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  • 1
    Electronic Resource
    Electronic Resource
    Renal and hormonal effects of alpha1-adrenoceptor blockade by bunazosin in essential hypertension (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 575-578 
    Details
    ISSN: 1432-1041
    Keywords: bunazosin ; hypertension ; alpha1-adrenoceptor blocker ; blood pressure ; renal blood flow ; renal function ; renin ; aldosterone ; atrial natriuretic peptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The renal and hormonal effects of the α1-adrenoceptor blocker bunazosin were examined in 6 patients with essential hypertension. Oral bunazosin for 4 to 12 weeks significantly decreased mean blood pressure by 10%, increased effective renal blood flow and creatinine clearance by 34% and 37%, respectively, the plasma norepinephrine concentration was elevated by 60%, and the plasma atrial natriuretic peptide level was lowered by 22%. The plasma renin activity and aldosterone concentration were unchanged. Thus, a moderate reduction in blood pressure was produced by bunazosin treatment while maintaining renal perfusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637738
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Plasma adenosine concentrations are elevated in Dahl salt-sensitive rats (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 227-229 
    Details
    ISSN: 1420-9071
    Keywords: Adenosine ; Dahl salt-sensitive rats ; high-performance liquid chromatography ; hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We measured plasma levels of adenosine in Dahl salt-sensitive rats (DS) and Dahl salt-resistant rats (DR) to examine the potential role of adenosine in cardiovascular regulation in this type of hypertension. Plasma adenosine concentrations were significantly higher in DS than in DR. The NaCl content in the diet did not affect plasma adenosine concentration in either DS or DR. Significant positive correlation was found between adenosine concentrations and systolic blood pressure when the data for DS and DR were analyzed together. These results suggest that adenosine may play an important role in the pathophysiology of hypertension in DS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01931102
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Role of adenosine A1 and A2 receptors in the regulation of aldosterone production in rat adrenal glands (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 726-728 
    Details
    ISSN: 1420-9071
    Keywords: Aldosterone ; cyclic AMP ; adenosine ; adenosine A1 ; receptor ; adenosine A2 receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary To investigate the roles of adenosine A1 and A2 receptors in the regulation of aldosterone production, we examined the effects of adenosine and adenosine agonists (N6-cyclohexyl adenosine; selective adenosine A1 receptor agonist and 5′-N-ethylcarboxamine adenosine; selective adenosine A2 receptor agonist) on aldosterone and cyclic AMP production in rat adrenal capsular cells. Neither adenosine nor 5′-N-ethylcarboxamine adenosine caused significant effects on basal aldosterone or cyclic AMP production. Also, adenosine (10−3M) showed no consistent effects on aldosterone and cyclic AMP production induced by ACTH. On the other hand, N6-cyclohexyl adenosine exhibited a significant inhibition of basal aldosterone and cyclic AMP production at doses of 10−4 M and 10−3 M; furthermore, 10−3 M N6-cyclohexyl adenosine inhibited aldosterone and cyclic AMP production stimulated by ACTH. These results suggest that adenosine A1 receptors are coupled to and inhibit adenylate cyclase and may be involved in the inhibition of aldosterone production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01939947
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of adenosine and adenosine analogs on [14C]aminopyrine accumulation by rabbit parietal cells (1989)
    Springer
    Digestive diseases and sciences 34 (1989), S. 1882-1889 
    Details
    ISSN: 1573-2568
    Keywords: rabbit parietal cells ; [14C]aminopyrine accumulation ; adenosine ; adenosine analogs ; cyclic AMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Adenosine receptors that modulate adenylate cyclase activity have been identified recently in a number of tissues. Adenosine A2 receptor is stimulatory to adenylate cyclase, whereas adenosine A1 receptor is inhibitory to adenylate cyclase. We investigated the effect of adenosine and its analogs on [14C]aminopyrine accumulation by rabbit parietal cells. Rabbit gastric mucosal cells were isolated by enzyme digestion. Parietal cells were enriched by nonlinear percoll gradients. [14C]Aminopyrine accumulation was used as an indicator of acid secretion. The effect of 2-chloroadenosine on histamine-stimulated [14C]aminopyrine accumulation was studied. The effects ofN-ethylcarboxamideadenosine, 2-chloroadenosine, stable analogs of adenosine, and adenosine on [14C]aminopyrine accumulation were assessed. Cyclic AMP content of parietal cells was determined by radioimmunoassay. Histamine and carbachol, known secretagogues, stimulated [14C]aminopyrine accumulation. 2-Chloroadenosine did not suppress histaminestimulated [14C]aminopyrine accumulation. 2-Chloroadenosine,N-ethylcarboxamideadenosine, and adenosine dose dependently increased [14C]aminopyrine accumulation. The order of potency wasN-ethylcarboxamideadenosine 〉 2-chloroadenosine 〉 adenosine. 8-Phenyltheophylline and theophylline, adenosine-receptor antagonists, or cimetidine did not have significant effects on the increase of AP uptake induced by 2-chloroadenosine. Coadministration of dipyridamole, an adenosine uptake inhibitor, augmented the effect of adenosine on [14C]aminopyrine accumulation. 2-Chloroadenosine,N-ethylcarboxamideadenosine, and adenosine each induced a significant increase in cellular cyclic AMP. We conclude that there may be adenosine A2 receptors on rabbit parietal cells which modulate gastric acid secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01536706
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    Paper (German National Licenses)
    Fulltext
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