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  • Articles: DFG German National Licenses  (6)
  • Non-Hodgkin lymphoma  (3)
  • stress proteins  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Lymphoplasmacytic/lymphoplasmacytoid lymphoma: A clinical entity distinct from chronic lymphocytic leukaemia? (1981)
    Springer
    Annals of hematology 43 (1981), S. 183-192 
    Details
    ISSN: 1432-0584
    Keywords: Non-Hodgkin lymphoma ; Chronic lymphocytic leukaemia ; Immunocytoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Clinical data of 116 patients with chronic lymphocytic leukaemia (CLL) and of 114 patients with lymphoplasmacytic/lymphoplasmacytoid lymphoma (synonym: LP immunocytoma, IC) as diagnosed according to the Kiel classification were compared. This interim evaluation of a prospective multicenter study of the Kiel Lymphoma Study Group characterizes IC the less favorable lymphoma entity as evidenced by a more rapid lymph node enlargement, by a higher incidence of constitutional symptoms and of marked anaemia, and by a higher percentage of patients requiring early treatment. In addition, in IC autoimmune haemolytic anaemia was detected in 11.2% of investigated patients as compared to none of the patients with CLL, and monoclonal gammopathy was disclosed in 34.2% of investigated patients as compared to only three patients with CLL who could be, however, unrecognized cases of IC. Actuarial survival data after a follow-up period of 40 months are in favor of an overall better prognosis of patients with CLL than of patients with IC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00363888
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Clinical and prognostic heterogeneity of non-hodgkin lymphomas of high-grade malignancy (1981)
    Springer
    Annals of hematology 43 (1981), S. 201-211 
    Details
    ISSN: 1432-0584
    Keywords: Non-Hodgkin lymphoma ; High-grade malignancy ; Lymphoblastic lymphoma ; Immunoblastic lymphoma ; Centroblastic lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Comparison of clinical data of 64 patients with centroblastic lymphoma, 55 patients with immunoblastic lymphoma and 31 patients with lymphoblastic lymphoma not only confirmed the original assumption of high-grade malignancy as proposed by the concept of the Kiel classification but also demonstrated distinct clinical differences, particularly between lymphoblastic lymphoma and the two other entities. Rapid lymph node enlargement as well as steep fall of survival curves within the first year after diagnosis were common characteristics. Bimodal age distribution, predominance of males and early generalization of disease were typical features of lymphoblastic lymphoma; elderly patients and patients with the unclassified subtypes of lymphoblastic lymphoma exhibited the worst prognosis. Whereas patients with centroblastic and immunoblastic lymphomas showed similar distribution of age, sex and initial stage of disease, patients with immunoblastic lymphoma presented more frequently with a reduced performance status and showed a poorer response to radio- and chemotherapy resulting in a worse prognosis discernible after the first year of follow-up. Generalization during course of the disease was significantly more frequent in immunoblastic than in centroblastic lymphoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00363890
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Non-hodgkin lymphoma following hodgkin's disease (1984)
    Springer
    Annals of hematology 49 (1984), S. 353-357 
    Details
    ISSN: 1432-0584
    Keywords: Hodgkin's disease ; Non-Hodgkin lymphoma ; Anticancer treatment ; Secondary neoplasms ; Immundeficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 40-year-old male developed 66 months after diagnosis of Hodgkin's disease a non-Hodgkin lymphoma of high grade malignancy. Initially he had been treated by irradiation because of Hodgkin's disease PS IIA. After 2 years of remission he had relapsed and had received MOPP and CCNU. After 2 years without any therapy he developed the secondary neoplasm. With increasing frequency of long term survivors late complications, either therapy related or caused by immunologic defects, are observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320210
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The induction of stress proteins (hsp) in Oniscus asellus (Isopoda) as a molecular marker of multiple heavy metal exposure: I. Principles and toxicological assessment (1997)
    Springer
    Ecotoxicology 6 (1997), S. 249-262 
    Details
    ISSN: 1573-3017
    Keywords: biomarkers ; heavy metal combinations ; hsp70 ; hsp60 ; isopods ; stress proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The induction of stress-70 (hsp70) and stress-60 (hsp60, chaperonin 60) in the terrestrial woodlouse, Oniscus asellus, after exposure to various heavy metals and heavy metal combinations was investigated by means of standard Western-blot using monoclonal antibodies. The expression of stress-70 was found to react much more sensitively to metal contamination than that of stress-60. The general course of the stress-70 response to increasing metal concentration was found to be similar for all treatments. Based on the obtained results, this course could be divided into three zones: in the first zone, the expression of stress-70 proteins was only marginally increased by comparatively low metal concentrations; in the second zone, strong induction of stress-70 occurred and the ability of the heat shock system to react to increased metal concentrations reached its climax; and in the third, non-compensation zone, a further increase in heavy metal concentration resulted in a decline of stress-70 levels, which can be interpreted as a result of pathological tissue damage. Combinations of metals were found to increase the stress- 70 level more intensely than related concentrations of singularly applied metals. Based on these studies, a ranking scheme of increasing toxicological impact of a variety of heavy metal combinations was composed
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018682928839
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The induction of stress proteins (hsp) in Oniscus asellus (Isopoda) as a molecular marker of multiple heavy metal exposure. II: Joint toxicity and transfer to field situations (1997)
    Springer
    Ecotoxicology 6 (1997), S. 263-274 
    Details
    ISSN: 1573-3017
    Keywords: isobologram ; isopods ; joint toxicity ; hsp70 ; stress proteins ; toxic unit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract In laboratory toxicity tests, woodlice (Oniscus asellus) exposed to a variety of different combinations of the metals cadmium, lead, and zinc exhibited a broad range in intensity of the induction of the 70 kDa stress protein (hsp70, stress-70). Using two-dimensional isobolograms and the ‘toxic unit’ concept, it could be shown that cadmium and lead as well as cadmium and zinc or lead and zinc act as synergists and cause superadditive effects on the stress response of these animals. Using a three- dimensional isobologram based on the stress-70 level in response to numerous combinations of all three tested metals, transfer to the field could be achieved: data obtained from O. asellus populations abundant at field sites, the soils of which are influenced mainly by different concentrations of these heavy metals, were found to fit this laboratory test-based model
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018635012910
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Induction of heat shock proteins, changes in liver ultrastructure, and alterations of fish behavior: are these biomarkers related and are they useful to reflect the state of pollution in the field? (1997)
    Springer
    Journal of aquatic ecosystem stress and recovery 6 (1997), S. 57-73 
    Details
    ISSN: 1573-5141
    Keywords: behavior ; biomarker ; liver ultrastructure ; stream contamination ; stress proteins ; trout
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Heat shock protein (hsp70) expression, changes inliver ultrastructure, and alterations of swimmingbehavior were simultaneously investigated in browntrout (Salmo trutta f. fario) exposed towater from test streams in southern Germany undersemi-field conditions during 1995 and 1996. Chemicalanalyses revealed different levels of contamination ofthe two streams by pesticides, PAHs, PCBs, and heavymetals, whereas stream pollution was only partlyreflected by body burdens of contaminants in fish.Biomarker responses were compared after differenttimes of exposure and with respect to differenttemperature conditions. Differences in pollutionstates of the streams were reflected by differentbiomarker responses of the trout. In the highlycontaminated stream, the biomarker responses were morecoincident with one another than in the moderatelypolluted stream in which the biomarkers showed littlerelation to one another. This is primarily due to thedifferential capacities of the biomarkers to integratestress responses over time. Understanding the dynamicsof the stress response curves and the effects oftemperature on biomarker responses is essential forevaluating the effects of environmental stressors suchas contaminants on the health of organisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008224301117
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    Paper (German National Licenses)
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