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Digitale Medien

Pharmacokinetics of intravenous salbutamol in renal insufficiency and its biological effects (1989)

Rey, E. ; Luquel, L. ; Richard, M. O. ; [weitere]

Springer

European journal of clinical pharmacology 37 (1989), S. 387-389

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Details

ISSN: 1432-1041

Schlagwort(e): salbutamol ; pharmacokinetics ; renal insufficiency ; biological effects

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary Salbutamol was administered intravenously to 5 patients with renal function impairment for estimation its pharmacokinetic parameters. The mean terminal half-life was 256 min, similar to previously reported values in healthy adults. The mean clearance (167 ml/min) and the mean volume of distribution (55 l) were decreased. These parameters were not correlated with the creatinine clearance. A slight but significant decrease was observed in the plasma potassium level up to 125 min after the salbutamol infusion. The heart rate was significantly increased, and the increase in 3 patients was correlated with the salbutamol concentration. The biological effects of the drug were less marked than expected.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00558505

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