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Digitale Medien

Stimulation of human fetal astrocyte proliferation by bacterial lipopolysaccharides and lipid A (1991)

Kato, M. ; Ohno, K. ; Takeshita, K. ; [weitere]

Springer

Acta neuropathologica 82 (1991), S. 384-388

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Details

ISSN: 1432-0533

Schlagwort(e): Bacterial endotoxin ; Lipopolysaccharide ; Lipid A ; Culture astrocyte

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary This report concerns the effect of bacterial endotoxin [lipopolysaccharide(LPS) and lipid A] on cultured human fetal astrocytes. Exposure to 1 μg/ml LPS or lipd A caused a striking stimulation of the rate of proliferation of the cells. The effect was most pronounced with exponentially growing cultures. Stimulation was associated with enhance DNA synthesis as ascertained by [3H]thymidine incorporation. These findings at the cellular level may be of relevance in the elucidation of the effects of bacterial endotoxins on the developing human brain.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00296549

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