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  • 1
    Electronic Resource
    Electronic Resource
    Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo (2000)
    [s.l.] : Nature America Inc.
    Nature medicine 6 (2000), S. 583-588 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The pro-inflammatory cytokine interleukin (IL)-6 (refs. 1–5) can bind to cells lacking the IL-6 receptor (IL-6R) when it forms a complex with the soluble IL-6R (sIL-6R) (trans signaling). Here, we have assessed the contribution of this system to the increased resistance of mucosal T cells ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/75068
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  • 2
    Electronic Resource
    Electronic Resource
    Thymidine phosphorylase expression results in a decrease in apoptosis and increase in intratumoral microvessel density in human gastric carcinomas (2000)
    Springer
    Virchows Archiv 437 (2000), S. 31-36 
    Details
    ISSN: 1432-2307
    Keywords: Key words Apoptosis ; Gastric carcinoma ; Intratumoral microvessel density ; Thymidine phosphorylase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Thymidine phosphorylase (dThdPase) / platelet- derived endothelial cell growth factor (PD-ECGF) is expressed at higher levels in a variety of human carcinomas than in adjacent normal tissue. The higher expression is associated with an increase in intratumoral microvessel density (IMVD) and an unfavorable patient prognosis. This study examined the role of dThdPase in apoptosis, IMVD and p53 expression in human gastric carcinomas. dThdPase expression was noted in 12 (35.3%) of 34 early carcinomas, and in 20 (55.6%) of 36 advanced carcinomas. At least 10 areas consisting of carcinoma cells with diffuse dThdPase expression from the 32 dThdPase-positive tumors (category I), and 10 areas without dThdPase expression from the 38 negative tumors (category II) were selected from each case. For early gastric carcinoma, the mean IMVD was 88.8±19.4 in category I and 61.4±17.3 in category II carcinomas, while for advanced gastric carcinoma, the mean IMVD was 98.8±21.0 in category I and 76.0±27.1 in category II carcinomas. The mean IMVD was significantly higher in category I than in category II tumors (P〈0.05). The mean apoptotic index (AI: percentage of apoptotic cells) was 1.95±1.30 in category I, and 3.76±1.49 in category II carcinomas for early gastric carcinoma, and 1.51±0.98 in category I and 2.14±0.66 in category II carcinomas for advanced gastric carcinoma, the value of the mean AI being significantly (P〈0.05) higher in dThdPase- negative tumors (category II) than in the positive tu-mors (category I), regardless of tumor stage or histological type. There was a significant inverse correlation (P〈0.001) between AI and IMVD. These results indicate that dThdPase expression is associated with both an increase in intratumoral microvessels and a decrease in apoptosis in human gastric carcinomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280000205
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  • 3
    Electronic Resource
    Electronic Resource
    Pediatric acoustic schwannoma showing rapid regrowth with high proliferative activity (2000)
    Springer
    Child's nervous system 16 (2000), S. 134-137 
    Details
    ISSN: 1433-0350
    Keywords: Key words Acoustic schwannoma ; MIB-1 staining index ; Pediatric patient
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Acoustic schwannoma is a slow-growing tumor and usually occurs in adult patients. We report a rare pediatric case of acoustic schwannoma with high proliferative potential. A 10-year-old boy was diagnosed as having a right cerebellopontine angle tumor. The tumor was subtotally resected. Histological examination revealed a typical acoustic schwannoma with a few mitotic figures. Chromosomal analysis showed no abnormality on the long arm of chromosome 22 associated with neurofibromatosis type 2. The lesion regrew rapidly as an acoustic schwannoma, necessitating subtotal resection on three occasions and CyberKnife radiosurgery. The immunohistochemical MIB-1 staining indices of the specimens obtained at the first, second, and third operations were 2.3%, 4.6% and 14.7%, respectively. The immunohistochemical proliferative potential of acoustic schwannoma is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050479
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  • 4
    Electronic Resource
    Electronic Resource
    Analysis of Osteoblast Activity around Beta-TCP Particles Implanted into Bone: Expression of Bone Matrix Protein mRNAs (2000)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 192-195 (Sept. 2000), p. 317-320 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/45/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.192-195.317.pdf
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  • 5
    Electronic Resource
    Electronic Resource
    Primary Intracranial Malignant Schwannoma of Trigeminal Nerve. A Case Report with Review of the Literature (2000)
    Springer
    Acta neurochirurgica 142 (2000), S. 591-595 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Intracranial malignant schwannoma; trigeminal nerve; electron microscopy; S-100 protein.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ The authors report a rare case of primary intracranial malignant schwannoma of the trigeminal nerve occuring in a 30-year-old woman without von Recklinghausen's neurofibromatosis (VRNF). The tumour arose from the intracranial part of the left trigeminal nerve, without skull base destruction. The tumour was partially removed operatively, followed by focal 50Gy irradiation, but unfortunately the tumour showed rapid regrowth. A second operation was attempted, but she died of cerebral infarction soon after operation. Histologically, the original tumour was characterized by the presence of foci of extremely high cellularity, pleomorphism and mitosis in an otherwise typical benign schwannoma. Immunohistochemically, the tumour cells were positive for S-100 protein even in the atypical areas, suggesting the tumour to be of Schwann cell origin. However, the recurrent tumour was composed of undifferentiated spindle cells, which were negative for S-100 protein.  Thus, it is possible to consider that the S-100 protein expression could reflect the degree of differentiation of Schwann cells. Furthermore, the postoperative irradiation might have exacerbated the malignant progression in the present case.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050475
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  • 6
    Electronic Resource
    Electronic Resource
    High 5HT2A receptor occupancy in M100907-treated schizophrenic patients (2000)
    Springer
    Psychopharmacology 148 (2000), S. 400-403 
    Details
    ISSN: 1432-2072
    Keywords: Key words Serotonin receptor ; 5HT2A ; M100907 ; [11C]M100907 ; Positron emission tomography ; PET ; Human brain ; Schizophrenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rationale: Selective drugs are required to test the hypothesis whether antipsychotic effects may be induced or modulated by 5HT2A receptor antagonism. M100907 (previously known as MDL 100,907) is a highly selective 5HT2A antagonist in clinical development. Objective: To test if the suggested clinical dose of 20 mg M100907 daily induces high 5HT2A receptor occupancy in patients with schizophrenia. Methods: The 5HT2A receptor occupancy was determined in two patients with schizophrenia treated with M100907, 20 mg once a day. Positron emission tomography (PET) with 11C-labeled M100907, was performed prestudy and under steady state conditions. Clinical ratings were performed weekly. Results: Clinical treatment with M100907, 20 mg daily induced a very high 5HT2A receptor occupancy in the frontal cortex of both patients (〉90%). M100907 was well tolerated. One patient improved minimally and one patient became minimally worse during treatment. Conclusions: The results confirm that an oral dose of 20 mg per day ensures adequate 5HT2A receptor occupancy for clinical proof of concept. The sample is too small to allow conclusions about the clinical effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050069
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  • 7
    Electronic Resource
    Electronic Resource
    Efficacy of HSP72 induction in rat liver by orally administered geranylgeranylacetone (2000)
    Springer
    Transplant international 13 (2000), S. S278 
    Details
    ISSN: 1432-2277
    Keywords: Key words Geranylgeranylacetone ; Heat-shock protein 72 ; Liver transplantation ; Warm ischemic injury ; Ischemia reperfusion injury
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It is well known that heat-shock proteins (HSPs) have a cytoprotective function as “molecular chaperones” when cells are exposed to several stress conditions. Geranylgeranylacetone (GGA) is an antiulcer drug that was developed in Japan and it has recently been reported to induce HSP72 in rat gastric mucosa. In this experiment, we investigated the induction of HSP72 in rat liver in response to oral administration of GGA and assessed its ability to induce tolerance to warm ischemic injury by this approach. We prepared donor rats by orally administering GGA to them and compared HSP72 expression in graft liver, survival rates, and serum TNF-α concentrations after liver transplantation with the findings in controls. The survival rates were significantly increased when the livers were obtained from donor rats given GGA. Western blotting revealed expression of HSP72 in graft livers given GGA, and the serum TNF-α levels were significantly suppressed in the rats given GGA. Oral administration of GGA induced HSP72 in graft livers, and they were better able to tolerate warm ischemic injury. Oral administration of GGA appears to provide a promising new strategy for preventing ischemia-reperfusion injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050341
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  • 8
    Electronic Resource
    Electronic Resource
    Congenital balloon digits in two neonates caused by constriction rings (2000)
    Springer
    Pediatric surgery international 16 (2000), S. 533-535 
    Details
    ISSN: 1437-9813
    Keywords: Key words Balloon digit ; Constriction ring ; Neonate ; Lymphatic vessel ; Fibrous tissue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Balloon digits were found in two neonates with congenital constriction ring syndrome. The affected digits were the right long finger and right great toe. They were surgically treated at the age of 10 and 9 days, respectively. Morphologic improvement was dramatic after surgery. In cases with extensive enlargement, severe cyanosis, redness, and no subsidence of edema within several days after birth, early operative treatment may be necessary to maintain digit viability and prevent autoamputation due to circulatory embarrassment. It can also be helpful to prevent fibrosis of the subcutaneous tissue. Pathologic examination revealed marked proliferation of fibrous tissue and lymphatic vessels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003839900330
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  • 9
    Electronic Resource
    Electronic Resource
    Simultaneous occurrence of prostate cancer and IgE myeloma, a rare hematolymphoid malignancy (2000)
    Springer
    International journal of clinical oncology 5 (2000), S. 334-336 
    Details
    ISSN: 1437-7772
    Keywords: Key words Prostate cancer ; IgE myeloma ; Asymptomatic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An unusual case of the simultaneous occurrence of prostate cancer and IgE myeloma is reported. A 74-year-old man with urinary disturbance and elevated serum prostate-specific antigen level, of 7.4 ng/ml, showed Bence-Jones protein in the urine. Immunoelectrophoresis of the serum showed elevation of IgE kappa monoclonal protein. Radical prostatectomy was performed as a curative therapy for T1c, Gleason 3-2 prostate cancer. The patient has remained free of progression of both the myeloma and the prostate cancer for 26 months after the initial diagnosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00012059
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  • 10
    Electronic Resource
    Electronic Resource
    Role of chromosomal loss in the progression of prostate cancers (2000)
    Springer
    International journal of clinical oncology 5 (2000), S. 345-354 
    Details
    ISSN: 1437-7772
    Keywords: Key words Prostate cancer ; Chromosome ; Loss of heterozygosity ; Tumor suppressor gene ; Metastasis suppressor gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cytogenetic, molecular cytogenetic, and molecular studies of prostate cancer have produced a large volume of data about chromosomal loci that are aberrant in prostate cancer. The cumulative data on prostate cancer reveal allelic losses on chromosome arms 2q, 3p, 5q, 6q, 7q, 8p, 9p, 10p, 10q, 11p, 11q, 12p, 13q, 16q, 17p, 17q, 18q, and 21q, but there is a great deal of variability between studies. In most cases, the frequency of allelic loss is higher in metastatic tissues or hormone-refractory tumors than in primary tumors. There also seem to be discrepancies in the genetic findings depending on methods employed. Molecular genetic studies, using polymerase chain reaction (PCR) analysis of microsatellite markers, demonstrated allelic loss at 7q31.1, whereas fluorescence in situ hybridization analysis showed a gain at the same region. Com-mon sites of allelic loss that are consistently observed by various methods seem to exist on chromosome arms 8p, 10q, 13q, and 16q. PTEN/MMAC1 has been identified on 10q23.3 and was found to be frequently mutated in advanced prostate cancer. Other regions are also considered to harbor genes associated with the development and progression of prostate cancer, and these could be included in the diagnostic methods for the substaging of prostate cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00012062
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