huang class generate the same sequence of points when applied to a quadratic functional with exact linear searches, is established. The convergence of a class of direct prediction methods based on some work of Dixon is then proved, and these methods are then applied to some control problems. Their performance is found to be comparable with methods involving exact linear searches.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00932520
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  • 7
    Digitale Medien
    Digitale Medien
    Photostabilizing effect of Ni(II) chelates in polymers. II. Effect of diamagnetic chelates on polypropylene phosphorescence (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 18 (1974), S. 2805-2807 
    Details
    ISSN: 0021-8995
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: Examination of the phosphorescence emission form polypropylene shows the lifetime of the emission to be unaffected by a hydroxybenzophenone light stabilizer but significantly shorted by a diamagnetic Ni(II) chelate stabilizer.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/app.1974.070180921
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  • 8
    Digitale Medien
    Digitale Medien
    XPS and SIMS Investigation of Covalently Bound Lipid on the Wool Fibre SurfacePaper presented at the 4th International Conference on Adhesion and Surface Analysis (1996)
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 24 (1996), S. 704-710 
    Details
    ISSN: 0142-2421
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Physik
    Notizen: Alcoholic alkali solutions, such as potassiumt-butoxide int-butanol and potassium hydroxide in ethanol, have been known to remove the covalently bound lipid from the wool fibre surface. In this study, x-ray photoelectron spectroscopy (XPS) and secondary ion mass spectrometry (SIMS) have been used to investigate the surface characteristics of unprocessed wool fibres (both base section and weathered tips), wool fabric and the relative effects of potassiumt-butoxide and potassium hydroxide treatments. Results comparing the fibre base and tip confirm that the weathering may result in partial loss of the covalently bound lipid from the tip. In addition, a loss of sulphur has been observed. While the extent of sulphur oxidation on the surface of the base section is insignificant, the tip section may have up to 30% oxidized sulphur. There is no apparent difference between the fibres and the fabric used in this study regarding the levels of carbon, sulphur and oxidation. Potassiumt-butoxide is found to be less effective than potassium hydroxide in removing the surface bound lipid. An explanation is given which supports a hypothesis that the bound lipid is located not only at the outer most surface, but that it is also trapped within the underlying protein layer. The potassiumt-butoxide, due to its bulky molecular structure, may not have easy access to the trapped lipid. While the extent of oxidation of surface sulphur after potassiumt-butoxide treatment is higher compared to that after potassium hydroxide treatment, the levels of sulphur loss caused by these two reagents are similar. The removal of bound surface lipid for fabric is more effective than for fibres. It is suggested that fine-scale damage to the fibre, which has been observed to occur during physical processing, is responsible for this difference.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
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  • 9
    Digitale Medien
    Digitale Medien
    A Rapid, Accurate Technique for Determining Densities of High Explosives (1977)
    Weinheim : Wiley-Blackwell
    Propellants, Explosives, Pyrotechnics 2 (1977), S. 81-84 
    Details
    ISSN: 0721-3115
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: An improved gas comparison pycnometer has been developed, based on precise differential pressure measurements coupled with a sample volume compensator. Using helium gas, volumes of solid and powdered explosives can be measured to a precision approaching one part in lo4. Coupled with a precise mass measurement, these volumes allow densities with an uncertainty of ∼± 0.002 g/ml to be inferred. Measurements performed on various explosives have allowed assessment of the purity and homogeneity of individual samples. It is also possible to infer void percentage or porosity in pressed explosive pellets.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/prep.19770020405
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