ISSN:
1420-908X
Keywords:
Lipopolysaccharide
;
Interleukin 13
;
Pyrexia
;
Flezelastine
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effects of the novel antiasthmatic/antiallergic compound flezelastine on LPS-induced actions were investigatedin vitro andin vivo. In monocytes, IL-1β generation stimulated by LPS was inhibited dose dependently.In vivo, LPS-induced fever in rats, which is at least partly driven by the release of IL-1β, was also inhibited by flezelastine. These findings suggest that flezelastine inhibits IL-1 synthesis and/or releasein vitro andin vivo.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01986405