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Digitale Medien

Potentiation of oxotremorine-induced hypothermia by alaproclate in PCA lesioned and non-lesioned rats (1989)

Dilsaver, Steven C. ; Normile, Howard J. ; Altman, Harvey J.

Springer

Psychopharmacology 97 (1989), S. 51-53

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Details

ISSN: 1432-2072

Schlagwort(e): Thermoregulation ; Acetylcholine ; Muscarinic ; Serotonin ; Interaction ; Alaproclate ; Oxotremorine ; Rat

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Stimulation of muscarinic cholinergic receptors with the highly potent and selective receptor agonist oxotremorine produced hypothermia in rats. Alaproclate, a purported selective serotonergic reuptake inhibitor, potentiated this response. Destruction of central presynaptic serotonergic terminals with the potent cytotoxin p-chloroamphetamine (PCA) failed to attenuate the hypothermic response to oxotremorine in alaproclate-pretreated animals. These results could be taken to suggest that alaproclate may act, at least in part, via a non-serotonergic mechanism to potentiate the oxotremorine-induced hypothermic response.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00443412

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