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  • 2000-2004  (4)
  • 1995-1999  (18)
  • 1
    Digitale Medien
    Digitale Medien
    Growth of vertical-cavity surface-emitting laser structures on GaAs (311)B substrates by metalorganic chemical vapor deposition (1997)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 70 (1997), S. 3395-3397 
    Details
    ISSN: 1077-3118
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: Vertical-cavity surface-emitting laser (VCSEL) structures have been grown on GaAs (311)B substrates by metalorganic chemical vapor deposition. C-doped GaAs and AlAs layers with smooth surface morphology and a hole concentration of 1018 cm−3 were obtained by optimizing the growth conditions; these conditions contributed to high-quality p-type distributed Bragg reflectors (DBRs). The devices on the (311)B substrates exhibited a threshold current of 9.6 mA, voltage of 2.1 V, and maximum power of 4.1 mW at a 20 μm φ size; these characteristics are similar to those obtained on (100) substrates. The polarization was aligned to [2¯33¯]. © 1997 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.119182
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  • 2
    Digitale Medien
    Digitale Medien
    Error-free 2.5 Gbit/s operation of a semi-insulating buried heterostructure side-injection light-controlled bistable laser diode (1997)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 70 (1997), S. 2946-2948 
    Details
    ISSN: 1077-3118
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: We demonstrate optical response from a side-injection light-controlled bistable laser diode buried with semi-insulating InP using hydride vapor phase epitaxy. The buried surface around both the 〈110〉 and 〈−110〉 oriented mesas is flat. The bistable operation is obtained by applying control voltage to the saturable absorption region. After optimization of the device parameters, we obtained error-free operation at a bit rate as high as 2.5 Gbit/s. © 1997 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.118752
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  • 3
    Digitale Medien
    Digitale Medien
    Functional Characterization of CD8+ Antigen-Specific Cytotoxic T Lymphocytes after Enrichment Based on Cytokine Secretion: Comparison with the MHC-Tetramer Technology (2000)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 52 (2000), S. 0 
    Details
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Cell therapy with antigen-specific T cells holds promise for various diseases including cancer and viral infections. The powerful enrichment procedure based on major histocompatibility complex (MHC)-tetramers, however, is of limited applicability so far. Therefore, the recently developed cell surface affinity matrix technology that allows direct identification and enrichment of life antigen-specific T cells based on cytokine secretion was evaluated in this respect. To this end, CD8+ T cells directed against the HLA-A*0201-restricted melanoma-associated peptide Melan-A (aa26–35) were generated by combining stimulation of peptide-pulsed autologous dendritic cells (DC) with antigen-independent expansion with anti-CD3/anti-CD28 monoclonal antibodies (MoAb). Antigen-specific cytotoxic T lympocyte (CTL) were detected based on stimulation-induced interferon (IFN)-γ and interleukin (IL)-4 secretion and enriched 〉 100-fold using the cell surface affinity matrix technology. The resulting IFN-γ- and IL-4-secreting CTL lines contained 〉 80% and 〉 70% cytokine positive T cells, respectively. They exhibited a cytotoxic activity against Melan-A expressing target cells that was significantly higher as compared to nonpurified CTL. Direct staining of enriched CTL with HLA-A2-Melan-A-tetramers revealed a high correlation between the results obtained from the cell surface affinity matrix technology and those obtained from tetrameric complexes. Altogether, our study demonstrates that cytokine-driven enrichment based on the cell surface affinity matrix technology enables selective isolation of functionally active antigen-specific CTL that may be used for an adoptive T cell transfer in immunotherapy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-3083.2000.00810.x
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  • 4
    Digitale Medien
    Digitale Medien
    Suppression of allergic reaction by λ-carrageenan: Toll-like receptor 4/MyD88-dependent and -independent modulation of immunity (2003)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 33 (2003), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background Recognition of foreign substances by innate immunity through pattern recognition receptors (PRRs) regulates acquired immunity such as allergic reaction. Because PRRs recognize heterogeneous ligands, daily food intake can potentially regulate immune allergic reaction.Objective Elucidation of the effect of λ-carrageenan on allergic reactions was aimed.Method IFN-γ and IL-4 was measured in in vitro T cell-stimulated culture. Cytokine production from macrophages in response to λ-carrageenan was measured as indicator for innate immunity activation. Mice were immunized with OVA in alum to induce specific IgE, and then histamine release was induced by systemic injection of OVA.Results Activation of innate immunity by λ-carrageenan is dependent on Toll-like receptor-4 (TLR4) and MyD88, in which induction of pro-inflammatory cytokines such as TNF-α and IL-6 was largely impaired in macrophages from TLR4- and MyD88-deficient mice. Footpad oedema, a model for in vivo inflammatory reactions, was significantly reduced in these mice. Similar to recent evidence showing a preference for the stimulation of Th1 via TLR/MyD88 signalling, λ-carrageenan showed enhanced IFN-γ and decreased IL-4 in stimulated T cell cultures. Interestingly, increased IFN-γ production was still seen in TLR4- and MyD88-deficient splenocytes. Oral administration of λ-carrageenan to immunized mice successfully decreased OVA-specific IgE, and λ-carrageenan was also effective in previously immunized mice. Further, serum histamine release upon systemic challenge of OVA was significantly inhibited. Neither OVA-specific IgG1/IgG2a nor cytokine secretion from in vitro cultures were altered, suggesting the involvement of multiple PRRs as demonstrated by TLR4/MyD88-independent IFN-γ up-regulation. The simultaneous feeding of OVA with lipopolysaccharide abrogated oral tolerance, but λ-carrageenan was not only devoid of such an effect but was also found to promote oral tolerance in the absence of TLR4.Conclusion λ-Carrageenan was suggested to be a useful dietary supplement to ameliorate allergic reactions while maintaining oral tolerance-dependent intestinal homeostasis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2222.2003.01575.x
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  • 5
    Digitale Medien
    Digitale Medien
    Structure of the exocrine pancreas of flounder (Paralichthys olivaceus): immunological localization of zymogen granules in the digestive tract using anti-trypsinogen antibody (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 46 (1995), S. 0 
    Details
    ISSN: 1095-8649
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie
    Notizen: Most fish have a diffuse exocrine pancreas located around the internal organs, but its exact structure is not well understood. In this study, we developed a method for analysing zymogen granules using anti-fish trypsinogen, and the structure of the flounder pancreas was examined by localizing pancreatic exocrine cells. Anionic trypsinogen was purified from eel pancreas by chromatography using DE-52-cellulose and Superose 12 columns. Rabbit antiserum (anti-eel trypsinogen antibody: anti-eTrg) was raised against purified trypsinogen. Immunoblotting analysis demonstrated that anti-eTrg recognized two isoforms of eel trypsinogens and trypsins. This antibody also reacted with flounder trypsin. Zymogen granules containing trypsinogen were visualized within pancreatic glandular cells of the flounder Paralichthys olivaceus by immunohistochemistry using anti-eTrg. The flounder exocrine pancreas was reconstructed from observations of serial sections of digestive tract. The exocrine pancreas cells were localized along the hepatic portal vein and the veins running to the portal vein from the intestine, stomach, pyloric appendage and spleen, forming a highly branched tissue. Interlobular ducts from pancreatic acini formed a pancreatic duct covered with smooth muscle at the point where it met (but did not join) the bile duct. The pancreatic duct opened into the intestinal lumen at the basal portion of the third pyloric appendage in parallel with the bile duct.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1095-8649.1995.tb05970.x
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  • 6
    Digitale Medien
    Digitale Medien
    Post-release adaptation processes of hatchery-reared honmasu salmon parr (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 56 (2000), S. 0 
    Details
    ISSN: 1095-8649
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie
    Notizen: Hatchery-reared honmasu salmon Oncorhynchus rhodurus × masou parr released into the Yanagisawa River, Tochigi Prefecture on 24 June 1996 increased significantly in length and weight by November, while siblings retained in hatchery tanks did not. Plasma growth hormone (GH) levels of the released parr increased from 1 day after the release until 23 August, while the GH levels of the wild parr in the river did not increase. The released parr started to consume various natural prey organisms within a day after release. However, stomach fullness of the released parr was considerably lower than that of the wild parr during the first week following release. Trypsin activity in the released parr increased after 23 August, 2 months post-release. The results demonstrate that the released parr adapt to the natural river environment within weeks. Endocrine control by GH and exocrine pancreas activity appear to play important roles in the post-release adaptation processes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1095-8649.2000.tb02092.x
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  • 7
    Digitale Medien
    Digitale Medien
    Prevention of equinus deformity during tibial lengthening (1997)
    Springer
    International orthopaedics 20 (1997), S. 359-362 
    Details
    ISSN: 1432-5195
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé. Nous avons examiné après traitement 28 allongements tibiaux chez 14 patients souffrant d’achondroplasie et ayant un âge moyen de 15 ans (étalement: de 9 à 24 ans) afin de comparer l’efficacité de la physiothérapie et de l’orthèse dans la prévention de l’équin. Une physiothérapie à raison de 15 minutes par jour à domicile (n = 12) n’a pas été efficace, même dans le cas de patients marchant et participant à des activités sociales telles que l’école ou le travail. La déformation en équin est apparue avec un allongement de 30% et a atteint une moyenne de 30 degrés avec un allongement de 50%. En revanche, l’orthèse avec un port d’au moins 16 heures par jour (n = 10) s’est révélée efficace dans la prévention de la déformation jusqu’à un allongement d’au moins 50%, la différence avec la physiothérapie étant significative (p 〈0.01) au-delà d’un allongement de 30%. Lorsque nous évaluons les deux méthodes de physiothérapie et de traitement par orthèse en fonction du mode d’étirement des tissus mous, l’effet de la physiothéraphie est intermittent et en général d’une durée insuffisante alors que celui de l’orthèse est continu et peut avoir une durée appropriée si l’appareil est porté assez longtemps. Il semble essentiel pour l’allongement des parties molles d’adopter une méthode leur appliquant un étirement continu et prolongé.
    Notizen: Summary. We have reviewed 28 tibial lengthenings in 14 patients with achondroplasia at an average age of 15 years, and compared the effectiveness of physiotherapy and an orthosis in preventing an equinus deformity. Physiotherapy of 15 min a day was ineffective even when the patients were able to walk. An orthosis worn for 16 h a day prevented equinus deformity up to at least 50% of lengthening, and the difference from physiotherapy was significant at more than 30% of lengthening.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002640050097
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  • 8
    Digitale Medien
    Digitale Medien
    Stimulation of bone formation by intraosseous injection of basic fibroblast growth factor in ovariectomised rats (1998)
    Springer
    International orthopaedics 22 (1998), S. 49-54 
    Details
    ISSN: 1432-5195
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé. L’effet d’une unique injection locale dans les os trabeculaires de facteur de croissance de base de fibroblaste humain recombinant (bFGF) sur la formation intra-osseuse a été examiné sur des rats ostéoporotiques ovariectomisés. L’injection bFGF (400 μg) ou véhicule seul (V) a été pratiquée dans l’ilion 16 semaines après ovariectomie (OVX) ou pseudo-opération (Sham). A 2 semaines, la densité osseuse moyenne des OVX+bFGF avait augmenté jusqu’à un niveau similaire aux Sham+V pour atteindre son maximum à 8 semaines, soit 19% de plus que les Sham+V. Au-delà de 8 semaines, la densité moyenne a décliné lentement, conservant à 24 semaines une valeur supérieure aux OVX+V. Le bFGF a stimulé la formation ostéoï de des 2 premières semaines. Le volume d’os minéralisé a atteint son sommet à 8 semaines. Entre 8 et 12 semaines, la résorption osseuse a été facilitée, conduisant à des baisses du volume osseux jusqu’aux niveaux Sham+V 24 semaines. Les analyses structurelles à 8 et 24 semaines ont montré que l’injection bFGF ramène à des niveaux égaux ou supérieurs à Sham+V la connectivité des trabeculae réduite par l’OVX. La présente étude établit qu’une application intraosseuse de bFGF après ovariectomie ramène le volume et la qualité osseuse au niveau des rats pseudo-opérés.
    Notizen: Summary. The effect on intraosseous bone formation of a single local injection of recombinant human basic fibroblast growth factor into trabecular bones was examined in ovariectomised osteoporotic rats. Fibroblast growth factor (400 μg), or the vehicle alone, was injected into the ilium at 16 weeks after ovariectomy or a simulated operation. Bone mineral density in the ovariectomised rats increased to a level similar to the latter at 2 weeks and reached a maximum at 8 weeks. After 8 weeks, BMD decreased slowly and the value at 24 weeks was still higher than that in the ovariectomised rats. Fibroblast growth factor stimulated osteoid formation in the first 2 weeks, bone volume reaching a peak at 8 weeks. From 8 to 12 weeks, bone resorption increased, resulting in decreases in bone volume to the levels of the group with simulated operations at 24 weeks. Structural analysis at 8 and 24 weeks showed that ovariectomy decreased the continuity of trabeculae and the injection of fibroblast growth factor restored it to levels higher than, or equal to, those who had the simulated operation. The present study demonstrated that intraosseous fibroblast growth factor given to ovariectomised rats restored bone volume and quality to the levels of the rats who had a simulated operation only.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002640050207
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  • 9
    Digitale Medien
    Digitale Medien
    The relation between osteoporosis of the spine and osteoarthritis of the knee (1995)
    Springer
    International orthopaedics 19 (1995), S. 282-284 
    Details
    ISSN: 1432-5195
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé Nous avons entrepris des recherches sur la relation entre l'ostéoporose de la colonne vertébrale et l'arthrose du genou au moyen de l'absorptiométrie à rayons X et de la radiographie standar sur 82 femmes sélectionnées au hasard (l'âge moyen est de 77 ans). La densité minérale de l'os (BMD=»Bone Mineral Density«) de la colonne lombaire a été évaluée par l'absorptiométrie. Nous avons évalué les informations provenant des radiographies des genoux pour classer l'arthrose en 2 groupes: »Normal« et »Evolue«. La BMD du groupe type »Evolue« était bien supérieure à celle du groupe type »Normal« (p〈0.01).
    Notizen: Summary We investigated the relation between osteoporosis of the spine and osteoarthritis of the knee using dual energy X-ray absorptiometry of the lumbar spine to measure bone mineral density and radiographs of the knee in 82 randomly selected females (mean age 77.5 years). Radiographs of the knee were divided into a normal and severe group. The bone mineral density of the severe group was significantly more than that of the normal group.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00181109
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  • 10
    Digitale Medien
    Digitale Medien
    Evaluation of Mode II Interlaminar Fracture Toughness of Composite Laminates under Impact Loading (1997)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 141-143 (Sept. 1997), p. 477-500 
    Details
    ISSN: 1013-9826
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Materialart: Digitale Medien
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/44/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.141-143.477.pdf
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