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  • 11
    Electronic Resource
    Electronic Resource
    Sekundäres Hypersplenie-Syndrom Ursache einer Thrombo- und Leukozytopenie bei Sarkoidose? (1998)
    Springer
    Der Internist 39 (1998), S. 1181-1184 
    Details
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Sarkoidose ; Leukozytopenie ; Thrombozytopenie ; Hypersplenismus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Die Sarkoidose ist eine granulomatöse Systemerkrankung, die sich bei über 90% der Patienten an der Lunge manifestiert, aber auch häufig extrapulmonale Organmanifestationen zeigt [8, 9]. Die Thrombozytopenie stellt eine seltene Komplikation der Sarkoidose dar, die in etwa 2% der Fälle gefunden wird [7]. Es wird eine Patientin mit einer Sarkoidose bei Multiorganbefall vorgestellt, bei der zudem eine Thrombo- und Leukozytopenie im Blutbild auffällig waren. Diagnostisch konnten eine Granulominfiltration des Knochenmarks sowie eine mäßiggradige Splenomegalie nachgewiesen werden, thrombozytäre Antikörper waren nicht zu objektivieren. Bei geringgradiger Knochenmarksinfiltration (ca. 5% Fläche des Markraums) muß ein sekundärer Hypersplenismus als wahrscheinlichste Ursache der Thrombo- und Leukozytopenie angesehen werden. Unter Stereoidtherapie fanden sich im Verlauf ein mäßiggradiger Anstieg der Thrombozyten- und Leukozytenwerte.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001080050289
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  • 12
    Electronic Resource
    Electronic Resource
    Attenuation of shock-induced inflammation in the rat liver depends on the time of TNF-α inhibition (1996)
    Springer
    Journal of molecular medicine 74 (1996), S. 51-58 
    Details
    ISSN: 1432-1440
    Keywords: Tumor necrosis factor ; Hemorrhagic shock ; Leukocyte adhesion ; Intravital microscopy ; Liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relevance of tumor necrosis factor-α (TNF-α) inducing early inflammatory reactions in the liver after hemorrhagic shock, for example, leukocyte adhesion, has been well described. This study evaluated the anti-inflammatory effects of a monoclonal antibody against TNF-α (TN3.19.12) in terms of the time of application, namely, prior to shock induction, at the time of resuscitation, and after resuscitation. The hepatic micro-circulation was investigated by intravital fluorescence microscopy in female Sprague-Dawley rats undergoing severe hemorrhagic shock for 60 min and subsequent resuscitation. TN3.19.12 or placebo was given in a randomized and blinded manner either 60 min prior to shock induction, l min prior to resuscitation, or 15 min after the onset of resuscitation. The number of firmly adherent leukocytes in the livers of treated animals depended on the time of application of TN3.19.12. Leukocyte adhesion was significantly reduced when TN3.19.12 was given prior to shock induction or at the time of resuscitation and was less effective when administered after the onset of resuscitation. The results further confirm that TNF-α initiates very early pathological leukocyte adhesion in the liver 5 h following shock. Inhibition of leukocyte adhesion after shock, however, depends strongly on the time of TNF-α blocking. While TN3.19.12 prior to shock induction resulted in most effective attenuation, only very early treatment allowed limitation of posttraumatically increased leukocyte adhesion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202072
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  • 13
    Electronic Resource
    Electronic Resource
    Receptor binding profile suggests multiple mechanisms of action are responsible for ibogaine's putative anti-addictive activity (1995)
    Springer
    Psychopharmacology 118 (1995), S. 369-376 
    Details
    ISSN: 1432-2072
    Keywords: Ibogaine ; Drug abuse ; Addiction ; Neurotransmitter receptors ; Radioligand binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The indole alkaloid ibogaine (NIH 10567, Endabuse) is currently being examined for its potential utility in the treatment of cocaine and opioid addiction. However, a clearly defined molecular mechanism of action for ibogaine's putative anti-addictive properties has not been delineated. Radioligand binding assays targeting over 50 distinct neurotransmitter receptors, ion channels, and select second messenger systems were employed to establish a broad in vitro pharmacological profile for ibogaine. These studies revealed that ibogaine interacted with a wide variety of receptors at concentrations of 1–100 µM. These included the mu, delta, kappa, opiate, 5HT2, 5HT3, and muscarinic1 and 2 receptors, and the dopamine, norepinephrine, and serotonin uptake sites. In addition, ibogaine interacted withN-methyl-d-aspartic acid (NMDA) associated ion and sodium ion channels as determined by the inhibition of [3H]MK-801 and [3H]bactrachotoxin A 20-α-benzoate binding (BTX-B), respectively. This broad spectrum of activity may in part be responsible for ibogaine's putative anti-addictive activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245936
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  • 14
    Electronic Resource
    Electronic Resource
    Quantitative study of laterally inhomogeneous wetting films (1999)
    Springer
    The European physical journal 10 (1999), S. 767-779 
    Details
    ISSN: 1434-6036
    Keywords: PACS. 68.45.Gd Wetting - 68.10.-m Fluid surfaces and fluid-fluid interfaces - 82.65.Dp Thermodynamics of surfaces and interfaces
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: Based on a microscopic density functional theory we calculate the internal structure of the three-phase contact line between liquid, vapor, and a confining wall as well as the morphology of liquid wetting films on a substrate exhibiting a chemical step. We present a refined numerical analysis of the nonlocal density functional which describes the interface morphologies and the corresponding line tensions. These results are compared with those predicted by a more simple phenomenological interface displacement model. Except for the case that the interface exhibits large curvatures, we find that the interface displacement model provides a quantitatively reliable description of the interfacial structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100510050907
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  • 15
    Electronic Resource
    Electronic Resource
    Water soluble calixarenes as possible metal ion extractants in polyethylene glycol-based aqueous biphasic systems (1996)
    Springer
    Journal of radioanalytical and nuclear chemistry 208 (1996), S. 153-161 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The behavior of a water soluble calixarene ligand has been investigated in an (NH4)2SO4/polyethylene glycol-2000 (PEG) aqueous biphasic system. Spectroscopic measurements indicate that 4-sulfonic-calix-6-arene partitions preferentially to the polymer-rich phase in this system. The utility of this ligand as a metal ion extractant was also investigated. The addition of the calixarene (10−2M in initial PEG-rich stock solution) did not significantly enhance the partitioning of Na+, Cs+, Sr2+, Ba2+, Co2+, Cd2+, or UO 2 2+ from the (NH4)2SO4-rich to the PEG-rich phase. The partitioning behavior of these metal ions is dependent, rather, on their Gibbs free energy of hydration (ΔGhyd *).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02039757
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  • 16
    Electronic Resource
    Electronic Resource
    Characterization of surface antigens ofEimeria nieschulzi (Sprozoa, Eimeriidae) merozoites (1995)
    Springer
    Parasitology research 81 (1995), S. 230-234 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Two surface antigens ofEimeria nieschulzi merozoites were characterized by monoclonal antibodies (Mcab) as follows: an antigen of 31 (reducing conditions), 25 and 31 kDa (nonreducing conditions), by Mcab A1F6; and an antigen of 52 and 30 kDa (reducing conditions) or 42 kDa (nonreducing conditions), by Mcab H7. The localization of the antigens in fluorescence and electron micrographs is presented. Despite being accessible to antibodies on live (nonpermeabilized) parasites, neither antigens were significantly labelled using lactoperoxidase radioiodination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00937114
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  • 17
    Electronic Resource
    Electronic Resource
    61. In-situ-Bestimmung globaler Kinetik-konstanten von Brennstoffpartikeln durch simultane Messung von Partikeltemperatur und -größe (1998)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 70 (1998), S. 1108-1108 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330700965
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