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  • Electronic Resource  (3)
  • 1980-1984  (2)
  • 1975-1979  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Termination of cortical afferents on identified neurons in the caudate nucleus of the cat (1981)
    Springer
    Experimental brain research 41 (1981), S. 329-337 
    Details
    ISSN: 1432-1106
    Keywords: Caudate nucleus ; Golgi/EM ; Corticocaudate projection ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A combined Golgi/electron microscopic technique was used to investigate the fine structure and synaptology of Golgi-stained spiny neurons in the caudate nucleus of the cat. In order to study the termination sites of cortical afferents on Golgistained spiny neurons, cortical fibres were caused to degenerate by making extensive cortical lesions 3 days prior to fixation of the animals. When examined in the electron microscope, perikarya of labelled spiny neurons have a round nucleus, a few mitochondria and microtubules, and a poorly developed Golgi apparatus and rough endoplasmic reticulum. Only rarely are axo-somatic contacts seen. Labelled dendrites exhibit a moderate number of microtubules and sometimes elongated mitochondria. Numerous labelled spines are seen in the vicinity of their parent dendrites. They are contacted by smaller type I and type III boutons and larger type IV boutons (Hassler et al. 1978). Large boutons filled with clear round vesicles establish symmetric contacts with labelled dendritic shafts. Degenerating boutons of cortical afferents are seen in contact with spines and, more rarely, with dendritic shafts of Golgi-stained spiny neurons. All degenerating boutons synapsing with labelled structures are found some distance from the cell body. No contacts of degenerating cortical boutons with the soma or with stem dendrites of Golgi-stained spiny neurons are found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238890
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Transneuronal effects of entorhinal lesions in the early postnatal period on synaptogenesis in the hippocampus of the rat (1977)
    Springer
    Experimental brain research 30 (1977), S. 549-560 
    Details
    ISSN: 1432-1106
    Keywords: Hippocampus ; Synaptogenesis ; Entorhinal lesion ; Transneuronal effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The granule cell axons of the dentate gyrus (mossy fibers, MF) terminate with large, characteristic boutons on neurons of the regio inferior of the hippocampus. To study transneuronal effects on mossy fiber synaptogenesis, the entorhinal cortex, which is the source of the main afferent to the granule cells, was removed in 3-day old rats. After a postoperative survival time of 27 days, the animals were killed and the brain prepared for electron microscopy. No clear postlesional changes were observed in the inner structure of the presynaptic mossy fiber terminals. The mean size of MF boutons was roughly the same in the experimental animals as compared to normal, unoperated rats of the same age (4.19 μm2, SD 1.9; and 4.29 μm2, SD 2.2, respectively). On the postsynaptic side, however, some remarkable changes were found. In the operated animals, the number and total area of dendritic spines in synaptic contact with MF has significantly decreased in comparison with the controls. Also the size of a single spine in the operated animals was only 64 % of that in the normal. These changes were accompanied by a decrease in MF total perimeter and MF-dendritic contact length in the experimental animals. The length of the MF specialized synaptic contact was found to be correlated with the number and size of dendritic spines. Thus accordingly, though the length of the MF specialized contact with the dendritic shaft did not change, the absolute length of MF specialized contact with postsynaptic spines was decreased in the lesioned animals due to the numerical and size reduction of the spines. This suggests that normally functioning entorhinal afferents to the granule cells are necessary for the normal development of dendritic spines in contact with hippocampal mossy fibers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237644
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Ultrastructure of mossy fiber endings in in vitro hippocampal slices (1981)
    Springer
    Experimental brain research 41 (1981), S. 247-255 
    Details
    ISSN: 1432-1106
    Keywords: Hippocampal slice ; Ultrastructure ; Mossy fiber synapses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 0.2 to 0.4 mm thick slices of guinea pig hippocampus were studied morphologically after varying periods of incubation at 36 ° C in Krebs-Ringer solution. Prior to fixation, the slices were tested for the presence of synaptically driven discharges of CA 3 neurons following mossy fiber (mf) stimulation because tissue preservation was satisfactory only in slices in which electrical responses were obtained. The fine structure of the mf layer in slices was compared with the ultrastructure of this region in hippocampal tissue fixed by transcardial perfusion or immersion of the tissue in the fixative. In the central part of the slices many intact neuronal structures of the mf layer could be seen even after 4 h of incubation. In the outer parts of the slices, neurons were swollen and vacuolated. These alterations were not observed in hippocampal tissue fixed by transcardial perfusion or by immersion. In all parts of the slices dark neurons and processes were found. Since dark neurons were also numerous in tissue blocks immersed in the fixative but were rare in perfused material, these changes were obviously caused by damage to unfixed tissue and fixation by immersion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238881
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    Paper (German National Licenses)
    Fulltext
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