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1

Electronic Resource

Phorbol ester induces desensitization of PTH-stimulated cyclic AMP production by decreasing the PTH receptor binding in UMR-106 cells

Ikeda, K. ; Sugimoto, T. ; Fukase, M. ; [et al.]

Amsterdam : Elsevier

Biochemical and Biophysical Research Communications 176 (1991), S. 764-768

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ISSN: 0006-291X

Keywords: [abr] BSA; bovine serum albumin ; [abr] DMSO; dimethyl sulfoxide ; [abr] IBMX; isobutylmethylxanthine

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Physics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/S0006-291X(05)80250-5

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2

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Kinetic properties of tyrosine hydroxylase with natural tetrahydrobiopterin as cofactor

Oka, K. ; Kato, T. ; Sugimoto, T. ; [et al.]

Amsterdam : Elsevier

BBA - Enzymology 661 (1981), S. 45-53

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ISSN: 0005-2744

Keywords: Cofactor kinetics ; Tetrahydrobiopterin ; Tyrosine hydroxylase

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2744(81)90082-6

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3

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Effects of structures of tetrahydropterin cofactors on tyrosine hydroxylase

Kato, T. ; Oka, K. ; Nagatsu, T. ; [et al.]

Amsterdam : Elsevier

BBA - Enzymology 612 (1980), S. 226-232

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ISSN: 0005-2744

Keywords: Stereoisomer ; Tetrahydropterin structure ; Tyrosine hydroxylase

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2744(80)90296-X

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4

Electronic Resource

Phorbol ester induces desensitization of PTH-stimulated cyclic AMP production by decreasing the PTH receptor binding in UMR-106 cells

Ikeda, K. ; Sugimoto, T. ; Fukase, M. ; [et al.]

Amsterdam : Elsevier

Biochemical and Biophysical Research Communications 176 (1991), S. 764-768

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ISSN: 0006-291X

Keywords: [abr] BSA; bovine serum albumin ; [abr] DMSO; dimethyl sulfoxide ; [abr] IBMX; isobutylmethylxanthine

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Physics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/S0006-291X(05)80250-5

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5

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Kinetic properties of tyrosine hydroxylase purified from bovine adrenal medulla and bovine caudate nucleus

Oka, K. ; Ashiba, G. ; Sugimoto, T. ; [et al.]

Amsterdam : Elsevier

Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular 706 (1982), S. 188-196

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ISSN: 0167-4838

Keywords: (Adrenal medulla, Caudate nucleus) ; Cofactor kinetics ; Tyrosine hydroxylase

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Medicine

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4838(82)90486-1

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6

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Dissociation of digoxin-like immunoreactivity and Na+,K+-ATPase inhibitory activity in rat plasma (1988)

Yamada, K. ; Goto, A. ; Ishii, M. ; [et al.]

Springer

Cellular and molecular life sciences 44 (1988), S. 992-993

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ISSN: 1420-9071

Keywords: Endogenous digitalis-like factor ; digoxin-like immunoreactivity ; Na+,K+-ATPase inhibitor

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary We measured endogenous digitalis-like factor (EDF) in rat plasma during acute saline infusion by two different procedures. Na+,K+-ATPase inhibitory activity in the rat plasma significantly increased during saline loading (7.8±2.2 vs 2.5±0.9%, with and without acute saline loading, respectively, p〈0.05). On the other hand, the plasma digoxin-like immunoreactivity significantly decreased during acute saline loading (16.9±1.6 vs 32.0±2.8 pg digoxin equivalents/ml. with and without acute saline loading, respectively, p〈0.01). These results indicate that the major substances detected by digoxin-like immunoreactivity and direct Na+,K+-ATPase inhibitory activity are completely different, at least in rat plasma.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01939897

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7

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Role of adenosine A1 and A2 receptors in the regulation of aldosterone production in rat adrenal glands (1990)

Matsuoka, H. ; Yamada, K. ; Atarashi, K. ; [et al.]

Springer

Cellular and molecular life sciences 46 (1990), S. 726-728

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ISSN: 1420-9071

Keywords: Aldosterone ; cyclic AMP ; adenosine ; adenosine A1 ; receptor ; adenosine A2 receptor

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary To investigate the roles of adenosine A1 and A2 receptors in the regulation of aldosterone production, we examined the effects of adenosine and adenosine agonists (N6-cyclohexyl adenosine; selective adenosine A1 receptor agonist and 5′-N-ethylcarboxamine adenosine; selective adenosine A2 receptor agonist) on aldosterone and cyclic AMP production in rat adrenal capsular cells. Neither adenosine nor 5′-N-ethylcarboxamine adenosine caused significant effects on basal aldosterone or cyclic AMP production. Also, adenosine (10−3M) showed no consistent effects on aldosterone and cyclic AMP production induced by ACTH. On the other hand, N6-cyclohexyl adenosine exhibited a significant inhibition of basal aldosterone and cyclic AMP production at doses of 10−4 M and 10−3 M; furthermore, 10−3 M N6-cyclohexyl adenosine inhibited aldosterone and cyclic AMP production stimulated by ACTH. These results suggest that adenosine A1 receptors are coupled to and inhibit adenylate cyclase and may be involved in the inhibition of aldosterone production.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01939947

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8

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Further evidence for the dissociation of digoxin-like immunoreactivity from Na+, K+-ATPase inhibitory activity (1990)

Yamada, K. ; Goto, A. ; Ishii, M. ; [et al.]

Springer

Cellular and molecular life sciences 46 (1990), S. 1041-1043

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ISSN: 1420-9071

Keywords: Endogenous digitalis-like factor ; digoxin-like immunoreactivity ; Na+, K+-ATPase inhibitor ; adrenalectomy

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary The effects of adrenalectomy or nephrectomy, carried out one hour previously, on the levels of endogenous digitalis-like factors were determined in rat plasma. Factors were assayed by digoxin-like immunoreactivity and direct Na+, K+-ATPase inhibitory activity. Digoxin-like immunoreactivity significantly decreased one hour after bilateral ablation of adrenals, while Na+, K+-ATPase inhibitory activity remained unaltered. There were no changes in either activity one hour after bilateral nephrectomy. These results suggest that digoxin-like immunoreactivity may be derived from the adrenal gland or under adrenal control and the major substances detected by digoxin-like immunoreactivity and direct Na+, K+-ATPase inhibitory activity may be different.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01940667

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9

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Plasma adenosine concentrations are elevated in Dahl salt-sensitive rats (1995)

Yamada, K. ; Goto, A. ; Ishii, M. ; [et al.]

Springer

Cellular and molecular life sciences 51 (1995), S. 227-229

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ISSN: 1420-9071

Keywords: Adenosine ; Dahl salt-sensitive rats ; high-performance liquid chromatography ; hypertension

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract We measured plasma levels of adenosine in Dahl salt-sensitive rats (DS) and Dahl salt-resistant rats (DR) to examine the potential role of adenosine in cardiovascular regulation in this type of hypertension. Plasma adenosine concentrations were significantly higher in DS than in DR. The NaCl content in the diet did not affect plasma adenosine concentration in either DS or DR. Significant positive correlation was found between adenosine concentrations and systolic blood pressure when the data for DS and DR were analyzed together. These results suggest that adenosine may play an important role in the pathophysiology of hypertension in DS.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01931102

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10

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Renal and hormonal effects of alpha1-adrenoceptor blockade by bunazosin in essential hypertension (1989)

Hirata, Y. ; Fukui, K. ; Dan, Y. ; [et al.]

Springer

European journal of clinical pharmacology 36 (1989), S. 575-578

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ISSN: 1432-1041

Keywords: bunazosin ; hypertension ; alpha1-adrenoceptor blocker ; blood pressure ; renal blood flow ; renal function ; renin ; aldosterone ; atrial natriuretic peptide

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The renal and hormonal effects of the α1-adrenoceptor blocker bunazosin were examined in 6 patients with essential hypertension. Oral bunazosin for 4 to 12 weeks significantly decreased mean blood pressure by 10%, increased effective renal blood flow and creatinine clearance by 34% and 37%, respectively, the plasma norepinephrine concentration was elevated by 60%, and the plasma atrial natriuretic peptide level was lowered by 22%. The plasma renin activity and aldosterone concentration were unchanged. Thus, a moderate reduction in blood pressure was produced by bunazosin treatment while maintaining renal perfusion.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00637738

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