ISSN:
1573-8353
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract 5-(Hydroxybenzyl)uracils are obtained by condensation of 5-hydroxymethyluracil (I) with phenols in the presence of CF3COOH [1]. However, the activity of CF3COOH is insufficient for aromatic compounds that do not contain electron-donor substituents. Thus, according to PMR data, the reaction between equivalent amounts of I and C6H6 in CF3COOH is complete only after 3 days. However, benzene derivatives containing electron-acceptor substituents are practically unreactive. Anhydrous HP, in which even benzotrifluoride reacts, is a considerably more efficient agent.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00470180
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