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  • 1
    Electronic Resource
    Electronic Resource
    COMPARISON OF LIPID EFFECTS ON K+-Mg2+ ACTIVATED p-NITROPHENYL PHOSPHATASE AND Na+-K+-Mg2+ ACTIVATED ADENOSINE TRIPHOSPHATASE OF MEMBRANE (1969)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 16 (1969), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— A comparison was made between K+-Mg2+ activated p-nitrophenyl phosphatase and Na+-K+-Mg2+ activated adenosine triphosphatase with a solubilized enzyme preparation from a membrane fraction of cerebral cortex. The NPPase showed activity even in the absence of phospholipid, whereas the ATPase required the lipid for its activity. More varied types of phospholipids were effective in activating the NPPase than the ATPase, and with each phospholipid the extent and the pattern of the NPPase activation differed from that of the ATPase. By deoxycholate treatment the pH optimum of the NPPase was shifted independently from the pH optimum shift of the ATPase. The specific activity ratio of the NPPase to the ATPase was not constant during purification. These two enzymes were, however, not separable with ammonium sulphate fractionation, and their thermo-lability was identical regardless of the presence of phospholipid. The results suggested two possibilities: (1) the NPPase is a separate enzyme entity from the ATPase; (2) although the NPPase is a part of the ATPase system, the mechanism of action of lipids on the former part differs from that on the rest of the system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1969.tb05980.x
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  • 2
    Electronic Resource
    Electronic Resource
    p-NITROPHENYL PHOSPHATASES OF A MEMBRANE FRACTION FROM BOVINE CEREBRAL CORTEX (1969)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 16 (1969), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Three different types of p-nitrophenyl phosphatases (NPPases) were solubilized by deoxycholate treatment from a membrane fraction of bovine cerebral cortex, and their characteristics were determined. Of these three NPPases (acid, Mg2+-activated, and K+, Mg2+-activated), only K-Mg NPPase was stimulated about two-fold by phospholipid and was inhibited by unsaturated neutral lipids and fatty acids. Unlike Na+-K+-Mga+-activated ATPase, the enzyme did not absolutely require phospholipid for its activity, but was similarly thermolabile and was protected by phospholipid from thermal inactivation. Acid NPPase was separable from the other two NPPases by ammonium sulphate fractionation, and partly solubilized by dialysis against ATP-mercaptoethanol solution. Hg2+ inhibited equally all three NPPases, but Ca2+ inhibited only Mg and K-Mg NPPases. Ouabain was effective on K-Mg NPPase alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1969.tb05962.x
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  • 3
    Electronic Resource
    Electronic Resource
    Interaction of hydrophobically modified hydroxyethyl cellulose with various added surfactants (1992)
    s.l. : American Chemical Society
    Macromolecules 25 (1992), S. 1304-1310 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00030a016
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  • 4
    Electronic Resource
    Electronic Resource
    9β-Lanostane-Type Triterpene Lactones from the Stem Bark of Abies veitchii (1991)
    s.l. : American Chemical Society
    Journal of natural products 54 (1991), S. 1337-1344 
    Details
    ISSN: 1520-6025
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/np50077a017
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  • 5
    Electronic Resource
    Electronic Resource
    Structure of (R)-tetrahydro-2-furancarboxylic acid monohydrate (1990)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 46 (1990), S. 106-108 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270189004877
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  • 6
    Electronic Resource
    Electronic Resource
    Model independent fitting to theZ line shape (1991)
    Springer
    The European physical journal 49 (1991), S. 645-655 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract An improved model independent formula to fit theZ line shape parameters is presented. The accuracy of the QED radiative corrections used in the formula is estimated, as is the absolute accuracy of the formula itself. The precision of the formula is compared with existing fitting formulae, in terms of cross sections produced and in terms of theZ parameters returned from a fit. The errors which the LEP-SLC experiments can expect to achieve on theZ parameters are examined as a function of total integrated luminosity. The formula presented here can fit theZ parameters with high accuracy: below 1 MeV for theZ mass, the order of 1 MeV for total width, and below 0.04% for the hadronic and leptonic peak cross sections. Such biases will remain much below the expected experimental uncertainties from LEP and SLC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01483581
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  • 7
    Electronic Resource
    Electronic Resource
    Prognosis of intracranial germ cell tumours: Effectiveness of chemotherapy with cisplatin and etoposide (CDDP and VP-16) (1993)
    Springer
    Acta neurochirurgica 120 (1993), S. 111-117 
    Details
    ISSN: 0942-0940
    Keywords: Germ cell tumour ; chemotherapy ; CDDP ; VP-16
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A co-operative study for patients with intracranial germ cell tumours was performed to analyze their prognosis and the effectiveness of Cisplatin/Etoposide (CDDP/VP-16) chemotherapy. A total of 46 patients; 30 primary and 16 recurrent cases were registered from 15 participating neurosurgical institutions in Japan. Based on histological criteria and tumour markers, they were classified into three groups; germinoma, germinoma with syncytiotro-phoblastic giant cell (STGC), and non-germinomatous malignant tumour. Sixteen patients were treated with CDDP/VP-16 chemotherapy alone and the other 30 patients were treated by a combination of surgery and/or radiation in addition to chemotherapy. Eleven out of 13 patients (85%) with germinoma showed a complete (n=10) or partial (n=1) response to CDDP/VP-16 chemotherapy even if their tumours were recurrent and there was evidence of CSF dissemination. For the germinoma with STGC and non-germinomatous malignant tumour, a high response rate; 100% for the former and 78% for the latter, could also be achieved in both the primary and the recurrent cases except in those cases of immature teratoma. Their survival times were still different between them. Two-year survival was 50% in germinoma with STGC and 48% in non-germinoma, while it was 88% in germinoma cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02112027
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  • 8
    Electronic Resource
    Electronic Resource
    Cerebral haemodynamic changes after endovascular treatment of arteriovenous malformations: Evaluation by single-photon emission CT (1994)
    Springer
    Acta neurochirurgica 127 (1994), S. 142-150 
    Details
    ISSN: 0942-0940
    Keywords: Arteriovenous malformation ; endovascular treatment ; cerebral haemodynamic changes ; single-photon emission CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cerebral haemodynamic changes in 17 patients with cerebral arteriovenous malformations (AVMs), who showed hypoperfusion on single-photon emission computed tomography (SPECT) before endovascular treatment, were studied after embolization. Nine of them had non-haemorrhagic clinical manifestations and the other eight had a history of intracranial haemorrhage. Obliteration of AVMs was nearly total in six patients and partial in eleven. New low density lesions on X-ray computed tomography (CT) developed in 3 of 6 patients after nearly total obliteration and one of 11 patients after partial obliteration. The first SPECT after embolization showed diminished hypoperfusion in 11 of 13 patients without new low density lesions and one of 4 patients with new low density lesions. Diminution of hypoperfusion was seen even in two patients who underwent SPECT study immediately after the embolization. Cerebral circulation was improved in five of eight patients with low density lesions before embolization and in nine of eleven patients after partial obliteration. Hypoperfused state in the haemorrhagic group tended to remain unchanged compared with that in the non-haemorrhagic group. The hypoperfused area was expanded after embolization in three patients with new cerebral infarction. It is important for improvement of cerebral circulation to reduce the shunt flow without causing new infarction due to the embolization itself. In one of two patients who had a hyperperfused area surrounding the AVM after embolization, an unexpected and abnormal degree of brain swelling and haemorrhage occurred at the end of the surgery 20 days after the embolization. In the other patient, total extirpation was successfully performed after confirming disappearance of hyperperfusion in the follow-up SPECT. SPECT allows repeated measurement of the cerebral blood flow pattern easily and safely, and is useful for AVM management.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01808757
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  • 9
    Electronic Resource
    Electronic Resource
    Anomaly of venous system in congenital occipital dermal sinus (1994)
    Springer
    Acta neurochirurgica 128 (1994), S. 174-179 
    Details
    ISSN: 0942-0940
    Keywords: Congenital occipital dermal sinus ; dural sinuses ; development ; embryology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report two cases of congenital occipital dermal sinus in which elongation of the vein of Galen, elevation of the straight sinus, division of the superior sagittal sinus, elevation of the confluence of sinuses, elevation of transverse sinus and narrowing of the torcular angle were observed in the venous phase of cerebral angiography. Enhanced computed tomography (CT) revealed enlargement of the supracerebellar cistern, elevation of the straight sinus and of the confluence of sinuses, but no evidence of intracranial lesions. In order to study the relationship between anomalies in the dural venous sinuses and congenital occipital dermal sinus, we examined both cases from an embryological viewpoint.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400671
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  • 10
    Electronic Resource
    Electronic Resource
    The long-term growth rate of residual acoustic neurinomas (1994)
    Springer
    Acta neurochirurgica 129 (1994), S. 127-130 
    Details
    ISSN: 0942-0940
    Keywords: Acoustic neurinoma ; computed tomography ; growthrate ; intracapsular removal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The growth rate of 19 residual acoustic neurinomas was examined in a long-term follow-up study (median, 10 years; range, 5 to 17 years) following intracapsular removal. Of these, 10 (53%) had regrowth, three (16%) showed regression, and six (32%) were unchanged. The 10 acoustic neurinomas showing regrowth were divided into two categories, either solid or cystic, according to computed tomographic findings. Five acoustic neurinomas with cyst formation showed rapid regrowth, with the tumour doubling time ranging from 0.15 to 5.0 years (median, 4.5 years), and required re-operation. Five solid tumours showed slow regrowth, with the tumour doubling time ranging from 9 to 34 years (median, 15 years). Although cyst formation is a major factor in rapid regrowth, residual acoustic neurinomas without cyst formation have a slower growth potential. In this study, 74% of the residual acoustic neurinomas have never required re-operation. It is advisable to choose intracapsular removal if there is major risk of neurological deficits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01406491
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