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Digitale Medien

Continuous production of patulin by immobilized cells ofPenicillium urticae in a stirred tank reactor (1983)

Jones, A. ; Berk, D. ; Lesser, B. H. ; [weitere]

Springer

Biotechnology letters 5 (1983), S. 785-790

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Details

ISSN: 1573-6776

Quelle: Springer Online Journal Archives 1860-2000

Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: Summary Production of the mycotoxin, patulin, by immobilized cells ofPenicillium urticae was chosen as a model system to study the formation of secondary metabolites on a long term basis. Spores of the fungus were immobilized in carrageenan beads and allowed to germinate in situ by incubation in a growth medium. Production of the antibiotic by the populated biocatalyst was then followed in a continuous stirred tank reactor (CSTR) under three different regimes of nutrient feed. Using a nitrogen free feed, antibiotic production gradually declined but the cells could be re-activated by addition of a diluted growth medium. Prolonged production of patulin (up to 440 h) was observed when a source of nitrogen (ie. yeast extract) was supplied to the feed medium.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01386648

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