Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Zur carcinogenen Wirkung von N-Nitroso-Verbindungen (1978)
    Springer
    Journal of cancer research and clinical oncology 91 (1978), S. 317-322 
    Details
    ISSN: 1432-1335
    Keywords: Alkyl-Acetoxymethyl-Nitrosamines ; Carcinogenic action in SD rats ; Tumors of the forestomach ; Alkyl-Acetoxymethyl-Nitrosamine ; Carcinogene Wirkung bei SD-Ratten ; Tumoren des Vormagens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die homologe Reihe der Alkyl-Acetoxymethyl-Nitrosamine wurden auf ihre carcinogene Wirkung an SD Ratten getestet. Alle Verbindungen induzieren bei oraler Gabe innerhalb der gleichen Zeit Vormagentoumoren. Die benötigten Gesamtdosen sind dabei abhängig von der Länge der Alkyl-Kette und damit der Wasserlöslichkeit. Diese Ergebnisse werden diskutiert.
    Notes: Summary The homologons alkyl-acetoxymethyl-nitrosamines were tested for carcinogenicity in SD rats. All compounds were found to be carcinogenic and induced within the same time carcinomas of the forestomach. The total doses necessary for induction of tumors are related to the length of the alkyl chain and hence to the watersolubility. These results are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00312293
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Experimentelle Untersuchungen zur Syncarcinogenese (1970)
    Springer
    Journal of cancer research and clinical oncology 74 (1970), S. 457-466 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Vier verschiedene hepatotrop wirkende Carcinogene (4-Dimethyl-amino-azobenzol, Dimethylnitrosamin, Diäthylnitrosamin, Nitrosomorpholin) wurden an 96 Ratten des Stammes BR 46 oral über 580 Tage in solchen Tagesdosen verabreicht, die bei alleiniger Gabe nur einer Substanz “unterschwellig” sind, also innerhalb der Lebenserwartung nicht zu Leberkrebs führen. Nach einer mittleren Induktionszeit von 700±110 Tagen beobachteten wir bei 34% der Ratten maligne und bei 9% benigne Lebertumoren. In der Kontrollgruppe entstand bei keinem einzigen Tier eine Lebergeschwulst. Damit ist die Addition und Summationsfähigkeit der carcinogenen Einzeleffekte auch dann nachweisbar wenn minimale Dosen chemisch verschiedener Carcinogene mit gleicher Organotropie gegeben werden.
    Notes: Summary 96 rats of the strain BR 46 were given orally for 580 days at the same time four different liver carcinogens (4-dimethyl-amino-azobenzene, dimethylnitrosamine, diethylnitrosamine, nitrosomorpholine) in such daily dosages which are “subtreshold” if only one of these carcinogens was given alone and produced no liver cancer during the normal life time of the animals. After a medium induction time of 700±110 days we observed in 34% of the rats malignant and in 9% benign liver tumors. In the controls no liver tumors were found. By this, the addition and ability of summation of carcinogenic single effects is also then demonstrable if minimum dosages of chemically different carcinogens with the same organotropic action are applied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00531227
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The carcinogenic effect of dibutylnitrosamine in Syrian and Chinese hamsters (1970)
    Springer
    Journal of cancer research and clinical oncology 74 (1970), S. 112-113 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Orally and subcutaneously administered dibutylnitrosamine caused tracheal papillomata, lung tumors, some papillomata of the forestomach and the urinary bladder in Syrian hamsters, while Chinese hamsters showed numerous papillomata of the forestomach and slight changes of the bladder epithelium.
    Notes: Zusammenfassung 13–30 Wochen nach oraler bzw. subcutaner Verabreichung von Dibutylnitrosamin entstanden bei syrischen Hamstern Trachealpapillome, Lungentumoren und einige Papillome des Vormagens und der Harnblase, während sich bei chinesischen Hamstern außer vergleichbaren Blasenepithelveränderungen in einem hohen Prozentsatz Vormagenpapillome entwickelten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00524687
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Carcinogenicity of acetoxymethyl-methyl-nitrosamine after subcutaneous, intravenous and intrarectal applications in rats (1978)
    Springer
    Journal of cancer research and clinical oncology 91 (1978), S. 217-221 
    Details
    ISSN: 1432-1335
    Keywords: Acetoxymethyl-methyl-nitrosamine ; Rats ; Different application methods ; Acetoxymethyl-methyl-nitrosamin ; Ratten ; verschiedene Applikationsmethoden
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Vergleichend zu den bekannten carcinogenen Eigenschaften von Acetoxymethyl-Methyl-Nitrosamin (AMMN) nach oraler oder intraperitonealer Gabe wurde das Dimethylnitrosaminderivat in subkutaner, intravenöser und intrarectaler Applikation an männlichen Sprague-Dawley oder Wistar-Ratten geprüft. AMMN erwies sich als ein überwiegend lokal wirkendes Carcinogen. Zusätzlich ist ein zweiter Wirkungsmechanismus anzunehmen, da nach i.v. und s.c. Zufuhr systemische und carcinogene Eigenschaften auftraten. Lunge und Herz und weniger ausgeprägt die Niere und der Gehörgang erweisen sich als Trefferorgane der carcinogenen Wirkung entfernt vom Applikationsort.
    Notes: Summary In comparison to the known carcinogenic properties of Acetoxymethyl-Methyl-Nitrosamine (AMMN) after oral or intraperitoneal application the dimethylnitrosamine derivative was tested by subcutaneous, intravenous and intrarectal route in male Sprague-Dawley or Wistar rats. AMMN proved to be primarily a locally acting carcinogen. However, a second mode of action is indicated by systemic carcinogenic properties found after i.v. and s.c. applications. The lung and heart, and to a less extent the kidney and earduct were found as target organs of distant carcinogenic response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284028
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Chemotherapy studies in autochthonous rat tumors intestinal cancer (1978)
    Springer
    Journal of cancer research and clinical oncology 92 (1978), S. 105-117 
    Details
    ISSN: 1432-1335
    Keywords: Intestinal tumors ; Experimental carcinogenesis ; Chemical carcinogens ; Combined chemotherapy ; Darmtumoren ; Experimentelle Karzinogenese ; Chemische Karzinogene ; Kombinationschemotherapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Durch drei chemische Carcinogene wurden Darmtumoren bei Ratten induziert. Nur bei durch 1,2-Dimethylhydrazin induzierten Tumoren konnte eine schwache Reaktion auf eine Kombinationschemotherapie mit Adriamycin, Methotrexat, 5-Fluorouracil und Cyclophosphamid beobachtet werden. Das gleiche Therapieschema versagte bei durch N-Methyl-N′-Nitro-N-Nitroso-Guanidin und durch Acetoxymethyl-Methyl-Nitrosamin induzierten Tumoren. Diese Ergebnisse und die Vergleichbarkeit der Chemotherapie autochthoner Tumoren mit experimentellen und klinischen Beobachtungen werden diskutiert.
    Notes: Summary Intestinal tumors in rats were induced by three different chemical carcinogens. Only tumors induced by 1,2-dimethylhydrazine responded slightly to combination chemotherapy of Adriamycin, Methotrexate, 5-Fluorouracil, and Cyclophosphamide. The same therapy failed in tumors induced by N-methyl-N′-nitro-N-nitroso-guanidine or acetoxymethyl-methyl-nitrosamine. These results and the comparability of chemotherapy in autochthonous tumors to experimental and clinical observations are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284097
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Zur carcinogenen Wirkung von Butyl-äthyl-nitrosamin bei rectaler Applikation an Ratten (1970)
    Springer
    Journal of cancer research and clinical oncology 74 (1970), S. 110-111 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 40 männliche Ratten des Sprague-Dawley-Stammes erhielten Butyläthyl-nitrosamin in einer Dosis von 50 mg/kg/Woche über 20 Wochen rectal appliziert. Neben toxischen Leberschäden entstanden bei 8 Tieren maligne und bei 7 benigne Lebertumoren. 9 Ratten zeigten Papillome bzw. Hyperkeratosen der Speiseröhre.
    Notes: Summary Butyl-ethyl-nitrosamine was given by rectal application in 40 male rats of the Sprague-Dawley-strain. The single dose was 50 mg/kg/week and we injected this dose over 20 weeks. Beside toxic liver injuries there arose in 8 animals malignant and in 7 benigne liver tumors. 9 rats showed papillomas and hyperkeratoses of the oesophagus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00524686
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Experiments on the carcinogenic effect of ortho-toluol-sulfonamid (OTS) (1978)
    Springer
    Journal of cancer research and clinical oncology 91 (1978), S. 19-22 
    Details
    ISSN: 1432-1335
    Keywords: Saccharin ; Orthotoluolsulfonamid ; Carcinogenic activity of saccharin impurities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ortho-toluol-sulfonamid was applied to male and female Sprague-Dawley rats in daily doses of 200 mg/kg and 20 mg/kg bodyweight respectively. The maximum dose applied amounted to 17 g/kg. A shortening of the average life expectation was not observed in comparison to the control animals. The incidence of malignant tumors in the animals treated with OTS was identical with the one of the control animals. We did, however, find one animal in the test groups that had a carcinoma of the urinary bladder and seven animals with papillomas of the bladder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305968
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...