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  • 1990-1994  (4)
  • 1985-1989  (3)
  • 1992  (4)
  • 1986  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Neuroendocrine effects of ipsapirone on the hypothalamic-pituitary adrenal axis: CRF, ACTH and cortisol in healthy volunteers (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 163-169 
    Details
    ISSN: 1432-1041
    Keywords: Ipsapirone ; CRF ; ACTH ; cortisol ; time series analysis ; hypothalamic-pituitary-adrenal axis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The neuroendocrine effects (changes in plasma CRF, ACTH and cortisol) of single and multiple (t.d.s. for 2 days) doses of ipsapirone (BAY Q 7821) 5 and 10 mg have been investigated in 6 healthy male volunteers. The study followed a balanced complete block, placebo-controlled and double blind design with two baseline phases (pre and post-treatment). Volunteers were investigated on identical days during 5 successive weeks. The results do not show a specific effect of ipsapirone on the hypothalamic-pituitary-adrenal axis when doses in the range of 5–30 mg per day were given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00278478
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  • 2
    Electronic Resource
    Electronic Resource
    Low antithrombin III in neonatal shock: DIC or non-specific protein depletion? (1986)
    Springer
    European journal of pediatrics 145 (1986), S. 500-503 
    Details
    ISSN: 1432-1076
    Keywords: Antithrombin III ; Albumin ; Shock
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Low antithrombin III (AT III) levels in shock are usually ascribed to disseminated intravascular coagulation (DIC). However, decreased activities of clotting factors and their inhibitors could reflect a generalised fall in plasma proteins rather than DIC. AT III and albumin were compared in 48 asphyxiated and non-asphyxiated newborn rabbits (pH6.70–7.30). Both AT III and albumin were markedly decreased in the sickest animals and there was a direct linear relationship between the two proteins (P〈0.001). Similar results were obtained in ten newborn infants suffering from shock and haemorrhagic diathesis. In all cases AT III and albumin were decreased below the normal range and significantly correlated (P〈0.01). Our findings suggest that AT III is not a useful diagnostic marker of DIC. Further, a similar fall of clottable and non-clottable proteins in shock questions the general assumption that the ensuing coagulopathy is due to intravascular coagulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02429051
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  • 3
    Electronic Resource
    Electronic Resource
    Purification and properties of a F420-nonreactive, membrane-bound hydrogenase from Methanosarcina strain Gö1 (1992)
    Springer
    Archives of microbiology 157 (1992), S. 505-511 
    Details
    ISSN: 1432-072X
    Keywords: Archaebacteria ; methanogenesis ; energy conservation ; membranes ; F420-dependent hydrogenase ; Methanosarcina
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The distribution of the F420-reactive and F420-nonreactive hydrogenases from the methylotrophic Methanosarcina strain Gö1 indicated a membrane association of the F420-nonreactive enzyme. The membrane-bound F420-nonreactive hydrogenase was purified 42-fold to electrophoretic homogeneity with a yield of 26.7%. The enzyme had a specific activity of 359 μmol H2 oxidized · min-1 · mg protein-1. The purification procedure involved dispersion of the membrane fraction with the detergent Chaps followed by anion exchange, hydrophobic and hydroxylapatite chromatography. The aerobically prepared enzyme had to be reactivated anaerobically. Maximal activity was observed at 80°C. The molecular mass as determined by native gel electrophoresis and gel filtration was 77000 and 79000, respectively. SDS gel electrophoresis revealed two polypeptides with molecular masses of 60000 and 40000 indicating a 1:1 stoichiometry. The purified enzyme contained 13.3 mol S2-, 15.1 mol Fe and 0.8 mol Ni/mol enzyme. Flavins were not detected. The amino acid sequence of the N-termini of the subunits showed a higher degree of homology to cubacterial uptake-hydrogenases than to F420-dependent hydrogenases from other methanogenic bacteria. The physiological function of the F420-nonreactive hydrogenase from Methanosarcina strain Gö1 is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00276770
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  • 4
    Electronic Resource
    Electronic Resource
    Clinical and pharmacokinetic studies on enoxacin in ear, nose and throat infections (1986)
    Springer
    Infection 14 (1986), S. S211 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 65 Patienten, die wegen Infektionen im Hals-Nasen-Ohren-Bereich mit 400 oder 600 mg Enoxacin zweimal täglich behandelt wurden, wurde die Wirksamkeit und Verträglichkeit von Enoxacin geprüft. Bei 32 der 60 auswertbaren Patienten war das klinische Gesamtergebnis nach Enoxacin-Behandlung ausgezeichnet, bei 17 Patienten gut, bei sechs mäßig und bei fünf schlecht. Drei Patientinnen klagten über Magendruck, ein Patient über leichte Übelkeit. Bei zwei Patienten traten allergische Hautreaktionen und bei einem Patienten Gelenk- und Muskelschmerzen auf. Die pharmakokinetischen Untersuchungen ergaben hohe Enoxacin-Konzentrationen in den untersuchten Sekreten, in Eiter und Geweben, insbesondere aus Mittelohr und Nasennebenhöhlen.
    Notes: Summary The efficacy and tolerance of enoxacin were tested in 65 patients treated for ear, nose and throat infections with doses of 400 or 600 mg b.i.d. The overall clinical efficacy of enoxacin was excellent in 32, good in 17, fair in six, and poor in five out of 60 evaluable patients. Three female patients complained of stomach pressure and one man of slight nausea, two of allergic skin reactions and one of arthromyalgia. The pharmacokinetic studies showed high enoxacin concentrations in the secretions, pus, and tissues studied, especially in those of the middle ear and the sinuses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01667846
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Funktionelle Biochemie des Menschen. Band 1 und 2. (Reihe: Wissenschaftliche Taschenbücher.) Von E. Hofmann. Akademie Verlag, Berlin. Band 1: 1990, 316 S., Broschur DM 16.00.  -  ISBN 3-05-500626-7; Band 2: 1991, 402 S., Broschur DM 29.80.  -  ISBN 3-05-500627-5 (1992)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 104 (1992), S. 494-495 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19921040438
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  • 6
    Electronic Resource
    Electronic Resource
    Mg2IrB2-x, ein Magnesium-Iridiumborid mit W2CoB2 -verwandter Struktur (1986)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 543 (1986), S. 89-96 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Mg2IrB2-x, a Magnesium Iridium Boride with a Structure Related to the W2CoB2-TypeThe new compound Mg2IrB2-x with a small homogeneity range determined approximately as 0,2 ≤ x ≤ 0,35 crystallizes monoclinically in the space group C2/m, Z=4 (lattice constants see Inhaltsübersicht). The structure which was solved by single crystal X-ray and powder neutron diffraction methods is related to the W2CoB2-type and contains distorted Mg4Ir2-prisms. The boron atoms are partly disordered. They are situated either inside the prisms forming pairs or with very short Ir-B distances (199 pm) on an elongated prism edge formed by two iridium atoms.
    Notes: Die neue Verbindung Mg2IrB2-x mit einem schmalen Homogenitätsbereich, der näherungsweise zu 0,2 ≤ x ≤ 0,35 bestimmt wurde, kristallisiert monoklin in der Raumgruppe C2/m, Z = 4. Bei x = 0,35 betragen die Gitterkonstanten a = 858,0(1) pm, b = 484,6(1) pm, c = 683,6(1) pm, β = 115°43′(1). Die Struktur, die mit Röntgen-Einkristall- und Pulver-Neutronenbeugungsmethoden bestimmt wurde, leitet sich vom W2CoB2-Typ ab und enthält verzerrte Mg4Ir2-Prismen. Die Boratome sind zum Teil fehlgeordnet. Sie befinden sich entweder innerhalb der Prismen und bilden Paare, oder sie liegen auf einer aufgeweiteten, aus zwei Iridiumatomen bestehenden Prismenkante, wobei sehr kurze Ir-B-Abstände ausgebildet werden (199pm).
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19865431211
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  • 7
    Electronic Resource
    Electronic Resource
    Die charakterisierung der porosität von polyacrylnitril-faserstoffen im gelzustand (1992)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 43 (1992), S. 151-158 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Measurement methods that are applicable for the characterization of porous structures, i.e. differential scanning calorimetry, low-temperature gas adsorption, mercury high pressure porosimetry, electron and light microscopy, X-ray small angle scattering, water retention value, and apparent density, are described with respect of the peculiarities of poly(acrylonitrile) fibres. The methods have been applied on differently stretched and thermally treated PAN fibres in the gel state and after dehydration, respectively. The observed effects are explained by the different stabilities of the gel fibre structure.
    Notes: Die zur Charakterisierung von Porenstrukturen anwendbaren Meßmethoden Differential-Scanning-Calorimetrie, Tieftemperatur-Gasadsorption, Quecksilber-Hochdruckporosimetrie, Elektronen- und Lichtmikroskopie, Röntgenkleinwinkelstreuung sowie Wasserrückhaltevermögen und scheinbare Dichte werden unter Berücksichtigung der Besonderheiten von Polyacrylnitrilfasern vorgestellt. Die genannten Methoden wurden auf unterschiedlich gereckte und thermisch behandelte PAN-Fasern im Gelzustand und nach Entwässerung angewendet. Die dabei auftretenden Effekte werden mit der unterschiedlichen Stabilität der Gelfaserstruktur erklärt.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1992.010430305
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