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  • 11
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 439-442 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Atom probe field ion microscopy was employed to investigate the distribution of Al in a nanocrystalline Fe88Zr7B3Al2 soft magnet with optimal magnetic performance. The atom probe concentration depth profiles show that the Al atoms preferentially partition into the residual amorphous phase, and the partitioning factor of Al is approximately five times larger in the amorphous phase than in the bcc Fe phase. Based on the experimental results, the beneficial effect of the addition of Al on the soft magnetic properties is attributed to the change of the inherent magnetostriction constant of the residual amorphous phase induced by Al partitioning. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 88 (2000), S. 6928-6930 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Atom probe field ion microscopy was employed to investigate the distribution of the alloying elements in a nanocrystalline Fe76.5Nd8Co8B6Nb1.5 (at. %) alloy consisting of soft magnetic α-Fe and hard magnetic Nd2Fe14B. It was found that Co atoms prefer to partition into Nd2Fe14B phase. The partitioning factor of Co in the hard magnetic phase is approximately 2 with respect to the soft magnetic phase, α-Fe. Atom probe concentration and integrated depth profiles showed that the Nb atoms segregate at the interfaces between the soft and the hard magnetic phases. Based on the atom probe results, the beneficial effects of Nb and Co on the microstructure and the hard magnetic properties of the nanocomposite are discussed. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 72 (2001), S. 3534-3536 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: An ultrafast quenched plastic scintillation detector was used to measure the fusion fuel ion temperature at low implosion (DT) neutron yield (5×108–3×109) in the initial experiment performed at the Shenguang II laser facility. The typical temperatures of exploding pusher targets for direct drive were around 4 keV and the uncertainties were ±15–23%. The detection efficiency of the detector to DT neutrons was calibrated at a K-400 accelerator. The time response function of the detection system was calibrated by implosion neutrons from a DT-filled capsule, which can be regarded as a δ function pulsed neutron source due to its much narrower pulse width than that of the measured neutron time-of-flight spectrum. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 79 (2001), S. 42-44 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: By differential scanning calorimetric measurement, the kinetics of the phase transformation present in Zr65Al7.5Ni10Cu12.5Ag5 bulk metallic glass during continuous heating was investigated. It was found that the effective activation energy from a supercooled liquid to an icosahedral quasicrystalline phase is much lower than that from the supercooled liquid to eutectic crystalline phases. In addition, the activation energy from the icosahedral phase to the crystalline phases is almost the same as that from the supercooled liquid to the crystalline phases. Both of them support that the local atomic structure is similar for the supercooled liquid and the icosahedral phase in the bulk metallic glass. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 76 (2000), S. 967-969 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: An icosahedral (I) quasicrystalline phase with a grain size below 40 nm was formed as a metastable phase in crystallization of the bulk glassy Zr65Al7.5Cu17.5−xNi10Mx (M=Ag, Pd, Au, or Pt; x=5 and 10 at %) alloys. The volume fraction (Vf) of the I phase is about 85% for the 5% M alloy and nearly 100% for the 10% M alloy. The I phase changes to Zr2Cu+Zr2Ni+Zr2Al3 in a fully annealed state. Compressive fracture strength (σc,f) and fracture elongation (εc,f) of the 10% Pd cylinder with a diameter of 2 mm are respectively 1640 MPa and 2.2% for the glassy phase and increase to 1830 MPa and 3.1% for the I phase. The increase in σc,f is due to the suppression effect of the I particles against the shear deformation of the intergranular glassy phase, and the increase in εc,f results from the localization effect of deformation into the glassy layer. The precipitation of the I phase implies that the glassy alloys include randomly oriented I configurations. The present work shows promise for the new class of high-strength nanoquasicrystalline materials. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 78 (2001), S. 676-678 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We report the development of an imaging layer technology for 50 kV electron-beam lithography based upon the displacement of noncovalently bound amine ligands from a siloxane host film. The patterned films were used as templates for the selective deposition of an electroless nickel film resulting in a positive tone imaging mechanism. The deposited nickel was sufficiently robust to function as an etch mask for pattern transfer by reactive ion etching. Metallized and etched patterns with linewidths to approximately 40 nm are demonstrated using an exposure dose of 500 μC/cm2. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 77 (2000), S. 4298-4300 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A method is proposed to measure the plastic deformation of thin metallic films on Si substrates induced by thermal cycling. The cross-sectional profiles of pattern-grown square Al films with a thickness of ∼250 nm and a size of ∼6 μm×6 μm were measured before and after thermal cycling by employing an atomic force microscope. With the assistance of statistical analysis, the change in the size and shape of the thin films were determined. Based on theoretical considerations, the thermal cycling deformation of thin films is attributed to creep and plasticity effects, accommodated by diffusion-controlled interfacial sliding. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 15 (2001), S. 0 
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The most frequent cause of episodic heartburn is food and beverage ingestion. Nizatidine, an H2-receptor antagonist, is currently approved for non-prescription use in the prevention and relief of heartburn at a dose of 75 mg up to twice a day.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:Two identical studies were carried out to evaluate the efficacy of nizatidine, 75 mg, compared with placebo in treating heartburn in an ‘at-home’ setting. The studies were multicentre, multiple-dose, placebo-controlled, randomized, parallel group design. A total of 994 subjects were randomized to treatment. Adequate relief of heartburn was assessed at 15, 30 and 45 min and 1, 2 and 3 h following a treatment dose. A subject’s responses with respect to time to relief and attainment of adequate relief were combined into a derived response profile, the sustained adequate relief score. Adverse experiences were noted throughout the study period.〈section xml:id="abs1-3"〉〈title type="main"〉Results:The individual and combined study results showed that nizatidine, 75 mg, relieved heartburn faster and/or more consistently than placebo. The mean sustained adequate relief score, calculated over a subject’s first four episodes, was 2.43 in the nizatidine-treated group compared with 2.14 in the placebo group (P 〈 0.001). Nizatidine-treated subjects attained sustained adequate relief in a significantly (P 〈 0.001) larger percentage (75%) of their heartburn episodes than did subjects treated with placebo (66%). No serious adverse experiences were associated with nizatidine treatment.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusion:Nizatidine, 75 mg, is a safe and effective treatment for episodic heartburn. The results showed that subjects taking nizatidine had heartburn relief that was achieved faster and/or more reliably than did subjects taking placebo.
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 150 (2004), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 20
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 28 (2003), S. 0 
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary One of the critical challenges for cellular genetic studies in primary human skin cells is lack of a gene delivery system that provides efficient transduction and sustained expression of the transgenes. Due to the limited time of survival in culture, the processes of drug selection and clonal expansion for establishing gene stably expressing cell lines are not a realistic option for primary skin cells. We have examined various gene transduction techniques in primary dermal fibroblasts and epidermal keratinocytes of human skin. We report here that vectors based on the human immunodeficiency virus (HIV, lentivirus) offer more than 90% gene transduction efficiency and sustained expression of transgenes in both human skin cell types. In contrast, most of the commonly used techniques have at best 30% transduction efficiency in these cells. Using two previously reported migration control genes, protein kinase Cδ and p38α-MAPK, as examples, we provide evidence that the unprecedented efficiency of the lentiviral system enables a clear detection of the genes' dominant negative effects, which are otherwise greatly compromised by ordinary transfection techniques. We believe that a wide application of this gene transduction system will greatly benefit studies of gene function in human skin cells.
    Type of Medium: Electronic Resource
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