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  • 1
    Electronic Resource
    Electronic Resource
    Efficient isolation of non-chimeric tetraploids artificially induced in a stable culture of Haplopappus gracilis (1996)
    Springer
    Theoretical and applied genetics 92 (1996), S. 157-162 
    Details
    ISSN: 1432-2242
    Keywords: Key words Plant tissue culture  ;  Haplopappus gracilis  ;  Artifical tetraploid  ;  Chimera  ;   Genetic stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  A method for reducing cytochimerism and inducing homogeneous tetraploids in Haplopappus gracilis was developed in which masses of shoot primordia treated with 0.5 mg/ml of colcemid for 3 days were cut into small meristematic domes. All of the shoot primordia sampled just after the colcemid treatment were cytochimeras that were mixoploids of 2x, 4x and 8x cells. However, when they were allowed to recover in a colcemid-free medium, the frequency of 4x cells spontaneously increased in most of the shoot primordia. Thirty days after the recovery, chimeric masses containing shoot primordia, each of which consisted uniformly of 4x or 2x cells, were observed. In order to obtain a completely homogeneous tetraploid mass, we then cut these primordia into small pieces, each of which had approximately one meristematic dome. Subsequent to this homogeneous tetraploid masses were easily obtained. Tetraploid shoot primordia could propagate with chromosomal stability over a year, and plants regenerated from these tetraploid shoot primordia were also completely tetraploid. These results show that nonchrimeric masses can be easily isolated from artificially induced cytochimeras using masses of shoot primordia as material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050108
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  • 2
    Electronic Resource
    Electronic Resource
    Development of fat within a meningioma (1996)
    Springer
    Neuroradiology 38 (1996), S. 214-216 
    Details
    ISSN: 1432-1920
    Keywords: Meningioma ; Intratumoral fat ; Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a tentorial meningioma containing fat. Multiple areas of fatty density or intensity in the tumour were seen on CT and MRI, which corresponded histologically to lipomatous components. CT 10 years previously had demonstrated a smaller tumour without evidence of fatty components. We found only five cases in the literature in which fatty density was demonstrated within a meningioma on CT and a lipomatous component histologically proved. Xanthomatous change, with lipid in tumour cells, causes decrease in density on CT, but not to the levels of fat. As both lipomatous components and xanthomatous change show similar intensity on MRI, CT can be helpful in differentiating these two conditions. To our knowledge, our case is the only one in which the advent of fatty tissue was confirmed during follow-up.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00596531
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  • 3
    Electronic Resource
    Electronic Resource
    Development of fat within a meningioma (1996)
    Springer
    Neuroradiology 38 (1996), S. 214-216 
    Details
    ISSN: 1432-1920
    Keywords: Key words Meningioma ; Intratumoral fat ; Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a tentorial meningioma containing fat. Multiple areas of fatty density or intensity in the tumour were seen on CT and MRI, which corresponded histologically to lipomatous components. CT 10 years previously had demonstrated a smaller tumour without evidence of fatty components. We found only five cases in the literature in which fatty density was demonstrated within a meningioma on CT and a lipomatous component histologically proved. Xanthomatous change, with lipid in tumour cells, causes decrease in density on CT, but not to the levels of fat. As both lipomatous components and xanthomatous change show similar intensity on MRI, CT can be helpful in differentiating these two conditions. To our knowledge, our case is the only one in which the advent of fatty tissue was confirmed during follow-up.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00596531
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  • 4
    Electronic Resource
    Electronic Resource
    Toxohormones responsible for cancer cachexia syndrome in nude mice bearing human cancer cell lines (1996)
    Springer
    Cancer chemotherapy and pharmacology 38 (1996), S. S48 
    Details
    ISSN: 1432-0843
    Keywords: Key words Cachexia ; LIF ; IL-6 ; IL-11 ; ob gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Toxohormones are tumor-derived factors that induce cancer cachexia syndrome in tumor-bearing animals. Nude mice bearing tumors induced by eight human cancer cell lines with this activity were studied for cytokine production and expression of a newly identified gene, ob, which has the ability to control body weight. A melanoma cell line, SEKI, and a neuroepithelioma cell line, NAGAI, produced a large amount of the cytokine, leukemia-inhibitory factor (LIF). A uterine carcinoma cell line, Yumoto, produced a large amount of interleukin 6 (IL-6), and an oral cavity carcinoma cell line, OCC-1C, concomitantly produced LIF, IL-6, and IL-11. Reverse transcription polymerase chain reaction studies revealed that ob gene mRNA was not expressed in any of these cell lines, suggesting that the gene does not have a role as a tumor product responsible for cancer cachexia in this model. These findings suggest that in four of eight animal models in which cancer cachexia syndrome developed, LIF, IL-6, or possibly IL-11 produced by cancer cells may be toxohormones, but in the remaining four cancer cell lines the mechanism responsible for cachexia syndrome remains unknown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800051038
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  • 5
    Electronic Resource
    Electronic Resource
    A source of haemorrhage in adult patients with moyamoya disease: The significance of tributaries from the choroidal artery (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 1282-1286 
    Details
    ISSN: 0942-0940
    Keywords: Moyamoya disease ; intraventricular haemorrhage ; angiography ; choroidal artery ; medullary artery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study concerns 19 patients over 16 years of age with Moyamoya disease. Ten cases of intracranial haemorrhage, as the initial haemorrhagic event in patients aged from 21 to 55 (haemorrhagic group) and 9 cases of ischaemic events in 18- to 53-year-old patients (ischaemic group) were included. All haemorrhages were associated with intraventricular haemorrhages (IVH); and all but one case of thalamic haemorrhage were thought to be primary IVH (2 cases of small paraventricular haemorrhage; 2 of small haemorrhages in the splenium; 5 with no intracerebral haematoma). In the 9 patients of the ischaemic group, there were 2 cases of transient ischaemic attacks and 7 of cerebral infarction. Angiographic evaluations demonstrated that the abnormal basal vessel formation and the collateral supplies from the external carotid arteries were poorly developed in both groups. In contrast, the collateral circulation via the choroidal and posterior pericallosal arteries was well demonstrated. Furthermore, marked enlargement of the choroidal arteries and the medullary arteries derived from them was seen more frequently in the haemorrhagic group. These findings suggested that the haemodynamic load in the vessels supplying the walls of the posterior parts of the ventricles and the periventricular region was increased, especially in the haemorrhagic group. Those vessels were considered to be important sites of IVH in adult patients with Moyamoya disase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411056
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  • 6
    Electronic Resource
    Electronic Resource
    Cystic acoustic neurinomas: Studies of 14 cases (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 695-699 
    Details
    ISSN: 0942-0940
    Keywords: Acoustic neurinoma ; computerized tomography ; cystic tumour ; magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cystic acoustic neurinomas (ANs) are less frequent and are different from solid ANs in clinical and radiological features. We had 14 cystic ANs (13.5% of 104 cases) in the last 17 years. Computerized tomographic or magnetic resonance images allowed for the classification of these cystic ANs into three types: Type A being large single cysts with a thin tumourous wall (7 cases); type B single cysts with a thick tumourous wall (3 cases); type C multicystic (4 cases). Half of the cystic ANs were not accompanied by enlargement of the internal auditory canal, despite the largeness of the cysts. The mean size of the tumours was 29 mm in diameter. Type A cysts had a shorter clinical history than types B and C. One patient had intact hearing. In five cases, an atypical initial symptom such as facial pain, dysgeusia, facial palsy, unsteadiness or vertigo presented. The trigeminal nerve was involved in 12 cases, the facial nerve in nine. The characteristic features of cystic ANs are largeness of the tumour, a short clinical history, an atypical initial symptom, facial nerve involvement, and/or no enlargement of the internal auditory canal. In addition, the histological features are a lobular growth pattern, high nuclear atypia, and numerous macro phages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411474
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  • 7
    Electronic Resource
    Electronic Resource
    Surgical experience with massive lobar haemorrhage caused by cerebral amyloid angiopathy (1995)
    Springer
    Acta neurochirurgica 132 (1995), S. 48-52 
    Details
    ISSN: 0942-0940
    Keywords: Intracerebral haemorrhage ; spontaneous cerebral haemorrhage ; amyloid angiopathy ; surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nineteen patients with massive lobar haemorrhage without angiographic lesions received direct or stereotactic surgery, and biopsy specimens were examined histologically. Ten patients (53%) were found to have vessels positive for Congo-red staining, and demonstrating amyloid angiopathy. In the patients with amyloid angiopathy, CT scan and surgical findings were investigated. Subarachnoid haemorrhage (9/10), irregularly shaped haematoma (9/10) and fluid-blood density level in the haematoma cavity (7/10) were frequently found on CT scan. The characteristic surgical findings in patients treated by direct surgery were subarachnoid haemorrhage adjacent to intracerebral haematoma (8/8) and the existence of a tangle of vessels in the haematoma cavity (4/8). Evacuation of haematomas was relatively easy, and difficulty of haemostasis was not encountered during surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01404847
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  • 8
    Electronic Resource
    Electronic Resource
    Frequent TIA in the territory fed by the anastomosed STA after combined therapeutic ICA occlusion and extracranial-intracranial bypass: Case report (1995)
    Springer
    Acta neurochirurgica 133 (1995), S. 206-210 
    Details
    ISSN: 0942-0940
    Keywords: Giant cerebral aneurysm ; carotid artery occlusion ; extracranial-intracranial bypass ; cerebral embolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Frequent transient ischaemic attacks (TIAs) in the territory fed by the anastomosed superficial temporal artery (STA) after combined therapeutic internal carotid artery (ICA) occlusion and extra-cranial-intracranial bypass is described in a 52-year-old woman with a giant aneurysm in the supraclinoid portion of the left ICA showing impairment of visual acuity in the left eye and right upper quadrantanopia. After the balloon test occlusion of the left ICA which was tolerated, the left STA-middle cerebral artery anastomosis was performed and occlusion of the left ICA using detachable balloons was carried out a day later. TIAs corresponding to the territory fed by the anastomosed STA occurred nine times two to four days and five times eight to nine days after the ICA occlusion without new infarction on computed tomography (CT) scan. Single-photon emission computed tomography showed no hypoperfusion immediately after the initial TIA. CT scan revealed thrombosis of half of the aneurysm a day after the ICA occlusion. The patient developed the same TIA as previously by compression of the left anastomosed STA at the time of follow-up angiography which was carried out eight days after the occlusion. Although heparin was continuously administered after the ICA occlusion for two days, the initial TIA occurred during heparinization. Anticoagulation seemed to be inadequate judging from activated coagulation time and incomplete thrombosis of the aneurysm occurred during heparinization. It is likely that the TIAs are caused by embolism via the STA, which is a rare ischaemic complication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01420076
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  • 9
    Electronic Resource
    Electronic Resource
    Psammomatous Meningioma Arising from the Diaphragma Sellae (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 291-292 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050099
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  • 10
    Electronic Resource
    Electronic Resource
    Haemodynamic Evaluation of Cerebral Gliomas Using XeCT (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 223-234 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Cerebral blood flow; XeCT; low grade glioma; high grade glioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of this study was to characterize regional blood flow (BF) in untreated cerebral gliomas (CG) using stable Xe-enhanced computed tomography (XeCT). XeCT of 38 patients with untreated CG were analyzed and compared with CT and magnetic resonance images (MRI) and histopathological findings. Individual averaged BF values for tumour in 29 high grade gliomas (HGGs) and 9 low grade gliomas (LGGs) were intermediate between averaged BF values for cortex and white matter in the non-tumour bearing hemisphere. All averaged BF values for cyst and central necrosis were very low. In 27 HGGs, BF in tumour was relatively high in ring-enhancement lesions on CT and MRI, but was low even in viable tumour centers showing no contrast enhancement. In the other 2 HGGs, BF was low in tumour center and relatively high in tumour periphery regardless of homogeneous enhancement. In 5 HGGs, averaged BF value of the cortex outside surrounding oedema was higher than that of cortex in the non-tumour bearing hemisphere. In LGGs, BF distribution in tumour was homogeneously low in 3 small-sized and heterogeneous in 6 large-sized lesions including moderately high and low BF regions. These differences in BF pattern between HGGs and LGGs on XeCT might be helpful in considering to some extent the histopathology of untreated cerebral glioma pre-operatively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050089
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