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  • 1
    Electronic Resource
    Electronic Resource
    Zirkulierende Immunkomplexe bei Patienten mit malignen Lymphomen (1979)
    Springer
    Annals of hematology 38 (1979), S. 435-446 
    Details
    ISSN: 1432-0584
    Keywords: Circulating immune complexes ; Malignant lymphoma ; Zirkulierende Immunkomplexe ; maligne Lymphome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mit der125J-Clq-Deviationsmethode nach Sobel, dem Polyethylenglykol-Präzipitationstests nach Nydegger und einer Sepharose 6B-Säulenchromatographie in Anlehnung an MacLennan wurden zirkulierende Immunkomplexe (ZIK) bei 20–27% der Patienten mit Hodgkin-Lymphomen, bei 8% der Patienten mit Nicht-Hodgkin-Lymphomen vom niedrigen und in 20–40% vom hohen Malignitätsgrad nachgewiesen. ZIK traten in fortgeschrittenen Stadien der Erkrankungen auf und korrelierten gut mit der Krankheitsaktivität. ZIK verschwanden in der Remission und erschienen im Rezidiv wieder. ZIK wurden nur bei Patienten mit allgemeinen Symptomen, d. h. mit B-Symptomen, gefunden. Die pathogenetische Rolle der ZIK bei der Entstehung der B-Symptome und bei der Tumorausbreitung ist noch nicht end gültig geklärt. Der Antikörperanteil der ZIK ist IgG, die antigene Komponente wurde nicht charakterisiert.
    Notes: Summary Using the125J-Clq deviation method according to Sobel, the polyethylenglycol precipitation test of Nydegger, and a Sepharose 6B column chromatography in a modification of MacLennan's method, circulating immune complexes (CIC) have been detected in 20–27% of patients with Hodgkin's lymphoma, in 8% of patients with non-Hodgkin lymphoma of low, and in 20–40% with high malignancy. CIC appeared in advanced stages of the diseases and correlated well with the activity of the disease. CIC disappeared in remissions and reappeared during reactivation of the disease. CIC were only found in patients with general symptoms, i.e. B-symptoms. The pathogenetic role of CIC in the initiation of B-symptoms and in tumor spread is still not fully explained. The antibody part of the CIC is IgG, the antigenic component has not yet been characterized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01013504
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  • 2
    Electronic Resource
    Electronic Resource
    Urodynamik (1979)
    Springer
    Archives of gynecology and obstetrics 228 (1979), S. 311-325 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02427507
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  • 3
    Electronic Resource
    Electronic Resource
    Weitere Anreicherung eines gewebsspezifischen Inhibitors der Lymphopoese (Lymphozytenchalon?) (1979)
    Springer
    Annals of hematology 39 (1979), S. 99-106 
    Details
    ISSN: 1432-0584
    Keywords: Lymphocyte inhibitor ; Inhibition of proliferation ; Lymphocyte chalone ; Lymphozyten-Inhibitor ; Proliferationshemmung ; Lymphozyten-Chalon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ein früher beschriebener, teilweise gereinigter Kalbsmilzextrakt weist bezüglich seiner biologischen Wirkung die Eigenschaften eines Lymphozytenchalons auf: er ist gewebsspezifisch, artunspezifisch, nicht toxisch und inhibiert die Zellproliferation reversibel. Dieser Extrakt wurde durch Ionenaustauschchromatographie mit DEAE-Sephacel aufgetrennt und liegt nun in 10 000-facher Anreicherung vor. Die aktivste Fraktion hemmte den Thymidineinbau von Phytohämagglutinin- oder Pokeweed-Mitogen-stimulierten Lymphozyten um 86% bzw. 70% in einer Konzentration von 100 ng/ml. Ehrlich-Ascites-Zellen wurden in derselben Konzentration nicht gehemmt. Der Hemmstoff wird mit anderen nicht bekanntgewordenen Lymphozyteninhibitoren verglichen.
    Notes: Summary A partially purified calf spleen extract, which exhibits the properties of a lymphocyte chalone (tissue-specific, species non-specific, non-toxic and reversible acting, endogenous inhibitor of cell proliferation) as concerning biological activities, has been described earlier. This fraction has been further purified by ion exchange chromatography with DEAE-Sephacel to a 10000-fold purification. The most active fraction inhibited3H-thymidine incorporation into phytohemagglutinin- or pokeweed-mitogen-stimulated lymphocytes by 86% resp. 70%, when given in a concentration of 100 ng/ml. Ehrlichascites-cells were not inhibited by the same concentration. The inhibiting activity is compared to other published lymphocyte inhibitors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01008085
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  • 4
    Electronic Resource
    Electronic Resource
    Water permeability of plant cuticles (1979)
    Springer
    Planta 144 (1979), S. 391-400 
    Details
    ISSN: 1432-2048
    Keywords: Citrus ; Cuticular transpiration ; Cuticles ; Permeability (water) ; Vapor saturation deficit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Using the system vapor/membrane/liquid, permeability coefficients of cuticular transpiration (P ct) were determined as functions of water activity in the vapor (a wv). Enzymatically isolated cuticular membranes (CM) of Citrus aurantium L. and nonisolated CM of onion bulb scales and eggplant fruits were investigated. P ct of Citrus and eggplant CM decreased with decreasing a wv, while permeability coefficients of CM of onion were independent of a wv. Extraction of soluble cuticular lipids (SCL) from the CM of Citrus increased permeability coefficients by a factor of approximately 500. This extraction had no effect on the dependence of P ct on a wv. Treating cuticular membranes as a resistance network consisting of SCL and the polymer matrix, it is shown that the permeability of onion CM is determined by the resistance of the SCL arranged in series with the polymer matrix. In this type of CM liquid and vapor are separated by a continuous, nonporous layer of SCL, and the driving force of transpiration is the gradient of partial pressure of water vapor across the SCL layer. In the CM of Citrus and eggplant, the SCL layer is traversed by polar pores that swell or shrink depending on a wv. However, liquid continuity is maintained across these membranes down to a wv=0.22, the lowest value used. In this type of membrane the driving force of transpiration is the water potential gradient across the membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00391583
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  • 5
    Electronic Resource
    Electronic Resource
    Contractile responses to direct stimulation of frog slow muscle fibres before and after denervation (1979)
    Springer
    Pflügers Archiv 382 (1979), S. 43-50 
    Details
    ISSN: 1432-2013
    Keywords: Slow fibres ; Contractile responses ; Effect of denervation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 1. The contractile responses of single slow muscle fibres were investigated under isometric conditions. The fibres were isolated from normal and denervated iliofibularis muscles ofRana temporaria. Direct stimulation was achieved by external application of electrical pulses or depolarizing solutions (40 mM K and acetylcholine 10\t-6 g/ml). 2. Upon electrical stimulation normal slow fibres developed contractions whose amplitude increased steadily with the strength of the pulses. These contractions did not exceed 0.22 kg/cm2, and their rates of rise and fall were approximately 1/6 of those observed in twitch fibres. During pulses of several 100 ms duration the tension continued to rise slowly until the end of the pulses. Application of 40 mM K or acetylcholine resulted in contractures which reached maximum values of 1.71 and 1.87 kg/cm2, respectively, after less than 1 min; little relaxation occurred during the following minutes. 3. The responses of slow fibres denervated for 9−76 days differed in several respects from those of normal slow fibres. a) The contractions elicited by electrical stimulation became faster but their amplitude decreased; the relationship between tension and pulse strength remained, however, essentially unchanged. b) Small and short contractions could be observed during and at the end of stimulating current pulses. Their amplitude was independent of the amplitude and duration of the stimuli; they were blocked by tetrodotoxin and must be attributed to action potentials. c) The ability to develop and maintain tension was reduced. Maximum values of K- and acetylcholine contractures were generally only 50% of those observed in normal slow fibres. Maintenance of tension was markedly reduced in some fibres, less so in others. 4. It is concluded that incorporation of Na channels into its membrane does not transform the slow fibre into a type of fibre which resembles a twitch fibre.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585902
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  • 6
    Electronic Resource
    Electronic Resource
    Disposition pharmacokinetics of bezafibrate in man (1979)
    Springer
    European journal of clinical pharmacology 16 (1979), S. 31-38 
    Details
    ISSN: 1432-1041
    Keywords: bezafibrate ; hyperlipoproteinemia ; bioavailability ; pharmacokinetics ; GC-MS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The disposition kinetics of bezafibrate, a newly developed drug of great lipid-lowering potency, were investigated in normal male subjects. Five male volunteers received14C-labelled bezafibrate orally in solution, and a further 10 were given the same dose (300 mg) of un-labelled drug as tablets. The concentration of bezafibrate in serum and urine from the latter was determined by GC, and in the former total radioactivity in serum, urine and feces was followed for 48 h, and urinary excretion products were analysed by TLC and GC-MS. Rapid absorption from the gastrointestinal tract led to peak serum levels 30 min and 2 h after administration of solution and tablets, respectively. Since approximately 95% of the administered14C-bezafibrate was excreted in urine within 48 h, and almost all the remainder was detected in feces, absorption can be regarded as complete after administration in solution. The relative optimal bioavailability from the tablets was also complete, since in both cases approximately 50% of the administered dose was detected as unchanged bezafibrate in urine within 24 h by GC in the tablet study, and by TLC in the solution study. Of the decomposition products, more than 20% of the dose was present as glucuronides and the remainder consisted of several more polar compounds, one of which was identified as a hydroxyderivative of bezafibrate. Since the apparent halflife of bezafibrate in serum was 2.1 h, this new drug possesses favourable pharmacokinetic features: rapid and complete absorption, even from tablets, combined with a conveniently short half-life, and clearance which is half renal (56 ml/min) and half metabolic (43 ml/min), giving a total clearance of 99 ml/min.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00644963
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  • 7
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1979)
    Springer
    European food research and technology 169 (1979), S. 114-115 
    Details
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01359520
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  • 8
    Electronic Resource
    Electronic Resource
    Continuous peritoneal dialysis as treatment of acute experimental pancreatitis in the rat (1979)
    Springer
    Digestive diseases and sciences 24 (1979), S. 111-116 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Continuous peritoneal dialysis significantly prolonged mean length of survival and reduced lethality rate of taurocholate-induced pancreatitis in the rat. The effect was improved by compensating protein loss due to pancreatitis and dialysis treatment. The beneficial effect of intravenous albumin treatment was enhanced when combined with dialysis treatment. Using hypothermic dialysate or adding aprotinin intraperitoneally had no additional effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01324737
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  • 9
    Electronic Resource
    Electronic Resource
    Cyclophosphamide-resistant Yoshida ascites tumor cells and their cross resistance to some alkylating agents (1979)
    Springer
    Journal of cancer research and clinical oncology 94 (1979), S. 257-263 
    Details
    ISSN: 1432-1335
    Keywords: Yoshida ascites tumor ; Cyclophosphamide ; Alkylating agents ; Resistance and cross resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A cyclophosphamide-resistant subline of a Yoshida ascites tumor was developed by giving increasing doses of the drug after transplantation. The effect of several alkylating agents on the cell proliferation of both the sensitive and resistant cell line was compared establishing dose response curves and D50 values. The developed subline revealed a 260 fold resistance to cyclophosphamide. It was completely cross-resistant to hydroperoxycyclophosphamide, whereas for triaziquone, N-oxide-mustard, and N-methyl-mustard only a partial cross resistance existed. These results give further evidence that cyclophosphamide and hydroperoxycyclophosphamide have the same mechanism of action. Regarding the other alkylating agents the results demonstrate differences concerning either the molecular mode of action or protecting effects. A decreased activation or uptake of substance is probably not the base for resistance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00419285
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  • 10
    Electronic Resource
    Electronic Resource
    Untersuchungen über die Wirkung von Bacillus thuringiensis Berliner auf die Dörrobstmotte (Plodia interpunctella Hbn.) (1979)
    Springer
    Journal of pest science 52 (1979), S. 36-39 
    Details
    ISSN: 1612-4766
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Zusammenfassung Es wurden die Sofort- und Dauerwirkung verschiedener Aufwandmengen eines Stäubemittels vonBacillus thuringiensis var.kurstaki, Serotyp 3a, 3b (THURICIDE-Sonderformulierung) mit einer Wirksamkeit von 3,2×103-internationalen Einheiten (IU) pro mg Präparat und einem Sporengehalt von 6 bis 10 Millionen pro mg, ausgebracht auf Roggen, auf Larven der Dörrobstmotte (Plodia interpunctella Hbn.) untersucht. Mit 20 mg (64 × 103 IU) Präparat pro 100g Substrat wurden 82% der Larven abgetötet, bei einer Aufwandmenge von 120 mg (384 × 103 IU) lag die Mortalität bei 99%. Die Wirksamkeit des Mittels blieb auch nach Lagerungszeiten von bis zu 5 Monaten bei Temperaturen von 12°C bis 28°C und einer relativen Luftfeuchte von ca. 75% erhalten. Sofern in behandeltem Getreide Larven überlebten, wurde eine drei- bis vierwöchige Verzögerung der Larvalentwicklung infolge derB. thuringiensis-Einwirkung festgestellt. Überlebende Falter, deren Larven sich in mitB. thuringiensis behandeltem Substrat entwickelten, waren fertil, so daß angenommen wird, daß Falter den Erreger nicht weiter übertragen.
    Notes: Abstract For testing the prompt and long-term effectiveness of a THURICIDE-dust containingBacillus thuringiensis var.kurstaki, serotype 3a, 3b with a viable spore count of 6 to 10 million per mg and an insecticidal activity of 3,2×103 international units (IU) per mg, the biopreparation was applied to rye on which larvae of the Indian Meal Moth (Plodia interpunctella Hbn.) were fed. A concentration of 20 mg (64×103 IU) of dust in 100 g of grain caused in 82% mortality, and a six-fold higher concentration (120 mg, 384 × 103 IU respectively) resulted in 99,0% mortality. The efficiency of the preparation was not reduced by storage for as long as 5 months in any five tests, which were at temperatures from 12°C to 28°C with 75% r.h. The larval stage of the surviving was prolonged by 3 to 4 weeks. Surviving moths, whose larvae were reared on grain to which the preparation was applied, were fertile and did not infest the following generation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01903165
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