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  • 11
    Electronic Resource
    Electronic Resource
    Elevated concentrations of the β-subunit of S100 protein in renal cell tumors in rats (1994)
    Springer
    Urological research 22 (1994), S. 251-255 
    Details
    ISSN: 1434-0879
    Keywords: S100 protein ; Rat ; Carcinogenesis ; Renal neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Concentrations of α and β-subunits of S100 protein (S100-α and S100-β) in rat kidney neoplasms, including renal cell and mesenchymal tumors, were determined using a highly sensitive enzyme immunoassay, and both types immunohistochemically localized in tissue sections. Concentration of S100-α in each histological type of rat tumor were lower than in normal kidney, whereas levels of S100-β (mean±SE: 29.7±14.2 ng/mg protein, n=15) in renal cell tumors were significantly higher than in normal kidneys (0.55±0.06 ng/mg protein, n=7), or mesenchymal tumors (1.21±0.43 ng/mg protein, n=9). In normal rat kidney tissues S100-α was immunohistochemically positive in epithelial cells of the distal tubules, the thin limbs of loops of Henle, and the collecting ducts. No appreciable immunostaining for S100-β was found in any nephron segment. Both S100-α and S100-β were positive for renal cell tumors, indicating new appearance of the latter during renal carcinogenesis in rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541902
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  • 12
    Electronic Resource
    Electronic Resource
    Regulatory effects of interleukin-7 on renal tumor infiltrating lymphocytes (1992)
    Springer
    Urological research 20 (1992), S. 205-210 
    Details
    ISSN: 1434-0879
    Keywords: Tumor infiltrating lymphocyte ; Interleukin-7 ; Renal cell carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Biological therapy using a combination of lymphokine and tumor infiltrating lymphocytes (TILs) is a new approach to the treatment of patients with advanced cancer. To improve the potency of TILs, new cytokines with T-cell stimulatory effects used alone or in combination with interleukin-2 (IL-2) are currently being investigated. We have studied the effect of interleukin-7 (IL-7) on TILs derived from renal cell carcinoma. Our data demonstrated that five of ten TILs proliferated in response to IL-7 alone. This proliferative response was 73–90% less than that obtained with IL-2 alone. The use of IL-7 plus IL-2 resulted in a 1.2- to 4.7-fold increase in proliferation of six of ten TILs compared with IL-2 alone. IL-7-driven TIL growth was consistently blocked by anti-IL-2, anti-IL-2R and anti-IL-7 antibodies (37.2%, 41.6% and 82.2% suppression, respectively). The expression of IL-2 receptors was also significantly increased in the presence of IL-7 or IL-7 phytohemagglutinin (40.6+3.8 and 72.5+1.5). In comparison with IL-2, IL-7 treatment was associated with a decrease in CD56 (46.3%±19 vs 10%±4.9) and increase in CD3 (29.3%±12 vs 73%±6.4) and CD 4 (19.3%±15 vs 58%±10). These studies suggest that in some renal TILs, IL-7 and IL-2 can have a synergistic proliferative effect. The IL-7 stimulatory effect appears to be mediated via both an IL-2 pathway and an IL-7-independent pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00299718
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  • 13
    Electronic Resource
    Electronic Resource
    Feeding induced by blockade of histamine H1-receptor in rat brain (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 216-218 
    Details
    ISSN: 1420-9071
    Keywords: Antihistamine ; H1-receptor ; feeding elicitation ; α-fluoromethylhistidine ; hypothalamic neuronal histamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Histamine antagonists were infused into the third ventricle of the cerebrum in rats. All the H1-, but none of the H2-antagonists tested, induced initial feeding during the early portion of the light phase when histamine level was highest. No periprandial drinking was observed. Ambulation increased during feeding. The effect on feeding was attenuated when brain histamine was normally low during the early portion of the dark phase, or was decreased by α-fluoromethylhistidine. Hypothalamic neuronal histamine may suppress food intake through H1-receptors, and diurnal fluctuations of food intake may mirror neuronal histamine levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01941710
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  • 14
    Electronic Resource
    Electronic Resource
    Hypothalamic histamine modulates adaptive behavior of rats at high environmental temperature (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 283-285 
    Details
    ISSN: 1420-9071
    Keywords: Histamine ; hypothalamus ; environmental temperature ; adaptive behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Histamine content in the rat hypothalamus was lower at 4°C and higher at 31°C compared to that at 21°C. Pretreatment with α-fluoromethylhistidine, a ‘suicide’ inhibitor of histidine decarboxylase, attenuated both the increased level of hypothalamic histamine and rat adaptive behavior at 31°C. Increase of histamine content in the hypothalamus appears to be an important factor contributing to rat adaptive behavior to high environmental temperature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951767
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  • 15
    Electronic Resource
    Electronic Resource
    Effect of laser induced crystallization of semiconductor particle CdS x Se1−x in glass matrix on reflectivity of phase-conjugated signal (1994)
    Springer
    Journal of materials science 13 (1994), S. 1727-1728 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00451754
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  • 16
    Electronic Resource
    Electronic Resource
    Structure of nm-sized InSb clusters formed by spontaneous alloying (1994)
    Springer
    The European physical journal 31 (1994), S. 209-212 
    Details
    ISSN: 1434-6079
    Keywords: 61.16.Di ; 36.40. + d ; 66.30. − h
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The alloying behavior of antimony atoms into nm-sized indium clusters has been studied in situ by TEM. When antimony atoms are vapor-deposited onto nm-sized indium clusters, a rapid dissolution of antimony atoms into indium clusters takes place and as a result InSb compound clusters are successfully formed. Such spontaneous alloying occurs even at ambient temperature. InSb clusters thus formed have the wurtzite structure. When these InSb clusters are annealed at 533 K, their structure changes into the sphalerite structure, which is the structure of the equilibrium phase of the bulk In50Sb50. The appearance of wurtzite-type InSb by spontaneous alloying is discussed in terms of ionicity of bonds in InSb.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01437838
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  • 17
    Electronic Resource
    Electronic Resource
    Determination of trichlormethiazide in human plasma and urine by high-performance liquid chromatography (1992)
    Springer
    Chromatographia 33 (1992), S. 339-343 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Trichlormethiazide ; Electrochemical detection ; Diuretics in plasma and urine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary This paper describes a high-performance liquid chromatographic (HPLC) assay method for the determination of trichlormethiazide (TCM) in human plasma and urine. After extraction and separation on an ODS column TCM from plasma was detected by oxidation in an electrochemical detector (ECD) by a porous graphite electrode. The sensitivity was better than HPLC with UV detection, enabling the determination of 2 ng ml−1 TCM in human plasma. This method also allows determination of TCM at higher concentrations by exchanging the UV for the electrochemical detector. To study the pharmacokinetics, TCM in plasma and urine was assayed with coefficients of variation in the range 2–3%. The method has the advantages of high sensitivity for plasma assay and high precision with a simple procedure for both plasma and urine samples. Small samples of 0.5 ml plasma per assay also reduced the total volume of plasma needed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02275914
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  • 18
    Electronic Resource
    Electronic Resource
    The effects of butyrate and glucagon on the proliferation of ruminal epithelial cells in culture (1989)
    Springer
    Veterinary research communications 13 (1989), S. 27-29 
    Details
    ISSN: 1573-7446
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract When the rate of ruminal epithelial cell proliferation was measured on the basis of 3H-thymidine incorporation into the cellular DNA, butyrate dose-dependently reduced 3H-thymidine incorporation. In contrast, glucagon at 10 and 100 pg/ml had a slight stimulatory effect on the incorporation, but only in the absence of butyrate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00366849
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  • 19
    Electronic Resource
    Electronic Resource
    Letters to the edior (1986)
    Hoboken, NJ [u.a.] : Wiley-Blackwell
    Journal of Orthopaedic Research 4 (1986), S. 129-131 
    Details
    ISSN: 0736-0266
    Keywords: Life and Medical Sciences
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jor.1100040117
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