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  • 1
    Electronic Resource
    Electronic Resource
    Stereocontrol by introduction of a sulfur functional group in the asymmetric reduction of β-ketoesters with baker's yeast; preparation of optically pure 3s-hydroxydithioesters as a new chiral synthon of natural product synthesis
    Amsterdam : Elsevier
    Tetrahedron Letters 27 (1986), S. 5405-5408 
    Details
    ISSN: 0040-4039
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4039(00)85223-5
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  • 2
    Electronic Resource
    Electronic Resource
    Interaction of blood with radiation-grafted materials
    Amsterdam : Elsevier
    Radiation Physics and Chemistry 18 (1981), S. 1207-1216 
    Details
    ISSN: 0146-5724
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0146-5724(81)90312-5
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  • 3
    Electronic Resource
    Electronic Resource
    Intracisternal dimer X: Toxicity and prophylaxis (1976)
    Springer
    Neuroradiology 11 (1976), S. 61-65 
    Details
    ISSN: 1432-1920
    Keywords: Dimer X ventriculography ; Epilepsy ; Valium ; Decadron
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Although Dimer X is said to be a low toxic water soluble contrast medium, epileptic seizures sometimes occur during or after Dimer X ventriculography. The toxicity of this dye was examined in rats and possible prophylactic measures were evaluated. From the results of our experiment it was concluded that Dimer X of low concentration should be used with premedication of Valium and Decadron.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00345014
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Cerebral vascular malformations: applications of magentic resonance imaging to differential diagnosis (1989)
    Springer
    Neuroradiology 31 (1989), S. 320-325 
    Details
    ISSN: 1432-1920
    Keywords: Brain ; Magnetic resonance imaging ; Cavernous angioma ; Arteriovenous malformation ; (AVM) ; Venous angioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twelve patients with cerebral vascular malformations (5 cavernous angiomas, 1 thrombosed arteriovenous malformation, and 6 venous angiomas) were studied with magnetic resonance (MR) imaging. All lesions were clearly depicted. Characteristic MR findings were obtained mainly on T2-weighted images: a markedly low intensity area was always seen. The margins of arteriovenous malformation (AVM) and venous angioma were irregular while those of cavernous angioma were smooth in all planes on T2-weighted images. Gradient-echo (GrE) pulse sequences were more sensitive than T2-weighted spin echo (SE) in lesion detection. MR imaging could play an important role in the differential diagnosis of cerebral vascular malformations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00344175
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  • 5
    Electronic Resource
    Electronic Resource
    Transvenous embolization of dural caroticocavernous fistulae: technical considerations (1993)
    Springer
    Neuroradiology 35 (1993), S. 475-479 
    Details
    ISSN: 1432-1920
    Keywords: Dural arteriovenous fistula ; Cavernous sinus ; Transvenous embolization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sixteen patients with symptomatic dural caroticocavernous fistulae were treated by transvenous embolization, via the jugular vein and inferior petrosal sinus. The fistula was occuladed by thrombogenic coils. Complete resolution of symptoms and signs was achieved in 14 patients, and complete angiographic resolution was also obtained in 14 patients. Failures to achieve angiographic cure were attributed to failure to reach the fistula within the cavernous sinus precisely. Factors which make placement of the catheter at the fistula difficult are trabeculae within the cavernous sinus, a specific configuration of the superior ophthalmic vein and venous thrombosis. To improve the efficacy of tranvenous embolization, every possible venous route to the cavernous sinus therefore should be tried, to facilitate reaching the fistula and the possibility of transvenous embolization should not be thwarted by venous thrombosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00602836
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  • 6
    Electronic Resource
    Electronic Resource
    Endovascular treatment of cerebral vasospasm: assessment of treatment effect by cerebral angiography and transcranial colour Doppler sonography (1999)
    Springer
    Neuroradiology 41 (1999), S. 453-462 
    Details
    ISSN: 1432-1920
    Keywords: Key words Vasospasm ; cerebral ; Sonography ; transcranial colour Doppler ; Balloon angioplasty ; Papaverine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a retrospective study of 30 consecutive patients with symptomatic vasospasm the mean degree of narrowing as compared to the initial angiogram was 35 % (± 24 %) in 12 intradural internal carotid arteries (ICA), 42 % (± 17 %) in 42 proximal middle cerebral (MCA) and 38 % (± 19 %) in 27 anterior cerebral arteries (ACA). The corresponding increase in mean flow velocities from baseline values obtained by transcranial colour Doppler sonography (TCD) within 12 h of the first angiogram to the time of clinical vasospasm was considerably higher, with 49 % (± 34 %) in the ICA, 119 % (± 92 %) in the MCA and 147 % (± 170 %) in the ACA. Following superselective intra-arterial papaverine application in 66 arteries and balloon angioplasty of 15 arteries, 78 (96.3 %) of 81 dilated. Sustained clinical improvement was achieved in 22 patients (73.3 %). The mean reversal of angiographic vasospasm was 71 % for the ICA (range 10–100 %), 81 % for the MCA (range 9–100 %) and 82 % (range 0–100 %) for the A1 segment. The mean reduction of flow velocities after treatment was much less with 23 % (± 21 %) in the ICA, 32 % (± 24 %) in the MCA and 25 % (± 22 %) in the A1 segment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050784
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  • 7
    Electronic Resource
    Electronic Resource
    Cerebellomedullary compression in recessive craniometaphyseal dysplasia (1996)
    Springer
    Neuroradiology 38 (1996), S. S193 
    Details
    ISSN: 1432-1920
    Keywords: Key words Craniometaphyseal dysplasia ; Skeletal dysplasia ; Basilar invagination ; Magnetic resonance imaging ; Posterior cranial fossa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Craniometaphyseal dysplasia (CMD) is a very rare disorder of bone remodelling characterised by sclerosis of the skull base, vault and facial bones and metaphyseal splaying of tubular bones. The recessive form appears to be more severe than the dominant. Cranial nerve deficits have been reported in infancy and early childhood in a few patients, but the long-term history of recessive CMD is not well documented. We report cerebellomedullary compression in a girl with recessive CMD recognised at 14 years because of progressive truncal ataxia. MRI revealed backward angulation of the thickened clivus, narrowing of the foramen magnum and upward deviation of the cerebellum by a markedly thickened occipital squama, tonsillar herniation and obliteration of the infratentorial cerebrospinal fluid spaces. Posterior cranial fossa decompression resulted in marked improvement of the ataxia. Compression of posterior cranial fossa structures has to be considered in the natural history and management of CMD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050952
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  • 8
    Electronic Resource
    Electronic Resource
    Cerebellomedullary compression in recessive craniometaphyseal dysplasia (1996)
    Springer
    Neuroradiology 38 (1996), S. S193 
    Details
    ISSN: 1432-1920
    Keywords: Craniometaphyseal dysplasia ; Skeletal dysplasia ; Basilar invagination ; Magnetic resonance imaging ; Posterior cranial fossa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Craniometaphyseal dysplasia (CMD) is a very rare disorder of bone remodelling characterised by sclerosis of the skull base, vault and facial bones and metaphyseal splaying of tubular bones. The recessive form appears to be more severe than the dominant. Cranial nerve deficits have been reported in infancy and early childhood in a few patients, but the long-term history of recessive CMD is not well documented. We report cerebellomedullary compression in a girl with recessive CMD recognised at 14 years because of progressive truncal ataxia. MRI revealed backward angulation of the thickened clivus, narrowing of the foramen magnum and upward deviation of the cerebellum by a markedly thickened occipital squama, tonsillar herniation and obliteration of the infratentorial cerebrospinal fluid spaces. Posterior cranial fossa decompression resulted in marked improvement of the ataxia. Compression of posterior cranial fossa structures has to be considered in the natural history and management of CMD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02278158
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  • 9
    Electronic Resource
    Electronic Resource
    Colour-coded Doppler sonographic study of the haemodynamics in the parent artery of intracranial aneurysms (1999)
    Springer
    Neuroradiology 41 (1999), S. 553-562 
    Details
    ISSN: 1432-1920
    Keywords: Key words Ultrasonography transcranial Doppler ; aneurysm intracranial ; haemodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the haemodynamics in the parent artery of 17 small (〈 9 mm) and 17 large (L 9.5 mm) saccular aneurysms by transcranial colour-coded Doppler sonography (TCCD) and related the findings to digital subtraction angiography (DSA). We measured flow velocity within the parent artery and, by positioning the Doppler gate within the colour flow image close to the ostium of the aneurysm, obtained a superselective Doppler spectral waveform. The parameters measured included the time-averaged maximal velocity (TAMX), peak systolic, and end-diastolic velocity and pulsatility index (PI). The values were compared to the contralateral side and between small and large aneurysms. DSA was analysed for parent artery stenosis. Mean systolic velocities in the parent arteries of large aneurysms were significantly higher than in the contralateral normal artery (1.08 ± 0.23 vs 0.80 ± 0.23 m/s; P = 0.0003) and higher than in the parent artery of small aneurysms (0.89 ± 0.18 m/s; P = 0.01). Increased systolic velocity accounted for a higher PI in the parent artery of large aneurysms (mean 1.48 ± 0.42) than on the other side (0.87 ± 0.12; P = 0.0001) and in the parent artery of small aneurysms (0.85 ± 0.14; P = 0.0001). PI proximal to seven thrombosed large aneurysms was higher (mean 1.85 ± 0.38) than close to unthrombosed large aneurysms (1.23 ± 0.22; P = 0.0005). Increased PI and systolic velocities could not be shown within branches of 5 large aneurysms and were reversible in the parent artery of four patients examined again after occlusion of the aneurysm. Systolic velocities and PI did not differ significantly (P = 0.41 and P = 0.25, respectively) in ruptured and unruptured aneurysms. Stenosis of the parent artery was not shown by DSA in any case.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050804
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of nerve growth factor on delayed neuronal death after cerebral ischaemia (1994)
    Springer
    Acta neurochirurgica 129 (1994), S. 64-71 
    Details
    ISSN: 0942-0940
    Keywords: Cytoskeleton ; delayed neuronal death ; nerve growth factor (NGF) ; neurofilament (NF)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated the protective action of nerve growth factor (NGF) on delayed neuronal death, and we also studied the involvement of the 200 kDa neurofilament (NF 200) cytoskeletal proteins. Wistar rats were divided into three groups: Group I, in which transient forebrain ischaemia was produced; Group II, ischaemic group which received intraventricular administration of artificial cerebrospinal fluid (CSF); and Group III, ischaemic group which received intraventricular administration of 2 Μg of 2.5 S NGF. Forebrain ischaemia in these rats was produced by causing transient bilateral occlusion of the common carotid arteries and lowering the mean blood pressure to 50 mmHg for 8 minutes. On the 1st and 7th day after ischaemia we histologically examined neuronal death in the hippocampal CA1 sector. On the 7th day after ischaemia, mean cell death (degenerative cell number/total cell number) was 87±9% in group I (n=7), 51±36% in group II (n=7), and 14±16% in group III (n=8) (p〈0.05 vs. group II). The concentration of NF 200 in the hippocampal homogenate was measured by the Western blotting method on the 1st and 7th day after ischaemia. On the 1st day it was found to be 67±11% of that in the control group in group I (n=6), 73±21% in group II (n=6), and 84±7% in group III (n=6) (p〈0.05 vs. group II). The concentration of NF 200 in all groups remained at the same level until the 7th day after ischaemia (each group, n=6). These results suggest that 1) intraventricular NGF has a protective effect on delayed neuronal death, 2) these protective actions occur within one day after ischaemia, and 3) these effects may be mediated by the suppressed degradation and/or promoted restoration of neuronal cytoskeletal proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400875
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