Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Elevated levels of eotaxin and interleukin-5 in blister fluid of bullous pemphigoid: correlation with tissue eosinophilia (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Bullous pemphigoid (BP) often provokes blood and tissue eosinophilia, which suggests that some chemoattractants modulate the eosinophil infiltration in BP. Eotaxin, a CC chemokine, strongly attracts eosinophils, and interleukin (IL)-5 induces eosinophil differentiation, proliferation and colony formation in vitro. Objectives To examine the correlation between levels of eotaxin and IL-5 and the number of lesional eosinophils, and the expression of eotaxin in BP lesions. Patients/methods In this study we measured eotaxin and IL-5 levels in blister fluid of BP by enzyme-linked immunosorbent assay. We also examined the expression of eotaxin in BP lesions by immunohistochemistry. Results Both eotaxin and IL-5 were detected at high levels in BP blister fluid. Blister fluid eotaxin, but not IL-5 levels, correlated significantly with the number of dermal infiltrating eosinophils. By immunohistochemistry, eotaxin was strongly expressed in epidermal keratinocytes around BP blisters. Conclusions These findings suggest that eotaxin and IL-5 are strongly associated with the tissue eosinophilia of BP. Therapies which aim to inhibit production of eotaxin and IL-5 may improve the inflammation and blister formation in BP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03599.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Metabolic characteristics of the Japanese clam Ruditapes philippinarum (Adams & Reeve) during aerial exposure (2000)
    Oxford, UK : Blackwell Science Ltd
    Aquaculture research 31 (2000), S. 0 
    Details
    ISSN: 1365-2109
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Some metabolic end-products in tissues and physiological parameters of haemolymph of the Japanese clam Ruditapes philippinarum (Adams & Reeve) were investigated under aerial exposure at 15 °C with low relative humidity (RH) (22%) or high RH (91%). Acclimated clams in water at 15 °C were used as a control and to supply the low or high RH experiment. The low RH experiment was conducted at air exposure for 50 h (LH50), and the high RH experiment for 50 h (HH50) and 100 h (HH100). Accumulation of succinate and alanine in the tissues proved that the clam shifted its metabolism to anaerobiosis. Lactate accumulation did not occur. Glucose concentrations in tissues increased slightly during exposure except for HH50. The total free amino acid contents (363–410 μmol g−1) were higher than those of glucose (530–804 μmol 100 g−1), suggesting that the free amino acids might play a more dominant role in the metabolism. Increase in the haemolymph pco2 did not influence the acid–base balance in the haemolymph during exposure at both humidity conditions. Increase in the haemolymph ammonia from 48.2 to 57.1 μmol 100 g−1 and to 131.0 μmol 100 g−1 at LH50 and HH100, respectively, suggested that ammonia might function as an important buffering factor during aerial exposure. Retention values of the haemolymph po2 even at the longest exposure time (16.30 mmHg at LH50 and 14.69 mmHg at HH100) indicated that the clams depend partially on some aerobic manner.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2109.2000.00402.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Mercury volatilization by the most mercury-resistant bacteria from the seawater of Minamata Bay in various physiological conditions (2000)
    Springer
    Clean products and processes 2 (2000), S. 174-178 
    Details
    ISSN: 1436-722X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract  The volatilization of mercuric chloride (HgCl2) and methyl mercuric chloride (CH3HgCl) by the 45 strains (35 Pseudoalteromonas sp., 2 Vibrio sp., 1 Aeromonas sp., and 7 unclassified) of the most mercury-resistant bacteria from Minamata Bay seawater was examined in various physiological conditions. The bacteria could grow and volatilize HgCl2 in the liquid medium containing 1–10% NaCl. Two Pseudoalteromonas strains could grow and volatilize HgCl2 at pH levels ranging from 5.0 to 10.0. The resting cells of 43 strains could volatilize HgCl2 at concentrations ranging from 30 to 68% after 1-h incubation at 30  °C. The resting cells of 41 strains could volatilize CH3HgCl at concentrations ranging from 13 to 88% after 1-h incubation at 30  °C. Ninety-two percent of mercury was removed from the phosphate buffer containing 0.1 μg/ml by a resting cell of Pseudoalteromonas strain H-4 after 30-min incubation at 30  °C. We were able to screen the special bacteria, which could volatilize mercury compounds at a high rate in various physiological conditions, for the purpose of developing mercury removal methods using bacteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100980000079
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Superplastic Deformation and Shape Memory Effects of Cu-Zn-Sn Alloys (2000)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 327-328 (Jan. 2000), p. 477-480 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/04/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.327-328.477.pdf
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Age and Sex Differences in the Bone Mineral Density of the Distal Forearm Based on Health Check-up Data of 6343 Japanese (2000)
    Springer
    Osteoporosis international 11 (2000), S. 772-777 
    Details
    ISSN: 1433-2965
    Keywords: Key words:Age – Bone mineral density (BMD) – Distal forearm – Ethnic difference – Japanese – Sex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Bone mineral density (BMD) predicts osteoporotic fractures. The incidence of osteoporotic fractures in Japan is lower than among Caucasians, but fewer data on the BMD of Asians have been reported. This study attempted to clarify the age and sex differences in the forearm BMD of healthy adult Japanese and to assess racial differences between Japanese and Caucasians. The subjects were 6343 healthy adult Japanese (5281 females, 1062 males) who underwent a health check-up at a health care service center between February 1995 and August 1999. Subjects’ age ranged from 15 to 80 years. The BMD of the distal radius and ulna of the non dominant forearm was measured by dual-energy X-ray absorptiometry. Overall, the forearm BMD of men was greater than that of women in all age groups. Peak BMD was 0.484 g/cm2 in the 40–44 year age group of women and 0.590 g/cm2 in the 30–34 year age group of men. The forearm BMD of women under 50 years of age (the average age at menopause) increased slightly with age (2.0%/decade, p〈0.0001), but it did not among their male counterparts. After 50 years of age, BMD of the women decreased linearly (–1.6%/year, p〈0.0001) with age, the rate of decrease being 1.7-fold faster than in their male counterparts. Rates of gain and loss of forearm BMD differ between the sexes. In comparison with data previously reported, we did not find any evidence of racial differences in BMD as an explanation for the lower incidence of osteoporotic fractures in Japan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001980070056
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Blunted effect of parathyroid hormone on adenosine 3′,5′-cyclic monophosphate production is derived from ATP depletion in proximal convoluted tubules of hypophosphatemic mice (2000)
    Springer
    Clinical and experimental nephrology 4 (2000), S. 11-17 
    Details
    ISSN: 1437-7799
    Keywords: Key words Extracellular phosphate ; Hypophosphatemic mice ; Adenosine 3′,5′-cyclic monophosphate ; Parathyroid hormone ; X-linked hypophosphatemic rickets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. To clarify the pathophysiological features associated with phosphate depletion in hypophosphatemic (Hyp) mice, we examined the effect of extracellular phosphate on parathyroid hormone (PTH)-stimulated adenosine 3′,5′-cyclic monophosphate (cAMP) production in the proximal convoluted tubules (PCT). Methods. PTH-Stimulated cAMP production and ATP content were determined by radioimmunoassay and luciferin-luciferase chemiluminescence methods, respectively. Results. The level of cAMP stimulated by PTH at an extracellular phosphate concentration of 0.78 mM was lower in the Hyp mice than in normal mice. The PTH-stimulated cAMP production in the Hyp mice was increased when the extracellular phosphate concentration was raised. In contrast, an increase in extracellular phosphate did not affect the PTH-stimulated cAMP production in the normal mice. Although the ATP content of the PCT was not different between the normal and Hyp mice immediately after microdissection, after 60 min of incubation, it had decreased to a greater extent in Hyp mice than in the normal animals. Raising the extracellular phosphate concentration from 0.78 to 2.3 mM prevented the decrease in ATP content in Hyp mice, and the intracellular ATP content then became comparable to that in the normal control. Conclusions. These results suggest that ATP content in the PCT tended to be decreased in Hyp mice by a decreased phosphate supply and that the blunted effect of PTH on cAMP production in these mice is due to ATP depletion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101570050055
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Inhibitory effects of newly synthesized active center-directed trypsin-like serine protease inhibitors on the complement system (2000)
    Springer
    Inflammation research 49 (2000), S. 42-46 
    Details
    ISSN: 1420-908X
    Keywords: Key words: FUT-175 (nafamostat mesilate) - Complement - Serine protease inhibitor - Complement-mediated hemolysis - Forssman systemic shock
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective: To obtain a synthetic anti-complement inhibitor which has stronger activity than FUT-175 (nafamostat mesilate), as a synthetic ester derivative containing amidino and guanidino groups.¶Methods: We synthesized several modified compounds of FUT-175. The anti-complement activities were measured using synthetic substrates and complement-mediated hemolysis in vitro. The anti-complement activity in vivo was evaluated via Forssman systemic shock in guinea pigs.¶Results: FUT-175 inhibited C1r- and C1s- with IC50s of 1.7 × 10-6 and 3.2 × 10-7 M, respectively. Inhibitory activities were decreased by substitution of the amidino group with a hydrogen atom (compound 2), but not the guanidino group with a hydrogen atom (compound 3). Compound 6, in which the benzene ring of compound 3 was substituted with a furan ring, inhibited C1r- and the complement-mediated hemolysis in high-diluted serum with higher potency than FUT-175. The inhibitory activity of compound 6 in hemolysis was weakened in low diluted serum. Compound 7 had a guanidino group inserted into compound 6; however, Compound 7 strongly inhibited hemolysis even in low-diluted serum, and suppressed Forssman systemic shock more potently than both FUT-175 and compound 6.¶Conclusions: These data suggest that the 2-furylcarboxylic acid derivatives have a strong potential for inhibiting the activities of the complement, and the guanidino group was required to retain high inhibitory activities in vivo, and compound 7 is a hopeful anti-complement agent.¶
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00000202
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Renal angiomyolipoma: evolutional changes of its internal structure on CT (2000)
    Springer
    Abdominal imaging 25 (2000), S. 651-654 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Kidney—Renal angiomyolipoma—Computed tomography—Tuberous sclerosis—Internal structure—Doubling time.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: We evaluated interval changes of the internal structure of renal angiomyolipomas in relation to the doubling time on computed tomography (CT). Methods: A retrospective review of 42 renal angiomyolipomas in 10 patients who had been followed up for more than 5 months with CT was performed. The doubling time of each tumor was estimated. We classified the internal structures of the tumors into five types, based on the fat component percentage. We compared changes between initial and follow-up CT, and the relationship with the doubling time was evaluated. Results: The fat component increased more than the soft tissue component in 15 tumors (36%). The soft tissue component increased more than the fat component in only one tumor, in which an intratumoral hemorrhage occurred during the follow-up period. Twenty-six tumors (62%) showed no change. Most tumors with relatively long doubling times did not show a change in their internal structures. Conclusion: The growth of renal angiomyolipoma is due mainly to an increase in its fat component. An increase in the soft tissue component suggests the development of an intratumoral hemorrhage. RID="" ID="" 〈E5〉Correspondence to:〈/E5〉 S. Yamamoto
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/s002610000051
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Cellular and molecular mechanism of low-turnover osteopenia in the klotho-deficient mouse (2000)
    Springer
    Cellular and molecular life sciences 57 (2000), S. 731-737 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Aging; osteoporosis; osteoprotegerin; klotho; bone.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The mouse homozygous for a disruption of the klotho locus (KL −/− or klotho mouse) exhibited multiple pathological conditions resembling human aging. We observed osteopenia in KL −/− mice with a low bone turnover, in which the decrease in bone formation exceeded the decrease in bone resorption and resulted in net bone loss. This pathophysiology resembles closely that of senile osteoporosis in humans. Osteoblastic cells from KL −/− mice proliferated normally in vitro; however, they showed much lower alkaline phosphatase activity and mineralized matrix formation than those from control mice. Cultured osteoclastic cells from KL −/− mice had normal resorbing activity and survival rate, but the differentiation of osteoclastic cells from their precursors was significantly disturbed: in the co-culture of osteoblastic cells and osteoclast precursor cells, the formation of tartrate-resistant acid phosphatase-positive multinucleated osteoclastic cells was extremely poor only when osteoclast precursor cells orginated from KL −/− mice independently of the origin of the osteoblastic cells. In addition, we found that osteoprotegerin a secreted factor which inhibits osteoclastogenesis, was up-regulated in KL −/− mice. We conclude that a defect in klotho gene expression leads to the independent impairment of osteoblast and osteoclast differentiation, which can be a cause of low-turnover osteoporosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000180050037
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Oxygen ordering in YBa2Cu3O7−y in terms of the Landau theory (2000)
    Springer
    Physics of the solid state 42 (2000), S. 1819-1824 
    Details
    ISSN: 1063-7834
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Oxygen ordering in nonstoichiometric compositions of YBa2Cu3O7−y is considered in terms of the Landau theory of second-order phase transitions. It is shown that there can only be ten types of homogeneous long-range order, of which two types correspond to the OI and OII phases. The Landau theory predicts that the filling of vacant positions 2(f)D 4h 1 by oxygen must follow a scenario that is far from forming chains but compatible with known facts. Such a scenario of filling vacancies with oxygen was not considered earlier. It is demonstrated that the predicted structures can be experimentally identified from the spectra of copper ions. In the course of identification of diffraction patterns, the symmetry-allowed displacement of copper ions from centrosymmetric positions in a Cu(1)(Ox□1−x )2 layer should be taken into account.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1134/1.1318870
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...