ISSN:
1569-8041
Schlagwort(e):
gastrointestinal lymphoma
;
non-Hodgkin's lymphoma
;
stomach lymphoma
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Background: In October 1992, an ongoing prospective study on primarygastrointestinal (GI) lymphoma was initiated to evaluate histologicalfeatures, sites of involvement, and management. Patients and methods: Until May 1996, 352 patients were enrolled, with 279being evaluable for clinical features (208 patients presented with primarygastric lymphoma). Standardized diagnostic workup included central histologicreview and endoscopic and radiologic evaluation of the complete GI tract.Primary surgery or conservative management depended on the physician'sdecision, followed by radiotherapy with or without chemotherapy. Treatmentoutcome is evaluable in 122 patients with gastric lymphoma. Results: In 279 evaluable patients, the distribution of NHL was asfollows: stomach 74.6%, small bowel 8.6%, ileocoecal region6.5%, multilocal GI involvement 6.8%. In gastric lymphoma,low-grade NHLs accounted for 39%. Of the remaining high-grade NHLs,36.1% showed simultaneous low-grade components, thus being also of MALTorigin. Of 208 patients with gastric NHL, 71.1% were classified asstage I and II1. CCR rate in stomach lymphoma is significantlyhigher compared to those of the small bowel, whereas involvement of multipleGI organs has the worst prognosis. So far only 7 patients with gastric NHL in stages I and IIpresented with progressive disease or relapse. Over all stages there seems tobe no difference in therapeutic outcome in surgically or conservativelytreated patients. Even after R0-resection in limited stages patients appearto have no better outcome. Conclusion: The value of surgery in treatment of primary gastriclymphoma – as favored by most authors – should be reexamined.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1023/A:1008218304133
