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  • 11
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1980)
    Springer
    Journal of molecular medicine 58 (1980), S. 1269-1270 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01478935
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  • 12
    Electronic Resource
    Electronic Resource
    Vergleichende Studie zum Wert der selektiven Darmdekontamination (SDD) bei der Behandlung akuter Leukämien (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 1093-1099 
    Details
    ISSN: 1432-1440
    Keywords: Selective gut decontamination ; Acute leukemia ; Selektive Darmdekontamination ; Akute Leukämie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Hinblick auf eine Senkung der Frühtodesrate durch Infektionen wurde in einer vergleichenden Studie der Wert einer selektiven Darmdekontamination (SDD) bei der zytostatischen Behandlung von Patienten mit akuter Leukämie untersucht. Es wurden drei Gruppen gebildet: 1) SDD (Neomycin, Colistin, Nystatin) bei einfacher Umkehrisolation auf der Normalstation; 2) keine SDD, aber einfache Umkehrisolation auf der Normalstation; 3) strikte Isolation, gefilterte Luft, sterilisierte Nahrung plus SDD. Es fanden sich graduell zwischen den drei Gruppen signifikant weniger Infektionen mit Gramnegativen Keimen: Isolierstation plus SDD versus Normalstation plus SDD versus Normalstation ohne SDD. Die Frühtodesrate durch Infektionen war in der Gruppe mit SDD auf der Normalstation signifikant geringer als in der Gruppe ohne SDD, umgekehrt die Remissionsrate nach zytostatischer Behandlung signifikant höher. Die Dekontamination wurde gut vertragen.
    Notes: Summary A comparative study of infectious morbidity and mortality in neutropenic patients with acute leukemia receiving chemotherapy was undertaken to test the effects of a suppression of endogenous and ambient microorganisms. Patients were allocated to receive [1] oral antibiotics (neomycin, colistin, and nystatin) in conventional ward isolation; [2] no antimicrobial suppression but conventional ward isolation; [3] strict isolation, filtered air, sterilized food and oral antibiotics. Significantly fewer infections with Gram-negative bacilli were seen in patients with strict isolation plus endogenous microbial suppression versus patients receiving selective gut decontamination versus patients without nonabsorbable antibiotics in simple reverse isolation. The death rate from infection was significantly reduced in patients who received antibiotics for gut flora suppression in conventional ward isolation compared with the corresponding control group. In addition, a significant improvement of leukemic remission rate was seen in this group. The protocol for decontamination was well tolerated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01746196
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  • 13
    Electronic Resource
    Electronic Resource
    Zum gegenwärtigen Stand der internistischen Therapie des Mammacarcinoms (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 921-926 
    Details
    ISSN: 1432-1440
    Keywords: Breast cancer ; Adjuvant chemotherapy ; Chemoimmunotherapy ; Combination chemotherapy ; Mamma-Ca ; Adjuvante Chemotherapie ; Chemoimmuntherapie ; Polychemotherapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Für die postoperative adjuvante Chemotherapie gibt es bisher keine genau definierte Risikogruppe, bei der die Rezidiv- oder Metastasierungsrate sicher vermindert werden kann. Weitere kontrollierte Studien müssen die Indikation für diese Therapie erst noch detaillierter herausarbeiten. Von einer generellen, unkontrollierten Anwendung der adjuvanten Chemotherapie wird abgeraten. Ähnliches gilt für die unspezifische Immunstimulation, die auch keinen gesicherten positiven Effekt hat. Für die palliative Polychemotherapie, eventuell in Kombination mit einer Antiöstrogentherapie, werden 4 verschiedene Therapie-Protokolle, die sich in unseren Händen gut bewährt haben, mit ihren Indikationen vorgestellt: Adriamycin/Cyclophosphamid (AC), Cyclophosphamid/Methotrexat/5-Fluorouracil (CMF), CMF/Vincristin/Prednison (CMFVP) und die Kombination von Adriamycin/Vincristin (AV) mit CMF auf der Basis einer Dauertherapie mit Tamoxifen.
    Notes: Summary There is no well defined group of patients with primary breast cancer which benefits from combination chemotherapy as an adjuvant treatment, since, at present, the effect of this therapy in respect to the duration of disease-free interval, survival, and possible long-term side effects remain unknown. Therefore, controlled studies need to be initiated. Similarly, there seems to be no beneficial effect from unspecific immunotherapy. As far as combination chemotherapy in advanced breast cancer is concerned, we review on four different protocols which proved to be quite successful in our hands: adriamycine/cyclophosphamide (AC), cyclophosphamide/methotrexate/5-fluorouracil (CMF), CMF/vincristine/prednisone (CMFVP), and adriamycine/vincristine plus CMF plus Tamoxifen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01478548
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  • 14
    Electronic Resource
    Electronic Resource
    A spell of chicken-pox on a cancer patients' ward (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 387-389 
    Details
    ISSN: 1432-1440
    Keywords: Chicken-pox ; Oncology ; Chemotherapy ; Zoster immune globulin ; Aciclovir
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Second episodes of varicella after a definite primary exposure to chicken-pox are well known in immunosuppressed children. We report an outbreak in adult cancer patients. This observation suggests that there is also a higher risk of varicella infection in immunosuppressed adults. As there is a trend for a pronounced severity of chicken-pox in patients receiving anticancer drugs or suffering from immunosuppressive diseases, the prophylactic use of varicella zoster immune globulin in adult patients has to be discussed, especially as positive experiences with children were recently gained. Following manifestation, therapy with systemic aciclovir seems to be effective.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01742293
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  • 15
    Electronic Resource
    Electronic Resource
    Rezidiv eines Wilms' Tumors nach 9jährigem krankheitsfreien Intervall (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 412-414 
    Details
    ISSN: 1432-1440
    Keywords: Nephroblastoma ; Late recurrence ; Combined treatment modalities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report the case of a 25-year old female patient, who presented with intrapulmonary metastases of a Wilms' tumor nine and a half year after initial therapy of a stage I tumor with surgery, local radiation and combined chemotherapy. In general, relapses of Wilms' tumor occur within two year after nephrectomy. Reccurences after more than 7 years are very rare. A relapse of a Wilms' tumor in an adult patient after more than 9 years is not yet published. We treated our patient according to the therapeutic procedure, which is recommended by the National Wilms' Tumor Study as curative treatment of relapses in childhood: complete resection of pulmonary metastases, irradiation of the whole lunge and repeatingly combined chemotherapy with actinomycin D and vincristin. The patient is doing well without evidence of tumor 13 months after thoractomy. A short review of the literature is given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01737946
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  • 16
    Electronic Resource
    Electronic Resource
    Auer bodies in acute lymphocytic leukaemia and B-cell lymphoma: Evidence for a common progenitor of myeloid and lymphoid cells? (1981)
    Springer
    Annals of hematology 43 (1981), S. 7-14 
    Details
    ISSN: 1432-0584
    Keywords: Auer bodies ; Mixed leukaemia ; Myeloid-lymphoid progenitor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a patient with acute lymphocytic leukaemia (pre-T ALL) and another patient with leukaemic generalization of B-cell lymphoma Auer bodies were found in a few immature cells. The diagnosis in both cases was based on clinical grounds, morphology, cytochemistry, and immunological marker analysis of the blasts. Auer bodies are known to be a marker of high significance for acute non-lymphocytic leukaemias. Therefore the findings described suggest mixed leukaemias with either T-cell or B-cell predominance. It provides further evidence for the existence of a common progenitor of myeloid and lymphoid cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319926
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  • 17
    Electronic Resource
    Electronic Resource
    Clinical trial of low-dose Ara-C in the treatment of acute leukemia and myelodysplasia (1984)
    Springer
    Annals of hematology 48 (1984), S. 255-261 
    Details
    ISSN: 1432-0584
    Keywords: Low-dose Ara-C ; Acute leukemia ; RAEB ; Dysmyelopoietic syndromes ; Differentiating agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a multicenter analysis, the effect of low-dose cytosine arabinoside (Ara-C) (10 mg/m2 q 12 h subcutaneously for a minimum of 15 days) has been assessed in 13 patients with acute leukemia (10 myeloid -AML-, 3 lymphocytic -ALL-) and 7 patients with dysmyelopoietic syndromes (DMPS), conditions classified as refractory anemia with an excess of blasts (RAEB). Seven patients suffering from acute leukemia and 1 with DMPS in blastic transformation displayed a leukocytosis of more than 10×109/1. Three out of 7 DMPS, 1 out of 10 AML achieved a complete remission, 1 out of 3 ALL-patients reached a partial remission twice. Seven patients showed a blast clearing in the bone marrow and peripheral blood, in another 7 instances examination of the bone marrow was not performed after therapy because of early death. The majority of patients were in their late phase of disease and refractory to conventional chemotherapy. Only 5 patients had no pretreatment at first presentation before low-dose Ara-C was initiated. At least for the DMPS-group, this therapeutic approach seems to be of some benefit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320395
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  • 18
    Electronic Resource
    Electronic Resource
    Auer-rod positive myelocytic leukemia cells in diffusion chambers: Differentiation along the eosinophilic pathway (1982)
    Springer
    Annals of hematology 45 (1982), S. 323-328 
    Details
    ISSN: 1432-0584
    Keywords: AML blast cells ; Eosinophilic differentiation ; Diffusion chambers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Auer-rod positive acute myelocytic leukemia (AML) blasts from a 33-year-old patient were cultured in diffusion chambers (DC) in order to test their differentiation potential. The cells were labeled with anti-human granulocyte antiserum known to be negative for eosinophils, and evaluated using the unlabeled peroxidase-antiperoxidase (PAP) method. Parallel to a decline in the number of leukemic blasts there was an increase of up to 86% in the number of granulocytic cells belonging to the eosinophilic series. Auer-rod bodies were found in the eosinophilic cells even after 20 days in culture. Staining with anti-granulocyte antiserum failed to demonstrate positive cells at any time during DC culture. Based on the negative reaction with the anti-granulocytic antibodies already at an early stage of development evidence is provided for the existence of a progenitor cell exclusively committed to the eosinophilic pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319526
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  • 19
    Electronic Resource
    Electronic Resource
    Spontaneous remission of acute myeloid leukemia (1986)
    Springer
    Annals of hematology 52 (1986), S. 165-168 
    Details
    ISSN: 1432-0584
    Keywords: Spontaneous remission ; Acute leukemia ; Prognostic factors ; Regulation of granulopoiesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A patient with acute myelomonocytic leukemia who experienced a spontaneous remission, is reported. He had precedent and concurrent bacterial infections as most of these cases described. Low peripheral WBC and myeloblasts, Auer-rod positive blasts, bone marrow eosinophilia with atypical eosinophils, and a partial deletion of chromosome 16 were favorable prognostic parameters. A brief review of the literature and possible explanations for the regulation of granulopoiesis are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320532
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  • 20
    Electronic Resource
    Electronic Resource
    Acute myeloid leukemia in the elderly: biological features and search for adequate treatment (1991)
    Springer
    Annals of hematology 63 (1991), S. 179-188 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary AML in elderly patients is a heterogeneous disease which is characterized by a number of unfavorable features such as development, cytogenetics, blast cell differentiation, and poor treatment response. Specifically, the association between a higher incidence of unfavorable cytogenetic abnormalities in elderly patients and poor prognosis has been well documented. Low treatment response may be due to the specific biology of AML in this patient group, but also to host-specific factors such as higher treatment-related morbidity and mortality. Treatment tolerance cannot be judged on grounds of chronological age alone; risk factor analysis with regard to performance status, organ function, and underlying systemic disease need to be considered as well. For effective induction treatment in elderly patients, instant and intensive chemotherapy appears to be necessary, while delayed treatment or administration of supportive care alone provide unsatisfactory results. Standard-dose ara-C/anthracycline-containing regimens are the treatment of choice in patients with good performance status. However, patients with a WHO grading of 〉3 might rather benefit from reduced regimens such as low-dose ara-C. At present, greatest improvement of AML treatment in elderly patients can be expected from an improvement of supportive care.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01703440
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