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  • 1
    Digitale Medien
    Digitale Medien
    APPEARANCE OF GAMMA AMINOBUTYRATE TRANSAMINASE ACTIVITY IN DEVELOPING RAT BRAIN (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 23 (1974), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: —The distribution, localization and changes in intensity of γ-aminobutyrate transaminase (4-aminobutyrate: 2-oxoglutarate aminotransferase, EC 2.6.1.19) in rat brain have been studied during the first 20 days of postnatal life by a histochemical technique.Enzyme activity at birth was seen only in Purkinje cells of the cerebellar cortex where it increased markedly during the first 20 days. A rapid increase in enzyme activity was seen in regions of the hind-brain after 3 days but a slower increase was apparent in areas of the fore- and mid-brain. The results indicated that by 10 days post-partum nerve cell GABA-T activity had developed in the majority of brain areas studied, while glial cell GABA-T activity developed between 10 and 15 days post-partum.Evidence is presented which indicates that there is a discontinuous function of GABA-T in the developing brain.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1974.tb04367.x
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  • 2
    Digitale Medien
    Digitale Medien
    HISTOCHEMISTRY OF RAT BRAIN STEM MONOAMINE OXIDASE DURING MATURATION (1968)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 15 (1968), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: —Monoamine oxidase (MAO) activity in the nuclei and tracts of the medulla and pons of the rat from birth to 90 days is reported.Prominent MAO activity was present in the locus coeruleus and nucleus ambiguus at birth. At 5 days a weak reaction localized mainly within the neuropil and glia cells was detected in several other nuclei. By 10 days all nuclei were identified with MAO activity varying from weak to intense, the activity showing further increases at 15 and 20 days. Staining in nerve fibres was negligible at 5 days but increased rapidly to 15 days in some tracts when the characteristic beading pattern was distinct. At 30 days differentiation in intensity of MAO activity between the nuclei diminished and no increase was apparent after 55 days.The results are compared with the distribution of brain stem acetylcholinesterase during maturation and also with regions specific in catecholamine or serotonin content in the adult rat brain stem.This and an earlier study on the cerebrum suggest that MAO is another component of the brain that falls into the caudal-rostral concept of biochemical maturation and that it fits into a group of enzymes exhibiting a similar pattern of increase in activity during development.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1968.tb06832.x
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  • 3
    Digitale Medien
    Digitale Medien
    PROTEIN SYNTHESIS IN THE MEDULLA OF THE RAT BRAIN. REPRODUCIBILITY OF THE RESULTS (1969)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 16 (1969), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract— [14C]Leucine was injected intracranially into the brainstem reticular formation at the level of the upper medulla by the stereotaxic method. Subcellular fractions prepared 3 hr after injection showed that the specific activities of leucine-incorporated proteins decreased in the order soluble, microsomal, nuclear and mitochondrial fractions. Specific activities of proteins in the sera were 2·2 per cent of whole homogenate proteins.The results from 27 experiments showed that 66·6 per cent of the mean specific activities of proteins extracted from whole homogenates fell within ·1 s.d. and 100 per cent within ± 2 s.d. (close to a normal distribution). The coefficients of variation were between 40 and 50 per cent for whole homogenates, sera and all subcellular fractions. Reproducibility of results and factors concerned with possible errors in the technique are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1969.tb10362.x
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  • 4
    Digitale Medien
    Digitale Medien
    Labelling of synaptosomes and axoplasmic flow in the brain stem of the rat (1970)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 17 (1970), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1970.tb06879.x
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  • 5
    Digitale Medien
    Digitale Medien
    TRANSPORT OF 14C INCORPORATED PROTEIN IN THE CORTICOSPINAL TRACT OF THE RAT BRAIN (1969)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 16 (1969), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract— The origin of fibres of a corticospinal pathway in rat brain was located by cortical ablation and Marchi staining and also by electrical stimulation of the motor cortex.Enzyme changes investigated histochemically over 0–14 days post-injection of 5 μ10.15 m NaCl into the neocortex indicated that very little apparent disturbance of nerve cell metabolism beyond a narrow band adjacent to the path of the microneedle within the cortex had occurred. [14 C]Leucine as a precursor of protein synthesis was used to study incorporation of the amino acid into protein. At the site of injection the maximum level of labelled protein was recorded at 30 min post-injection, the level decreasing to less than 2 per cent of this at 6 hr.The subsequent axonal flow of labelled protein along the corticospinal pathway was investigated during the period 15 min to 21 days post-injection. Within 24 hr increasing amounts of labelled proteins were measured caudally, but not more than 6 per cent had migrated beyond 5 mm from the site of injection. At 3 days this percentage had increased to 14.6 per cent, the labelled proteins being distributed in progressively decreasing amounts to a further 13 mm caudal. Very little change from this position was seen during the following 18 days.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1969.tb05976.x
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  • 6
    Digitale Medien
    Digitale Medien
    HISTOCHEMISTRY OF MONOAMINE OXIDASE IN THE DEVELOPING RAT BRAIN (1967)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 14 (1967), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1967.tb09519.x
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  • 7
    Digitale Medien
    Digitale Medien
    ENZYME HISTOCHEMISTRY OF THE RAT HYPOTHALAMUS DURING EARLY DEVELOPMENT (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 19 (1972), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: —The distribution, localization and changes in intensity of enzymes in major metabolic pathways of brain metabolism during the first 16 days postnatal life of the rat anterior hypothalamus are reported. Thiamine pyrophosphatase, acid phosphatase and 5′-nucleotidase showed rapid increases in activity between 0 and 5 days whilst AChE, Mg2+–ATPase and monoamine oxidase exhibited little or no activity before 3 days. Most enzymes showed a moderate intensity at 16 days in all nuclei whilst for some enzymes of phosphate metabolism the reaction was strong. The precocity of some enzymes particularly monoamine oxidase, lactate dehydrogenase and NADH2-diaphorase seen in other regions at birth, was not apparent in hypothalamic nuclei. Comparisons are made with other regions of the brain and the findings discussed in relation to function.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1972.tb05101.x
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  • 8
    Digitale Medien
    Digitale Medien
    SOME SOURCES OF ERROR IN OUR METHODS OF DETERMINING POTASH IN FERTILIZERS AND GERMAN POTASH SALTS.1 (1894)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 16 (1894), S. 364-372 
    Details
    ISSN: 1520-5126
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ja02104a002
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  • 9
    Digitale Medien
    Digitale Medien
    Anaesthesia in the morbidly obese (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 38 (1983), S. 0 
    Details
    ISSN: 1365-2044
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Seventy morbidly obese patients presented for upper abdominal surgery; 17% had pre-existing cardiovascular disease and 23% pre-existing respiratory disease. Twenty-eight patients received general anaesthesia, plus narcotic analgesia postoperatively, and 42 general anaesthesia plus thoracic epidural analgesia intra- and postoperatively. Aspects of anaesthetic management are discussed and compared with previous similar reports. Doses of local anaesthetic for induction of epidural analgesia were less than those for the non-obese but doses of local anaesthetic for maintenance of epidural analgesia were similar to those in non-obese patients. Patients who had thoracic epidural analgesia required less volatile anaesthesia than the group who had general anaesthesia and narcotic analgesics. Postoperative respiratory complications were more common in patients with pre-existing cardiovascular and respiratory disease, and occurred less frequently in patients who had thoracic epidural analgesia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2044.1983.tb12249.x
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  • 10
    Digitale Medien
    Digitale Medien
    Preparation and properties of chiral titanocene and zirconocene dichloride complexes of a chiral ligand (1992)
    s.l. : American Chemical Society
    Organometallics 11 (1992), S. 1869-1876 
    Details
    ISSN: 1520-6041
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/om00041a021
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