Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 11
    Electronic Resource
    Electronic Resource
    Experimentelle Xenotransplantation in entfernt stammesverwandten Speciessystemen (1971)
    Springer
    Journal of molecular medicine 49 (1971), S. 164-166 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Beurteilung der Bedeutung von Zellen (Erythrocyten, Leukocyten, Thrombocyten), sowie Serumkomponenten (präformierte Antikörper, Komplement,γ-Globuline etc.) bei der hyperakuten Abstoßungsreaktion von vascularisierten Xenotransplantaten im entfernt stammesverwandten Speciessystem wurde ein in vitro-Modell der isolierten Xenohämoperfusion von Nieren erprobt, das die separate Untersuchung der einzelnen für die Reaktion verantwortlichen Faktoren erlaubt. In einem Perfusionssystem, bestehend aus Rollerpumpe, Wärmeaustauscher, Perfusionskammer und Capillaroxygenator wurden Rattennieren mit heparinisiertem Vollblut von Hunden perfundiert (n=10). Die Befunde zeigten, daß alle Hauptkriterien der hyperakuten in vivo Abstoßung von Nieren in diesem System (=rapider Anstieg des peripheren Widerstandes mit Sistieren der Blutdurchströmung innerhalb 10–25 min, Stauung und Hämorrhagie des Organes, Endothelnekrosen an Glomerula, Capillaren Arteriolen) ebenfalls bei einer in vitro Xenohämoperfusion dieser Organe regelmäßig zu beobachten sind. Bei entsprechend durchzuführender Variation der Zusammensetzung des Xenohämoperfusates scheint das Testsystem geeignet, einige an der hyperakuten xenogenen Abstoßungsreaktion beteiligte Komponenten des Blutes näher zu definieren.
    Notes: Summary In an aim to evaluate the role of formed elements (erythrocytes, leukocytes, thrombocytes) and of humoral serum components (preformed antibodies, complement,γ-globulins, etc.) in the hyperacute rejection of vascularized xenografts in widely divergent species, anin vitro model of isolated xenogeneic hemoperfusion of the kidneys was devised allowing for separate testing of the different factors involved in the rejection process. In a perfusion system consisting of a roller pump, heat exchanger, perfusion chamber and a capillary oxygenator, rat kidneys were perfused with heparinized blood from dogs (n=10). The results showed that all the main criteria of the hyperacutein vivo rejection of kidneys in this species system (rapid increase of resistance with subsequent cessation of renal blood flow within 10–25 min, congestion and hemorrhage of the organ, endothelial cell damage of glomeruli, capillaries, arterioles) could also be observed in the xenogeneic perfusion of these organsin vitro. By varying the composition of the xenogeneic hemoperfusate, this test system seems to be suited to define more exactly some blood components responsible for the hyperacute xenogeneic graft rejection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01496813
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 12
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 323-324 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01489183
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 13
    Electronic Resource
    Electronic Resource
    Der Einfluß von PEEP-Beatmung auf Gesamthämodynamik und regionale Organdurchblutung (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 1289-1295 
    Details
    ISSN: 1432-1440
    Keywords: Hemodynamics ; Pulmonary circulation ; Regional blood flow ; Heart function ; Artificial ventilation ; Hämodynamik ; Lungenkreislauf ; Organdurchblutung ; Herzfunktion ; Künstliche Beatmung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Den günstigen Wirkungen von PEEP auf die Lungenfunktion stehen ausgeprägte hämodynamische Nebenwirkungen gegenüber, deren Ursachen vor allem in einer Verminderung des venösen Rückflusses bei erhöhtem intrathorakalem Druck sowie in einer Zunahme der rechtsventrikulären Nachlast aufgrund des erhöhten pulmonalen Gefäßwiderstandes zu sehen sind. PEEP führt zu einer Umverteilung des reduzierten Herzzeitvolumens zugunsten von Gehirn, Herz, Nebennieren und Darm, während die Durchblutung von Magen, Pankreas und Schilddrüse überproportional vermindert wird. Die Nierengesamtdurchblutung nimmt in der Regel nur geringfügig ab; eine Änderung der intrarenalen Hämodynamik bedingt jedoch eine Beeinträchtigung der Salz-Wasser-Ausscheidung. Die arterielle Durchblutung der Leber kann bei höheren Stufen von PEEP soweit reduziert werden, daß eine ausreichende O2-Versorgung nicht mehr gewährleistet ist. Unter klinischen Bedingungen können individuell unterschiedliche Voraussetzungen die Änderungen von globaler und regionaler Hämodynamik im günstigen wie im ungünstigen Sinne modifizieren.
    Notes: Summary The benficial effects of PEEP on lung function may be counteracted by its hemodynamic sequenlae induced by a reduction of venous return due to the elevated intrathoracic pressure, and by an increased right ventricular afterload secondary to the rise of pulmonary vascular resistance. PEEP redistributes cardiac output in favor of brain, heart, adrenals and intestines, whereas the perfusion of stomach, pancreas and thyroid is diminished out of proportion to the fall of cardiac output. Total renal blood flow is relatively little affected; however, redistribution of intrarenal blood flow will result in a marked salt-water-retention. Reduction of hepatic artery flow, at higher levels of PEEP, may jeopardice liver tissue oxygenation. — Under clinical conditions, individual differences regarding preexisting cardiopulmonary and peripheral-vascular diseases may modify the PEEP-induced hemodynamic alterations in a wide range.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711178
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 14
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 196-196 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468888
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 15
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 1089-1089 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476558
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 16
    Electronic Resource
    Electronic Resource
    Inhalation of prostacyclin (PGI2) for 8 hours does not produce signs of acute pulmonary toxicity in healty lambs (1996)
    Springer
    Intensive care medicine 22 (1996), S. 426-433 
    Details
    ISSN: 1432-1238
    Keywords: Aerosols ; Epoprostenol ; Toxicity ; Lung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To study the potential side effects and toxicity of inhaling prostacyclin (PGI2) aerosol for 8 h. Design In a prospective, randomized study 14 healthy lambs received either PGI2 (n=7) or 0.9% NaCl (n=7) as an aerosol for 8 h. Setting Institute for Surgical Research of the Ludwig-Maximilians-University of Munich. Interventions All animals were studied under general anesthesia in a prone position. They were first intubated endotracheally and later tracheotomized. PGI2 solution (median dose 28 ng/kg per min) or 0.9% NaCl was administered with a jet nebulizer (delivery rate 4–10 ml/h; mass median diameter of aerosol particles 3.1 μm). Bronchoalveolar lavage was performed before and after the inhalation period to collect epithelial lining fluid of alveoli. Measurements and results Hemodynamic and respiratory parameters, systemic resorption (plasma levels of 6-keto-prostaglandin-F1α), in vitro bleeding time, collagen-induced platelet aggregation and global biochemical and cellular composition of the epithelial lining fluid were examined in order to assess the sie effects and signs of acute pulmonary toxicity induced by inhaled PGI2. No statistically significant differences were found between the PGI2 and the control groups for any of the parameters examined. Conclusion Inhalation of PGI2 (28 ng/kg per min) over a period of 8 h in healthy lambs does not produce major side effects or acute pulmonary toxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01712159
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 17
    Electronic Resource
    Electronic Resource
    The nitric oxide donor sodium nitroprusside protects against hepatic microcirculatory dysfunction in early endotoxaemia (1998)
    Springer
    Intensive care medicine 24 (1998), S. 1257-1263 
    Details
    ISSN: 1432-1238
    Keywords: Key words Sepsis ; Nitric oxide ; Sodium nitroprusside ; Liver ; Microcirculation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: Endotoxin rapidly inhibits the activity of the constitutive endothelial nitric oxide synthase (ecNOS); this precedes the production of NO from inducible NOS (iNOS). This leaves a period in early endotoxaemia with a supposed scarcity of NO. The present study was conducted to examine the effects of external supplementation of NO on liver microcirculation and function. Material: 13 male Sprague Dawley rats. Interventions: The rats underwent laparotomy, and the left liver lobe was exteriorised. All animals were given a bolus dose of endotoxin (LPS) 5 mg/kg intraportally. One group (n = 6) had a continuous infusion of sodium nitroprusside (SNP) 1.4 μg/kg per min started concurrently, the other group (n = 7) was treated with normal saline. The study was terminated after 3 h LPS. Measurements and results: Intravital microscopy was performed at baseline, at 2 h and 3 h LPS. Hepatic function was assessed by arterial ketone body ratio, acid base values, and bile flow. At baseline 1 % of the sinusoids were without perfusion. After 2 h LPS this figure had risen to 9.8 ± 1.5 % in the SNP group versus 16.9 ± 1.4 % in the controls (p 〈 0.05 vs controls). The corresponding values after 3 h LPS were 13.5 ± 1.5 versus 19.3 ± 1.5 % (p 〈 0.05 vs controls). The leukocyte count in sinusoids and venules had a similar development. Functional parameters were all slightly better preserved in the SNP group, but with no individual significance versus controls. Conclusions: Infusion of the NO donor SNP in early endotoxaemia attenuates the detrimental effects of LPS on liver microcirculation, most probably by alleviating a relative deficit of NO at the microcirculatory level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050759
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 18
    Electronic Resource
    Electronic Resource
    Eight hours‘ inhalation of prostacyclin (PGI2) in healthy lambs: effects on tracheal, bronchial, and alveolar morphology (1996)
    Springer
    Intensive care medicine 22 (1996), S. 1232-1238 
    Details
    ISSN: 1432-1238
    Keywords: Key words Aerosols ; Epoprostenol ; Toxicity lung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To study potential toxic effects of long-term (8 h) inhaled prostacyclin (PGI2) on respiratory tract tissues. Design: In a prospective, randomized order, either PGI2 (n=7) or normal saline (n=7) was aerosolized during a time period of 8 h in healthy lambs. Setting: Institute for Surgical Research of the Ludwig-Maximilians University of Munich. Animals: 14 healthy, anesthetized, ventilated lambs. Interventions: All animals were endotracheally intubated followed by tracheotomy. PGI2 solution or normal saline was administered with a jet nebulizer (delivery rate 4–10 ml/h; mass median diameter of aerosol particles 3.1 μm). Measurements and results: Histomorphological changes after 8-h inhalation of PGI2 solution were compared to those after 8-h inhalation of normal saline. Tracheal and bronchoalveolar tissues were examined by light and electron microscopy in order to assess tissue damage induced by inhaled PGI2. Pathological changes were ranked by a blinded observer following a graduation system ranging from ”absence of pathological changes“ to ”maximal pathological changes“. Abnormalities were restricted to the trachea (focal flattening of the epithelium, loss of cilia, slight inflammatory cell infiltration) and alveolar tissue (focal alveolar septal thickening with slight inflammatory cell infiltration), but no statistically significant differences between the PGI2 and control groups were encountered. Conclusion: Our findings indicate the absence of PGI2 aerosol-related respiratory tissue damage after 8-h inhalation of PGI2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709341
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 19
    Electronic Resource
    Electronic Resource
    Inhalation of prostacyclin (PGI2) for 8 hours does not produce signs of acute pulmonary toxicity in healthy lambs (1996)
    Springer
    Intensive care medicine 22 (1996), S. 426-433 
    Details
    ISSN: 1432-1238
    Keywords: Key words Aerosols ; Epoprostenol ; Toxicity ; Lung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To study the potential side effects and toxicity of inhaling prostacyclin (PGI2) aerosol for 8 h. Design: In a prospective, randomized study 14 healthy lambs received either PGI2 (n=7) or 0.9% NaCl (n=7) as an aerosol for 8 h. Setting: Institute for Surgical Research of the Ludwig-Maximilians- University of Munich. Interventions: All animals were studied under general anesthesia in a prone position. They were first intubated endotracheally and later tracheotomized. PGI2 solution (median dose 28 ng/kg per min) or 0.9% NaCl was administered with a jet nebulizer (delivery rate 4–10 ml/h; mass median diameter of aerosol particles 3.1 μm). Bronchoalveolar lavage was performed before and after the inhalation period to collect epithelial lining fluid of alveoli. Measurements and results: Hemodynamic and respiratory parameters, systemic resorption (plasma levels of 6-keto-prostaglandin-F1α), in vitro bleeding time, collagen-induced platelet aggregation and global biochemical and cellular composition of the epithelial lining fluid were examined in order to assess the side effects and signs of acute pulmonary toxicity induced by inhaled PGI2. No statistically significant differences were found between the PGI2 and the control groups for any of the parameters examined. Conclusion: Inhalation of PGI2 (28 ng/kg per min) over a period of 8 h in healthy lambs does not produce major side effects or acute pulmonary toxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01712159
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 20
    Electronic Resource
    Electronic Resource
    Eight hours' inhalation of prostacyclin (PGl2) in healthy lambs: Effects on tracheal, bronchial, and alveolar morphology (1996)
    Springer
    Intensive care medicine 22 (1996), S. 1232-1238 
    Details
    ISSN: 1432-1238
    Keywords: Aerosols ; Epoprostenol ; Toxicity lung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To study potential toxic effects of long-term (8 h) inhaled prostacyclin (PGI2) on respiratory tract tissues. Design In a prospective, randomized order, either PGI2 (n=7) or normal saline (n=7) was aerosolized during a time period of 8 h in healthy lambs. Setting Institute for Surgical Research of the Ludwig-Maximilians University of Munich. Animals 14 healthy, anesthetized, ventilated lambs. Interventions All animals were endotracheally intubated followed by tracheotomy. PGI2 solution or normal saline was administered with a jet nebulizer (delivery rate 4–10 ml/h; mass median diameter of aerosol particles 3.1 μm). Measurements and results Histomorphological changes after 8-h inhalation of PGI2 solution were compared to those after 8-h inhalation of normal saline. Tracheal and bronchoalveolar tissues were examined by light and electron microscopy in order to assess tissue damage induced by inhaled PGI2. Pathological changes were ranked by a blinded observer following a graduation system ranging from “absence of pathological changes” to “maximal pathological changes”. Abnormalities were restricted to the trachea (focal flattening of the epithelium, loss of cilia, slight inflammatory cell infiltration) and alveolar tissue (focal alveolar septal thickening with slight inflammatory cell infiltration), but no statistically significant differences between the PGI2 and control groups were encountered. Conclusion Our findings indicate the absence of PGI2 aerosol-related respiratory tissue damage after 8-h inhalation of PGI2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709341
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...