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  • Electronic Resource  (13)
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  • Electronic Resource  (13)
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  • 11
    Electronic Resource
    Electronic Resource
    Effect of Woven Fabric Biodegradable Polyglycolic Acid on Joint Resurfacing with Fresh Chondrocytes in a Rabbit Model (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 1197-1200 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: To evaluate the effectiveness of the cell-material in situ on joint resurfacing, a wovenfabric polyglycolic acid (PGA) treated with fresh chondrocytes was used for repairing cartilagedefects. Full-thickness defects were created in the weight-bearing surfaces of the femoralintercondylar fossa in a rabbit model. The defect was filled with and without PGA under surgicalcondition. Before implantation, chondrocytes were co-cultured with PGA for one day. The animalswere sacrificed at eight weeks after implantation and evaluated grossly and histological score.Morphological examination showed that for PGA/chondrocytes group, the repaired tissue appearedsimilar in color and texture to the surrounding articular surface. While for the untreated control, nocartilage-like tissue was observed at all defects, but connective fibrous tissue. Histological analysisrevealed neochondrogenesis and clusters of cartilage matrix with specific safranin-O staining for thePGA/cell group. The Gross and histological evaluation indicated a significantly higher score forPGA/cell group than for PGA and control group. These results suggest that the woven fabric PGAmay facilitate the formation of cartilage tissues by providing a biodegradable and good-handlevehicle for the delivery to and retention of organized cell matrix constructs in vivo site. It mighttherefore enhance neochondrogenesis because of the superior biodegradable and biocompatible ofPGA scaffold sheet, while the more suitable biological environment might sustain cell growth andin situ cell function, suggesting a promising candidate for functional tissue engineering of clinicalenvironment
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.1197.pdf
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    Paper (German National Licenses)
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  • 12
    Electronic Resource
    Electronic Resource
    In vitro Investigation of Mesenchymal Stem Cells with Nanophase PLGA/HA Composite (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 1153-1156 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Bone grafts have been used to fill bone defects caused by disease or trauma. The amount ofautografts is limited and allogenic bone grafts may transmit diseases and cause immune responses.Numerous materials have been proposed and used as scaffolds for bone tissue reconstruction. In thisstudy, we tested nanophase PLGA/HA composite with mesenchymal stem cells in vitro to examineits biological response and cellular activity. The nanophase composite was compared toconventional polystyrene on cytocompatibility by cell attachment, proliferation, alkalinephosphotase activity test and scanning electron microscopy (SEM) analysis. The resultsdemonstrated that human mesenchymal cells showed more cell attachment and higher cellproliferation rate when growing on nanophase PLGA/HA composite than those growing onpolystyrene alone. And the composite also promoted MSC cells differentiate to osteoblast cells ascompared with control. It was suggested that the combination of bone marrow mesenchymal cellswith artificial materials or differentiation factors may enhance bone formation and regeneration,nanophase PLGA/HA composite might therefore be a promising scaffold material for bone tissuesubstitute in clinical application
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.1153.pdf
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    Paper (German National Licenses)
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  • 13
    Electronic Resource
    Electronic Resource
    Nano-Calcium Phosphate/PLLA Incorporated with bFGF as In Situ-Transplantable Carrier for Cartilage Regeneration (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 309-311 (May 2006), p. 953-956 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A novel composite of biodegradable Poly-L-lactic acid (PLLA) with the deposition of the nanosized amorphous calcium phosphate (NCP) particles was developed as tissue engineering scaffold. To improve the minor intrinsic healing capacity of cartilage tissue, the porous composite with desired degradation rate was incorporated with basic fibroblast growth factor (bFGF) andevaluated in the in vivo environment. Full-thickness defects were created in the weight-bearing surface of the femoral condyles in a rabbit model. The defect was filled with and without NCP/PLLA scaffold as a carrier of bFGF. Gross morphology for the test implant showed that the defect was filled with regenerated tissue. It resembled cartilaginous tissue and restored the contour of the condyle at 8 weeks after operation. For the untreated control, no cartilage-like tissue wasobserved at all defects. Histological analysis revealed neochondrogenesis and clusters of cartilaginous extracellular matrix observed with safranin-O staining at 4 weeks for the NCP/PLLA with bFGF treated defects. At 8 weeks after operation, well-formed and mature cartilage was resurfaced the defects. While only fibrous tissue replacement was observed for the control either at4 or 8 weeks. Special staining for cartilage indicated the presence of highly sulfatedglycosaminoglycans and collagen, which were the major extracellular matrices of cartilage. This investigation showed the potential of NCP/PLLA loaded with bFGF in the study of in situ-transplantable carrier to improve healing of cartilage tissue lesion
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/51/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.309-311.953.pdf
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    Paper (German National Licenses)
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