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  • Electronic Resource  (9)
  • Inorganic Chemistry  (4)
  • Calcitonin  (3)
  • Anaerobic ischemia  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Calcitonin gene products and the kidney (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 870-875 
    Details
    ISSN: 1432-1440
    Keywords: Calcitonin ; Calcitonin gene-related peptide ; Renovascular effects ; Renotubular effects ; Renin secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Calcitonin gene-related peptide (CGRP) is localized in capsaicin-sensitive nerve fibres in the kidney and urogenital tract whereas calcitonin reaches the kidney through the general circulation. Systemic infusion of CGRP and perfusion of isolated rat kidney reduces vascular resistance, and increases renal blood flow and glomerular filtration. CGRP stimulates renin secretion in vivo and in vitro and inhibits contraction of isolated rat mesangial cells by angiotensin II. Calcitonin does not affect vascular resistance, renal blood flow and glomerular filtration, and is less potent in stimulating renin secretion, and does not alter contraction of isolated rat mesangial cells by angiotensin II. CGRP also exerts renal tubular effects brought about probably through interaction with calcitonin receptors. To this end, increased excretion of sodium and chloride, and stimulation of urinary flow are less pronounced with CGRP than with calcitonin. Calcitonin, moreover, stimulates the fractional urinary excretion of calcium and phosphate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01717342
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  • 2
    Electronic Resource
    Electronic Resource
    Formation of neutralizing antibodies during intranasal synthetic salmon calcitonin treatment of postmenopausal osteoporosis (1991)
    Springer
    Osteoporosis international 1 (1991), S. 72-75 
    Details
    ISSN: 1433-2965
    Keywords: Antibodies ; Calcitonin ; Salmon calcitonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nineteen patients with postmenopausal osteoporosis were treated with 200 u (15 nmol) synthetic salmon calcitonin (sCT) intranasally per day for 15 months. Six months after the start of the nasal administration of sCT, antibodies were recognized in 7, and after 15 months in 10 of the 19 patients studied. The half-maximal dilution of serum binding to 60 pmol/1 [125I] sCT (dilution-50) ranged from 2 to 490, and half-maximal inhibition of [125I]sCT binding (60 pmol/1) from 91 to 221 pmol/l sCT. In a cultured breast cancer cell line (T47D) cAMP production was stimulated by sCT (EC50 70 pmol/l). Stimulated cAMP production by sCT (50 pmol/1) was reduced to between 4% and 23% in the presence of serum from patients with antibody dilution-50 of [125I]sCT binding exceeding 32. In patients with lower titer antibodies cAMP production was only marginally suppressed. The values of patients with postmenopausal osteoporosis were in the range of those of earlier studied patients with Paget's disease and clinical resistance to sCT. There was a linear relation between the antibody dilution-50 and the serum dilution required for half-maximal inhibition of cAMP production (P〈0.01). In conclusion, neutralizing antibodies to sCT may contribute to the decreased responsiveness of bone mineral loss during prolonged treatment with sCT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01880446
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  • 3
    Electronic Resource
    Electronic Resource
    Function and metabolism of canine kidneys after aerobic ischemia by retrograde persufflation with gaseous oxygen (1974)
    Springer
    Research in experimental medicine 164 (1974), S. 35-44 
    Details
    ISSN: 1433-8580
    Keywords: Renal preservation ; Anaerobic ischemia ; Aerobic ischemia ; Retrograde renal O2 persufflation ; Post-ischemic renal function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Retrograde persufflation of ischemic kidneys of dogs via the renal vein with gaseous O2 was evaluated as a method of kidney preservation (retrograde aerobic ischemia) and compared to conventional ischemic storage without additional measures (anaerobic ischemia). Renal preservationin situ lasted 4 hrs at 6°C. A contralateral nephrectomy was performed before the preservation period. For retrograde aerobic ischemia the persufflation pressure was 30 mm Hg, the gas flowed off via opened capsular vessels. While dogs which had undergone renal anaerobic ischemia showed a marked temporary post-ischemic increase in renal blood flow and in the systemic blood pressure, dogs submitted to renal retrograde aerobic ischemia did not exhibit a storage induced loss of the renal vascular autoregulation. During and after retrograde aerobic ischemia the renal tissue levels of ATP, ADP, and AMP remained within normal ranges; ATP and the sum of adenine nucleotides decreased markedly during anaerobic ischemia. In both the groups a normal renal function was resumed again; but the recovery time of various parameters of renal function (clearance from inulin and PAH, urea excretion, serum concentrations of urea and creatinine) was shorter after retrograde aerobic ischemia than after anaerobic ischemia. Kidneys subjected to retrograde aerobic ischemia exhibited a better functional adaption to the contralateral nephrectomy during the 3 weeks of post-ischemic observation than kidneys stored in anaerobic ischemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851962
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  • 4
    Electronic Resource
    Electronic Resource
    Function and metabolism of canine kidneys after aerobic ischemia by orthograde persufflation with gaseous oxygen (1973)
    Springer
    Research in experimental medicine 159 (1973), S. 288-297 
    Details
    ISSN: 1433-8580
    Keywords: Renal preservation ; Anaerobic ischemia ; Aerobic ischemia ; Renal O2-persufflation ; Post-ischemic renal function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In search for new techniques of renal preservation, kidneys were persufflatedin situ with gaseous O2 at a pressure of 90–100 mm Hg via their vascular system (orthograde aerobic ischemia). The results on post-ischemic function and blood flow, and on the changes in the renal tissue levels of the adenine nucleotides were compared to those obtained from kidneys ischemically stored without additional measures (anaerobic ischemia). The kidneys were stored for 4 hrs at 6°C. A contralateral nephrectomy was performed before the preservation period. All dogs subjected to renal anaerobic ischemia survived. After orthograde aerobic ischemia, 3 out of 4 dogs died from uremia within 8 days, 1 animal survived. Although the aerobic ischemic preservation resulted in the maintenance of a metabolic status characteristic for aerobiosis, post-ischemic renal function recovered too slowly and insufficiently on the average. Renal blood flow was within normal ranges after anaerobic ischemia, it was reduced to about one third of this after orthograde aerobic ischemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851603
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  • 5
    Electronic Resource
    Electronic Resource
    Intracolonic bioavailability of human calcitonin in man (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 527-531 
    Details
    ISSN: 1432-1041
    Keywords: Calcitonin ; Colonic administration ; Bioavailability ; pharmacokinetics ; pharmacodynamics ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Human calcitonin (hCT) injected into the lumen of the descending colon of normal human subjects was absorbed within minutes and could be recognized intact in plasma as shown by RIA in combination with reverse-phase HPLC. The absorption was low and variable, with bioavailabilities ranging from 0.01% to 2.7% relative to intravenously administered hCT (area under the concentrationtime curve). With intravenous hCT serum calcium was lowered and the fractional urinary excretion of calcium, phosphorus, sodium and chloride was significantly stimulated. With the intracolonic hCT, the fractional urinary excretions of calcium, sodium and chloride were also marginally stimulated relative to intracolonic vehicle (placebo). In conclusion, hCT is absorbed intact from the colon, but the bioavailability is low and highly variable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02285096
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  • 6
    Electronic Resource
    Electronic Resource
    Beitrag zur Kenntnis der sauren Barium-diphosphateProfessor Paul Royen zum 60, Geburtstage am 17. Dezember 1964 gewidmet. (1964)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 334 (1964), S. 15-20 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The precipitation of diphosphate from solutions of secondary alkali diphosphates by means of Ba2+ yields the acid salt Ba7H2P8O28·6H2O. With increasing alkalinity of the solutions, the hydrogen ion content of the Ba salt precipitate decreases. Precipitation from Na4-diphosphate solutions yields the neutral Ba2P2O7·1,5 H2O. From X-ray investigations (no structural differences between the two precipitates being found) it in concluded that the “neutral” Ba diphosphate has a phase range from Ba:H = 2:0 to 7:2.
    Notes: Ba2+ bildet-im Unterschied zu vielen anderen zweiwertigen Metallen-bei der Fällung aus Lösungen sekundärer Diphosphate ein saures Diphosphat, Ba7H2P8O28·6H2O. Mit steigender Alkalität der Fällungslösung nimmt die Acidität der Ba-Verbindung ab. Das neutrale Na-Diphosphat entsteht nur bei der Fällung aus quaternären Diphosphat-Lösungen. Bemerkenswerterweise besteht kein struktureller Unterschied zwischen den sauren Verbindungen und dem quaternären Salz, was zu der Annahme führt, daß das quaternäre Ba-Diphosphat eine Phasenbreite zwischen Ba:H = 2:0 und 7:2 besitzt.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19643340104
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  • 7
    Electronic Resource
    Electronic Resource
    Pseudochalkogenverbindungen. XI. Über einen neuen Typ pseudochalkogen-modifizierter PhosphateProfessor Kurt Issleib zum 60. Geburtstage gewidmet (1979)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 458 (1979), S. 177-182 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Pseudochalcogeno Compounds. XI. On a New Type of Pseudochalcogeno-Modified PhosphatesThe preparation of pseudochalcogenophosphates of the general formulas [PO3Y]3- and [P2O7-nYn]4- (Y = C(CN)2, n = 1, 2) is described. Chromatography of sodium salts, the formation of silver and calcium salts, characteristic IR and 31P-NMR data are discussed.
    Notes: Es wird über die Synthese von Pseudochalkogenophosphaten der allgemeinen Formeln [PO3Y]3-, [P2O7-nYn]4- (Y = C(CN)2, n = 1, 2) berichtet. Chromatographisches Verhalten der Natriumsalze, Silber- und Calciumsalzbildung, charakteristische IR- und 31P-NMR-Daten werden diskutiert.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19794580124
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  • 8
    Electronic Resource
    Electronic Resource
    Die Reaktionsfähigkeit α-und γ-ständiger Methylgruppen in Pyryliumsalzen. (Über Pyryliumverbindungen, XIII.) (1924)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 57 (1924), S. 1653-1656 
    Details
    ISSN: 0365-9631
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19240570904
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  • 9
    Electronic Resource
    Electronic Resource
    Die Konstitution der Methyldiphenyl-pyryliumsalze. (Über Pyrylium-Verbindungen, XII) (1923)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 56 (1923), S. 1012-1013 
    Details
    ISSN: 0365-9631
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19230560504
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