ZIB

1

Digitale Medien

Structural analysis by mass spectrometry of the major mammalian retinal ganglioside, a sialyl-sialyl-dihexosyl-ceramide (1977)

Holm, M. ; Pascher, I. ; Samuelsson, B. E.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 77-81

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The major mammalian retinal ganglioside was analysed by mass spectrometry. Three types of derivatives were used, the fully methylated, the methylated and reduced and the methylated, reduced and trimethylsilylated compound. The mass spectra unambiguously showed the ganglioside to be a sialyl-sialyl-dihexosyl-ceramide. This is the first conclusive proof that the two N-acetylneuraminic acids are bound to each other constituting the terminal disaccharide. The major species contained sphingosine and stearic acid.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040204

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2

Digitale Medien

Cyclic alkylboronates as derivatives for the characterization of cannabinolic acids by combined gas chromatography and mass spectrometryAbbreviations: BSTFA = N, O-bis-(trimethylsilyl)trifluoroacetamide; TMCS = trimethylchlorosilane; THC-tetrahydrocannabinol; CBN = cannabinol; CBD = cannabidiol. (1977)

Harvey, D. J.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 88-93

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Stable cyclic methyl-and n-butylboronates were prepared from the cannabinolic acids and used as derivatives for the characterization of these compounds by combined gas chromatography mass spectrometry. Retention times of the methylboronates were comparable with those of the trimethylsilyl derivatives. The mass spectra of these derivatives were more characteristic of the cannabinoid skeleton than were the spectra of the trimethylsilyl derivatives where fragmentation was associated with the trimethylsilyl groups. Molecular weights were lower and abundant molecular ions were obtained. These derivatives also offered the possibility of distinguishing between isomeric cannabinolic acids where only isomers possessing adjacent phenolic and carboxylic functions form cyclic boronates.

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040206

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3

Digitale Medien

A comparison between 14CO2 and 13CO2 measurements in the respired breath of rats fed sodium acetate (1977)

Ampulski, R. S. ; Boggs, R. W.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 98-102

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: 13CO2/12CO2 ratios in the respired breath of rats fed carbon-13 labeled compounds have been continuously assayed using a mass spectrometer to monitor m/e 44 and 45 in real time. Rats dosed with sodium [1-13C]acetate were restrained in a specially designed glass metabolism cage. A constant air flow through the cage was continuously monitored for respired carbon dioxide by a commercial analytical organic high resolution mass spectrometer. The mass spectrometer was operated in the peak matching mode while alternately recording the ion intensities of m/e 44 and 45 at a cycle rate of 30 s. The appearance and decay in the breath of excess 13CO2 was interpreted for the metabolism of sodium acetate. The minimum dose of label was found to be 1.4 × 10-4 mol kg-1. The precision of the mass ratio measurement was ± 1%. Details of the experimental design and limitations of the technique are discussed. In order to compare 13CO2 results with an established radiochemical method the rats were also dosed with sodium [1-14C]acetate.The appearance of 14CO2 in the respired breath was followed by bubbling the breath through sodium hydroxide traps with quantitation of radioctivity by means of liquid scintillation counting. A comparison of the rates of respiration of 13CO2 and 14CO2 showed that the two methods produced comparable results in rats. This finding further substantiates the feasibility of using carbon-13 labeled compounds in metabolism studies.

Zusätzliches Material: 6 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040208

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4

Digitale Medien

Quantitative determination of enantiomeric compounds. I - simultaneous measurement of the optical isomers of amphetamine in human plasma and saliva using chemical ionization mass spectrometryAbbreviation: PFBPI = N-pentafluorobenzoyl-S-(-)-prolyl-1-imidazolide. (1977)

Matin, Shaikh B. ; Wan, Suk Han ; Knight, James B.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 118-121

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: A sensitive and specific method for the quantitative determination of the optical isomers of amphetamine from human plasma and saliva is described. Amphetamine was extracted from basified plasma or saliva with hexane and then derivatized by reaction with N-pentafluorbenzoyl-S-(-)-prolyl-1-imidazolide. The reaction of the amphetamine enantiomers with this chiral reagent yields diasteriomers which are easily resolved by gas liquid chromatography. The resolved diasteriomers upon elution from the gas chromatograph were measured quantitatively by chemical ionization mass spectrometry. Plasma and saliva levels achieved following the oral administration of 10 mg of dl-, d- and l-amphetamine in man are reported.

Zusätzliches Material: 5 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040212

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5

Digitale Medien

The electron impact induced fragmentation of Aspergillus amstelodami alkaloids and Derivatives (1977)

Selva, A. ; Traldi, P.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 143-145

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The mass spectral data of four isoprenylated indole alkaloids containing a piperazinedione group, neoechinuline, cryptoechinuline C, and A and echinuline, isolated from Aspergillus amstelodami cultures, and of two derivatives obtained by catalytic hydrogenation of neoechinuline and echinuline, are reported and discussed. Their fragmentation patterns are strongly dependent upon the presence of a single or a double bond between C-8 and C-9.

Zusätzliches Material: 6 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040304

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6

Digitale Medien

Location of functional groups in antipyrine metabolites by mass spectrometry (1977)

Zietz, Eberhard ; Spiteller, Gerhard

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 155-158

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The mass spectra of antipyrine metabolites show characteristic fragmentation patterns which depend on the presence and position of functional groups. A substituent at position 4 is indicated by an intense key fragment at m/e 56 and a substituent at the methyl group in position 3 causes a significant increase in the intensity of the peak at m/e 82. The fragment at m/e 96, which is characteristic for antipyrine itself, is suppressed if there is a substituent in either position 3 or 4. Mass spectra of the glucuronides of 4-hydroxyantipyrine and 3-hydroxymethylantipyrine are also discussed.

Zusätzliches Material: 8 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040307

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7

Digitale Medien

Sample derivatization and structure analysis by field desorption mass spectrometry. Peptide methylation - methanolysis (1977)

Frick, Willi ; Daves, G. Doyle ; Barofsky, Douglas F. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 152-154

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Analysis by field desorption mass spectrometry of reaction product mixtures produced by treatment of peptides with methanol and hydrogen chloride augments significantly structural data derived by direct field desorption mass spectrometry analysis of the peptides. Analyses of data obtained by three peptides, β-Ala-HisOH, p-Glu-Ser-GlyOH and Glu-Ser-Gly-AspOH are used for illustration. Data from field desorption mass spectrometry of peptide methylation-methanolysis product mixtures are used to (a) distinguish [M]+ from [M + H]+ in peptide field desorption mass spectrometry spectra, (b) ascertain the number of carboxyl groups present in a peptide, (c) identify a pyro-glutamyl N-terminus and (d) derive peptide sequence information. Definitive assignments of ion relationships are facilitated by use of methanol and deuteromethanol in paired experiments.

Zusätzliches Material: 1 Tab.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040306

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8

Digitale Medien

Peptide sequencing: The utility of chemical ionization mass spectrometry (1977)

Mudgett, M. ; Bowen, D. V. ; Field, F. H. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 159-171

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Chemical ionization mass spectrometry is used at low resolution to determine the sequences of permethylated acetyl peptides. The method has been tested with 45 peptides, between 2 and 5 residues long, including examples of all of the common amino acids except cysteine and N-terminal asparagine. The isobutane chemical ionization spectra contain three principal types of N-terminal sequence ion and one type of C-terminal sequence ion. The redundant information available from these four types of sequence ion increases the reliability of the sequence determination. In prospect, isobutane chemical ionization mass spectrometry seems to be a useful technique for peptide sequence determination, and may have advantages in some cases.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040308

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9

Digitale Medien

High performance liquid chromatographic and mass spectrometric identification of dimethylxanthine metabolites of caffeine in human plasma (1977)

Midha, K. K. ; Sved, S. ; Hossie, R. D. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 172-177

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: High performance liquid chromatography and mass spectrometry were used to isolate and identify theophylline, theobromine and 1,7-dimethylxanthine (paraxanthine) in plasma of human volunteers following administration of 300 mg caffeine to methylxanthine-free volunteers. Plasma from these subjects was extracted and the dimethylxanthines were separated from each other and caffeine by high performance liquid chromatography. The effluents at the chromatographic peaks corresponding to the dimethylxanthine metabolites were collected, rechromatographed in a second system and the dried residues were subjected to mass spectrometry. By comparison of their retention times and mass spectra with those of authentic compounds, theophylline, theobromine and paraxanthine were positively identified as metabolic products of caffeine.

Zusätzliches Material: 3 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040309

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10

Digitale Medien

Source identification of urban airborne polycyclic aromatic hydrocarbons by gas chromatographic mass spectrometry and high resolution mass spectrometryAbbreviation: PAH = polycyclic aromatic hydroacarbons. (1977)

Lee, M. L. ; Prado, G. P. ; Howard, J. B. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 182-186

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Polycyclic aromatic hydrocarbons formed during the combustion of three common fuels (coal, wood and kerosene) were separated and identified by capillary-column gas chromatographic mass spectrometry and were compared to airborne polycyclic aromatic hydrocarbons from Indianapolis, a high coal consuming area, and Boston, a low coal consuming area. High resolution mass spectral data were utilized in the construction of alkyl homolog plots for the comparison of alkyl distribution within each sample.

Zusätzliches Material: 6 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040311

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11

Digitale Medien

Rapid and quantitative blood amino acid analysis by chemical ionization mass spectrometryAbbreviations: PKU = phenylketonuria; MSU = maple syrup urine disease. (1977)

Mee, John M. L. ; Korth, John ; Halpern, Berthold ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 178-181

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: A quantitative analysis of amino acids in microsamples of dried blood spots by chemical ionization mass spectrometry has been developed. Isotope ratio determination was used as the quantitating technique via multiple labelled internal standards. This procedure yields excellent precision and accuracy as demonstrated by the analysis of known amino acid mixtures and of phenylalanine in the blood from newborns.

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040310

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12

Digitale Medien

Masthead (1977)

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977)

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040401

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13

Digitale Medien

MASSFORM: A computer program for the assignment of elemental compositions to high resolution mass spectral dataThe program MASSFORM and its user documentation are available through the American Society for Mass Spectrometry, Committee on Computers and Data Processing (III). (1977)

Robertson, Alan L. ; Hamming, Mynard C.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 203-208

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: This paper describes a computer program which calculates all possible empirical formulas for each accurately measured mass in a high resolution mass spectrum. The program, MASSFORM, incorporates a novel mechanism for classifying the empirical formulas generated according to their empirical formula. This mechanism makes it possible to use a set of general empirical formulas to aid in the analysis of complex mixtures in much less time than most other such programs. The program is being used as an important aid to environmental studies.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040403

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14

Digitale Medien

A novel inexpensive device for the electrochemical generation of metallic emitters for field desorption (1977)

Rechsteiner, Carl E. ; Mathis, Dale E. ; Bursey, Maurice M. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 52-54

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Details for the construction of a novel, inexpensive device for the electrochemical generation of metallic emitters for field desorption mass spectrometry are described. Use of the device for the generation of cobalt and nickel emitters is demonstrated.

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040107

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15

Digitale Medien

Some simple modifications to the LKB 9000S to achieve improved selected ion monitoring and repetitive scanning performance (1977)

King, Graham S. ; Talbert, David ; Mangez, Jean

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 62-65

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Modifications are described to the electron multiplier pre-amplifier, selected ion monitor, magnet current supply and scan controller of the LKB 9000S gas chromatograph mass spectrometer. The modifications described have secured an improved performance for specific ion monitoring and fast repetitive scanning gas chromatography mass spectrometry.

Zusätzliches Material: 7 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040109

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16

Digitale Medien

Masthead (1977)

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977)

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040501

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17

Digitale Medien

Phosphazenes: High molecular weight reference compounds for field desorption mass spectrometryAbbreviation: PFA = perfluoroalkane. (1977)

Olson, Keith L. ; Rinehart, Kenneth L. ; Cook, J. Carter

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 284-290

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Because of poor field ionization sensitivity or an insufficient number of peaks, conventional reference materials are inadequate for field desorption mass spectrometry. Hexakis (multifluoroalkoxy)cyclotriphosphazenes satisfy a growing need for high molecular weight reference compounds amenable to either electron impact or field ionization. In comparison with tris(perfluoroalkyl)-s-triazine standards, the substituted phosphazenes offer greater volatility, easier synthesis and better mass spetral characteristics. Phosphazene mixtures, in particular, cover a broad mass range in either ionization mode, creating new measurement capabilities for ions at high masses.

Zusätzliches Material: 9 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040503

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18

Digitale Medien

Field ionization mass spectrometry. I - Field desorption spectra of nucleotides - experimental problemsAbbreviations: A-3′-MP = adenosine-3′-monophosphoric acid; A-5′-MP = adenosine-5′-monophosphoric acid; U-5′-MP = uridine-5′-monophosphoric acid; U-5′-MPNa2 = di-Na salt of U-5′-MP (analogously also for other salts); C-5′-MP = cytidine-5′-monophosphoric acid; G-2′, 3′-MP = guanosine-2′,3′-cyclophosphate; UpG = uridylyl (3′-5′) guanosine. (1977)

Budzikiewicz, H. ; Linscheid, M.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 103-106

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Instrumental and substance inherent problems typical for field-desorption spectra of highly sensitive polar substances are discussed and illustrated with examples from the nucleotide field.

Zusätzliches Material: 5 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040209

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19

Digitale Medien

Product news (1977)

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. iii

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040216

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20

Digitale Medien

Structure and fragmentation mechanisms of some ions in the mass spectrum of ephedrinePresented in part at the 89th Annual Meeting of the AOAC, Washington, D.C., U.S.A., 15 October 1975. (1977)

Barry, Thomas L. ; Petzinger, Glenn

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 129-133

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: This paper describes the use of gas chromatography mass spectrometry for the confirmation of ephedrine in adulterated powdered ipecac and ipecac fluid extract. Deuteration studies of ephedrine hydrochloride and some related compounds were also performed in an attempt to postulate structures for some of the fragment ions appearing in the spectrum of ephedrine.

Zusätzliches Material: 5 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040302

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21

Digitale Medien

Gas chromatography mass spectrometry analysis of polyamines using deuterated analogs as internal standards (1977)

Smith, Ronald G. ; Daves, G. Doyle

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 146-151

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Quantitative analyses of subnanomole quantities of the polyamines putrescine, cadaverine, spermidine and spermine by the gas chromatography mass spectrometry technique of selected ion monitoring are complicated by effects of the chromatographic column. These effects include sample retention by the column and chromatographic band broadening, and are sufficiently serious that spermine (as the trifluoroacetylated derivative) was not detectable at levels below 50 picomoles. Because the chromatographic behaviors of the four polyamines vary, quantiative analysis using a single internal standard is not feasible. The deuterated polyamine analogs, putrescine-2H4, cadaverine-2H4, spermidine-2H6 and spermine-2H8, have been synthesized and used to accomplish quantiative analyses of the corresponding isotopically natural abundance polyamines to the one picomole level. This enhancement in analytical sensitivity is accomplished by use of large excesses (≥100 picomoles) of the deuterated analogs to improve chromatographic band profiles. The use of such large molar excesses of deuterated analogs for selected ion monitoring analyses is possible because their electron impact spectra exhibit high mass ions {[M-F3C]+, [M-F3CCO]+} which possess ≥ 4 deuterium atoms and have intensity ratios (I2H(max): IH) of 500 or greater.

Zusätzliches Material: 5 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040305

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22

Digitale Medien

Limitations of diazomethane for the quantification of 15-Oxo-prostaglandin F2α (1977)

Cockerill, Anthony F. ; Gutteridge, Norman J. A. ; Mallen, David N. B. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 187-189

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The relatively rapid formation of pyrazoline adducts is a serious side reaction in the esterification of 15-oxo-PGF2α with ethereal diazomethane under conditions used routinely in the chemical derivatization of prostaglandins.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040312

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Synthesis and characterization of glucuronides of cannabinol, cannabidiol, Δ9-tetrahydrocannabinol and Δ8-tetrahydrocannabinolAbbreviations: THC = tetrahydrocannabinol; UDPG = uridine diphosphoglucuronyl. (1977)

Lyle, Michael A. ; Pallante, Sharon ; Head, Ken ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 190-196

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Partially purified glucuronyltransferase immobilized on beaded sepharose has been used to synthesize the glucuronide conjugates of cannabidol, cannabidol, Δ9-tetrahydrocannabinol and Δ8-tetrahydrocannabinol. Trimethylsilylated methyl esters and per(trimethylsilyl) derivatives of these conjugates have been characterized by their gas chromatographic retention times and their electron impact and ammonia chemical ionization mass spectra.

Zusätzliches Material: 11 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040313

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Quinoxalinol derivatives of aliphatic 2-oxocarboxylic acidsSupported by the Deutsche Forschungsgemeinschaft, Bad Godesberg, G.F.R. (SFB 33).. Infrared and mass spectra of the O-trimethylsilylated compoundsAbbreviation: BSTFA = bis(trimethylsilyl)trifluoroacetamide. (1977)

Langenbeck, U. ; Möhring, H. -U. ; Hinney, B. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 197-202

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: In acidic media o-phenylenediamine and 2-oxoacids react to yield quinoxaline derivatives. On derivatization in pyridine with silylating reagents quinoxalinol-O-TMS ethers or O-TMS-ether-TMS-esters are formed exclusively as shown by gas chromatography infrared spectrometry and gas chromatography mass spectrometry. These derivatives have very favourable properties for gas chromatographic detection and quantitation of the parent 2-oxoacids. The mass spectra have characteristic fragments which facilitate easy identification. In addition, ‘single ion monitoring’ of all aliphatic 2-oxoacids can be performed with only three fragments at m/e 217, 232 and 245. In some aspects the mass spectra resemble those of other heterocyclic compounds which contain an O-alkyl sidechain. The fragmentation mechanisms were deduced by low resolution mass spectrometry with and without deuteration, high resolution mass spectrometry and metastable ion evidence. A new type of rearrangement α-β-elimination of ethylene or propylene from the aliphatic sidechain, is proposed for some O-TMS quinoxalinols.

Zusätzliches Material: 1 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040402

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Analysis of hexosaminitol-containing disaccharide alditols from rat brain glycoproteins and gangliosides as O-trimethylsilyl derivatives by gas chromatography mass spectrometry (1977)

Finne, Jukka ; Mononen, Ilkka ; Kärkkäinen, Jorma

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 281-283

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The O-trimethylsilyl derivatives of five reference disaccharide alditols composed of a N-acetylhexosaminitol substituted at C-3, C-4 or C-6 with a hexose moiety were studied by gas chromatography mass spectrometry. The data were used in the determination of the linkage in disaccharide alditols derived from rat brain glycoproteins and gangliosides. The O-glycosidically linked carbohydrate units of brain glycoproteins contained two oligosaccharides, β-galactosyl-(1 → 3)-N-acetylgalactosaminitol and α-galactosyl-(1 → 3)-N-acetylgalacto-saminitol, whereas only the latter was obtained from brain gangliosides after partial acid hydrolysis and reduction.

Zusätzliches Material: 2 Tab.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040502

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The mass spectra of 8-azapurines (1977)

Bose, Samarendra N. ; Davies, R. Jeremy H. ; Boyd, Derek R.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 305-309

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The mass spectra of 8-azaadenine, 8-azahypoxanthine, 2,6-diamino-8-azapurine, 8-azaxanthine and 8-azaguanine are all characterized by intense molecular ion peaks. Fragmentation pathways are advanced to account for the other ions observed in the mass spectra and are supported by metastable transitions, accurate mass measurements and deuterium labelling studies. 8-azaadenine and 8-azahypoxanthine fragment initially by elimination of nitrogen from the molecular ion, but this is a minor process with the other compounds. In many respects the electron impact induced fragmentation of the 8-azapurines is analogous to that of the corresponding purine derivatives.

Zusätzliches Material: 5 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040506

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Forthcoming meetings (1977)

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. v

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040512

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J. Throck Watson. Introduction to mass spectrometry: Biomedical, environmental and forensic applications. Raven Press, New York, 1976. 239 pp. $20.00 (1977)

Markey, S. P.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. v

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040511

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Studies on molecular species of fetal lung lecithins by gas-liquid chromatography mass spectrometryPresented in part at the Japanese Society for Medical Mass Spectrometry Meeting, 2 October 1976.Abbreviation: PC32 symbolizes a phosphatidylcholine and the number indicates the sum of fatty acid residues on the C-1 and C-2 positions. (1977)

Ogino, Hirotaro ; Matsumura, Tadaki ; Satouchi, Kiyoshi ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 326-329

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The molecular species of lung lecithins obtained from rabbit and rat fetuses at different days of gestation and from newborns were analysed as TMS derivatives of the corresponding diglycerides in a gas chromatograph mass spectrometer system by selected ion retrieval. In the latter part of gestation, the order of the main molecular species of lung lecithins, PCn, was PC32 〉 PC34 〉 PC30, while at an earlier stage it was PC34 〉 PC32 〉 PC30. During gestation the change of PC32:0, dipalmitoyllecithin, was remarkable. Ether lecithins are also discussed.

Zusätzliches Material: 5 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040510

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Characterization and mass spectral analysis of some grayanotoxin derivativesAbbreviation: G = grayanotoxin. (1977)

Jawad, Fuad H. ; Kinghorn, A. Douglas ; Doorenbos, Norman J. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 331-336

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The mass spectra of grayanotoxin III and some of its mono-, di-, and tri-ester derivatives are discussed. Some of the physiological reponses of this compound class are also presented. The extraction of this material from a natural source is discussed as well as the schemes for ester derivatization and spectral characterization of all compounds studied. High resolution mass spectral analysis and comparison of the mass spectra of similar compounds were used to define possible fragmentation mechanisms.

Zusätzliches Material: 8 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040603

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Ring-D fragmentation of cardenolidesSee Ref. 1. (1977)

Flaskamp, E. ; Budzikiewicz, H.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 354-357

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The major fragmentation paths typical for the cardenolides system have been elucidated by labelling studies.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040606

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Masthead (1977)

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977)

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040101

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Eight peak index of mass spectra, 2nd Edition, 4 Volumes, 2933 pages, 1975. Her Majesty's Stationery Office, London. $336.00 (1977)

Milne, G. W. A.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 68-68

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040111

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Product news (1977)

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. iii

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040114

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Meetings (1977)

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. iii

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040115

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Identification of dihydrothiazoles in urine of male mice (1977)

Liebich, H. M. ; Zlatkis, A. ; Bertsch, W. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 69-72

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The compounds 2-isopropyl-4,5-dihydrothiazole and 2-sec-butyl-4,5-dihydrothiazole were identified in urine of male mice. Their excretion in mouse urine is sex-dependent. In the urine of female mice the two dihydrothiazoles are either absent or present only in trace amounts. The analytical procedure includes the adsorption of the volatile mouse urine constituents on Tenax GC, their gas chromatographic separation and the detection of the sulfur compounds by the sulfur-specific detector. The identified compounds were synthesized. Natural and synthetic compounds had the same mass spectrometric properties and retention data.

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040202

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Amobarbital metabolism in man determination of N-hydroxyamobarbital and 3′-hydroxyamobarbital in urine by gas chromatography chemical ionization mass spectrometry (1977)

Tang, B. K. ; Inaba, T. ; Kalow, W.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 73-76

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: An accurate and sensitive g.c.m.s. procedure was developed to determine both N-hydroxyamobarbital and 3′-hydroxyamobarbital, which are the two major metabolites of amobarbital in man.

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040203

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Hydantoin ring glucuronidation: Characterization of a new metabolite of 5,5-diphenylhydantoin in man and the rat (1977)

Smith, Ronald G. ; Daves, G. Doyle ; Lynn, R. K. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 275-279

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: A new metabolite of 5,5-diphenylhydantoin has been found in human urine and in rat bile. This new metabolite arises by direct glucuronidation of 5,5-diphenylhydantoin (i.e. no prior aryl hydroxylation occurs) and is characterized as the N-3 glucuronide. This structure assignment is based on (a) study of mass spectra of permethyl, perdeuteriomethyl, N-methyl-per-O-deuteriomethyl and deuteriomethyl ester permethyl derivatives and (b) comparison of the reactions of the new glucuronide metabolite and 5,5-diphenyl-3-methylhydantoin with diazomethane. Prominent ions at m/e 322 and 378 in the mass spectrum of the permethylated derivative of the glucuronide metabolite arise via retro Diels-Alder reactions of the glycone ring.

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040415

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H. M. Rosenstock, K. Draxl, B. W. Steiner,J. T. Herron, C. Fenselau. Energetics of gaseous ions. Published as Supplement No. 1 to the Journal of Physical and Chemical Reference Data, Vol. 6, 1977 by the American Chemical Society and the American Institute of Physics. 783 pages. Hardcover, $70.00; Softcover, 65.00; for members of the American Society for Mass Spectrometry, $30.00 (1977)

Fenselau, C.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. iii

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040416

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The measurements of propantheline ion in biological fluids after administering propantheline bromide to manAbbreviations: PB = propantheline bromide; DPB = trideuteropropantheline bromide; deMPB = demethyl propantheline; dePPB = deisopropyl propantheline; dePDPB = deisopropyl trideuteropropantheline. (1977)

Ford, G. C. ; Grigson, S. J. W. ; Haskins, N. J. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 94-97

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The measurement of propantheline ion has been accomplished in urine and plasma following administration of propantheline bromide to man. Trideuteropropantheline bromide is added to the biological fluid to act as a carrier and internal standard to quantify the propantheline ion using multiple ion monitoring. Methane was used as reactant gas but following the discovery of exchange of the trideuteromethyl group when using methane, ammonia was used for later analyses. The determination of propantheline ion in urine and plasma after administration of propantheline bromide to man is described.

Zusätzliches Material: 3 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040207

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Preclinical toxicological study of phosphonoacetic acid: Determination in blood by selected ion monitoringAbbreviations: PAA = phosphonoacetic acid; PPA = phosphonopropionic acid; HVS = H. saimiri; HVA = H. ateles; BSTFA = N,O-bistrimethylsilyltrifluoroacetamide; TMCS = trimethylchlorosilane. (1977)

Roboz, John ; Suzuki, Robert ; Bekesi, George ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 291-296

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Confirmed observations of the inhibition of oncogenic viruses by phosphonoacetic acid led to preclinical trials in animal model systems. Circulating phosphonoacetic acid was detected in the blood of mouse, rabbit and monkey after oral or subcutaneous administration of the drug. Phosphonoacetic acid is quantified in blood, after removing proteins and lipids, as the trimethylsilylated derivative, by monitoring the intensity of the protonated molecular ion and also that of phosphonopropionic acid (internal standard) using chemical ionization mass spectrometry combined with gas chromatography. The detection limit is 20 ng ml-1 when 0.2 ml serum is analyzed. A dosage of 230 mg kg-1 day-1 by continuous infusion is proposed for therapeutic trials in monkeys. This dose is well tolerated and results in slowly increasing blood levels of phosphonoacetic acid which reach a maximum of approximately 50 μg ml-1 in a four day infusion, and decrease to 2 μg ml-1 24 h after termination.

Zusätzliches Material: 8 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040504

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42

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Gas chromatography mass spectrometry assay for ketamine and its metabolites in plasma (1977)

Lau, Serrine S. ; Domino, Edward F.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 317-321

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: A highly sensitive and specific method for quantitation of ketamine and two of its metabolites found in monkey, dog and human plasma was developed using a gas chromatography selected ion monitoring assay operated in both electron impact and chemical ionization modes. This technique yields excellent precision, reproducibility and accuracy. From 1 ng to 3 μg of ketamine or its metabolites in 1 ml of plasma can be detected. The technique of electron capture gas chromatography is compared. All three assays were found to be quite useful but the gas chromatography mass spectrometry techniques were more specific.

Zusätzliches Material: 8 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040508

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Determination of bupivacaine in human fetal and neonatal blood samples by quantitative single ion monitoringAbbreviation: pentyl PPX = 1-n-pentyl-2-(2′,6′-xylylcarbamoyl)-piperidine hydrochloride. (1977)

Caldwell, John ; Moffatt, John R. ; Smith, Robert L. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 322-325

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The blood levels of bupivacaine administered epidurally during labour have been determined in mother, fetus and the newborn infant by quantitative single ion monitoring, following gas chromatographic separation. Concentrations were determined from the height of the peak obtained at m/e 140 derived from bupivacaine compared with that at m/e 154 derived from the internal standard, 1-n-pentyl-2-(2′,6′-xylylcarbamoyl)piperidine. Results from six mothers and their infants showed that the drug passed rapidly from the maternal circulation to the infant. The plasma half-life of the drug in the newborn infant was 18 h compared with 1.25 h for the adult.

Zusätzliches Material: 5 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040509

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Product news (1977)

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. vi

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

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Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040513

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Editorial (1977)

Fenselau, C. C. ; Millard, B. J.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. i

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040602

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Digitale Medien

Masthead (1977)

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977)

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040601

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Digitale Medien

Mass spectra of some specifically deuterated tryptamines (1977)

Shaw, G. John ; Wright, Graeme J. ; Milne, G. W. A.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 348-353

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The mass spectra of the four tryptamine derivatives, N-acetyl-5-methoxytryptamine (melatonin), N-acetyl-5-hydroxytryptamine (N-acetyl-serotonin), N,N-dimethyl-5-hydroxytryptamine (bufotenine) and N,N-dimethyl-5-methoxytryptamine (O-methylbufotenine), with specifically labeled [D4]aminoethyl sidechains have been measured. Comparison of these spectra with those of the unlabeled compounds enable the major fragmentations of the compounds to be defined.

Zusätzliches Material: 3 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040605

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48

Digitale Medien

In vivo metabolism of cannabinol by the mouse and rat and a comparison with the metabolism of Δ1-tetrahydrocannabinol and cannabidiolAbbreviations: THC = tetrahydrocannabinol; CBD = cannabidiol; CBN = cannabinol. (1977)

Harvey, D. J. ; Martin, B. R. ; Paton, W. D. M.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 364-370

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The in vivo liver metabolism of cannabinol has been studied in the mouse and rat by combined gas chromatography and mass spectrometry. Cannabinol glucuronide was the major metabolite of cannabinol in the mouse and was accompanied by relatively large amounts of 7-hydroxycannabinol, cannabinol-7-oic acid and their corresponding glucuronide conjugates. Lower concentrations of glucuronides were found in the rat. Two series of disubstituted metabolites were found containing either a 7-hydroxyl or a 7-carboxylic acid group and a second hydroxyl group in the 1″-4″ positions of the sidechain. These were of low concentration in the mouse but higher in the rat; 1″-hydroxy metabolites were particularly abundant in the latter species. Also found in the rat livers were small amounts of sidechain monohydroxy metabolites and larger quantities of 4″,5″-bisnorcannabinol-3″-oic acid; these were absent in the mouse. The metabolites were identified using the trimethylsilyl (TMS),[2H9]TMS and methyl ester-TMS derivatives, and by reduction of acid metabolites with lithium aluminium deuteride to the corresponding alcohols.

Zusätzliches Material: 7 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040608

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Application of deuterium labelling mass spectrometry in a study of the metabolism of the enantiomers of cyclophosphamideAbbreviation: CP = cyclophosphamide. (1977)

Cox, P. J. ; Farmer, P. B. ; Foster, A. B. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 371-375

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The antitumour agent cyclophosphamide - {2-[bis(2-chloroethyl)amino]-tetrahydro-2H -1,3,2-oxaza-phosphorine 2-oxide} - is chiral owing to asymmetry at phosphorus. The differential metabolism of the enantiomers [(+)-cyclophosphamide and (-)-cyclophosphamide] can be monitored by mass spectrometry if pseudoracemates consisting of either unlabelled [2H0] (+)- and tetradeuterated [2H4] (-)-cyclophosphamide or of [2H0](-) and [2H4](+) enantiomers are administered. Using this principle, methodology has been developed for determining the enantiomer ratios of cyclophosphamide and two metabolites, 4-ketocyclophosphamide {2-[bis(2-chloroethyl)amino] tetrahydro-2H-1,3,2-oxazaphosphorin-4-one 2-oxide} and carboxyphosphamide [2-carboxyethyl N,N-bis(2-chloroethyl)phosphorodiamidate] recovered from the urine of mice. The drug and the two metabolites were quantified using [2H10]cyclophosphamide, 4-keto-[2H8]cyclophosphamide and [2H6]carboxyphosphamide respectively, as internal standards. The amount of cyclophosphamide excreted was small and neither enantiomer preponderated markedly, but the minor metabolite, 4-ketocyclophosphamide, was markedly depleted in the enantiomer derived from (-)-cyclophosphamide, whereas the major metabolite, carboxyphosphamide, was slightly depleted in the enantiomer derived from (+)-cyclophosphamide.

Zusätzliches Material: 2 Tab.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040609

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50

Digitale Medien

Environmental applications of mass spectrometry (1977)

Alford, Ann

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 1-22

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The 1975 publications reporting organic and spark source mass spectrometric studies on environmental samples were compiled. Emphasis was placed on pollutants identified rather than methods and techniques used, and reports that did not incorporate data obbtained by a technique's application were not included. The 272 reports cited vary from those reporting hundreds of identified pollutants to those describing the analysis of only one sample containing one or a few pollutants. The following sample types were not considered to be environmental samples: forensic samples, synthetic or ‘standard’ samples, and samples analyzed for drug residues.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040102

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51

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Use of new silylating agents for identification of hydroxylated steroids by gas chromatography and gas chromatography mass spectrometryAbbreviations: DMAS = dimethylalkylsilyl; DMES = dimethylethylsilyl; DMPS = dimethyl-n-propylsilyl; I = imidazole; DMECS = dimethylethylchlorosilane; DMPCS = dimethyl-n-propylchlorosilane; BSTFA = N, O-bis-(trimethylsilyl)trifluoroacetamide; E-BSTFA = N, O-bis-(dimethylethylsilyl)trifluoroacetamide; PBSTFA = N, O-bis-(dimethyl-n-propylsilyl)trifluoroacetamide. (1977)

Miyazaki, Hiroshi ; Ishibashi, Masataka ; Itoh, Masahiro ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 23-35

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Differences in methylene unit values were used for the determination of the hydroxyl group number of a steroid by means of gas chromatography. This index is defined as the difference in the methylene unit value between trimethylsilyl and other dimethylalkylsilyl (DMAS) ether derivatives of hydroxylated steroids, namely dimethylethylsilyl (DMES) and dimethyl-n-propylsilyl (DMPS) ethers. The reactivities of DMES and DMPS imidazoles as silylating agents were nearly equal to that of TMS-I. Mass spectra of these derivatives were characterized by the molecular ion cluster, [M]+., [M-15]+ and [M-29]+ (or [M-43]+). The molecular ion cluster of these derivatives is most useful for estimating the molecular weight. Therefore, these DMAS ethers provide valuable information for structural elucidation of hydroxylated steroids by gas chromatography electron impact mass spectrometry.

Zusätzliches Material: 21 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040103

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52

Digitale Medien

Mass spectrometry of cyclopenta[a]phenanthrenes. Metabolites formed in vitro and in vivo from the carcinogen 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one (1977)

Vose, Colin ; Coombs, Maurice M.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 48-51

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The mass spectra of a number of synthetic cyclopenta[a]phenanthrenes are described, and identitication of an in vitro metabolite of a carcinogen of this series is reported. The correlation of the mass spectra of the major urinary metabolite, its dehydration product and its triacetate with the structure assigned to the metabolite is described.

Zusätzliches Material: 3 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040106

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53

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Letter to the editors (1977)

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 66-67

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040110

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54

Digitale Medien

An emission-controlled field desorption and electron impact spectrometry study of some N-substituted propane and butane sultams (1977)

Schulten, H.-R. ; Nibbering, N. M. M.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 55-61

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: It is shown that the production of field desorption mass spectra with an emission-controlled emitter heating device is a useful tool in obtaining information about molecular structures. Since the structurally significant signals are sometimes missing in the corresponding electron impact spectra but not in the field desorption spectra the use of field desorption mass spectrometry appears to be more advantageous. This will be especially true for substances that are thermally labile, unvolatile or unstable upon electron impact (both at high and low electron energy), the latter being the case for some of the compounds presently investigated which are derivatives of a drug with antitumour and antiepileptic effects. Further, emission-controlled desorption improves the reproducibility of the spectra obtained and thus appears to be a prerequisite for quantification in biomedical and pharmacokinetic studies.

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040108

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55

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Compilation of mass spectral data, 2nd Edition, compiled by A. Cornu and R. Massot, 2 Volumes, 1096 pages, 1975. Heyden, London. $108.00 (1977)

Milne, G. W. A.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 68-68

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040112

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56

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Meeting (1977)

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. iii

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040215

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57

Digitale Medien

Masthead (1977)

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977)

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040301

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Digitale Medien

Determination of phenylbutazone, tolbutamide and metabolites in plasma and urine using chemical ionization mass spectrometry (1977)

Weinkam, Robert J. ; Rowland, Malcolm ; Meffin, Peter J.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 42-47

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Quantitative analytical procedures for the analysis of phenylbutazone and tolbutamide levels in plasma have been developed which involve the addition of deuterium labeled internal standards to plasma followed by extraction and direct sample insertion into a mass spectrometer operating under chemical ionization conditions. Peak height ratios used to calculate plasma levels were determined by using either selected ion monitoring or repetitive scan data. The scan approach was used in a related procedure for the simultaneous determination of tolbutamide and two metabolites from urine. The accuracy, precision and sensitivity of the direct sample insertion approach to drug level measurement has been determined. Examples are given of data obtained in the course of pharmacokinetic studies in which this analytical approach appears to offer advantages in the analysis of multicomponent mixtures encountered in drug-drug interaction studies.

Zusätzliches Material: 9 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040105

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Single and multiple ion recording techniques for the analysis of diphenylhydantoin and its major metabolite in plasmaAbbreviations: DPH = diphenylhydantoin; HPPH = 5-(p-hydroxyphenyl)-5-phenylhydantoin; TMAH = trimethylanilinium hydroxide; BSA = N, O-bis-(trimethylsilyl)acetamide. (1977)

Baty, J. D. ; Robinson, P. R.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 36-41

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: A method has been developed for single ion monitoring of diphenylhydantoin and its major metabolite 5-(p-hydroxyphenyl)-5-phenylhydantoin in plasma. A plasma extract is reacted with N, O-bis(trimethylsilyl)acetamide and single ion recording is carried out using a gas chromatograph mass spectrometer system. The mass value selected, m/e 254, is common to the TMS ethers of diphenylhydantoin and its principal metabolite 5-(p-hydroxyphenyl)-5-phenylhydantoin. The results indicate that one cause of an adverse reaction to diphenylhydantoin could be a reduced ability to hydroxylate the drug. Quantitative methods for the analysis of the drug and its major metabolite have also been developed. Diphenylhydantoin and 5-(p-hydroxyphenyl)-5-phenylhydantoin can be analysed in plasma after addition of deuterium labelled internal standards and conversion to volatile derivatives for mass fragmentographic analysis. Diphenylhydantoin and its internal standard are analysed as the N, N-dimethyl derivative, and the hydroxylated metabolite and its internal standard are converted to a pertrimetylsilyl compound by reaction with N, O-bis-(trimethylsilyl)acetamide.

Zusätzliches Material: 6 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040104

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60

Digitale Medien

Location of functional groups with the aid of mass spectrometry. XVIFor Part XV, see Ref. 1. - Mass spectra of trimethylsilylated androstan-3,16,17 β-triols (1977)

Grote, Heinfried ; Spiteller, Gerhard

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 216-219

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The mass spectra of androstan-3,16,17β-triols are very similar, so that a distinction between isomers is rather difficult. Main degradation reactions correspond to expulsion of substituents and loss of parts of the D-ring system.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040405

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61

Digitale Medien

Workshop report (1977)

Watson, J. Throck

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. ix

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040613

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62

Digitale Medien

Organic structural analysis. J. B. Lambert, H. F. Shurvell, L. Berbit, R. G. Cooks, G. H. Stout, Macmillan Publishing Co. Inc., New York, N. Y., 1976. 596 pp. $22.95 (1977)

Amzel, L. M. ; Covey, D. F. ; Fenselau, C. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. vii

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040612

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63

Digitale Medien

Product news (1977)

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. x

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040614

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64

Digitale Medien

Mass spectrometric studies of twenty-one metabolically important acylglycines (1977)

Ramsdell, H. S. ; Baretz, B. H. ; Tanaka, K.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 220-225

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The mass spectra of the methyl esters of twenty-one metabolically important N-acylglycines are reported. The spectra are discussed in terms of their fragmentations and their application to studies of metabolic diseases. In particular, the high relative abundance of the peak at m/e 30 in the spectra of many aliphatic acylglycine methyl esters was studied by using ([2,2-2H2]propionyl)glycine and high resolution mass spectrometry. This fragment was assigned to the even-electron ion [CH2 = NH2]+.

Zusätzliches Material: 1 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040406

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65

Digitale Medien

Mass spectrometric characterization of activated N-(2-chloroethyl)amido oxazaphosphorine derivativesPresented in part at the International Symposium on ‘Mass Spectrometry in Drug Metabolism’, Milan, Italy, 21-23 June 1976.Abbreviations: CP = cyclophosphamide, 2-bis(2-chloroethyl)-amino tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; IP = ifosfamide, 3-(2-chloroethyl)-2-(2-chloroethylamino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; TP=trofosfamide, 3-(2-chloroethyl)-2-(bis(2-chloroethyl)amino) tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; 4-OH-CP = 4-hydroxycyclophosphamide; 4-keto-CP = 4-ketocyclophosphamide; 4-keto-IP = 4-ketoifosfamide; 4-OOH-CP = 4-hydroperoxycyclophosphamide; 4-OOH-IP = 4-hydroperoxyifosfamide; 4-OOH-TP = 4-hydroperoxytrofosfamide; 4-ethylthio-CP= 4-ethylthiocyclophosphamide; 4-t-butylthio-CP = 4-t-butylthiocyclophosphamide; 4-benzylthio-CP = 4-benzylthio-cyclophosphamide; 4-ethane-(3-ol)thio-CP = 4-ethane-(3-ol)thio-cyclophosphamide; 4-ethoxy-CP = 4-ethoxycyclophosphamide; TCA = trichloroacetic acid. (1977)

Przybylski, M. ; Ringsdorf, H. ; Lenssen, U. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 209-215

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The hydroperoxy and several alkylthio derivatives of the antitumor agents cyclophosphamide (2-bis(2-chloroethyl)amino tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide), ifosfamide (3-(2-chloroethyl)-2-(2-chloroethylamino) tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide) and trofosfamide (3-(2-chloroethyl)-2- (bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide) were characterized by electron impact and field desorption mass spectrometry. The compounds, which are stabilized derivatives of the activated hydroxylated intermediates of cyclophosphamide (ifosfamide, trofosfamide), could be identified as 4-hydroperoxy and 4-alkylthio oxazaphosphorines. The existence of diastereomers of these products was demonstrated by thin-layer chromatography and f.d. mass spectra. Derivatization with benzylmercaptan was found to be an appropriate method for the quantitative isolation and mass spectral identification of the activated metabolic intermediates of cyclophosphamide from biological material. Using this reaction, 4-hydroxycyclophosphamide and its acyclic tautomer, aldophosphamide, which are too unstable for direct identification, were detected in urine and serum of patients treated with 3H-cyclophosphamide.

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040404

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66

Digitale Medien

Mass spectrometric determination of new prostaglandin derivatives (series A and E)Abbreviations: PGAs = prostaglandins A1 and A2; PGEs = prostaglandins E1 and E2; TMS = Trimethylsilyl; BSA = N,O-bis-trimethylsilylacetamide; BSTFA = N,O-bis-trimethylsilyltrifluoroacetamide. (1977)

Roselló, Juan ; Suñol, Cristina ; Tusell, José M. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 237-240

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The reaction of prostaglandins E1, E2, A1 and A2 with a 1:1 mixture of N,O-bis-trimethylsilyltrifluoroacetamide and piperidine favours the quantitative enolization of the 9-keto group of prostaglandins E, thus giving the corresponding tetrakis-TMS derivatives with molecular ions at m/e 642 and m/e 640 for prostaglandins E1 and E2, respectively, and also gives a new type of prostaglandin A-piperidyl-TMS derivative characterized by very strong base peaks at m/e 464 and 462, with molecular ions at m/e 637 and 635 for prostaglandins A1 and A2, respectively. The probable reaction mechanisms prevailing in both cases are discussed in accordance with the low and high resolution mass spectral data presented.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040409

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Analysis of drugs by pyrolysis. IPresented in part at the 10th Annual Symposium of Organic and Biomedical Mass Spectrometry, Nagoya, Japan, 11-13 November 1975.-selected ion monitoring combined with a pyrolysis method for the determination of carpronium chloride in biological samplesAbbreviation: MTB = (3-methoxycarbopropyl)trimethyl-ammonium chloride, carpronium chloride. (1977)

Ohya, Kazumi ; Sano, Mitsuji

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 241-247

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: In order to establish an analytical method for carpronium chloride, a parasympathomimetic agent, the pyrolysis reaction of carpronium chloride was examined in a g.c.m.s. system, which revealed that γ-butyrolactone was produced directly from the drug as the main pyrolysis product. In the case of conversion of [2,2,3,3-2H4]carpronium chloride into the deuterated γ-butyrolactone, 2H/1H scrambling was observed and confirmed to occur during the pyrolysis process of the deuterated compound. The proportion of γ-[2H4]butyrolactone among the pyrolysis products was almost independent of the operating conditions, so [2,2,3,3-2H4]carpronium chloride was of practical use as an internal standard for selected ion monitoring. By incorporation of the pyrolysis reaction of carpronium chloride with selected ion monitoring and the use of [2,2,3,3-2H4]carpronium chloride as an internal standard, a rapid, sensitive and selective method was devised for the determination of the drug in biological samples. The method was utilized successfully for the biopharmaceutical studies of carpronium chloride in man.

Zusätzliches Material: 7 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040410

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68

Digitale Medien

Gas chromatography chemical ionization mass spectrometry of prostaglandin Fα cyclic boronate derivatives (1977)

Smith, Andrew G. ; Brooks, Charles J. W.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 258-264

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The electron impact mass spectra of prostaglandins F1α, F2α and F3α methyl ester cyclic 9,11-methane-, n-butane-, cyclohexane- and benzeneboronate 15-trimethylsilyl ethers show base peaks corresponding to [M - (C-16 - C-20)]+, i.e. [M - 71]+ for prostaglandins F1α and F2α but [M - 69]+ for prostaglandin F3α yielding identical ions in the latter two cases. Derivatives of prostaglandin F2α and F3α are difficult to separate by gas chromatography, so that the use of this ion type for single ion monitoring of either prostaglandin (as has been reported) is ambiguous. The chemical ionization mass spectra of these cyclic boronates, however, show distinctive base peaks for prostaglandins F1α, F2α and F3α at m/e 317, 315 and 313 respectively, corresponding to [M - RBO2H2 - TMSO]+. Fragmentation patterns have been investigated by the use of [3,3,4,4-2H4]prostaglandin F2α and by the formation of [2H9]trimethylsilyl ethers and a [2H3]methyl ester. Cleavage of the C-15 - C-16 bond is of minor importance under chemical ionization conditions. The possible value of the [M - RBO2H2 - TMSO]+ ions for single ion monitoring is explored: specificity is aided by the formation of the same ions from a series of boronates of characteristic retention indices.

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040413

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Allyldimethylsilyl ethers as derivatives for the characterization of steroids and cannabinoids by combined gas chromatography and mass spectrometryAbbreviations: BSTFA = N, O-bis-trimethylsilyltrifluoroacetamide; THC = tetrahydrocannabinol; CBN = cannabinol; CBD = cannabidiol. (1977)

Harvey, D. J.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 265-274

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The allyldimethylsilyl ethers of thirteen mono- and dihydroxy steroids and eleven cannabinoids were examined by combined gas chromatography mass spectrometry and their properties compared with those of the corresponding trimethylsilyl and t-butyldimethylsilyl ethers. The spectra of the allyldimethylsilyl derivatives of the steroids exhibited abundant ions produced by elimination of the larger (allyl) silyl substituent and were thus found to be useful for single ion monitoring studies. Ion currents carried by the [M-allyl]+ ions were slightly less than those carried by the [M-t-butyl]+ ions from the t-butyldimethylsilyl derivatives, but the spectra exhibited more abundant molecular ions and ions characteristic of the presence of specific functional groups such as a Δ5-3β-hydroxy structure. In addition they produced a lower molecular weight increase than the t-butyldimethylsilyl derivatives and had shorter retention times. The mass spectral fragmentations shown by the corresponding derivatives of the cannabinoids were very similar to those of the trimethylsilyl derivatives with the addition of abundant ions resulting from loss of the allyl or t-butylsilyl radical. However, these ions did not carry such high ion currents as the corresponding ions in the steroid spectra and were thus of limited use for single ion studies. The allyldimethylsilyl derivatives of the cannabinoid metabolites produced more abundant molecular ions than either the trimethylsilyl or t-butyldimethylsilyl derivatives. Fragmentation pathways involving elimination of C3H6 were found to be specific for the allyldimethylsilyl derivatives.

Zusätzliches Material: 12 Tab.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040414

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Digitale Medien

Forthcoming meetings (1977)

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. iv

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040418

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71

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Identification of hydroxyhalobiphenyls as their methyl ethers by gas chromatography mass spectrometry (1977)

Tulp, M. Th. M. ; Olie, K. ; Hutzinger, O.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 310-316

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The mass spectra and gas chromatographic properties of 17 synthetic fluoro-, chloro- and Bromomethoxybiphenyls and 12 dichlorodimethoxybiphenyls have been examined. From this representative series it appears that the position of the methoxy group (ortho, meta and para to the biphenyl bond) in all monomethoxy compounds examined, and the positions of the two methoxy groups in most of the dimethoxy compounds, can be assigned unambiguously by their difference in fragmentation pattern. The value of this method was shown by metabolism experiments in which 4,4′-difluoro- and 4,4′-dibromobiphenyl were fed to rats and 4,4′-dichlorobiphenyl was administered to plants. All hydroxylated metabolites found were identified by gas chromatography mass spectrometry. Relationships between structure and gas chromatographic retention time of these compounds are discussed.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040507

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Digitale Medien

The saturated methyl branched fatty acids of adult human skin surface lipidAbbreviations: AHSSL = adult human skin surface lipid; VCL = vernix caseosa lipid; i = iso = a terminal -group; ai = anteiso = a terminal -group; ECL = equivalent chain length (see Refs. 3 and 5); FCL = fraction of a carbon number attributable to the Me branch at a specific position in a fatty chain (see Ref. 3). (1977)

Nicolaides, N. ; Apon, J. M. B.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 337-347

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: In adult human skin surface lipid, the saturated branched fatty acids are made up of the same type of compounds present in vernix caseosa lipid but in different amounts. This implies that these compounds are truly endogenous products of the adult human being. The basic carbon skeletons of these compounds are normal even, normal odd, iso even, iso odd and anteiso odd (‘even’ and ‘odd’ referring to the number of C-atoms in the chain). The internal portion of each type of chain can contain additionally mainly one but sometimes two and rarely even three methyl branches all located on the even numbered C-atoms from the carboxyl group. The 4-methyl position is favored. These internal methyl branched acids are most likely biosynthesized by substitution of an occasional methylmalonyl-CoA for malonyl-CoA by the appropriate starter after the chain has been begun to yield the five basic carbon skeletal types of chain listed above. Thus, by varying the starter, the chain length, and the position of the internal methyl branch, numerous acids are formed even though they constitute only about 11% of the total saturated acids of AHSSL. It is postulated that these acids are made in slightly different amounts for each individual and constitute a part of his ‘chemical signature’.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040604

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73

Digitale Medien

Mass spectral characterization of 6-oxo-PGF1α (1977)

Cockerill, Anthony F. ; Mallen, David N. B. ; Osborne, David J. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 358-363

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The mass spectra of eleven derivatives are presented to provide structural support for the recently discovered prostaglandin, 6-oxo-PGF1α, which we have isolated from incubations of arachidonic acid with ram seminal vesicles or released during isolated perfusions of sensitized guinea pig lungs.

Zusätzliches Material: 1 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040607

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74

Digitale Medien

The mass spectral fragmentation of 9α-hydroxy steroids and related compounds (1977)

Horváth, Gyula ; Ambrus, Gábor

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 376-380

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The fragmentation processes occurring in various 9α-hydroxy steroids upon electron have been studied. The mechanisms proposed for the formation of the prominent ions in these spectra have been confirmed with the aid of deuterium labelling, measurements on metastable ion decompositions, low eV spectra and high resolution mass measurements. The fragmentation of the corresponding 9-oxo-9,10 seco steroids, which shows analogy to that of the 9α-hydroxy compounds in many respects, has also been discussed.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040610

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75

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Evidence for the lack of a carrier effect in the solvent extraction and determination of octopamine by gas chromatography mass spectrometry (1977)

Millard, B. J. ; Tippett, P. A. ; Couch, M. W. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 381-384

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: It has been shown that there is no significant carrier effect when low levels of [3H]octopamine (100 pg) are extracted by ethyl acetate from aqueous solutions containing a 103 or 106 times excess of unlabelled octopamine. It is also shown that there is no carrier effect when low levels of octopamine as the tetrakis-TMS derivative are injected with 100 times the amount of the [2H3] analogue on an SE 30 column.

Zusätzliches Material: 3 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040611

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76

Digitale Medien

Registry of mass spectral data, 1st Edition, compiled by E. Stenhagen, S. Abrahamsson and F. W. McLafferty, 4 Volumes, 3136 pages, 1974. Wiley, New York. $362.10 (1977)

Milne, G. W. A.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 68-68

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040113

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77

Digitale Medien

Masthead (1977)

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977)

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040201

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78

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Studies on trimethylsilyl derivatives of 1-alk-1-enyl-2-acyl glycerols by gas-liquid chromatography mass spectrometry (1977)

Satouchi, Kiyoshi ; Saito, Kunihiko

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 107-112

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Trimethylsilyl derivatives of 1-hexadec-1-enyl-2-decanoyl and -2-octadecenoylglycerols and 1-octadec-1-enyl-2-decanoyl and -2-octadecenoylgycerols were subjected to analysis by a gas chromatograph mass spectrometer system.The characteristic ions are as follows: (1) ions at [M - 15]+ and [M - 90]+ are observed, 2 or 16 mass units less than those of the corresponding 1-alkyl-2-acyl or 1,2-diacyl derivatives; (2) the base peak is m/e 129; (3) the ion at [M - R1CH = CHO]+ or [R2COO + 130]+ is present in high abundance; (4) ions at m/e 311 and 339, characteristic of trimethylsilyl derivatives of 1-hexadec-1-enyl and 1-octadec-1-enylglycerols, are due to [(R1CH = CHO-1) + 73]+, also confirmed from studies on the perdeuteriotrimethylsilyl derivatives; (5) several ions based on one acyl group, [R2CO]+, [R2CO + 74]+ and [R2COO + 74]+ are also observed.

Zusätzliches Material: 6 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040210

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79

Digitale Medien

Courses (1977)

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. iii

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040214

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80

Digitale Medien

Mass spectrometry of Alternaria mali toxins and related cyclodepsipeptides (1977)

Ueno, Tamio ; Nakashima, Tadakazu ; Uemoto, Miyuki ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 134-142

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The structures of AM-toxins I, II and III, host specific phytotoxic metabolities of Alternaria mali, can be readily deduced from low and high resolution mass spectral data, since the amino acids and their sequences are demonstrated by this technique. Additionally, the general fragmentation of these compounds by electron impact is discussed by comparing the spectra of analogous synthetic compounds.

Zusätzliches Material: 13 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040303

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81

Digitale Medien

Characterization of diastereomeric and enantiomeric ephedrines by gas chromatography combined with electron impact mass spectrometry and isobutane chemical ionization mass spectrometry (1977)

Gilbert, Mary T. ; Brooks, Charles J. W.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 226-231

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The diastereomeric hydroxyamines, ephedrine and ψ-ephedrine, were well differentiated by gas chromatography of their N-acetyl O-trimethylsilyl derivatives. For the analytical separation of enantiomers, conversion into N-(R)-ψ-phenylbutyryl O-trimethylsilyl derivatives was effective in the cases of ephedrine, ψ-ephedrine and nor-ψ-ephedrine (but not that of nor-ephedrine, on the two stationary phases used). Electron impact mass spectra showed structurally diagnostic fragmentations, but the two diastereomeric amides from each pair of enantiomers yielded generally similar spectra. Molecular ions were of low abundance, but under chemical ionization conditions (isobutane) abundant protonated molecular ions were produced.

Zusätzliches Material: 6 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040407

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82

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Mass spectrometric and nuclear magnetic resonance confirmation of a 3,3-spirocyclic indole derivative formed from melatonin and related acyl tryptaminesAbbreviations: PFP = pentafluoropropionyl; PFPA = pentafluoropropionic anhydride; PFPI = 1-pentafluoropropionylimidazole. (1977)

Blau, Karl ; King, Graham S. ; Sandler, Merton

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 232-236

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: When melatonin is reacted with pentafluoropropionic anhydride for selected ion monitoring or electron capture gas chromatographic analysis a volatile product results. Examination of the product by combined gas chromatography mass spectrometry has established that the molecular weight of 360 corresponds to the addition of one molecule of pentafluoropropionic acid followed by dehydration. Further spectroscopic and chemical examination using mass spectrometry and nuclear magnetic resonance with isotopic labelling has established that the product is a 3,3-spirocyclic indole derivative. Several analogous compounds were also examined and their mass spectra studied.

Zusätzliches Material: 5 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040408

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83

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The measurement of acetanilide in plasma by spectrophotometric and selected ion monitoring methods (1977)

Baty, J. D. ; Playfer, J. ; Evans, D. A. Price ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 255-257

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Plasma samples from volunteers who had received an oral dose of acetanilide have been analysed by gas chromatography mass spectrometry and ultraviolet absorption techniques. The gas chromatography mass spectrometry method involved extraction of the plasma and analysis of the acetanilide using selected ion monitoring with a deuterated internal standard. In the ultraviolet method the plasma was hydrolysed with acid to convert the acetanilide to aniline, and this compound was diazotized and coupled with N-1-naphthylethylene-diamine. The absorbance of the resulting complex was read at 550 nm. Acetanilide levels in plasma determined by the selected ion monitoring method were significantly lower than those measured by spectrophotometry. Pharmacokinetic data calculated from the results obtained using these two assays are very different and illustrate the need for an accurate and specific method of analysis. The major metabolites of acetanilide are shown not to interfere with these assays and the results suggest the possible presence of a new metabolite of acetanilide.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040412

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84

Digitale Medien

Precise measurement of total body water using trace quantities of deuterium oxide (1977)

Halliday, D. ; Miller, A. G.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 82-87

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: This study was undertaken to investigate the possibility of measuring total body water in human subjects to better than ±0.5%. Accurate serial estimates of total body water were required to complement densitometric and anthropometric measurements used to monitor body compositional changes in obese patients undergoing dietary or surgical weight reduction therapy. The method required the oral administration of 1-2 g of deuterium oxide and the analysis of pre-dose and respective equilibrated samples of urine, plasma or saliva. The sample size required for analysis was 5 μl and the conversion of gaseous phase was accomplished using a uranium reduction furnace. Isotopic erichment of samples was measured using a mass spectrometer incorporating several features designed to cope with problems inherent in H2/H2H isootopic analysis. Reproducibility of sample preparation and accuracy of the mass spectrometer were tested using international standards and shown to give an overall sensitivity of 2 parts in 107 for the determination of deuterium in H2O/H2HO mixtures. This precision has enabled us to demonstrate that isotopic fractionation of deuterium with respect to hydrogen occurs within the body and expands the potential use of this isotope for quantitative biochemical studies in the human subject.

Zusätzliches Material: 1 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040205

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85

Digitale Medien

Product news (1977)

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. iii

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Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040417

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86

Digitale Medien

Determination of mass spectrometric sensitivity of different metalloporphyrin esters relative to porphyrin ester (1977)

Larsen, Elfinn ; Egsgaard, Helge ; Møller, Jørgen ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 113-117

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Quantitative determination of metalloporphyrin contamination in preparations of biologically important porphyrins was achieved mass spectrometrically by application of the integrated ion current technique. For this purpose, the relative molecular ion sensitivities of the contaminating metal complexes were determined from the ratios of the integrated molecular ion currents of a series of calibration samples containing a porphyrin ester and one of its metal complexes in known molar ratio. Complexes formed with divalent ions of Cu, Zn, Fe, Co and Ni of copro- as well as uro-prophyrin permethylester were all found to have the same molecular ion sensitivities as their metal-free porphyrin ester. The relative metalloporphyrin ester content in a sample of porphyrin ester was thus obtained directly as the integrated ion current ratios of the normalized molecular ions. The preparation of calibration samples, including complex formation and the mass spectrometric methodology, is described and discussed.

Zusätzliches Material: 3 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040211

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87

Digitale Medien

Variance analysis of error in selected ion monitoring assays using various internal standards. A practical study caseAbbreviations: TFA = trifluoroacetyl; TFAI = trifluoroacetylimidazole. (1977)

Claeys, M. ; Markey, S. P. ; Maenhaut, W.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 122-128

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: This study contains a practical application of variance analysis for the evaluation of precision in selected ion monitoring using stable isotope variants or chemically related compounds as internal standards. Variance analysis is applied to determine the relative contributions of the errors due to long-term and short-term effects of instrument stability. The technique allows the resolution of variance due to sample manipulation from that introduced by the gas chromatography mass spectrometry instrumentation. This provides an objective measure of potential internal standards. Evaluation of the dependency of these erros upon concentration indicates appropriate weighing factors to be applied for regression analysis.

Zusätzliches Material: 1 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040213

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88

Digitale Medien

The gas chromatography mass spectrometry of the major metabolites of flurazepam (1977)

Clatworthy, A. J. ; Jones, L. V. ; Whitehouse, M. J.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 248-254

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Mass spectra and gas chromatographic data are presented for flurazepam and its metabolites; monodesethyl flurazepam, didesethylflurazepam, hydroxyethylflurazepam, N1-desalkylflurazepam, N1-desalkyl-3-hydroxy flurazepam, and flurazepam-N1-acetic acid. The on-column thermal degradation of didesethylflurazepam, N1-desalkyl-3-hydroxyflurazepam and flurazepam-N1-acetic acid is reported and discussed. Mass spectrometric and gas chromatographic data are also presented for the benzophenones obtained by acid hydrolysis of flurazepam and its metabolites. The occurrence of flurazepam metabolites in urine from five forensic cases after various treatments has been investigated. A possible new ‘metabolite’ of flurazepam was detected in two of these cases.

Zusätzliches Material: 12 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040411

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89

Digitale Medien

Metabolism of DL-[14C]prenylamine in manAbbreviation: DPPA = 3,3-diphenylpropylamine. (1977)

Remberg, G. ; Eichelbaum, M. ; Spiteller, G. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 4 (1977), S. 297-304

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Following oral administration of DL-[14C]prenylamine, about 40% of the dose administered was excreted in urine within 10 days. Less than 0.1% of the dose was excreted as unchanged prenylamine. The drug was extensively metabolized to at least 20 to 25 metabolites. The structure of 12 metabolites could be elucidated by means of g.c.m.s. Ring hydroxylation and further methylation of the phenolic metabolites are the main metabolic pathways involved. A substantial part of the drug and/or its metabolites is metabolized via cleavage of the C—N—C bond, giving rise to amphetamine and diphenylpropylamine which are further metabolized by aromatic and sidechain hydroxylation.

Zusätzliches Material: 11 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200040505

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90

Digitale Medien

Masthead (1977)

New York, NY : Wiley-Blackwell

Journal of Morphology 151 (1977)

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ISSN: 0362-2525

Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Medizin

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jmor.1051510101

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91

Digitale Medien

Postembryonic ontogeny and functional anatomy of the ligamentum mandibulo-hyoideum and the ligamentum interoperculo-mandibulare, with notes on the opercular bones and some other cranial elements in Salmo gairdneri Richardson, 1836 (Teleostei: Salmonidae) (1977)

Verraes, Walter

New York, NY : Wiley-Blackwell

Journal of Morphology 151 (1977), S. 111-119

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ISSN: 0362-2525

Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Medizin

Notizen: This study deals with the development of the opercular bones the ligamentum mandibulo-hyoideum, the ligamentum interoperculo-mandibulare and with some aspects of the development of the ceratohyale and the cartilago meckeli during postembryonic ontogeny of Salmo gairdneri (rainbow trout). It is stated that the ligamentum mandibulo-hyoideum is present from hatching onward, while the development of the ligamentum interoperculo-mandibulare appears during the period of active feeding. Some functional reasons are proposed to explain these facts. It is further suggested that the opercular bones develop under influence of the opercular muscles.

Zusätzliches Material: 3 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jmor.1051510106

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92

Digitale Medien

Comparative fine structural studies of planulae and primary polyps of identical age of the sea pen, Ptilosarcus gurneyl (1977)

Chia, Fu-Shiang ; Crawford, Bruce

New York, NY : Wiley-Blackwell

Journal of Morphology 151 (1977), S. 131-157

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ISSN: 0362-2525

Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Medizin

Notizen: Electron microscopic study of an 18-day-old planulae and primary polyps of the sea pen, Ptilosarcus gurneyi, reveals 14 cell types: sustentacular cell A, sustentacular cell B, nerve cell, sensory cell, cnidoblast, interstitial cell, five types of gland cell (A, B, C, D and E), amoebocyte, style cell and endodermal cell. Of these, 9 are found in the planula, 12 in polyps and 7 are common to both stages. The fine structure of all cell types is described.Since the planulae and polyps in this study were identical in age of development, the gaining and losing of certain types of cells in the polyp are attributed to changes associated with settlement and metamorphosis. Modifications of the seven common cell types during metamorphosis can also be attributed to the change of life style from pelagic to benthic.

Zusätzliches Material: 1 Tab.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jmor.1051510108

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93

Digitale Medien

The effect of the hormone(s) from the corpus allatum complex on the ovarian tissue of Oncopeltus fasclatus. A light and electron microscopic investigation (1977)

Schreiner, Berit

New York, NY : Wiley-Blackwell

Journal of Morphology 151 (1977), S. 81-109

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ISSN: 0362-2525

Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Medizin

Notizen: (1) In an animal where the corpus allatum complex is inhibited by glucose feeding, the ovariole develops to a certain size without yolk deposition in the oocytes. Histologically this can be registered as: (a) Lipid spheres are found in the young oocytes in the vicinity of the Balbiani body (as in young normal oocytes). However, this lipid decreases in amount and “new” lipid (from the fat body via haemolymph) is not deposited in the later oocytes. (b) No carbohydrate/protein yolk is formed. (c) Glycogen is not synthesized in the oocytes. (d) The follicle cells aggregate glycogen instead of lipid. (e) No qualitative differences have been observed regarding the contributions from the tropharium (the so-called Type 1 vacuole, ribosomes, mitochondria, annulated lamellae: Schreiner, '77).(2) Implantation of a corpus allatum complex results in deposition of lipid, carbohydrate/protein and glycogen yolk. However, the restoration period differs histologically from the normal development as: (a) Glycogen appears in the oocyte earlier than normal, i.e., at Stage 4, while normally at Stage 6′. (b) Glycogen appears in the nutritive tube adjacent to the interfollicular plug cells. (c) Both the inner and outer layer of the ovariole sheath contain glycogen, the outer layer contains lipid spheres as well.

Zusätzliches Material: 3 Tab.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jmor.1051510105

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94

Digitale Medien

Masthead (1977)

New York, NY : Wiley-Blackwell

Journal of Morphology 151 (1977)

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ISSN: 0362-2525

Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Medizin

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jmor.1051510201

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95

Digitale Medien

Ultrastructure and histochemistry of the supportive structures associated with the radula of the slug, Limax maximus (1977)

Curtis, Sherill K. ; Cowden, Ronald R.

New York, NY : Wiley-Blackwell

Journal of Morphology 151 (1977), S. 187-211

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ISSN: 0362-2525

Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Medizin

Notizen: The odontophore and connective tissue-filled portion of the radular sac (called the “collostyle”) of the slug, Limax maximus, were examined by light and electron microscopy. While both of these structures grossly resemble vertebrate cartilage, neither is composed of a type of tissue with the microscopic appearance and histochemical properties of cartilage. The roughly U-shaped odontophore possesses a thin capsule composed of connective tissue. The parenchyma of the odontophore consists of modified muscle cells which are organized into irregular groups by incomplete trabeculae composed of conventional muscle cells. The odontophoral cells are variable in size; they contain glycogen-filled “cores” as well as bundles of peripherally located filaments resembling myofilaments; and they are innervated like muscle cells. The nuclei of the cells are located eccentrically in the glycogen-filled portions of the cells and typically contain prominent nucleoli. The nuclei are surrounded by multiple small Golgi complexes and pleomorphic dense bodies resembling lysosomes. The extracellular matrix of the odontophore is very sparse and contains glycogen and fibrillar material but no histochemically demonstrable acidic mucosubstances. The collostyle consists of a gelatinous type of tissue somewhat like vertebrate mucoid connective tissue. The abundant extracellular matrix contains cross banded filaments, a flocculent material disposed in wavy indefinite strands, and small electron-dense particles. The matrix contains histochemically demonstrable neutral and weakly acidic mucosubstances. The cell population of the collostyle includes solitary muscle cells and fibrocytes containing large quantities of glycogen.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jmor.1051510203

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96

Digitale Medien

Ca+2-accumulating components in developing skeletal muscle (1977)

Smalls, Charley M. ; Goode, Dennis

New York, NY : Wiley-Blackwell

Journal of Morphology 151 (1977), S. 213-237

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ISSN: 0362-2525

Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Medizin

Notizen: This ultrastructural study on the localization of Ca+2 in developing skeletal muscle indicates that the formation of calcium-accumulating components begins during embryonic development. Both oxalate and pyroantimonate techniques are used to localize Ca+2 in distinct cellular components of chick pectoral and sartorius muscles. Two major sites for Ca+2 accumulation are present in ultrathin sections of embryonic and post-embryonic muscles: the terminal cisternae of the sarcoplasmic reticulum and specific lines in the I-bands. Calcium oxalate-accumulating vesicles are present in the smallest recognizable myotubes at the twelfth day of incubation, but calcium-accumulating components are not seen at myofibrillar I-band sites until the fourteenth to seventeenth days of incubation. The fact that myofibrils first form and later in development accumulate a Ca+2-binding component suggests that this Ca+2-binding component is not necessary for the formation of myofibrils, but is added to myofibrils before hatching to serve a probable regulatory role in contraction.

Zusätzliches Material: 1 Tab.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jmor.1051510204

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97

Digitale Medien

The fibrocartilage skeleton and related structures of the ventral pouch of Balaenopterid whales (1977)

Pivorunas, August

New York, NY : Wiley-Blackwell

Journal of Morphology 151 (1977), S. 299-313

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ISSN: 0362-2525

Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Medizin

Notizen: The mandibular symphysis of rorqual whales, whales of the genera Megaptera and Balaenoptera, is characterized by a Y-shaped fibrocartilage structure that lies in the substance of the muscular ventral pouch of these animals. The stem of the structure joins with the symphysis and is usually indicated externally by an unfurrowed median strip of blubber that has been called the “cutwater” by earlier writers. The arms of the Y pass back and are superficially indicated in all rorqual whales as a ridge running parallel to the rami of the mandibles. This fibrocartilage skeleton of the pouch is most closely related to the mylohyoid muscle. The function of the fibrocartilage Y is probably linked with the jaw mechanics of these whales, but its precise function is otherwise not known.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jmor.1051510207

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98

Digitale Medien

Structural correlates of forelimb function in fur seals and sea lions (1977)

English, Arthur W. M.

New York, NY : Wiley-Blackwell

Journal of Morphology 151 (1977), S. 325-352

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ISSN: 0362-2525

Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Medizin

Notizen: Dissections, manipulation of ligamentary preparations, analysis of limb proportions, and quantitative aspects of forelimb myology are used to correlate forelimb morphology in fur seals and sea lions (sub-family Otariinae) with previously published data as to their locomotor function (English, '76a). Comparisons to structure and function in generalized fissiped carnivores are then used to elucidate locomotor adaptations in fur seals and sea lions. Unique features of forelimb function during swimming in these pinnipeds include the amounts of abduction-adduction and rotary movements used. Modifications of the size, attachments and fascicle architecture of the muscles and the structure and range of possible movement of the joints suggest that in fur seals and sea lions these movements (1) take place about the glenohumeral (shoulder) joints, (2) that the movements are probably finely controlled, and (3) that they contribute to the generation of massive forward thrust via the cooperative activity of muscles capable of generating large amounts of force throughout the range of movement. Recovery movements occur through a similarly large range, and modifications of forelimb anatomy either to minimize or overcome water resistance are noted. The adaptive significance of these modifications is interpreted as allowing fur seals and sea lions to swim at speeds necessary to feed on the fast swimming prey presumably abundant in their adaptive zone.

Zusätzliches Material: 16 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jmor.1051510303

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99

Digitale Medien

Structure of the sinus hair follicle in the big-clawed shrew, Sorex unguiculatus (1977)

Yohro, Takeshi

New York, NY : Wiley-Blackwell

Journal of Morphology 153 (1977), S. 333-353

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ISSN: 0362-2525

Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Medizin

Notizen: The structural features of sinus hair follicles in Sorex unguiculatus were studied by macroscopic dissection, serial section light microscopy and electron microscopy. The shrew has about 540 sinus hairs regularly arranged on the snout. The maxillary nerves innervating them are extremely thick, while the optic nerves are very thin. Thus the follicle must be one of the most important sense organs in this animal. In the follicle the ring sinus is well-developed and the trabeculae of the cavernous sinus are reduced in number and thickness. The ring bulge is not a unified structure but a pair of bodies which consist of head, stalk and attachment plaque. It is characterized by the presence of numberous thick collagen fibrils (400 nm) and appears to be mechanically rigid. Lanceolate nerve terminals, free endings, Merkel cells with nerve terminals and unmyelinated fibers are observed, but encapsulated endings are lacking in and around the follicles. Straight lanceolate terminals on the posterior side of the follicle are thick and three-sided in cross section, while those on the anterior side are thin and two-sided. Free endings are located on the anterior side of the follicle. These and other findings are discussed on the basis of the assumption that the Sorex sinus hair follicle is more specialized as a vibrating system than in other mammals.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jmor.1051530211

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100

Digitale Medien

The diversity of neurosecretory cell types in the cave tick Ornithodoros tholozani (1977)

Gabbay, Shoshana ; Warburg, M. R.

New York, NY : Wiley-Blackwell

Journal of Morphology 153 (1977), S. 371-385

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ISSN: 0362-2525

Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Medizin

Notizen: Neurosecretory cells are arranged in 16 NSC centers in the different regions of the brain of O. tholozani. The component cells belong to 13 different types, of which five types are paraldehyde fuchsin positive and the remaining types are negative. Three of these cell types are here described for the first time. Some of these NSC show an affinity to certain localities inside the brain. Cells comprising a neurohaemal organ were found near the exit of the esophagus.

Zusätzliches Material: 6 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jmor.1051530304

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