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  • 11
    Electronic Resource
    Electronic Resource
    Cerebral infarction due to systemic necrotizing vasculitis in a patient with rheumatic heart disease, subacute bacterial endocarditis and status epilepticus (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 11 (1987), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Systemic necrotizing vasculitis involving cerebral blood vessels is described in a 30-year-old man with rheumatic heart disease and subacute bacterial endocarditis. Fever, anaemia, splenomegaly and positive blood cultures for Gram-negative bacteria were found on admission. The fever resolved with antibiotic therapy on the third hospital day but he then developed hemiplegia and multifocal seizures. The seizures progressed to uncontrollable status epilepticus accompanied by congestive heart failure and the patient died 20 d after admission. At autopsy, exudative and necrotizing vasculitis involving medium- to small-sized arteries was seen in the brain, the heart and the skeletal muscles. Rheumatic myocarditis and endocarditis and old rheumatic mitral valve deformities were also present. In addition, verrucous endocarditis in the mitral valve and Löhlein's focal glomerulonephritis were noted. We discuss the possible mechanism of the systemic necrotizing vasculitis in relation to rheumatic fever.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1987.tb01848.x
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  • 12
    Electronic Resource
    Electronic Resource
    Analysis of the significance of the measurement of acceleration with respect to lateral laxity of the anterior cruciate ligament insufficient knee (2000)
    Springer
    International orthopaedics 24 (2000), S. 276-278 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé   A partir d’une évaluation dynamique de l’instabilité de genoux atteints d’insuffisance du ligament croisé antérieur (LCA), nous avons tenté de déterminer la relation entre l’apparition de l’arthrose du genou et l’insuffisance du LCA. Notre étude a porté sur 40 patients (80 genoux) devant subir une opération de reconstruction du LCA et 25 patients (25 genoux) après l’opération de reconstruction du LCA. Des détecteurs d’accélération ont été placé sur la tubérosité tibiale antérieure. Les pics d’accélération latérale suivant immédiatement le contact au sol du talon étaient significativement plus élevés chez les patients avec un genou atteint d’insuffisance du LCA que chez les patients normaux. Il est également apparu que les pics d’accélération latérale étaient significativement plus élevés dans les cas ou le délai après l’altération du LCA étaient de 3 ans ou plus que dans les cas ou cette période était inférieure à 3 ans. L’opération de reconstruction a permis une diminution significative des pics d’accélération au point que ceux-ci ne présentaient aucune différence significative avec ceux enregistrés avec les genoux normaux.
    Notes: Abstract  The purpose of this study was to assess dynamically the lateral thrust of anterior cruciate ligament (ACL) insufficient knees, and from the findings determine any relationship between ACL insufficiency and the later development of osteoarthritis (OA). We investigated 80 knees in 40 patients awaiting ACL reconstruction and 25 knees of 25 patients, which had undergone ACL reconstruction. An acceleration sensor was fixed to the anterior tibial tubercle and this ’acted’ in two directions – medial lateral and perpendicular. The peak value of the lateral acceleration immediately after heel strike was significantly greater in the ACL insufficient knees when compared to their opposite normal knees. When the periods from injury were compared, the lateral thrust of the injured side after 3 years or more was significantly greater than in the first 3 years. There was no significant difference between the normal knees and the ACL reconstructed knees. The results indicated that the lateral acceleration peak value was significantly greater in the ACL insufficient knees than in their opposite normal knees.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002640000171
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  • 13
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    Unknown
    Scheuer, J.: Siva dans le Mahabharata (Book Review) (1986)
    Berlin : Periodicals Archive Online (PAO)
    Orientalistische Literaturzeitung. 81:1 (1986:Jan./Feb.) 82 
    Details
    ISSN: 0030-5383
    Topics: Linguistics and Literary Studies , Ethnic Sciences , History
    Notes: Besprechungen
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4148-1986-081-01-000039
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  • 14
    Electronic Resource
    Electronic Resource
    No diabetes-associated mutations in the coding region of the hepatocyte nuclear factor-4γ gene (HNF4G) in Japanese patients with MODY (2000)
    Springer
    Diabetologia 43 (2000), S. 1064-1069 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Maturity-onset diabetes of the young ; MODY ; transcription factor ; nuclear receptor ; HNF-4γ ; diabetes mellitus ; insulin ; genetics ; mutation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Mutations in the transcription factor hepatocyte nuclear factor (HNF)-4α are the cause of one form of maturity-onset diabetes of the young, MODY1. The HNF-4γ is structurally related to HNF-4α and is expressed together with HNF-4α in pancreatic islets. We therefore tested the hypothesis that genetic variation in the HNF-4γ gene (HNF4G) is associated with MODY in Japanese subjects. Methods. We screened the protein coding region of HNF4G (exons 3–11) for mutations in 57 unrelated Japanese subjects with MODY by amplifying each exon and adjacent intron region using the polymerase chain reaction (PCR) and specific primers and then directly sequencing the PCR products. The frequency of each variant was compared between patients with MODY and a group of non-diabetic subjects. Results. We found ten sequence variants, two of these were located in exons: exon 6, a silent substitution in codon 144, c.432A/G and exon 7, a G-to-A substitution in codon 190 (c.570G/A) resulting in a conservative Met-to-Ile substitution (M/I190) in the putative ligand-binding region of HNF-4γ protein. The remaining eight variants were located in introns. There was no significant difference in the frequency of these polymorphisms between subjects with MODY and non-diabetic control subjects. Conclusion/interpretation. Genetic variation in the coding region of HNF4G is unlikely to be a major cause of MODY in Japanese people. [Diabetologia (2000) 43: 1064–1069]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051491
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  • 15
    Electronic Resource
    Electronic Resource
    Alterations of monoamine metabolites and of tryptophan in the basal cisternal CSF of patients after subarachnoid haemorrhage (1987)
    Springer
    Acta neurochirurgica 87 (1987), S. 58-62 
    Details
    ISSN: 0942-0940
    Keywords: Homovanillic acid (HVA ; 5-hydroxyindoleacetic acid (5-HIAA) ; Tryptophan (TRP) ; subarachnoid haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and tryptophan (TRP) were measured in the CSF obtained from the basal cistern of 20 patients, who had undergone surgical obliteration of bleeding aneurysms within 3 days after subarachnoid haemorrhage (SAH). The concentrations of these substances, which were assayed by high performance liquid chromatography (HPLC), were the highest on days 3 or 4, and thereafter showed a gradual decrease with an increase in time. The cisternal CSF in patients who had severe pre-operative clinical grades of SAH or vasospasm contained relatively higher concentrations of HVA, 5-HIAA and TRP than those contained in patients who did not. It is proposed that SAH stimulates the release of monoamines from the brain with the resultant extracellular accumulation of their metabolites and their diffusion into CSF during the acute stage. This stimulatory effect of SAH on the brain monoamine system may be consistent with those previously reported in cases of cerebral haemorrhage or infarction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02076018
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  • 16
    Electronic Resource
    Electronic Resource
    Elevation of Nitric Oxide Metabolites in the Cerebrospinal Fluid of Patients with Moyamoya Disease (2000)
    Springer
    Acta neurochirurgica 142 (2000), S. 1275-1280 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Collateral circulation; intracranial-extracranial bypass surgery; moyamoya disease; nitric oxide.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  Background. To investigate whether nitric oxide (NO) contributes to formation of abnormal collateral circulation in patients with moyamoya disease.  Methods. Cerebrospinal fluid (CSF) samples were obtained from the subarachnoid space of the Sylvian fissure during combined bypass surgery for moyamoya disease and kept frozen until NO metabolites, nitrate and nitrite, were measured using a Griess method.  Results. Compared with control CSF obtained from 18 patients with hemifacial spasm, unruptured aneurysm, etc., concentrations of NO metabolites in 26 CSF samples of 18 patients with moyamoya disease were significantly higher (mean±SE; 17.6±1.2 vs. 10.5±1.0 μM, p〈0.01). In eight patients, the CSF samples from both the first and second operation could be obtained. NO metabolite concentrations (20.5±2.3 μM) in CSF obtained from the first surgery decreased to 15.7±1.8 μM (p〈0.01) in CSF obtained from the second, contralateral procedure. The cases of moyamoya disease with greater development of moyamoya vessels at angiographic stage 3 and 4 tended to show higher concentrations of NO metabolites than cases at earlier or later stages with a few moyamoya vessels.  Interpretation. Nitric oxide concentrations in CSF are chronically elevated in moyamoya disease, probably reflecting development of abnormal collateral circulation. i.e. moyamoya vessels. Vascular bypass surgery can reduce abnormal collateral circulation with reduced production of nitric oxide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010070025
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  • 17
    Electronic Resource
    Electronic Resource
    Brain stem auditory evoked potentials monitoring in the diagnosis of brain death - clinical application and reliability (1989)
    Springer
    Neurosurgical review 12 (1989), S. 328-339 
    Details
    ISSN: 1437-2320
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01790670
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  • 18
    Electronic Resource
    Electronic Resource
    Differential abnormality in cell-cycle stage of peripheral B cells from patients with systemic lupus erythematosus (1987)
    Springer
    Rheumatology international 7 (1987), S. 83-87 
    Details
    ISSN: 1437-160X
    Keywords: Cell cycle ; B cells ; Systemic lupus erythematosus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to clarify the stage of abnormal activation of systemic lupus erythematosus (SLE) B cells, we investigated the cell-cycle phase of SLE B cells by flow-cytometric analysis. This study uses the simultaneous flow-cytometric analysis of cellular DNA content and incorporated bromodeoxyuridine, an analogue of thymidine, as indicators for DNA synthesis to detect activated B cells in peripheral blood of patients with SLE. In active SLE, the percentage of B cells increased in the S and G2M phase and decreased in the G0G1 phase as compared with normal control subjects. In inactive SLE, the percentage of B cells in the S phase also increased. Active SLE B cells did not progress through the cell cycle with the stimulation of anti-IgM plus PMA or SAC plus BSF, although normal B cells transit into S and G2M phase with such stimulation. These data suggest that SLE B cells are already activated and shifted to a matured state and that for this reason the B cells were poorly responsive to mitogen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00270312
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  • 19
    Electronic Resource
    Electronic Resource
    Aggregation behavior of halato-telechelic ionomers in a low-polarity solvent (1988)
    Springer
    Polymer bulletin 20 (1988), S. 493-498 
    Details
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary The solution behavior of halato-telechelic ionomers (polybutadiene with carboxylate end groups) in a low-polarity solvent (tetrahydrofuran (THF)) was studied. It was shown that the degree of aggregation can be expressed as a function of polymer concentration by an empirical equation, DA - 10βc, where DA is the degree of aggregation, c is polymer concentration, and β is a constant relating to the rate of aggregation with polymer concentration. It was also shown that the aggregation effect of the Na salt was larger than that of the Cs salt, which was reflected in the value of β.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01153443
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  • 20
    Electronic Resource
    Electronic Resource
    Synthesis of nanometer-sized hematite single crystals through NAC-FAS method (2000)
    Springer
    Journal of materials science 35 (2000), S. 943-949 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Nanometer-sized spherical hematite single crystals were prepared by heating the precipitate which was synthesized from Fe(OH)(CH3COO)2 and NaOH in alkaline ethanol-water solutions without the deliberate addition of surfactants or adsorbing ligands. Hematite nanocrystals (5–10 nm in diameter) and ferrihydrite (〈5 nm) were obtained from the mixture of H2O/EtOH (Rs) = 100 ml/100 ml as a initial medium, whereas goethite, hematite (20–40 nm), and ferrihydrite were precipitated at Rs = 200/0. Adsorbing ligands such as acetoxy groups and ethanol on particles retarded the hematite growth and goethite formation. TEM observation of the particles prepared at Rs = 100/100 with heat treatment at 400°C for 2 hours showed them consisting of single spherical hematite crystals 22 nm in mean diameter with narrow size distribution. Various individual effects were investigated for their contributions to crystal structure and size of precipitates; they included NaOH to Fe(OH)(CH3COO)2 ratio, solvent, dropping rate of alkaline solution, and aging time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004710810785
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