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  • Electronic Resource  (9)
  • Inorganic Chemistry  (4)
  • Calcitonin  (3)
  • Acute leukaemia  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Calcitonin gene products and the kidney (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 870-875 
    Details
    ISSN: 1432-1440
    Keywords: Calcitonin ; Calcitonin gene-related peptide ; Renovascular effects ; Renotubular effects ; Renin secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Calcitonin gene-related peptide (CGRP) is localized in capsaicin-sensitive nerve fibres in the kidney and urogenital tract whereas calcitonin reaches the kidney through the general circulation. Systemic infusion of CGRP and perfusion of isolated rat kidney reduces vascular resistance, and increases renal blood flow and glomerular filtration. CGRP stimulates renin secretion in vivo and in vitro and inhibits contraction of isolated rat mesangial cells by angiotensin II. Calcitonin does not affect vascular resistance, renal blood flow and glomerular filtration, and is less potent in stimulating renin secretion, and does not alter contraction of isolated rat mesangial cells by angiotensin II. CGRP also exerts renal tubular effects brought about probably through interaction with calcitonin receptors. To this end, increased excretion of sodium and chloride, and stimulation of urinary flow are less pronounced with CGRP than with calcitonin. Calcitonin, moreover, stimulates the fractional urinary excretion of calcium and phosphate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01717342
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  • 2
    Electronic Resource
    Electronic Resource
    Formation of neutralizing antibodies during intranasal synthetic salmon calcitonin treatment of postmenopausal osteoporosis (1991)
    Springer
    Osteoporosis international 1 (1991), S. 72-75 
    Details
    ISSN: 1433-2965
    Keywords: Antibodies ; Calcitonin ; Salmon calcitonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nineteen patients with postmenopausal osteoporosis were treated with 200 u (15 nmol) synthetic salmon calcitonin (sCT) intranasally per day for 15 months. Six months after the start of the nasal administration of sCT, antibodies were recognized in 7, and after 15 months in 10 of the 19 patients studied. The half-maximal dilution of serum binding to 60 pmol/1 [125I] sCT (dilution-50) ranged from 2 to 490, and half-maximal inhibition of [125I]sCT binding (60 pmol/1) from 91 to 221 pmol/l sCT. In a cultured breast cancer cell line (T47D) cAMP production was stimulated by sCT (EC50 70 pmol/l). Stimulated cAMP production by sCT (50 pmol/1) was reduced to between 4% and 23% in the presence of serum from patients with antibody dilution-50 of [125I]sCT binding exceeding 32. In patients with lower titer antibodies cAMP production was only marginally suppressed. The values of patients with postmenopausal osteoporosis were in the range of those of earlier studied patients with Paget's disease and clinical resistance to sCT. There was a linear relation between the antibody dilution-50 and the serum dilution required for half-maximal inhibition of cAMP production (P〈0.01). In conclusion, neutralizing antibodies to sCT may contribute to the decreased responsiveness of bone mineral loss during prolonged treatment with sCT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01880446
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  • 3
    Electronic Resource
    Electronic Resource
    Intracolonic bioavailability of human calcitonin in man (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 527-531 
    Details
    ISSN: 1432-1041
    Keywords: Calcitonin ; Colonic administration ; Bioavailability ; pharmacokinetics ; pharmacodynamics ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Human calcitonin (hCT) injected into the lumen of the descending colon of normal human subjects was absorbed within minutes and could be recognized intact in plasma as shown by RIA in combination with reverse-phase HPLC. The absorption was low and variable, with bioavailabilities ranging from 0.01% to 2.7% relative to intravenously administered hCT (area under the concentrationtime curve). With intravenous hCT serum calcium was lowered and the fractional urinary excretion of calcium, phosphorus, sodium and chloride was significantly stimulated. With the intracolonic hCT, the fractional urinary excretions of calcium, sodium and chloride were also marginally stimulated relative to intracolonic vehicle (placebo). In conclusion, hCT is absorbed intact from the colon, but the bioavailability is low and highly variable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02285096
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  • 4
    Electronic Resource
    Electronic Resource
    Der cytochemisch ermittelte Leukosetyp als prognostischer Parameter bei unreifzelligen Leukosen (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 134-137 
    Details
    ISSN: 1432-1440
    Keywords: Acute leukaemia ; classification ; effect of therapy ; prognosis ; Unreifzellige Leukosen ; Klassifizierung ; Therapieeffekt ; Prognose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Komplette Remissionen und Überlebenszeiten von 81 Patienten mit unreifzelligen (akuten) Leukosen wurden zwischen Gruppen, die nach cytochemischen Kriterien ermittelt worden waren, verglichen. Die Klassifizierung erfolgte nach den Ergebnissen von PAS-, Peroxydase-und Esterase-Reaktionen. Eine signifikant höhere Rate an kompletten Remissionen und längere Überlebenszeiten wurden bei den Leukosen vom PAS-Typ im Vergleich zu allen anderen Formen festgestellt. Bei Erwachsenen und Kindern unterschied sich dieser Leukosetyp in der Remissionsrate nicht. Hieraus wird die Forderung abgeleitet, daß Erwachsene mit Leukosen vom PAS-Typ dieselbe intensive Behandlung erfahren sollten wie Kinder.
    Notes: Summary 81 cases of acute leukaemia were classified according to cytochemical criteria. PAS, peroxidase and esterase reactions were used for classification. Rates of complete remissions and duration of survival after diagnosis in the different groups were compared. A significant higher rate of complete remissions and longer duration of survival was detected in PAS type leukaemias compared to all the other types in adults. There was no significant difference in the remission rates between PAS type leukaemias in children and adults treated for at least 7 days. These results lead to the conclusion that adults with this type of acute leukaemia should receive the same treatment as children do.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01620751
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  • 5
    Electronic Resource
    Electronic Resource
    Akute Leukämie bei multiplem Myelom (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 769-777 
    Details
    ISSN: 1432-1440
    Keywords: Multiple myeloma ; Acute leukaemia ; Secondary neoplasia ; Life table method ; Multiples Myelom ; Akute Leukämie ; Zweitneoplasie ; Sterbetafelmethode
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es werden die Ergebnisse einer Follow-up-Studie vorgelegt, in deren Rahmen insgesamt 112 Plasmozytom-Patienten maximal 11 Jahre lang unter klinischer Beobachtung standen. 3 Patienten entwickelten innerhalb des Beobachtungszeitraumes eine akute Leukämie. Hierbei handelte es sich um je einen Fall von akuter myeloblastischer Leukämie, myelomonozytärer Leukämie und Erythroleukämie. Zur Schätzung der Inzidenz von akuter Leukämie bei Ausgangsbefund Plasmozytom wird eine erweiterte Sterbetafelmethode benutzt. Aus unseren Daten erhielten wir hiermit als Wahrscheinlichkeit, daß bei einem Plasmozytompatienten irgendwann im weiteren Krankheitsverlauf eine akute Leukämie auftritt, die Zahl 5,9%. Dieses Ergebnis wird auf Grund einer ausführlichen methodischen Diskussion als Hinweis auf ein stark erhöhtes AL-Risiko bei Plasmozytom-Patienten gewertet. In einer Literaturübersicht werden wichtige Daten von 100 Fällen mit der Assoziation von Plasmozytom und akuter Leukämie zusammengestellt.
    Notes: Summary The results of a follow-up study of 112 patients with multiple myeloma are presented. Three of these patients developed acute leukaemia during the respective period of clinical observation (maximum: 11 years) — one case of acute myeloblastic leukaemia, myelomonocytic leukaemia and erythroleukaemia, myelomonocytic leukaemia and erythroleukaemia, respectively. For estimating the incidence of acute leukaemia in the presence of multiple myeloma an extended life table method was applied. On the basis of our data this method gave a probability of 5.9% for a patient to develop acute leukaemia at any time after the diagnosis of multiple myeloma. In a statistical discussion this result is considered to confirm the assumption of a highly increased AL-risk in patients with multiple myeloma. In a survey of the literature some important data of 100 cases with the association acute leukaemia — multiple myeloma are reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01478035
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  • 6
    Electronic Resource
    Electronic Resource
    Beitrag zur Kenntnis der sauren Barium-diphosphateProfessor Paul Royen zum 60, Geburtstage am 17. Dezember 1964 gewidmet. (1964)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 334 (1964), S. 15-20 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The precipitation of diphosphate from solutions of secondary alkali diphosphates by means of Ba2+ yields the acid salt Ba7H2P8O28·6H2O. With increasing alkalinity of the solutions, the hydrogen ion content of the Ba salt precipitate decreases. Precipitation from Na4-diphosphate solutions yields the neutral Ba2P2O7·1,5 H2O. From X-ray investigations (no structural differences between the two precipitates being found) it in concluded that the “neutral” Ba diphosphate has a phase range from Ba:H = 2:0 to 7:2.
    Notes: Ba2+ bildet-im Unterschied zu vielen anderen zweiwertigen Metallen-bei der Fällung aus Lösungen sekundärer Diphosphate ein saures Diphosphat, Ba7H2P8O28·6H2O. Mit steigender Alkalität der Fällungslösung nimmt die Acidität der Ba-Verbindung ab. Das neutrale Na-Diphosphat entsteht nur bei der Fällung aus quaternären Diphosphat-Lösungen. Bemerkenswerterweise besteht kein struktureller Unterschied zwischen den sauren Verbindungen und dem quaternären Salz, was zu der Annahme führt, daß das quaternäre Ba-Diphosphat eine Phasenbreite zwischen Ba:H = 2:0 und 7:2 besitzt.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19643340104
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  • 7
    Electronic Resource
    Electronic Resource
    Pseudochalkogenverbindungen. XI. Über einen neuen Typ pseudochalkogen-modifizierter PhosphateProfessor Kurt Issleib zum 60. Geburtstage gewidmet (1979)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 458 (1979), S. 177-182 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Pseudochalcogeno Compounds. XI. On a New Type of Pseudochalcogeno-Modified PhosphatesThe preparation of pseudochalcogenophosphates of the general formulas [PO3Y]3- and [P2O7-nYn]4- (Y = C(CN)2, n = 1, 2) is described. Chromatography of sodium salts, the formation of silver and calcium salts, characteristic IR and 31P-NMR data are discussed.
    Notes: Es wird über die Synthese von Pseudochalkogenophosphaten der allgemeinen Formeln [PO3Y]3-, [P2O7-nYn]4- (Y = C(CN)2, n = 1, 2) berichtet. Chromatographisches Verhalten der Natriumsalze, Silber- und Calciumsalzbildung, charakteristische IR- und 31P-NMR-Daten werden diskutiert.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19794580124
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  • 8
    Electronic Resource
    Electronic Resource
    Die Reaktionsfähigkeit α-und γ-ständiger Methylgruppen in Pyryliumsalzen. (Über Pyryliumverbindungen, XIII.) (1924)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 57 (1924), S. 1653-1656 
    Details
    ISSN: 0365-9631
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19240570904
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  • 9
    Electronic Resource
    Electronic Resource
    Die Konstitution der Methyldiphenyl-pyryliumsalze. (Über Pyrylium-Verbindungen, XII) (1923)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 56 (1923), S. 1012-1013 
    Details
    ISSN: 0365-9631
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19230560504
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