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  • 11
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 153 (1994), S. 123-128 
    ISSN: 1432-1076
    Keywords: Aminophylline ; Cerebral blood volume ; Cytochrome c oxidase ; Near infrared spectroscopy ; Newborn infant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of aminophylline on cerebral blood volume and oxidative metabolism in newborn infants was investigated with near infrared spectroscopy (NIRS). Thirteen mechanically ventilated premature infants who received aminophylline to facilitate weaning from the respirator were selected. Gestational age ranged between 26 and 34 weeks, postnatal age between 1 and 7 days and birth weight between 760 and 2300 g. A bolus of 6 mg aminophylline/kg body weight was infused within 2 min. NIRS was performed continuously across the head to monitor changes in cerebral blood volume and cytochrome c oxidase. Heart rate, transcutaneous carbon dioxide tension (tcpCO2) and arterial haemoglobin oxygen saturation (SO2) were recorded simultaneously. The infusion of aminophylline was associated with an increase in heart rate (median 12, interquartile range 5–20 beats per min,P=0.0004) and a drop in tcpCO2 (median −0.4, interquartile range −0.1 to −0.5 kPa,P=0.015). Oxygen saturation remained stable (±3%). A decrease in cerebral blood volume was measured with NIRS in 9/13 patients (median −0.15 ml/100g brain tissue, interquartile range +0.08 to −0.28,P=0.10). Oxidized cytochrome c oxidase decreased in 11/13 patients (median −0.27 μmol/l, interquartile range −0.19 to −0.44,P=0.01). Our findings demonstrate an immediate step-response of heart rate and tcpCO2 to aminophylline in premature infants. The simultaneous reduction of cytochrome c oxidase in the brain cannot be explained as a consequence of changes in tcpCO2 or changes in cerebral blood volume. We therefore speculate that aminophylline interferes directly with cerebral metabolism.
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric nephrology 3 (1989), S. 189-190 
    ISSN: 1432-198X
    Keywords: Pregnancy ; Advanced renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe a successful pregnancy in a 22-year-old patient with advanced renal failure, who gave birth to a living boy in the 35th week of pregnancy. At the time of spontaneous delivery the mother had a serum creatinine of 851 μmol/l. No dialysis treatment had been instituted during this successful pregnancy.
    Type of Medium: Electronic Resource
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  • 13
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Extrem Frühgeborene ; Visus ; Strabismus ; Amblyopie ; Retinopathie ; Key words Extremely low birth weight infants ; Strabismus ; Vision ; Amblyopia ; Retinopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Aim of the study: The goal of this study was to assess the prevalence of ophthalmological abnormalities in 10 year old survivors with extremely low birthweight of 500–999 g. In addition the association between retinopathy of prematurity and other ophthalmological disorders was studied. Methods: The parents of all surviving newborns (N=117) with birthweight 500–999 g born in Switzerland between 1983 and 1985, were asked for eye problems in their children. When the history was positive, additional information was obtained from the ophthalmologist. Results: At the age of 10±1 years the very low birthweight infants had significantly more ophthalmological problems (37%) than found in the general population (10%). Whereas low vision ( 〈1.0) of at least one eye (35%), strabism (19%), amblyopia (11%) and astigmatism (7.5%) were significantly more frequent compared with the normal population, myopia (12%) was not. Retinopathy was not significantly associated with other ophthalmological disorders. Conclusions: We conclude that all extremely low birth weight infants irrespectively of retinopathy have a significantly increased risk for ophthalmological disorders. Therefore they should have regular ophthalmological reevaluations until school age.
    Notes: Zusammenfassung Fragestellung: Wie häufig sind ophthalmologische Störungen bei ehemals sehr kleinen Frühgeborenen im Alter von 10 Jahren? Bestehen Assoziationen zu einer durchgemachten Frühgeborenenretinopathie? Methode: Die Eltern aller überlebenden Frühgeborenen (n=117), die in den Jahren von 1983–1985 in der Schweiz mit einem Geburtsgewicht zwischen 500–999 g geboren worden waren, wurden nach Augenproblemen ihrer Kinder befragt. Bei positiver Anamnese wurden zusätzliche Informationen vom Ophthalmologen eingeholt. Ergebnisse: Die Frühgeborenen zeigten im Alter von 10±1 Jahren hochsignifikant mehr ophthalmologische Störungen (37%) als die Durchschnittsbevölkerung (10%). Signifikant häufiger waren Visusminderung (35%), Strabismus (19%), Amblyopie (11%) und Astigmatismus (18%). Die Myopierate (12%) war nicht wesentlich erhöht. Nach einer durchgemachten Retinopathie waren die Werte noch höher, die Unterschiede zu ehemaligen Frühgeborenen ohne Retinopathie waren jedoch nicht signifikant. Schlußfolgerung: Sehr kleine Frühgeborene weisen ein deutlich erhöhtes Risiko für ophthalmologische Störungen auf und nicht nur, wenn in der Neonatalperiode eine Retinopathie nachgewiesen wurde. Sie sollten deshalb alle mindestens bis ins Schulalter regelmäßig ophthalmologisch kontrolliert werden.
    Type of Medium: Electronic Resource
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