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  • 11
    Digitale Medien
    Digitale Medien
    Association of HLA-DRB1*07 and DRB1*04 to citrus red mite (Panonychus citri) and house dust mite sensitive asthma (2000)
    Oxford BSL : Blackwell Science Ltd
    Clinical & experimental allergy 30 (2000), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Specific IgE responses to allergens provide useful models for evaluating the genetic factors that control human immune responses. A recent survey demonstrated that the citrus red mite (Panonychus citri, CRM) is the most important allergen in the development of asthma in citrus farmers.〈section xml:id="abs1-2"〉〈title type="main"〉ObjectiveThe aim of this study was to evaluate whether susceptibility or resistance to CRM-induced asthma was associated with HLA-DRB1 gene.〈section xml:id="abs1-3"〉〈title type="main"〉MethodsDNAs were extracted from two groups of unrelated Korean adults living around citrus farms: (1) Ninety-one adults with CRM-sensitive asthma; and (2) 98 exposed, healthy nonatopic controls. Genotypes of HLA-DRB1 alleles were carried out using PCR-based methods.〈section xml:id="abs1-4"〉〈title type="main"〉ResultsAllelic frequency of HLA-DRB1*07 was higher in the CRM-sensitive asthmatics compared to the controls (17.6% vs 4.1%, Pc = 0.01). Conversely, the frequency of DRB1*04 was lower in the CRM-sensitive asthmatics compared to the controls (19.8% vs 40.8%, Pc = 0.01). No significant difference was found in the distributions of the other HLA-DRB1 gene-encoded antigens between the two groups.〈section xml:id="abs1-5"〉〈title type="main"〉ConclusionHLA-DRB1 genes may be involved in the development of CRM-induced asthma. In addition, HLA-DR7 may increase, and DR4 decrease, the risk of developing the asthma in CRM-exposed adults.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2222.2000.00915.x
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  • 12
    Digitale Medien
    Digitale Medien
    IgE binding components in Tetranychus urticae and Panonychus ulmi-derived crude extracts and their cross-reactivity with domestic mites (2001)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 31 (2001), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background Recent investigation has revealed that spider mites such as Tetranychus urticae and Panonychus ulmi are important allergens in the development of occupational asthma among apple farmers.Objective To evaluate IgE binding components in T. urticae and P. ulmi-derived crude extracts and their cross-reactivity with Panonychus citri, Tyrophagus putrescentiae and Dermatophagoides pteronyssinus in apple cultivating farmers.Methods Thirty-one apple farmers with positive skin responses to T. urticae or P. ulmi were randomly recruited, and specific IgE levels in their sera were measured using ELISA. Cross-reactivity was evaluated by ELISA inhibition. IgE binding components were evaluated by IgE immunoblotting.Results A total of 11 IgE binding components in T. urticae and 10 in P. ulmi were found. Among them, the 17 kDa, 27 kDa, 33 kDa, 37 kDa, 41 kDa, 56 kDa, and 75 kDa allergens in T. urticae, and the 33 kDa, 41 kDa, and 51 kDa allergens in P. ulmi were identified as dominant allergens. T. urticae-specific IgE binding was completely inhibited by 100 μg/mL of T. urticae (99.7%), but only partially inhibited by P. citri (83.0%), P. ulmi (71.6%), T. putrescentiae (69.7%), and D. pternonyssinus (60.1%). P. ulmi-specific IgE binding was completely inhibited by additions of P. citri (92.3%) and P. ulmi (91.2%), but only partially inhibited by the addition of T. urticae (61.5%), T. putrescentiae (57.7%), and D. pteronyssinus (54.4%).Conclusion There were seven dominant allergens found in T. urticae and three in P. ulmi. T. urticae- and P. ulmi-specific IgE bindings were partially inhibited by crude extracts derived from D. pteronyssinus and T. putrescentiae.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2222.2001.01153.x
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  • 13
    Digitale Medien
    Digitale Medien
    IgE-mediated occupational asthma induced by herbal medicine, Banha (Pinellia ternata) (2001)
    Oxford, UK : Blackwell Science, Ltd
    Clinical & experimental allergy 31 (2001), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: There have been few reported cases of occupational asthma induced by Pinellia ternata (Banha), and the mechanism responsible for this type of asthma is still undetermined. We report a case of Banha-induced occupational asthma with IgE-mediated mechanism. The patient had positive skin responses to Banha extract and Banha-specific bronchial challenge elicited an early asthmatic response. The serum-specific IgE binding to Banha extract was detectable and completely inhibited with the additions of 0.1 µg/mL of Banha extract on ELISA inhibition. Seven IgE binding components to Banha extract (6.5, 22, 24, 32, 34, and 48 kDa) were detected using SDS–PAGE and immunoblot analysis. In conclusion, the results of this study suggest that P. ternata (Banha)-derived allergens are able to cause IgE-mediated bronchoconstriction in exposed workers.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2222.2001.01067.x
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  • 14
    Digitale Medien
    Digitale Medien
    HLA-DRB1*07 may have a susceptibility and DRB1*04 a protective effect upon the development of a sensitization to house dust mite Dermatophagoides pteronyssinus (2001)
    Oxford, UK : Blackwell Science, Ltd
    Clinical & experimental allergy 31 (2001), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: IgE responses to house dust mite-derived allergens seem to be the most important in the development of atopic asthma and rhinitis, but it has been difficult to demonstrate genetic control of the IgE response to the allergens.This study was undertaken to investigate the association between sensitization to house dust mite, D. pteronyssinus (DP), and genotypes of HLA-DRB1 alleles.DNAs were extracted from two groups of unrelated Koreans: (1) 178 with sensitization to DP; and (2) 99 age-matched non-atopic controls. Genotypes of the HLA-DRB1 alleles were determined using polymerase chain reaction (PCR)-based methods.The frequency of HLA-DRB1*07 was significantly increased in the DP-sensitive subjects compared with the controls (15.7% vs 4.0%, P = 0.009). Conversely, the frequencies of HLA-DRB1*04 and *14 were decreased in the DP-sensitive subjects compared with the controls (27.5% vs 45.5%, P = 0.002; 13.5% vs 24.2%, P = 0.02). Of the DRB1*04 alleles, DRB1*0403 was significantly decreased in the DP-sensitive subjects compared with the controls (3.9% vs 13.1%, P = 0.005). No significant differences were found in the distributions of the other HLA-DRB1 alleles between the two groups.HLA-DRB1*07 may have a susceptibility, and DRB1*04 and DRB1*14 may have a protective effect, upon the development of a sensitization to DP.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2222.2001.00950.x
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  • 15
    Digitale Medien
    Digitale Medien
    Prevalence of childhood asthma based on questionnaires and methacholine bronchial provocation test in Korea (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 27 (1997), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background In most epidemiological survey studies, only subjective symptoms and past medical history of asthma have been used as diagnostic criteria. Even though a questionnaire survey can be performed in a large population study at low cost, limitations such as lack of objectivity and poor predictability in non-specific bronchial hyperresponsiveness cannot be avoided.Objectives The purpose of this study was to elucidate the prevalence of current asthma based on questionnaires and methacholine bronchial provocation test, and the prevalence of atopy in Korea.Methods We performed modified ATS respiratory questionnaires and allergen skin-prick test with 10 common inhalant allergens among 3219 subjects aged 7–19 years in Seoul and a rural part of a small city, Chungju in Korea. Methacholine bronchial provocation tests were also performed among those who had asthma symptoms according to the questionnaire. The criteria of asthma was presence of both asthma symptoms and non-specific bronchial hyperresponsiveness. Atopy was defined as when an allergen induced weal size is same or larger than that caused by histamine.Results The prevalence of asthma based on questionnaires and methacholine bronchial provocation tests was 4.6%, while the prevalence of wheeze was 8.2% and 19.3% of total population complained of one or more respiratory symptoms related to asthma on the questionnaires. There was no significant difference according to age, sex and living area. The mean prevalence of atopy was 35.0% and the most common allergens were Dermatophagoides farinae (30.9%), Dermatophagoides pteronyssinus (27.5%), cat fur (20.4%) and cockroach (11.8%). The atopy prevalence in Chungju area was higher than that in Seoul and males showed a higher prevalence than females. The asthma prevalence was higher among atopies (6.8%) than among non-atopies (2.7%). None of questionnaire items were enough to predict the presence of bronchial hyperresponsiveness in terms of sensitivity, specificity and positive predictive value.Conclusion The prevalence rate of current asthma in Korea was 4.6% and the prevalence rate of atopy in Korea was 35.0%. Questionnaire-based surveys are not enough to predict the actual prevalence of asthma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2222.1997.710839.x
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  • 16
    Digitale Medien
    Digitale Medien
    Effect of bacterial growth-inhibiting ingredients on the Ames mutagenicity of medicinal herbs
    Amsterdam : Elsevier
    Mutation Research Letters 192 (1987), S. 99-104 
    Details
    ISSN: 0165-7992
    Schlagwort(e): Bacterial growth inhibition ; Korea ; Medicinal herbs ; Rhei ; Scutellariae ; es mutagenicity test
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1016/0165-7992(87)90104-7
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  • 17
    Digitale Medien
    Digitale Medien
    Numerical investigation on J-integral testing of heterogeneous fracture toughness testing specimens: Part I – weld metal cracks (2003)
    PO Box 1354, 9600 Garsington Road, Oxford OX4 2XG, UK. : Blackwell Science Ltd
    Fatigue & fracture of engineering materials & structures 26 (2003), S. 0 
    Details
    ISSN: 1460-2695
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Maschinenbau
    Notizen: Based on extensive two-dimensional (2D) finite element (FE) analyses, the present work provides the plastic η factor solutions for fracture toughness J-integral testing of heterogeneous specimens with weldments. Solutions cover practically interesting ranges of strength mismatch and relative weld width, and are given for three typical geometries for toughness testing: a middle cracked tension (M(T)) specimen, single edge cracked bend (SE(B)) specimen and (C(T)) specimen. For mismatched M(T) specimens, both plane strain and plane stress conditions are considered, whereas for SE(B) and C(T) specimens, only the plane strain condition is considered. For all cases, only deep cracks are considered, and an idealized butt weld configuration is considered, where the weld metal strip has a rectangular cross section. Based on the present solutions for the strength mismatch effect on plastic η factors, a window is provided, within which the homogeneous J estimation procedure can be used for weldment toughness testing. The effect of the weld groove configuration on the plastic η factor is briefly discussed, concluding the need for further systematic analysis to provide guidance to practical toughness testing.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1460-2695.2003.00676.x
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  • 18
    Digitale Medien
    Digitale Medien
    Enhanced reference stress-based J and crack opening displacement estimation method for leak-before-break analysis and comparison with GE.EPRI method (2001)
    Oxford, UK : Blackwell Science Ltd
    Fatigue & fracture of engineering materials & structures 24 (2001), S. 0 
    Details
    ISSN: 1460-2695
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Maschinenbau
    Notizen: Three-dimensional, elastic–plastic finite element analyses for circumferential through-wall cracked pipes are performed using actual tensile data of stainless steels, for two purposes. The first one is to validate the recently proposed enhanced reference stress (ERS) method to estimate the J-integral and rack-opening displacement (COD) for circumferential through-wall cracked pipes. The second one is to compare the J and COD results from the ERS method with those based on the GE/EPRI method, together with the finite element results. It is found that the GE/EPRI method generally provides poor estimations of J and COD, and such poor estimation results from the Ramberg–Osgood (R–O) fit. Moreover, the GE/EPRI results can be very sensitive to how the stress–strain data are fitted using the R–O relation. The most appropriate fitting range for the R–O fit depends on the material, and thus no specific guideline can be given. On the contrary, the J and COD estimations based on the ERS method give more accurate and robust results than the GE/EPRI estimation. The present results, together with the experimental validation presented in the previous paper, provide sufficient confidence in using the proposed method in the leak-before-break analysis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1460-2695.2001.00388.x
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  • 19
    Digitale Medien
    Digitale Medien
    Estimations of creep fracture mechanics parameters for through-thickness cracked cylinders and finite element validation (2003)
    Oxford, UK : Blackwell Science, Ltd
    Fatigue & fracture of engineering materials & structures 26 (2003), S. 0 
    Details
    ISSN: 1460-2695
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Maschinenbau
    Notizen: This paper compares engineering estimation schemes of C* and creep crack opening displacement (COD) for cylinders with circumferential and axial through-thickness cracks at elevated temperatures with detailed 3D elastic-creep finite element results. Engineering estimation schemes include the GE/EPRI method; the reference stress (RS) method where the reference stress is defined based on the plastic limit load; and the enhanced reference stress (ERS) method where the reference stress is defined based on the optimised reference load, recently proposed by the authors. Systematic investigations are made not only on the effect of creep-deformation behaviour on C* and creep COD, but also on effects of the crack location, the cylinder geometry, the crack length and the loading mode. Comparison of the finite element (FE) results with engineering estimations provides that for idealised power law creep, estimated C* and COD rate results from the GE/EPRI method agree best with FE results, suggesting that published plastic influence functions for plastic J and COD for through-thickness cracked cylinders are reliable. For general creep-deformation laws where either primary or tertiary creep is important and thus the GE/EPRI method is hard to apply, on the other hand, the ERS method provides more accurate and robust estimations for C* and COD rate than the reference stress method. As these two methods differ only in the definition of the reference stress, the ERS method maintains benefits of the reference stress method in terms of simplicity, but improves accuracy of the estimated J, C* and COD results.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1460-2695.2003.00623.x
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  • 20
    Digitale Medien
    Digitale Medien
    Caveolin-1 is down-regulated and inversely correlated with HER2 and EGFR expression status in invasive ductal carcinoma of the breast (2005)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 47 (2005), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Aims : To evaluate the caveolin-1 status of invasive ductal carcinoma and its correlation with other important parameters of breast carcinogenesis. Caveolin-1, the main structural protein of caveolae, is involved in the regulation of several intracellular signalling pathways and also functions as a tumour suppressor in breast carcinogenesis.Methods and results : One hundred and thirty cases of invasive ductal carcinomas with matched normal breast tissue were evaluated immunohistochemically for caveolin-1 expression. Using a tissue microarray, caveolin-1 expression was also correlated with the expression of other antigens such as eostrogen receptor, progesterone receptor, epidermal growth factor receptor (EGFR), HER2, β-catenin, E-cadherin, p53, Ki67 and with clinicopathological parameters. Immunohistochemical results showed strong expression of caveolin-1 in all normal breast epithelial cells, but a reduction of caveolin-1 expression in 56 cases (43.1%) of invasive ductal carcinoma. Furthermore, a statistically significant inverse correlation between caveolin-1 and EGFR and HER2 was noted (P 〈 0.001).Conclusions : Our results indicate a reduction in caveolin-1 expression in invasive ductal carcinoma of the breast, which supports in vitro studies of its role as a tumour suppressor. Caveolin-1 also shows an inverse correlation with EGFR and HER2, which fits with its function as a negative regulator of signal transduction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.2005.02303.x
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