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Digitale Medien

Reactivity of monoclonal antibody BE 2 in different stages of mycosis fungoides and in benign dermal infiltrates (1986)

Kaudewitz, P. ; Soldner, R. ; Burg, G. ; [weitere]

Springer

Archives of dermatological research 279 (1986), S. 83-88

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ISSN: 1432-069X

Schlagwort(e): Mycosis fungoides ; Histopathology ; Benign inflammatory dermatoses

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The cutaneous infiltrate in mycosis fungoides (MF) is predominantly composed of T4-positive T-cells. Attempts to distinguish the early stages of this condition from benign inflammatory infiltrates using anti-T3, T4 and other T-cell-associated antibodies have hitherto been unsucessful. Recently a monoclonal antibody BE 2 has been described as selectively reacting against leukemic cells in patients with cutaneous T-cell lymphoma. To investigate whether the BE 2 antigen is differentially expressed in different stages of MF and benign dermatoses, thus facilitating diagnosis, especially of early MF, the reactivity of monoclonal antibody BE 2 against cutaneous infiltrates from such conditions was assessed. In the early stages of MF only a small number of reactive cells was present. In benign inflammatory infiltrates, especially in those that clinically and histologically were hardly distinguishable from early MF, BE 2 reactivity was essentially the same as in eczematous-stage MF. Lesions from plaque and tumor stage MF contained large numbers of BE 2-reactive cells. Our results indicate that expression of BE 2 is associated with the stage of a given MF lesion and is essentially identical in early MF and eczematous lesions with a similar histopathological appearance.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00417527

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Digitale Medien

Treatment of thrombocytosis in myeloproliferative disorders with interferon alpha-2a (1989)

Tichelli, A. ; Gratwohl, A. ; Berger, C. ; [weitere]

Springer

Annals of hematology 58 (1989), S. 15-19

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ISSN: 1432-0584

Schlagwort(e): rIFN alpha-2a ; Thrombocytosis ; Myeloproliferative disorders

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary In an open prospective pilot trial, we tested the effect of recombinant interferon alpha-2a (rIFN alpha-2a) on thrombocytosis in myeloproliferative disorders (MPD). Since October 1986, 13 patients with MPD (4 with chronic granulocytic leukemia, 4 with polycythemia vera, 3 with essential thrombocythemia and 2 with myeloid metaplasia) were treated with rIFN alpha-2a. Platelet counts decreased in all treated patients within 2 to 10 weeks from a median value of 1,050×109/l (range 610−1,940×109/l) to 340×109/l (range 230−495×109/l). The response was dose-dependent. In 11 patients we observed a simultaneous reduction of the white blood cell count. Six patients still continue the IFN alpha-2a therapy. In 7 treatment was discontinued, because of chronic side effects in 3, and because of noncompliance in one. In these patients, thrombocytosis recurred after discontinuation of the therapy. These results show that rIFN alpha-2a is effective in controlling thrombocytosis in MPD. However, the long-term benefit of interferon in these disorders remains to be established.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00320230

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Digitale Medien

In situ primary production, biomass and light regime in the Wolderwijd, the most stable Oscillatoria agardhii lake in The Netherlands (1989)

Berger, C.

Springer

Hydrobiologia 185 (1989), S. 233-244

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ISSN: 1573-5117

Schlagwort(e): Oscillatoria agardhii ; bloom ; production ; euphotic volume ; morphometry ; light-dark rhythm

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Notizen: Abstract During the entire period of research from 1971 to 1982 Oscillatoria agardhii Gomont was overwhelmingly present in the Wolderwijd. Six years of measurements of primary production has pointed out that the gross production per day firstly is related to temperature and secondly to irradiation. However, the production per year is neither related to temperature nor to irradiation. In a cold summer gross production is as high as in a warm summer due to higher production in the lower part of the euphotic zone. In the discussion attention is focused on production characteristics and light climate in relation to the morphometry of the lake. Up to an average depth of 2.5 m blooming of O. agardhii occurs easily, whilst light saturated production achieves its maximum between 2.0 and 2.5 m depth. Increasing depth leads to photo-inhibition in the upper layers followed by lowering of light saturated production. Only special circumstances such as days with microstratification allow growth, resulting then in a monoculture of the alga.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00036611

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